KAE1 - SULSO - GREMLIN Contacts

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KAE1 - tRNA N6-adenosine threonylcarbamoyltransferase

UniProt:	Q97ZY8	Sequences: MFVLGIESTAHTFGVGIVRDSPPYILANERDTFIPKEGGMKPGDLLKHHAEVSATILRRALEKAKISINDINYIAVALGPGIGPALRVGATLARAIALKYNKKLVPVNHGIGHIEIGYLTTEARDPLILYLSGGNTIITTFYKGRFRVFGETLDIALGNMMDVFVREVSLAPPYIINGIHVIDICAEKGNKLLKLPYVVKGQDMSFSGLLTAALRVVGKEKLEDICYSVREIAFDMLLEATERALALTSKKELMIVGGVAASVSLRKKLEELGKEWNVQIKIVPPEFAGDNGAMIAYAGMLAASKGVFIDVDKSYIRPRWRVDEVDIPWRN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	331 (313)
Sequences:	4237 (2357)
Seq/√Len:	133.2

ECOLI - TSAD
BACSU - TSAD
HALSA - KAE1B
SULSO - KAE1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_F	145_R	3.967	1.00
5_G	296_A	3.215	1.00
120_T	284_P	3.165	1.00
202_Q	247_L	3.104	1.00
75_A	299_G	2.998	1.00
59_R	63_K	2.991	1.00
112_G	295_I	2.943	1.00
189_G	224_D	2.786	1.00
19_R	24_Y	2.767	1.00
165_V	178_G	2.763	1.00
74_I	96_I	2.567	1.00
2_F	66_I	2.518	1.00
57_L	92_L	2.484	1.00
171_A	181_V	2.464	1.00
141_F	147_R	2.407	1.00
76_V	104_L	2.388	1.00
231_E	264_S	2.327	1.00
183_D	263_V	2.327	1.00
195_L	216_V	2.264	1.00
252_E	279_Q	2.264	1.00
2_F	19_R	2.230	1.00
214_L	218_G	2.178	1.00
270_E	274_K	2.161	1.00
71_I	102_K	2.152	1.00
68_I	100_Y	2.119	1.00
164_F	213_A	2.019	1.00
246_A	276_W	2.004	1.00
229_V	233_A	1.982	1.00
197_Y	235_D	1.974	1.00
245_L	253_L	1.970	1.00
187_E	263_V	1.964	1.00
15_V	56_I	1.961	1.00
9_T	77_A	1.936	1.00
300_M	304_S	1.930	1.00
29_E	59_R	1.926	1.00
182_I	226_C	1.924	1.00
241_T	253_L	1.908	1.00
48_H	51_E	1.908	1.00
58_R	62_E	1.843	1.00
193_L	216_V	1.835	1.00
97_A	104_L	1.824	1.00
15_V	57_L	1.814	1.00
112_G	298_A	1.795	1.00
215_R	218_G	1.772	1.00
76_V	90_A	1.767	1.00
3_V	73_Y	1.762	1.00
29_E	63_K	1.761	1.00
164_F	229_V	1.751	1.00
127_L	140_T	1.723	1.00
68_I	96_I	1.710	1.00
181_V	184_I	1.706	1.00
5_G	299_G	1.682	1.00
110_G	130_Y	1.657	1.00
157_L	233_A	1.648	1.00
268_K	271_E	1.647	1.00
68_I	71_I	1.631	1.00
73_Y	303_A	1.628	1.00
196_P	212_A	1.619	1.00
197_Y	232_I	1.600	1.00
245_L	278_V	1.594	1.00
72_N	102_K	1.592	1.00
188_K	223_E	1.591	1.00
61_L	68_I	1.591	1.00
153_L	203_D	1.555	1.00
227_Y	231_E	1.543	1.00
185_C	222_L	1.539	1.00
20_D	300_M	1.536	1.00
29_E	56_I	1.524	1.00
242_E	272_L	1.523	1.00
111_I	146_F	1.508	1.00
238_L	268_K	1.505	1.00
273_G	280_I	1.504	1.00
195_L	212_A	1.503	1.00
142_Y	145_R	1.499	1.00
185_C	223_E	1.462	1.00
255_I	282_I	1.457	1.00
195_L	225_I	1.446	1.00
264_S	268_K	1.428	1.00
167_E	214_L	1.428	1.00
183_D	230_R	1.422	1.00
93_A	104_L	1.411	1.00
27_A	60_A	1.382	1.00
28_N	286_E	1.380	1.00
6_I	89_G	1.380	1.00
31_D	52_V	1.378	1.00
213_A	229_V	1.351	1.00
302_A	307_V	1.350	1.00
180_H	184_I	1.348	1.00
149_F	248_T	1.335	1.00
95_A	99_K	1.320	1.00
138_I	241_T	1.317	1.00
231_E	268_K	1.315	1.00
3_V	75_A	1.304	1.00
234_F	268_K	1.300	1.00
25_I	287_F	1.300	1.00
209_L	233_A	1.295	1.00
131_L	265_L	1.292	1.00
19_R	26_L	1.262	1.00
14_G	292_G	1.258	1.00
17_I	60_A	1.250	1.00
264_S	267_K	1.246	1.00
297_Y	301_L	1.241	1.00
267_K	271_E	1.233	1.00
67_S	70_D	1.229	1.00
17_I	27_A	1.227	1.00
125_D	143_K	1.226	1.00
28_N	60_A	1.224	1.00
14_G	30_R	1.223	1.00
252_E	281_K	1.220	1.00
234_F	265_L	1.215	1.00
5_G	292_G	1.207	1.00
184_I	188_K	1.205	1.00
192_L	224_D	1.204	1.00
142_Y	305_K	1.200	1.00
3_V	303_A	1.198	0.99
2_F	17_I	1.189	0.99
190_N	224_D	1.188	0.99
117_G	254_M	1.182	0.99
12_T	34_I	1.178	0.99
106_P	309_I	1.157	0.99
261_A	285_P	1.149	0.99
127_L	254_M	1.146	0.99
200_K	243_R	1.143	0.99
61_L	66_I	1.140	0.99
271_E	275_E	1.140	0.99
73_Y	105_V	1.140	0.99
230_R	264_S	1.139	0.99
155_I	210_L	1.138	0.99
138_I	204_M	1.136	0.99
118_Y	301_L	1.133	0.99
213_A	225_I	1.132	0.99
272_L	275_E	1.131	0.99
183_D	187_E	1.130	0.99
184_I	187_E	1.129	0.99
20_D	304_S	1.127	0.99
27_A	64_A	1.124	0.99
272_L	276_W	1.120	0.99
60_A	64_A	1.116	0.99
167_E	217_V	1.106	0.99
241_T	269_L	1.106	0.99
29_E	60_A	1.104	0.99
76_V	93_A	1.096	0.99
21_S	300_M	1.095	0.99
83_G	316_I	1.091	0.99
128_I	248_T	1.089	0.99
242_E	276_W	1.087	0.99
190_N	227_Y	1.084	0.99
215_R	219_K	1.082	0.99
74_I	97_A	1.078	0.99
92_L	95_A	1.070	0.99
150_G	244_A	1.064	0.99
78_L	106_P	1.059	0.99
66_I	70_D	1.050	0.99
181_V	185_C	1.050	0.99
6_I	57_L	1.042	0.99
96_I	100_Y	1.033	0.98
217_V	225_I	1.024	0.98
17_I	71_I	1.024	0.98
238_L	272_L	1.020	0.98
197_Y	236_M	1.016	0.98
164_F	167_E	1.015	0.98
185_C	188_K	1.010	0.98
268_K	272_L	1.007	0.98
191_K	231_E	1.001	0.98
222_L	226_C	1.000	0.98
301_L	304_S	1.000	0.98
197_Y	239_E	0.993	0.98
192_L	228_S	0.989	0.98
235_D	268_K	0.989	0.98
17_I	66_I	0.988	0.98
303_A	308_F	0.983	0.98
124_R	252_E	0.981	0.98
2_F	72_N	0.971	0.98
16_G	292_G	0.967	0.98
227_Y	230_R	0.966	0.98
83_G	318_P	0.965	0.98
137_I	151_E	0.963	0.98
239_E	243_R	0.959	0.98
148_V	151_E	0.959	0.98
18_V	297_Y	0.956	0.98
79_G	108_N	0.955	0.97
189_G	227_Y	0.954	0.97
255_I	269_L	0.954	0.97
71_I	100_Y	0.953	0.97
187_E	267_K	0.952	0.97
185_C	226_C	0.951	0.97
168_V	217_V	0.949	0.97
308_F	312_D	0.947	0.97
201_G	247_L	0.941	0.97
53_S	92_L	0.939	0.97
15_V	60_A	0.936	0.97
69_N	100_Y	0.936	0.97
183_D	264_S	0.932	0.97
242_E	275_E	0.927	0.97
121_T	279_Q	0.924	0.97
161_M	183_D	0.924	0.97
242_E	246_A	0.922	0.97
231_E	235_D	0.917	0.97
232_I	236_M	0.915	0.97
117_G	256_V	0.915	0.97
317_R	320_W	0.914	0.97
26_L	66_I	0.914	0.97
111_I	144_G	0.912	0.97
91_T	95_A	0.911	0.97
304_S	307_V	0.911	0.97
284_P	287_F	0.907	0.97
90_A	94_R	0.906	0.97
106_P	314_S	0.906	0.97
193_L	224_D	0.905	0.97
157_L	237_L	0.904	0.97
28_N	293_A	0.903	0.96
273_G	278_V	0.891	0.96
90_A	316_I	0.889	0.96
74_I	102_K	0.884	0.96
253_L	273_G	0.882	0.96
123_A	127_L	0.881	0.96
118_Y	297_Y	0.879	0.96
192_L	221_K	0.878	0.96
139_T	148_V	0.875	0.96
104_L	314_S	0.867	0.96
201_G	243_R	0.866	0.96
105_V	308_F	0.864	0.95
54_A	92_L	0.863	0.95
62_E	65_K	0.862	0.95
115_E	297_Y	0.856	0.95
78_L	317_R	0.853	0.95
111_I	302_A	0.851	0.95
139_T	146_F	0.848	0.95
115_E	143_K	0.845	0.95
14_G	28_N	0.839	0.95
46_L	84_P	0.833	0.94
105_V	303_A	0.830	0.94
15_V	29_E	0.829	0.94
224_D	228_S	0.827	0.94
267_K	270_E	0.825	0.94
168_V	222_L	0.824	0.94
270_E	280_I	0.819	0.94
202_Q	243_R	0.818	0.94
137_I	148_V	0.816	0.94
157_L	206_F	0.813	0.94
74_I	100_Y	0.810	0.94
43_G	47_K	0.809	0.94
197_Y	231_E	0.808	0.94
168_V	226_C	0.801	0.93
261_A	289_G	0.799	0.93
161_M	230_R	0.798	0.93
195_L	209_L	0.791	0.93
131_L	237_L	0.790	0.93
97_A	102_K	0.790	0.93
236_M	240_A	0.786	0.93
96_I	102_K	0.786	0.93
270_E	282_I	0.786	0.93
238_L	241_T	0.783	0.92
170_L	185_C	0.783	0.92
115_E	146_F	0.781	0.92
115_E	298_A	0.778	0.92
159_N	210_L	0.777	0.92
251_K	279_Q	0.777	0.92
27_A	63_K	0.775	0.92
160_M	229_V	0.772	0.92
43_G	84_P	0.766	0.92
242_E	245_L	0.765	0.92
165_V	171_A	0.759	0.91
12_T	172_P	0.758	0.91
73_Y	106_P	0.757	0.91
164_F	168_V	0.754	0.91
119_L	293_A	0.752	0.91
59_R	62_E	0.748	0.91
245_L	248_T	0.746	0.91
194_K	228_S	0.745	0.90
206_F	233_A	0.744	0.90
18_V	25_I	0.744	0.90
221_K	224_D	0.743	0.90
212_A	216_V	0.739	0.90
83_G	86_L	0.735	0.90
15_V	292_G	0.728	0.89
12_T	85_A	0.726	0.89
245_L	272_L	0.724	0.89
302_A	308_F	0.721	0.89
161_M	229_V	0.720	0.89
90_A	104_L	0.719	0.89
12_T	32_T	0.718	0.89
166_R	226_C	0.716	0.89
94_R	104_L	0.714	0.89
128_I	250_K	0.712	0.88
224_D	227_Y	0.708	0.88
8_S	13_F	0.705	0.88
74_I	93_A	0.704	0.88
115_E	127_L	0.704	0.88
157_L	209_L	0.703	0.88
18_V	296_A	0.701	0.88
66_I	71_I	0.700	0.88
6_I	15_V	0.700	0.88
114_I	130_Y	0.696	0.87
25_I	293_A	0.696	0.87
78_L	320_W	0.694	0.87
260_A	288_A	0.692	0.87
21_S	24_Y	0.691	0.87
299_G	303_A	0.684	0.86
87_R	316_I	0.682	0.86
78_L	314_S	0.675	0.86
10_A	40_M	0.675	0.86
130_Y	137_I	0.674	0.86
57_L	96_I	0.672	0.85
30_R	286_E	0.671	0.85
269_L	280_I	0.670	0.85
128_I	245_L	0.669	0.85
309_I	312_D	0.669	0.85
26_L	60_A	0.669	0.85
234_F	264_S	0.668	0.85
242_E	273_G	0.668	0.85
28_N	287_F	0.667	0.85
199_V	236_M	0.667	0.85
189_G	228_S	0.666	0.85
183_D	234_F	0.663	0.85
150_G	203_D	0.659	0.84
37_E	44_D	0.658	0.84
116_I	256_V	0.658	0.84
18_V	73_Y	0.657	0.84
82_I	173_P	0.656	0.84
53_S	88_V	0.656	0.84
8_S	89_G	0.654	0.84
129_L	241_T	0.652	0.84
32_T	40_M	0.651	0.84
6_I	53_S	0.650	0.83
79_G	320_W	0.647	0.83
155_I	159_N	0.645	0.83
68_I	102_K	0.643	0.83
309_I	314_S	0.641	0.83
164_F	233_A	0.641	0.83
149_F	247_L	0.641	0.83
235_D	239_E	0.641	0.83
25_I	296_A	0.640	0.82
238_L	269_L	0.635	0.82
3_V	299_G	0.634	0.82
19_R	22_P	0.632	0.82
18_V	24_Y	0.630	0.82
159_N	163_V	0.630	0.82
76_V	89_G	0.627	0.81
69_N	102_K	0.624	0.81
73_Y	299_G	0.622	0.81
78_L	90_A	0.622	0.81
54_A	292_G	0.620	0.80
117_G	255_I	0.620	0.80
191_K	228_S	0.620	0.80
31_D	56_I	0.619	0.80
230_R	262_S	0.619	0.80
212_A	215_R	0.618	0.80
232_I	235_D	0.618	0.80
127_L	143_K	0.617	0.80
15_V	27_A	0.617	0.80
153_L	199_V	0.617	0.80
20_D	24_Y	0.616	0.80
76_V	314_S	0.616	0.80
160_M	210_L	0.616	0.80
260_A	284_P	0.615	0.80
46_L	88_V	0.615	0.80
161_M	182_I	0.611	0.80
271_E	274_K	0.610	0.79
90_A	314_S	0.609	0.79
307_V	310_D	0.609	0.79
107_V	298_A	0.607	0.79
220_E	223_E	0.607	0.79
105_V	309_I	0.603	0.79
43_G	46_L	0.600	0.78
18_V	21_S	0.598	0.78
25_I	28_N	0.596	0.78
202_Q	248_T	0.596	0.78
12_T	30_R	0.595	0.78
216_V	225_I	0.594	0.78
85_A	108_N	0.591	0.77
115_E	118_Y	0.590	0.77
87_R	91_T	0.589	0.77
2_F	5_G	0.588	0.77
30_R	289_G	0.585	0.77
273_G	276_W	0.584	0.76
121_T	281_K	0.582	0.76
2_F	71_I	0.582	0.76
154_D	205_S	0.581	0.76
297_Y	300_M	0.580	0.76
72_N	308_F	0.578	0.76
123_A	281_K	0.576	0.75
169_S	222_L	0.575	0.75
114_I	256_V	0.574	0.75
243_R	247_L	0.573	0.75
193_L	221_K	0.572	0.75
8_S	53_S	0.572	0.75
17_I	64_A	0.571	0.75
110_G	137_I	0.571	0.75
47_K	173_P	0.569	0.75
92_L	96_I	0.567	0.74
52_V	55_T	0.567	0.74
143_K	304_S	0.566	0.74
22_P	122_E	0.566	0.74
110_G	139_T	0.566	0.74
220_E	224_D	0.565	0.74
266_R	282_I	0.564	0.74
138_I	244_A	0.563	0.74
310_D	314_S	0.563	0.74
199_V	203_D	0.562	0.74
9_T	292_G	0.560	0.73
108_N	111_I	0.560	0.73
61_L	100_Y	0.559	0.73
189_G	193_L	0.559	0.73
228_S	231_E	0.557	0.73
127_L	252_E	0.557	0.73
119_L	254_M	0.557	0.73
216_V	219_K	0.554	0.73
199_V	240_A	0.554	0.73
242_E	278_V	0.552	0.72
249_S	281_K	0.552	0.72
143_K	301_L	0.551	0.72
5_G	110_G	0.551	0.72
82_I	210_L	0.550	0.72
17_I	61_L	0.550	0.72
155_I	160_M	0.550	0.72
27_A	61_L	0.550	0.72
35_P	171_A	0.549	0.72
150_G	202_Q	0.549	0.72
115_E	125_D	0.547	0.72
120_T	287_F	0.547	0.72
165_V	289_G	0.544	0.71
4_L	15_V	0.543	0.71
101_N	271_E	0.542	0.71
19_R	300_M	0.538	0.70
118_Y	125_D	0.535	0.70
8_S	31_D	0.535	0.70
130_Y	135_N	0.535	0.70
146_F	302_A	0.532	0.70
147_R	248_T	0.532	0.70
210_L	214_L	0.532	0.70
43_G	173_P	0.531	0.69
95_A	100_Y	0.530	0.69
2_F	26_L	0.530	0.69
128_I	253_L	0.529	0.69
8_S	135_N	0.528	0.69
131_L	136_T	0.527	0.69
296_A	299_G	0.523	0.68
44_D	47_K	0.522	0.68
82_I	159_N	0.520	0.68
287_F	297_Y	0.520	0.68
128_I	241_T	0.519	0.68
192_L	227_Y	0.519	0.68
211_T	215_R	0.515	0.67
253_L	280_I	0.514	0.67
153_L	201_G	0.514	0.67
140_T	254_M	0.514	0.67
48_H	151_E	0.514	0.67
262_S	288_A	0.514	0.67
114_I	139_T	0.512	0.67
263_V	266_R	0.510	0.66
107_V	295_I	0.510	0.66
125_D	140_T	0.509	0.66
74_I	104_L	0.509	0.66
61_L	67_S	0.509	0.66
123_A	252_E	0.509	0.66
241_T	245_L	0.508	0.66
270_E	278_V	0.507	0.66
32_T	172_P	0.507	0.66
50_A	83_G	0.506	0.66
48_H	52_V	0.506	0.66
171_A	178_G	0.506	0.66
12_T	50_A	0.505	0.66
202_Q	244_A	0.505	0.66
193_L	225_I	0.505	0.66
25_I	119_L	0.503	0.65
251_K	278_V	0.502	0.65
236_M	243_R	0.502	0.65
204_M	240_A	0.501	0.65
144_G	302_A	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3en9A	1	0.9758	100	0.32	Contact Map
4k25A	2	0.9426	100	0.381	Contact Map
2ivnA	1	0.9758	100	0.425	Contact Map
3zeuB	1	0.9728	100	0.433	Contact Map
3enoA	1	0.9789	100	0.435	Contact Map
3venA	1	0.9335	100	0.481	Contact Map
3vthA	1	0.8459	100	0.599	Contact Map
4g9iA	1	0.8792	100	0.616	Contact Map
3ttcA	1	0.8278	100	0.629	Contact Map
4m7xA	2	0.7613	100	0.689	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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