GREMLIN Database
Q97ZZ3 - Protein L-isoaspartate methyltransferase
UniProt: Q97ZZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (248)
Sequences: 1147 (705)
Seq/√Len: 44.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_L125_I6.0901.00
112_T125_I6.0521.00
27_G40_D5.6111.00
124_K152_V5.3681.00
132_E136_K4.0371.00
6_E43_I3.8751.00
6_E26_R3.6321.00
102_I167_V3.4431.00
4_L24_L3.1961.00
176_D179_N2.9331.00
106_T127_T2.6651.00
139_K143_N2.6441.00
81_L86_I2.6231.00
100_T126_Y2.6091.00
210_A213_N2.5891.00
168_D189_K2.4151.00
25_E28_K2.4091.00
46_E49_T2.3951.00
221_V250_I2.3201.00
92_T220_H2.3111.00
116_A150_R2.2031.00
135_Q155_L2.2031.00
38_F41_N2.1851.00
45_L49_T2.0710.99
129_D135_Q2.0240.99
126_Y154_K1.9390.99
120_S150_R1.8290.99
184_L194_I1.8110.99
220_H228_E1.8100.99
29_R38_F1.7930.98
96_N99_K1.7800.98
88_Y92_T1.7640.98
115_L125_I1.7170.98
88_Y222_E1.7120.98
194_I211_M1.7120.98
135_Q153_F1.6760.98
193_T253_R1.6710.97
208_Y250_I1.6600.97
156_K161_G1.6440.97
90_L95_L1.6080.97
4_L61_L1.5890.97
175_P199_P1.5840.97
136_K139_K1.5750.96
42_L61_L1.5720.96
143_N148_Q1.5690.96
24_L42_L1.5380.96
181_I184_L1.5370.96
103_E112_T1.5360.96
12_I59_A1.5290.96
132_E155_L1.5220.96
20_Y30_L1.5200.96
170_I184_L1.5060.95
198_V250_I1.5030.95
98_V123_A1.5020.95
51_L61_L1.5000.95
29_R36_V1.4890.95
185_Y216_I1.4820.95
196_I207_T1.4820.95
228_E239_R1.4810.95
26_R40_D1.4630.95
27_G39_Y1.4570.94
100_T167_V1.4480.94
128_Y164_E1.4270.94
104_A172_L1.4250.94
204_I221_V1.4210.94
211_M252_G1.4060.93
104_A158_I1.4030.93
113_I145_L1.3950.93
225_I242_G1.3650.92
188_L192_S1.3520.92
81_L89_I1.3440.92
197_F247_G1.3390.91
95_L101_V1.3340.91
111_L247_G1.3220.91
86_I90_L1.3090.90
158_I180_A1.3050.90
116_A151_I1.3040.90
112_T142_A1.2960.90
181_I210_A1.2960.90
223_E227_R1.2710.89
12_I42_L1.2600.89
102_I170_I1.2500.88
195_I251_R1.2460.88
178_W206_K1.2180.87
4_L47_Y1.1750.85
100_T124_K1.1590.84
70_Y145_L1.1570.84
229_Y248_F1.1490.84
158_I161_G1.1460.83
219_I252_G1.1340.83
182_P186_E1.1170.82
6_E25_E1.1080.81
112_T115_L1.0880.80
12_I218_D1.0880.80
142_A151_I1.0840.80
154_K163_D1.0780.80
106_T153_F1.0710.79
182_P214_S1.0700.79
92_T222_E1.0700.79
24_L39_Y1.0650.79
93_L193_T1.0580.78
168_D192_S1.0440.77
82_Y197_F1.0400.77
211_M216_I1.0350.77
41_N45_L1.0310.76
11_V68_D1.0040.74
90_L118_S1.0040.74
235_A240_N1.0010.74
104_A112_T0.9950.74
221_V231_V0.9880.73
52_T58_K0.9870.73
120_S123_A0.9790.73
65_T68_D0.9750.72
94_S145_L0.9660.72
93_L195_I0.9510.70
210_A214_S0.9500.70
202_N205_E0.9490.70
164_E187_S0.9400.69
130_I134_M0.9270.68
154_K164_E0.9250.68
181_I214_S0.9130.67
31_D36_V0.9090.67
128_Y163_D0.9080.67
204_I250_I0.8980.66
182_P210_A0.8960.66
76_R130_I0.8940.66
71_S74_L0.8930.65
70_Y113_I0.8900.65
52_T56_G0.8780.64
78_S134_M0.8760.64
42_L163_D0.8750.64
81_L171_F0.8720.64
51_L217_I0.8720.64
143_N147_V0.8700.63
116_A119_L0.8700.63
141_N145_L0.8600.63
161_G183_K0.8590.62
121_E150_R0.8540.62
208_Y219_I0.8510.62
42_L51_L0.8490.61
95_L169_A0.8490.61
198_V202_N0.8470.61
134_M141_N0.8440.61
27_G212_K0.8440.61
154_K167_V0.8430.61
174_M198_V0.8430.61
127_T153_F0.8370.60
70_Y142_A0.8350.60
90_L114_S0.8300.60
245_H252_G0.8270.59
76_R131_R0.8270.59
159_R179_N0.8260.59
68_D117_L0.8240.59
93_L169_A0.8220.59
119_L123_A0.8170.59
180_A224_L0.8130.58
47_Y72_K0.8130.58
225_I244_M0.8120.58
110_F176_D0.8090.58
24_L27_G0.8030.57
55_T58_K0.8000.57
98_V177_P0.7980.57
37_V61_L0.7960.57
88_Y220_H0.7910.56
101_V138_A0.7860.56
209_F212_K0.7840.55
131_R134_M0.7820.55
36_V54_K0.7790.55
42_L201_V0.7780.55
25_E37_V0.7750.55
100_T166_E0.7740.54
48_G108_S0.7730.54
91_T114_S0.7660.54
111_L221_V0.7620.53
174_M199_P0.7500.52
230_Q239_R0.7490.52
95_L209_F0.7450.52
129_D134_M0.7430.51
74_L120_S0.7430.51
164_E186_E0.7430.51
78_S82_Y0.7390.51
202_N251_R0.7380.51
13_W21_I0.7350.51
132_E139_K0.7330.50
116_A125_I0.7310.50
27_G128_Y0.7280.50
8_D63_K0.7250.50
238_P253_R0.7250.50
195_I244_M0.7240.50
229_Y236_I0.7240.50
84_K141_N0.7240.50
222_E228_E0.7230.49
106_T138_A0.7210.49
135_Q139_K0.7200.49
97_Q248_F0.7170.49
245_H249_I0.7150.49
237_R253_R0.7130.49
80_V177_P0.7110.48
8_D61_L0.7110.48
37_V150_R0.7100.48
112_T119_L0.7090.48
129_D155_L0.7090.48
220_H243_I0.7090.48
231_V236_I0.7080.48
98_V119_L0.7050.48
84_K131_R0.7040.48
181_I207_T0.7020.47
111_L129_D0.7020.47
106_T142_A0.6990.47
156_K162_I0.6940.47
100_T189_K0.6920.46
80_V110_F0.6890.46
88_Y224_L0.6880.46
74_L113_I0.6840.46
46_E127_T0.6810.45
72_K82_Y0.6790.45
32_T35_G0.6790.45
30_L128_Y0.6780.45
112_T116_A0.6720.45
102_I162_I0.6700.44
89_I111_L0.6680.44
185_Y214_S0.6660.44
89_I171_F0.6640.44
121_E149_D0.6640.44
32_T157_D0.6630.44
86_I114_S0.6630.44
45_L61_L0.6620.44
115_L119_L0.6620.44
128_Y166_E0.6620.44
78_S108_S0.6580.43
178_W207_T0.6570.43
49_T61_L0.6560.43
79_Q177_P0.6550.43
151_I167_V0.6530.43
131_R141_N0.6530.43
198_V207_T0.6530.43
110_F195_I0.6510.43
128_Y180_A0.6490.42
158_I172_L0.6450.42
103_E125_I0.6440.42
106_T151_I0.6440.42
90_L112_T0.6430.42
79_Q200_T0.6420.42
140_F143_N0.6410.42
175_P205_E0.6370.41
7_G189_K0.6350.41
102_I128_Y0.6330.41
104_A174_M0.6320.41
235_A242_G0.6310.41
104_A153_F0.6300.41
123_A200_T0.6300.41
9_P23_K0.6290.40
62_L206_K0.6230.40
32_T37_V0.6230.40
81_L225_I0.6210.40
84_K238_P0.6190.40
141_N200_T0.6190.40
83_P238_P0.6180.39
13_W19_V0.6170.39
175_P200_T0.6170.39
182_P248_F0.6150.39
4_L8_D0.6140.39
82_Y200_T0.6140.39
235_A239_R0.6080.39
63_K84_K0.6080.39
199_P221_V0.6080.39
140_F214_S0.6070.38
79_Q161_G0.6070.38
181_I216_I0.6070.38
28_K37_V0.6040.38
206_K212_K0.6040.38
82_Y229_Y0.6010.38
82_Y94_S0.6010.38
94_S118_S0.6010.38
30_L39_Y0.6000.38
191_S237_R0.6000.38
67_Q71_S0.6000.38
45_L51_L0.5990.38
62_L79_Q0.5990.38
12_I22_S0.5980.38
8_D44_G0.5970.38
111_L115_L0.5970.38
12_I20_Y0.5970.38
165_K186_E0.5950.37
84_K226_L0.5910.37
13_W120_S0.5900.37
114_S119_L0.5890.37
184_L187_S0.5870.37
137_V141_N0.5870.37
40_D52_T0.5850.36
171_F174_M0.5850.36
11_V21_I0.5840.36
101_V169_A0.5800.36
83_P227_R0.5790.36
142_A147_V0.5770.36
136_K140_F0.5770.36
23_K144_V0.5770.36
157_D183_K0.5770.36
208_Y231_V0.5760.36
47_Y116_A0.5760.36
8_D23_K0.5760.36
50_S58_K0.5750.36
201_V250_I0.5740.35
79_Q175_P0.5720.35
239_R243_I0.5710.35
9_P80_V0.5710.35
95_L115_L0.5650.35
158_I162_I0.5650.35
91_T189_K0.5610.34
11_V73_G0.5600.34
201_V204_I0.5580.34
140_F211_M0.5580.34
8_D87_G0.5560.34
236_I248_F0.5540.34
112_T153_F0.5520.34
116_A235_A0.5520.34
79_Q211_M0.5520.34
102_I161_G0.5510.33
162_I166_E0.5510.33
111_L185_Y0.5500.33
99_K111_L0.5490.33
19_V128_Y0.5490.33
198_V204_I0.5480.33
205_E208_Y0.5480.33
175_P197_F0.5460.33
25_E30_L0.5450.33
37_V137_V0.5450.33
81_L124_K0.5370.32
80_V104_A0.5350.32
29_R54_K0.5320.32
151_I169_A0.5310.32
14_I32_T0.5310.32
90_L149_D0.5310.32
248_F251_R0.5290.32
74_L110_F0.5290.32
29_R61_L0.5290.32
14_I20_Y0.5270.31
197_F248_F0.5260.31
9_P22_S0.5260.31
40_D213_N0.5260.31
123_A177_P0.5260.31
238_P242_G0.5250.31
31_D204_I0.5240.31
44_G49_T0.5240.31
81_L232_K0.5230.31
80_V87_G0.5220.31
78_S197_F0.5220.31
117_L172_L0.5220.31
20_Y59_A0.5210.31
92_T251_R0.5200.31
22_S213_N0.5200.31
19_V51_L0.5200.31
86_I106_T0.5190.31
80_V165_K0.5180.31
5_N46_E0.5150.30
128_Y156_K0.5130.30
103_E171_F0.5130.30
90_L159_R0.5110.30
50_S61_L0.5110.30
80_V106_T0.5100.30
53_L56_G0.5090.30
20_Y33_D0.5070.30
78_S200_T0.5070.30
57_V143_N0.5060.30
207_T252_G0.5050.30
5_N164_E0.5050.30
181_I221_V0.5040.30
188_L216_I0.5030.29
234_N237_R0.5020.29
237_R242_G0.5020.29
117_L129_D0.5010.29
128_Y154_K0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o54A 4 0.9922 100 0.433 Contact Map
1i9gA 3 0.9961 100 0.474 Contact Map
3mb5A 3 0.9844 100 0.494 Contact Map
2pwyA 3 0.9648 100 0.498 Contact Map
2b25A 3 0.9297 100 0.541 Contact Map
2yvlA 4 0.9531 100 0.589 Contact Map
1yb2A 2 0.8516 100 0.6 Contact Map
3e05A 4 0.7422 99.8 0.783 Contact Map
3ckkA 1 0.6797 99.8 0.788 Contact Map
3njrA 4 0.7109 99.8 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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