GREMLIN Database
NTPA - Non-canonical purine NTP pyrophosphatase
UniProt: Q97ZZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (181)
Sequences: 4629 (3253)
Seq/√Len: 241.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_S49_E3.3931.00
131_V160_F3.0811.00
140_R162_E2.9691.00
95_L150_I2.6871.00
81_F101_L2.6761.00
74_F111_Y2.4241.00
164_S167_E2.3991.00
43_Q53_T2.3831.00
111_Y130_I2.3231.00
97_G101_L2.3001.00
136_S159_T2.2731.00
51_S117_T2.2621.00
7_K31_E2.2621.00
158_R167_E2.2531.00
111_Y132_K2.2351.00
7_K33_E2.2131.00
76_Q109_S2.1881.00
127_F184_F2.1681.00
90_K93_I2.1501.00
75_V98_I2.0021.00
89_V101_L1.9911.00
76_Q111_Y1.9861.00
48_E128_I1.9781.00
74_F113_M1.9511.00
16_N19_I1.9071.00
136_S152_I1.9041.00
100_K103_E1.8791.00
76_Q107_D1.8541.00
113_M128_I1.8151.00
96_K139_I1.7671.00
92_T96_K1.7311.00
56_N124_I1.6811.00
92_T139_I1.6761.00
52_R56_N1.6601.00
18_F34_H1.6451.00
7_K64_R1.6301.00
23_E169_N1.6111.00
156_E167_E1.5831.00
117_T126_T1.5581.00
175_A179_A1.5361.00
40_I57_L1.4981.00
65_P118_F1.4721.00
52_R124_I1.4561.00
95_L139_I1.4521.00
136_S140_R1.4461.00
10_V21_L1.4401.00
81_F89_V1.4161.00
40_I53_T1.4161.00
176_R179_A1.4071.00
52_R126_T1.4001.00
55_A117_T1.3871.00
45_D49_E1.3851.00
56_N60_L1.3811.00
13_N36_R1.3571.00
9_G58_A1.3501.00
125_K184_F1.3261.00
134_A154_E1.3171.00
47_L74_F1.3081.00
96_K100_K1.2971.00
167_E170_R1.2831.00
48_E126_T1.2661.00
118_F181_F1.2641.00
134_A152_I1.2591.00
38_E61_I1.2321.00
152_I157_K1.2131.00
163_M167_E1.2061.00
12_T18_F1.2051.00
59_Y119_T1.1971.00
104_G137_E1.1881.00
152_I155_G1.1651.00
57_L61_I1.1621.00
47_L71_S1.1581.00
153_P163_M1.1431.00
110_A135_I1.1351.00
62_F66_L1.1341.00
99_L150_I1.1211.00
158_R163_M1.1111.00
113_M130_I1.1071.00
59_Y120_D1.0991.00
156_E171_Y1.0921.00
48_E117_T1.0871.00
180_K183_E1.0841.00
52_R117_T1.0811.00
15_E19_I1.0661.00
132_K154_E1.0561.00
58_A66_L1.0461.00
21_L116_L1.0381.00
9_G64_R1.0351.00
44_S53_T1.0271.00
155_G176_R1.0121.00
67_I116_L1.0081.00
98_I150_I1.0071.00
91_N94_G1.0021.00
73_L135_I1.0001.00
119_T124_I0.9881.00
153_P156_E0.9871.00
53_T57_L0.9751.00
67_I181_F0.9621.00
94_G97_G0.9541.00
27_N182_A0.9521.00
76_Q80_N0.9511.00
33_E37_G0.9491.00
95_L149_P0.9491.00
99_L108_R0.9481.00
156_E163_M0.9431.00
52_R119_T0.9351.00
13_N35_L0.9321.00
116_L181_F0.9321.00
46_D84_P0.9281.00
55_A119_T0.9271.00
143_L164_S0.9251.00
109_S132_K0.9211.00
56_N119_T0.9161.00
71_S114_T0.9131.00
182_A186_E0.9061.00
127_F181_F0.9031.00
153_P171_Y0.9011.00
160_F163_M0.8891.00
86_T147_F0.8881.00
9_G66_L0.8871.00
18_F22_K0.8840.99
180_K184_F0.8810.99
115_A128_I0.8720.99
179_A182_A0.8690.99
40_I58_A0.8650.99
41_E53_T0.8510.99
116_L178_F0.8510.99
77_A105_I0.8490.99
93_I96_K0.8410.99
23_E165_L0.8390.99
16_N21_L0.8390.99
141_G161_A0.8360.99
127_F180_K0.8230.99
115_A126_T0.8170.99
38_E57_L0.8030.99
18_F32_L0.7850.99
50_I84_P0.7840.99
131_V176_R0.7830.99
179_A183_E0.7790.99
94_G98_I0.7740.99
23_E26_K0.7720.99
57_L60_L0.7720.99
131_V171_Y0.7560.98
89_V97_G0.7540.98
102_L135_I0.7460.98
136_S150_I0.7450.98
90_K94_G0.7440.98
153_P160_F0.7410.98
21_L178_F0.7380.98
10_V67_I0.7370.98
99_L136_S0.7340.98
183_E186_E0.7330.98
148_D168_K0.7320.98
120_D123_I0.7310.98
153_P157_K0.7310.98
95_L98_I0.7270.98
45_D85_Y0.7240.98
109_S134_A0.7180.98
104_G108_R0.7180.98
73_L112_F0.7170.98
105_I108_R0.7160.98
19_I23_E0.7150.98
9_G62_F0.7110.98
84_P88_F0.7070.98
34_H37_G0.7070.98
159_T162_E0.7030.97
168_K172_S0.7030.97
115_A127_F0.7010.97
10_V32_L0.6980.97
21_L25_A0.6880.97
16_N91_N0.6800.97
134_A137_E0.6770.97
46_D49_E0.6770.97
45_D84_P0.6700.97
105_I109_S0.6690.97
16_N24_I0.6640.96
91_N98_I0.6620.96
19_I165_L0.6610.96
95_L99_L0.6600.96
76_Q132_K0.6590.96
142_N162_E0.6580.96
15_E36_R0.6550.96
145_F168_K0.6540.96
20_E169_N0.6510.96
176_R180_K0.6500.96
67_I118_F0.6490.96
71_S95_L0.6470.96
19_I22_K0.6470.96
47_L113_M0.6450.96
97_G100_K0.6430.96
24_I178_F0.6390.96
158_R162_E0.6390.96
15_E22_K0.6380.96
114_T177_A0.6360.95
6_V30_I0.6350.95
103_E137_E0.6340.95
129_G176_R0.6320.95
33_E36_R0.6310.95
8_I118_F0.6300.95
102_L108_R0.6280.95
145_F148_D0.6270.95
140_R152_I0.6260.95
20_E168_K0.6250.95
160_F171_Y0.6240.95
101_L104_G0.6190.95
112_F147_F0.6170.95
152_I158_R0.6140.95
112_F150_I0.6120.94
181_F185_L0.6120.94
22_K31_E0.6100.94
13_N38_E0.6070.94
59_Y65_P0.6060.94
24_I165_L0.6050.94
170_R175_A0.6030.94
24_I116_L0.5990.94
112_F160_F0.5990.94
139_I149_P0.5930.93
152_I156_E0.5920.93
60_L63_R0.5860.93
39_K54_A0.5830.93
43_Q84_P0.5770.93
59_Y66_L0.5760.92
51_S126_T0.5750.92
140_R159_T0.5740.92
118_F125_K0.5710.92
35_L58_A0.5710.92
99_L102_L0.5650.92
47_L72_G0.5650.92
169_N172_S0.5630.92
63_R66_L0.5580.91
22_K26_K0.5560.91
79_Q82_P0.5510.91
23_E166_E0.5510.91
13_N40_I0.5490.91
42_I50_I0.5480.91
92_T95_L0.5460.90
42_I88_F0.5450.90
74_F80_N0.5440.90
154_E157_K0.5440.90
93_I97_G0.5440.90
22_K37_G0.5430.90
28_F186_E0.5430.90
21_L67_I0.5420.90
158_R164_S0.5410.90
135_I150_I0.5400.90
161_A169_N0.5390.90
108_R135_I0.5360.90
48_E115_A0.5330.89
140_R158_R0.5300.89
128_I180_K0.5300.89
107_D134_A0.5290.89
108_R136_S0.5270.89
15_E18_F0.5250.89
75_V110_A0.5250.89
91_N95_L0.5230.88
20_E174_R0.5190.88
139_I150_I0.5190.88
13_N58_A0.5160.88
143_L165_L0.5150.88
15_E37_G0.5140.88
144_G148_D0.5120.87
119_T122_K0.5120.87
75_V150_I0.5110.87
145_F149_P0.5080.87
141_G145_F0.5070.87
6_V31_E0.5070.87
24_I169_N0.5070.87
8_I67_I0.5040.87
65_P120_D0.5040.87
69_D116_L0.5030.86
43_Q85_Y0.5000.86
115_A129_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v7rA 1 0.9688 100 0.052 Contact Map
1b78A 2 0.9479 100 0.071 Contact Map
1k7kA 1 0.974 100 0.085 Contact Map
2carA 2 0.9792 100 0.086 Contact Map
1vp2A 3 0.9479 100 0.092 Contact Map
3tquA 2 0.9583 100 0.122 Contact Map
4bnqA 2 0.9583 100 0.154 Contact Map
2amhA 1 0.8229 94.4 0.907 Contact Map
4jhcA 2 0.7865 94.1 0.908 Contact Map
4p0eA 2 0.7865 93.4 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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