GREMLIN Database
Q97ZZ1 - Oxidoreductase
UniProt: Q97ZZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (299)
Sequences: 23870 (15438)
Seq/√Len: 892.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_R312_E3.5701.00
60_T95_K3.3701.00
98_E143_R3.0621.00
136_K177_I3.0121.00
280_K327_D2.9341.00
69_R73_V2.5791.00
33_R40_T2.5731.00
324_T327_D2.5681.00
279_S330_Y2.5561.00
132_E175_D2.5341.00
135_L172_L2.5191.00
170_R174_K2.4511.00
132_E171_S2.3571.00
274_K278_S2.2341.00
32_R43_E2.2321.00
88_K91_E2.1881.00
146_Y179_R2.1231.00
45_G77_F2.0411.00
151_M205_S2.0171.00
128_I171_S2.0081.00
325_E329_K1.9991.00
294_S328_L1.9711.00
108_T147_I1.9631.00
100_K103_N1.9401.00
59_D62_K1.9401.00
64_E99_T1.9261.00
73_V312_E1.9031.00
272_K275_E1.8911.00
279_S327_D1.8911.00
171_S174_K1.8671.00
110_I131_L1.8671.00
221_F225_E1.8261.00
275_E330_Y1.8151.00
316_K319_N1.8001.00
171_S175_D1.7991.00
73_V315_V1.7771.00
151_M230_I1.7621.00
48_V78_Y1.7591.00
69_R308_I1.7431.00
329_K333_E1.7371.00
128_I132_E1.7351.00
282_M320_L1.7051.00
290_K320_L1.6961.00
135_L150_L1.6941.00
70_A75_I1.6921.00
64_E95_K1.6871.00
107_L151_M1.6861.00
31_Y40_T1.6811.00
64_E96_V1.6641.00
110_I150_L1.6541.00
133_F137_R1.6461.00
91_E141_R1.6261.00
30_L43_E1.6181.00
283_T313_K1.6131.00
168_F171_S1.6011.00
222_L229_H1.5991.00
60_T64_E1.5901.00
106_I144_T1.5841.00
64_E68_R1.5791.00
67_I96_V1.5791.00
135_L147_I1.5761.00
137_R141_R1.5591.00
308_I312_E1.5591.00
108_T138_S1.5591.00
178_I181_Y1.5551.00
187_P190_G1.5401.00
62_K65_D1.5391.00
82_D134_A1.5141.00
282_M286_D1.4891.00
132_E136_K1.4511.00
195_G198_A1.4441.00
223_K296_K1.4381.00
330_Y333_E1.4301.00
39_I105_V1.4181.00
147_I178_I1.4131.00
71_Y104_I1.4071.00
155_P190_G1.3901.00
69_R72_E1.3701.00
188_T221_F1.3671.00
137_R140_E1.3671.00
283_T286_D1.3581.00
295_N332_G1.3581.00
282_M287_L1.3511.00
132_E168_F1.3471.00
172_L178_I1.3461.00
272_K330_Y1.3331.00
152_I169_L1.3311.00
33_R38_N1.3211.00
78_Y93_I1.3131.00
39_I180_M1.3091.00
196_I200_N1.3091.00
275_E279_S1.3061.00
76_N105_V1.2991.00
223_K297_N1.2941.00
95_K143_R1.2861.00
217_P229_H1.2861.00
209_I214_E1.2761.00
128_I167_S1.2751.00
250_D254_H1.2731.00
193_E197_E1.2711.00
215_Q218_G1.2681.00
68_R99_T1.2571.00
312_E316_K1.2481.00
271_L274_K1.2461.00
228_G300_T1.2411.00
68_R72_E1.2351.00
66_I311_L1.2341.00
309_N312_E1.2331.00
91_E95_K1.2291.00
94_A143_R1.2251.00
101_R144_T1.2211.00
290_K294_S1.2201.00
274_K284_L1.2201.00
105_V149_I1.2111.00
245_W274_K1.1991.00
193_E196_I1.1951.00
275_E278_S1.1941.00
65_D308_I1.1831.00
136_K140_E1.1771.00
212_I331_I1.1661.00
82_D130_Y1.1661.00
180_M204_E1.1611.00
169_L181_Y1.1581.00
208_Y229_H1.1581.00
61_N65_D1.1561.00
77_F107_L1.1531.00
67_I78_Y1.1511.00
48_V93_I1.1431.00
149_I205_S1.1401.00
43_E293_L1.1301.00
90_E138_S1.1291.00
292_I301_V1.1271.00
113_D125_R1.1251.00
181_Y203_Y1.1201.00
286_D316_K1.1111.00
276_F287_L1.1031.00
68_R96_V1.1001.00
220_K224_Y1.0991.00
91_E140_E1.0941.00
129_P133_F1.0931.00
65_D69_R1.0921.00
183_V203_Y1.0901.00
101_R146_Y1.0891.00
30_L321_S1.0841.00
286_D313_K1.0811.00
212_I288_A1.0811.00
167_S171_S1.0771.00
136_K175_D1.0641.00
210_Y218_G1.0551.00
191_W227_V1.0501.00
271_L275_E1.0491.00
128_I168_F1.0481.00
305_I311_L1.0461.00
73_V316_K1.0421.00
223_K298_V1.0411.00
254_H258_K1.0401.00
43_E318_E1.0341.00
42_S76_N1.0321.00
132_E135_L1.0311.00
97_L104_I1.0281.00
42_S75_I1.0231.00
142_L147_I1.0201.00
37_T204_E1.0201.00
194_E197_E1.0181.00
128_I164_E1.0151.00
77_F230_I1.0091.00
172_L177_I1.0081.00
273_L284_L1.0051.00
210_Y295_N0.9941.00
185_L232_R0.9881.00
305_I310_E0.9871.00
170_R173_K0.9861.00
326_D329_K0.9811.00
264_N268_K0.9811.00
295_N328_L0.9791.00
132_E172_L0.9661.00
130_Y133_F0.9651.00
172_L175_D0.9651.00
311_L315_V0.9561.00
62_K308_I0.9551.00
173_K204_E0.9541.00
183_V191_W0.9531.00
71_Y100_K0.9521.00
228_G299_S0.9491.00
245_W271_L0.9481.00
31_Y76_N0.9441.00
148_D179_R0.9441.00
205_S230_I0.9421.00
329_K332_G0.9381.00
167_S170_R0.9371.00
164_E167_S0.9301.00
46_I70_A0.9301.00
48_V89_G0.9271.00
293_L317_V0.9271.00
168_F172_L0.9231.00
246_P271_L0.9231.00
253_L256_S0.9091.00
254_H257_L0.9081.00
251_P255_R0.9041.00
60_T88_K0.9001.00
231_I301_V0.9001.00
154_N185_L0.8931.00
126_F152_I0.8911.00
194_E198_A0.8881.00
45_G300_T0.8871.00
193_E224_Y0.8831.00
313_K316_K0.8821.00
134_A137_R0.8781.00
131_L172_L0.8741.00
272_K334_Y0.8671.00
75_I315_V0.8631.00
67_I93_I0.8601.00
306_T310_E0.8581.00
107_L149_I0.8571.00
250_D253_L0.8551.00
309_N313_K0.8551.00
60_T92_I0.8511.00
196_I199_I0.8511.00
326_D330_Y0.8381.00
294_S325_E0.8381.00
65_D68_R0.8361.00
80_T93_I0.8351.00
268_K271_L0.8331.00
173_K201_M0.8331.00
45_G303_P0.8281.00
323_L328_L0.8251.00
267_I271_L0.8221.00
195_G199_I0.8221.00
165_I168_F0.8201.00
234_P303_P0.8181.00
71_Y103_N0.8181.00
46_I51_L0.8171.00
68_R100_K0.8161.00
268_K272_K0.8121.00
133_F136_K0.8111.00
197_E201_M0.8071.00
37_T180_M0.8061.00
212_I335_Y0.8001.00
183_V186_G0.8001.00
125_R130_Y0.7991.00
102_D146_Y0.7951.00
307_S310_E0.7911.00
139_L177_I0.7891.00
44_I293_L0.7871.00
276_F280_K0.7861.00
127_D130_Y0.7831.00
252_K255_R0.7811.00
63_A92_I0.7771.00
67_I71_Y0.7761.00
220_K223_K0.7761.00
51_L63_A0.7741.00
193_E225_E0.7731.00
252_K256_S0.7711.00
36_D226_K0.7701.00
61_N64_E0.7651.00
285_S313_K0.7631.00
100_K104_I0.7621.00
278_S281_G0.7601.00
41_V77_F0.7601.00
51_L66_I0.7551.00
166_L181_Y0.7521.00
261_K264_N0.7521.00
221_F224_Y0.7481.00
82_D141_R0.7481.00
222_L227_V0.7471.00
213_I239_V0.7471.00
294_S321_S0.7461.00
206_L222_L0.7451.00
251_P256_S0.7441.00
276_F327_D0.7441.00
198_A202_G0.7441.00
280_K324_T0.7441.00
173_K178_I0.7421.00
170_R201_M0.7401.00
251_P254_H0.7331.00
197_E200_N0.7331.00
166_L203_Y0.7331.00
162_N165_I0.7281.00
239_V270_S0.7251.00
66_I308_I0.7231.00
287_L331_I0.7211.00
95_K99_T0.7201.00
277_A287_L0.7131.00
230_I300_T0.7091.00
276_F334_Y0.7081.00
169_L173_K0.7081.00
183_V206_L0.7081.00
231_I234_P0.7081.00
82_D137_R0.7061.00
289_L317_V0.7041.00
210_Y292_I0.7041.00
118_E123_R0.7031.00
287_L320_L0.7001.00
79_D207_E0.6981.00
270_S274_K0.6971.00
151_M182_G0.6961.00
250_D255_R0.6951.00
80_T89_G0.6891.00
70_A78_Y0.6891.00
173_K181_Y0.6861.00
88_K92_I0.6831.00
34_I228_G0.6821.00
155_P186_G0.6811.00
276_F330_Y0.6781.00
245_W248_I0.6761.00
110_I126_F0.6741.00
71_Y78_Y0.6711.00
198_A201_M0.6681.00
231_I298_V0.6631.00
90_E141_R0.6591.00
30_L319_N0.6591.00
282_M290_K0.6591.00
279_S324_T0.6591.00
71_Y76_N0.6581.00
267_I270_S0.6581.00
135_L168_F0.6571.00
31_Y42_S0.6501.00
52_V89_G0.6481.00
152_I165_I0.6471.00
135_L177_I0.6471.00
110_I134_A0.6461.00
273_L331_I0.6451.00
250_D256_S0.6431.00
97_L100_K0.6431.00
45_G302_I0.6421.00
214_E217_P0.6411.00
310_E313_K0.6401.00
287_L323_L0.6401.00
78_Y97_L0.6401.00
273_L288_A0.6381.00
290_K317_V0.6371.00
87_G141_R0.6351.00
196_I225_E0.6341.00
234_P292_I0.6341.00
107_L230_I0.6341.00
193_E221_F0.6341.00
49_W233_V0.6331.00
282_M316_K0.6331.00
138_S150_L0.6331.00
126_F165_I0.6311.00
280_K287_L0.6301.00
293_L301_V0.6291.00
323_L327_D0.6291.00
113_D124_Q0.6291.00
131_L165_I0.6281.00
132_E177_I0.6251.00
90_E108_T0.6241.00
170_R181_Y0.6231.00
253_L258_K0.6231.00
149_I182_G0.6211.00
288_A292_I0.6211.00
182_G205_S0.6191.00
130_Y134_A0.6181.00
135_L139_L0.6091.00
139_L145_D0.6071.00
246_P249_S0.6061.00
66_I305_I0.6051.00
112_Y154_N0.6041.00
42_S77_F0.6031.00
150_L178_I0.6031.00
253_L257_L0.5991.00
58_A63_A0.5961.00
327_D330_Y0.5951.00
265_E268_K0.5951.00
246_P264_N0.5941.00
147_I150_L0.5931.00
239_V266_G0.5931.00
195_G202_G0.5911.00
156_K159_A0.5911.00
96_V99_T0.5901.00
195_G225_E0.5891.00
109_K153_H0.5891.00
234_P289_L0.5881.00
263_L266_G0.5881.00
77_F105_V0.5861.00
41_V300_T0.5861.00
289_L314_Y0.5841.00
83_T112_Y0.5831.00
162_N197_E0.5801.00
71_Y96_V0.5791.00
260_I263_L0.5781.00
157_M190_G0.5771.00
35_G41_V0.5751.00
260_I264_N0.5751.00
199_I202_G0.5741.00
67_I97_L0.5741.00
44_I303_P0.5711.00
170_R200_N0.5701.00
97_L106_I0.5681.00
186_G191_W0.5671.00
139_L144_T0.5661.00
287_L327_D0.5651.00
210_Y215_Q0.5651.00
286_D320_L0.5631.00
252_K258_K0.5621.00
195_G201_M0.5551.00
291_F332_G0.5551.00
85_G88_K0.5531.00
289_L303_P0.5521.00
174_K200_N0.5511.00
64_E92_I0.5501.00
308_I311_L0.5461.00
91_E143_R0.5461.00
73_V311_L0.5441.00
78_Y104_I0.5421.00
196_I202_G0.5421.00
108_T153_H0.5411.00
45_G230_I0.5401.00
255_R258_K0.5371.00
191_W206_L0.5361.00
246_P267_I0.5351.00
34_I205_S0.5341.00
189_L224_Y0.5331.00
305_I314_Y0.5331.00
118_E121_K0.5311.00
62_K309_N0.5301.00
131_L168_F0.5301.00
264_N267_I0.5291.00
231_I292_I0.5281.00
175_D178_I0.5281.00
191_W222_L0.5271.00
215_Q332_G0.5271.00
70_A311_L0.5251.00
113_D123_R0.5251.00
41_V105_V0.5251.00
303_P314_Y0.5201.00
263_L267_I0.5201.00
208_Y217_P0.5191.00
48_V80_T0.5191.00
282_M319_N0.5191.00
163_L167_S0.5181.00
44_I317_V0.5181.00
59_D63_A0.5171.00
36_D204_E0.5161.00
246_P268_K0.5161.00
214_E335_Y0.5131.00
58_A62_K0.5131.00
101_R148_D0.5101.00
139_L147_I0.5081.00
290_K321_S0.5081.00
152_I186_G0.5051.00
163_L194_E0.5051.00
81_A153_H0.5031.00
251_P257_L0.5031.00
139_L146_Y0.5021.00
233_V237_S0.5001.00
53_T88_K0.5001.00
46_I66_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.8503 100 0.233 Contact Map
4xk2A 5 0.8588 100 0.233 Contact Map
3v0sA 1 0.7599 100 0.236 Contact Map
3eauA 3 0.8616 100 0.24 Contact Map
1pz1A 1 0.8983 100 0.242 Contact Map
3n2tA 1 0.8927 100 0.242 Contact Map
1lqaA 2 0.8757 100 0.247 Contact Map
3lutA 3 0.8616 100 0.248 Contact Map
3n6qA 5 0.8559 100 0.249 Contact Map
3erpA 6 0.8418 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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