GREMLIN Database
KAE1 - tRNA N6-adenosine threonylcarbamoyltransferase
UniProt: Q97ZY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (313)
Sequences: 4237 (2357)
Seq/√Len: 133.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_F145_R3.9671.00
5_G296_A3.2151.00
120_T284_P3.1651.00
202_Q247_L3.1041.00
75_A299_G2.9981.00
59_R63_K2.9911.00
112_G295_I2.9431.00
189_G224_D2.7861.00
19_R24_Y2.7671.00
165_V178_G2.7631.00
74_I96_I2.5671.00
2_F66_I2.5181.00
57_L92_L2.4841.00
171_A181_V2.4641.00
141_F147_R2.4071.00
76_V104_L2.3881.00
231_E264_S2.3271.00
183_D263_V2.3271.00
195_L216_V2.2641.00
252_E279_Q2.2641.00
2_F19_R2.2301.00
214_L218_G2.1781.00
270_E274_K2.1611.00
71_I102_K2.1521.00
68_I100_Y2.1191.00
164_F213_A2.0191.00
246_A276_W2.0041.00
229_V233_A1.9821.00
197_Y235_D1.9741.00
245_L253_L1.9701.00
187_E263_V1.9641.00
15_V56_I1.9611.00
9_T77_A1.9361.00
300_M304_S1.9301.00
29_E59_R1.9261.00
182_I226_C1.9241.00
241_T253_L1.9081.00
48_H51_E1.9081.00
58_R62_E1.8431.00
193_L216_V1.8351.00
97_A104_L1.8241.00
15_V57_L1.8141.00
112_G298_A1.7951.00
215_R218_G1.7721.00
76_V90_A1.7671.00
3_V73_Y1.7621.00
29_E63_K1.7611.00
164_F229_V1.7511.00
127_L140_T1.7231.00
68_I96_I1.7101.00
181_V184_I1.7061.00
5_G299_G1.6821.00
110_G130_Y1.6571.00
157_L233_A1.6481.00
268_K271_E1.6471.00
68_I71_I1.6311.00
73_Y303_A1.6281.00
196_P212_A1.6191.00
197_Y232_I1.6001.00
245_L278_V1.5941.00
72_N102_K1.5921.00
188_K223_E1.5911.00
61_L68_I1.5911.00
153_L203_D1.5551.00
227_Y231_E1.5431.00
185_C222_L1.5391.00
20_D300_M1.5361.00
29_E56_I1.5241.00
242_E272_L1.5231.00
111_I146_F1.5081.00
238_L268_K1.5051.00
273_G280_I1.5041.00
195_L212_A1.5031.00
142_Y145_R1.4991.00
185_C223_E1.4621.00
255_I282_I1.4571.00
195_L225_I1.4461.00
264_S268_K1.4281.00
167_E214_L1.4281.00
183_D230_R1.4221.00
93_A104_L1.4111.00
27_A60_A1.3821.00
28_N286_E1.3801.00
6_I89_G1.3801.00
31_D52_V1.3781.00
213_A229_V1.3511.00
302_A307_V1.3501.00
180_H184_I1.3481.00
149_F248_T1.3351.00
95_A99_K1.3201.00
138_I241_T1.3171.00
231_E268_K1.3151.00
3_V75_A1.3041.00
234_F268_K1.3001.00
25_I287_F1.3001.00
209_L233_A1.2951.00
131_L265_L1.2921.00
19_R26_L1.2621.00
14_G292_G1.2581.00
17_I60_A1.2501.00
264_S267_K1.2461.00
297_Y301_L1.2411.00
267_K271_E1.2331.00
67_S70_D1.2291.00
17_I27_A1.2271.00
125_D143_K1.2261.00
28_N60_A1.2241.00
14_G30_R1.2231.00
252_E281_K1.2201.00
234_F265_L1.2151.00
5_G292_G1.2071.00
184_I188_K1.2051.00
192_L224_D1.2041.00
142_Y305_K1.2001.00
3_V303_A1.1980.99
2_F17_I1.1890.99
190_N224_D1.1880.99
117_G254_M1.1820.99
12_T34_I1.1780.99
106_P309_I1.1570.99
261_A285_P1.1490.99
127_L254_M1.1460.99
200_K243_R1.1430.99
61_L66_I1.1400.99
271_E275_E1.1400.99
73_Y105_V1.1400.99
230_R264_S1.1390.99
155_I210_L1.1380.99
138_I204_M1.1360.99
118_Y301_L1.1330.99
213_A225_I1.1320.99
272_L275_E1.1310.99
183_D187_E1.1300.99
184_I187_E1.1290.99
20_D304_S1.1270.99
27_A64_A1.1240.99
272_L276_W1.1200.99
60_A64_A1.1160.99
167_E217_V1.1060.99
241_T269_L1.1060.99
29_E60_A1.1040.99
76_V93_A1.0960.99
21_S300_M1.0950.99
83_G316_I1.0910.99
128_I248_T1.0890.99
242_E276_W1.0870.99
190_N227_Y1.0840.99
215_R219_K1.0820.99
74_I97_A1.0780.99
92_L95_A1.0700.99
150_G244_A1.0640.99
78_L106_P1.0590.99
66_I70_D1.0500.99
181_V185_C1.0500.99
6_I57_L1.0420.99
96_I100_Y1.0330.98
217_V225_I1.0240.98
17_I71_I1.0240.98
238_L272_L1.0200.98
197_Y236_M1.0160.98
164_F167_E1.0150.98
185_C188_K1.0100.98
268_K272_L1.0070.98
191_K231_E1.0010.98
222_L226_C1.0000.98
301_L304_S1.0000.98
197_Y239_E0.9930.98
192_L228_S0.9890.98
235_D268_K0.9890.98
17_I66_I0.9880.98
303_A308_F0.9830.98
124_R252_E0.9810.98
2_F72_N0.9710.98
16_G292_G0.9670.98
227_Y230_R0.9660.98
83_G318_P0.9650.98
137_I151_E0.9630.98
239_E243_R0.9590.98
148_V151_E0.9590.98
18_V297_Y0.9560.98
79_G108_N0.9550.97
189_G227_Y0.9540.97
255_I269_L0.9540.97
71_I100_Y0.9530.97
187_E267_K0.9520.97
185_C226_C0.9510.97
168_V217_V0.9490.97
308_F312_D0.9470.97
201_G247_L0.9410.97
53_S92_L0.9390.97
15_V60_A0.9360.97
69_N100_Y0.9360.97
183_D264_S0.9320.97
242_E275_E0.9270.97
121_T279_Q0.9240.97
161_M183_D0.9240.97
242_E246_A0.9220.97
231_E235_D0.9170.97
232_I236_M0.9150.97
117_G256_V0.9150.97
317_R320_W0.9140.97
26_L66_I0.9140.97
111_I144_G0.9120.97
91_T95_A0.9110.97
304_S307_V0.9110.97
284_P287_F0.9070.97
90_A94_R0.9060.97
106_P314_S0.9060.97
193_L224_D0.9050.97
157_L237_L0.9040.97
28_N293_A0.9030.96
273_G278_V0.8910.96
90_A316_I0.8890.96
74_I102_K0.8840.96
253_L273_G0.8820.96
123_A127_L0.8810.96
118_Y297_Y0.8790.96
192_L221_K0.8780.96
139_T148_V0.8750.96
104_L314_S0.8670.96
201_G243_R0.8660.96
105_V308_F0.8640.95
54_A92_L0.8630.95
62_E65_K0.8620.95
115_E297_Y0.8560.95
78_L317_R0.8530.95
111_I302_A0.8510.95
139_T146_F0.8480.95
115_E143_K0.8450.95
14_G28_N0.8390.95
46_L84_P0.8330.94
105_V303_A0.8300.94
15_V29_E0.8290.94
224_D228_S0.8270.94
267_K270_E0.8250.94
168_V222_L0.8240.94
270_E280_I0.8190.94
202_Q243_R0.8180.94
137_I148_V0.8160.94
157_L206_F0.8130.94
74_I100_Y0.8100.94
43_G47_K0.8090.94
197_Y231_E0.8080.94
168_V226_C0.8010.93
261_A289_G0.7990.93
161_M230_R0.7980.93
195_L209_L0.7910.93
131_L237_L0.7900.93
97_A102_K0.7900.93
236_M240_A0.7860.93
96_I102_K0.7860.93
270_E282_I0.7860.93
238_L241_T0.7830.92
170_L185_C0.7830.92
115_E146_F0.7810.92
115_E298_A0.7780.92
159_N210_L0.7770.92
251_K279_Q0.7770.92
27_A63_K0.7750.92
160_M229_V0.7720.92
43_G84_P0.7660.92
242_E245_L0.7650.92
165_V171_A0.7590.91
12_T172_P0.7580.91
73_Y106_P0.7570.91
164_F168_V0.7540.91
119_L293_A0.7520.91
59_R62_E0.7480.91
245_L248_T0.7460.91
194_K228_S0.7450.90
206_F233_A0.7440.90
18_V25_I0.7440.90
221_K224_D0.7430.90
212_A216_V0.7390.90
83_G86_L0.7350.90
15_V292_G0.7280.89
12_T85_A0.7260.89
245_L272_L0.7240.89
302_A308_F0.7210.89
161_M229_V0.7200.89
90_A104_L0.7190.89
12_T32_T0.7180.89
166_R226_C0.7160.89
94_R104_L0.7140.89
128_I250_K0.7120.88
224_D227_Y0.7080.88
8_S13_F0.7050.88
74_I93_A0.7040.88
115_E127_L0.7040.88
157_L209_L0.7030.88
18_V296_A0.7010.88
66_I71_I0.7000.88
6_I15_V0.7000.88
114_I130_Y0.6960.87
25_I293_A0.6960.87
78_L320_W0.6940.87
260_A288_A0.6920.87
21_S24_Y0.6910.87
299_G303_A0.6840.86
87_R316_I0.6820.86
78_L314_S0.6750.86
10_A40_M0.6750.86
130_Y137_I0.6740.86
57_L96_I0.6720.85
30_R286_E0.6710.85
269_L280_I0.6700.85
128_I245_L0.6690.85
309_I312_D0.6690.85
26_L60_A0.6690.85
234_F264_S0.6680.85
242_E273_G0.6680.85
28_N287_F0.6670.85
199_V236_M0.6670.85
189_G228_S0.6660.85
183_D234_F0.6630.85
150_G203_D0.6590.84
37_E44_D0.6580.84
116_I256_V0.6580.84
18_V73_Y0.6570.84
82_I173_P0.6560.84
53_S88_V0.6560.84
8_S89_G0.6540.84
129_L241_T0.6520.84
32_T40_M0.6510.84
6_I53_S0.6500.83
79_G320_W0.6470.83
155_I159_N0.6450.83
68_I102_K0.6430.83
309_I314_S0.6410.83
164_F233_A0.6410.83
149_F247_L0.6410.83
235_D239_E0.6410.83
25_I296_A0.6400.82
238_L269_L0.6350.82
3_V299_G0.6340.82
19_R22_P0.6320.82
18_V24_Y0.6300.82
159_N163_V0.6300.82
76_V89_G0.6270.81
69_N102_K0.6240.81
73_Y299_G0.6220.81
78_L90_A0.6220.81
54_A292_G0.6200.80
117_G255_I0.6200.80
191_K228_S0.6200.80
31_D56_I0.6190.80
230_R262_S0.6190.80
212_A215_R0.6180.80
232_I235_D0.6180.80
127_L143_K0.6170.80
15_V27_A0.6170.80
153_L199_V0.6170.80
20_D24_Y0.6160.80
76_V314_S0.6160.80
160_M210_L0.6160.80
260_A284_P0.6150.80
46_L88_V0.6150.80
161_M182_I0.6110.80
271_E274_K0.6100.79
90_A314_S0.6090.79
307_V310_D0.6090.79
107_V298_A0.6070.79
220_E223_E0.6070.79
105_V309_I0.6030.79
43_G46_L0.6000.78
18_V21_S0.5980.78
25_I28_N0.5960.78
202_Q248_T0.5960.78
12_T30_R0.5950.78
216_V225_I0.5940.78
85_A108_N0.5910.77
115_E118_Y0.5900.77
87_R91_T0.5890.77
2_F5_G0.5880.77
30_R289_G0.5850.77
273_G276_W0.5840.76
121_T281_K0.5820.76
2_F71_I0.5820.76
154_D205_S0.5810.76
297_Y300_M0.5800.76
72_N308_F0.5780.76
123_A281_K0.5760.75
169_S222_L0.5750.75
114_I256_V0.5740.75
243_R247_L0.5730.75
193_L221_K0.5720.75
8_S53_S0.5720.75
17_I64_A0.5710.75
110_G137_I0.5710.75
47_K173_P0.5690.75
92_L96_I0.5670.74
52_V55_T0.5670.74
143_K304_S0.5660.74
22_P122_E0.5660.74
110_G139_T0.5660.74
220_E224_D0.5650.74
266_R282_I0.5640.74
138_I244_A0.5630.74
310_D314_S0.5630.74
199_V203_D0.5620.74
9_T292_G0.5600.73
108_N111_I0.5600.73
61_L100_Y0.5590.73
189_G193_L0.5590.73
228_S231_E0.5570.73
127_L252_E0.5570.73
119_L254_M0.5570.73
216_V219_K0.5540.73
199_V240_A0.5540.73
242_E278_V0.5520.72
249_S281_K0.5520.72
143_K301_L0.5510.72
5_G110_G0.5510.72
82_I210_L0.5500.72
17_I61_L0.5500.72
155_I160_M0.5500.72
27_A61_L0.5500.72
35_P171_A0.5490.72
150_G202_Q0.5490.72
115_E125_D0.5470.72
120_T287_F0.5470.72
165_V289_G0.5440.71
4_L15_V0.5430.71
101_N271_E0.5420.71
19_R300_M0.5380.70
118_Y125_D0.5350.70
8_S31_D0.5350.70
130_Y135_N0.5350.70
146_F302_A0.5320.70
147_R248_T0.5320.70
210_L214_L0.5320.70
43_G173_P0.5310.69
95_A100_Y0.5300.69
2_F26_L0.5300.69
128_I253_L0.5290.69
8_S135_N0.5280.69
131_L136_T0.5270.69
296_A299_G0.5230.68
44_D47_K0.5220.68
82_I159_N0.5200.68
287_F297_Y0.5200.68
128_I241_T0.5190.68
192_L227_Y0.5190.68
211_T215_R0.5150.67
253_L280_I0.5140.67
153_L201_G0.5140.67
140_T254_M0.5140.67
48_H151_E0.5140.67
262_S288_A0.5140.67
114_I139_T0.5120.67
263_V266_R0.5100.66
107_V295_I0.5100.66
125_D140_T0.5090.66
74_I104_L0.5090.66
61_L67_S0.5090.66
123_A252_E0.5090.66
241_T245_L0.5080.66
270_E278_V0.5070.66
32_T172_P0.5070.66
50_A83_G0.5060.66
48_H52_V0.5060.66
171_A178_G0.5060.66
12_T50_A0.5050.66
202_Q244_A0.5050.66
193_L225_I0.5050.66
25_I119_L0.5030.65
251_K278_V0.5020.65
236_M243_R0.5020.65
204_M240_A0.5010.65
144_G302_A0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3en9A 1 0.9758 100 0.32 Contact Map
4k25A 2 0.9426 100 0.381 Contact Map
2ivnA 1 0.9758 100 0.425 Contact Map
3zeuB 1 0.9728 100 0.433 Contact Map
3enoA 1 0.9789 100 0.435 Contact Map
3venA 1 0.9335 100 0.481 Contact Map
3vthA 1 0.8459 100 0.599 Contact Map
4g9iA 1 0.8792 100 0.616 Contact Map
3ttcA 1 0.8278 100 0.629 Contact Map
4m7xA 2 0.7613 100 0.689 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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