GREMLIN Database
RUBPS - Putative ribose 1,5-bisphosphate isomerase
UniProt: Q97ZY5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (252)
Sequences: 314 (173)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_Y256_I4.4301.00
114_K117_T4.1360.99
46_A124_A3.7390.99
54_L257_T3.4430.97
217_K220_E3.3840.97
45_A172_V3.3300.97
52_A257_T2.9850.94
87_E250_K2.9840.94
75_L129_G2.9300.94
24_D78_K2.8550.93
48_Y250_K2.7160.91
46_A58_V2.6620.90
69_I111_F2.5800.88
14_S18_I2.4970.86
223_Y252_V2.3540.83
20_E97_K2.3280.82
38_A58_V2.3100.81
65_F116_A2.2480.80
201_S207_A2.2000.78
182_I232_V2.0600.73
8_V13_I2.0240.72
113_A116_A1.9780.70
77_H114_K1.9710.70
114_K121_D1.9170.67
135_V181_V1.8760.66
65_F113_A1.8760.66
47_Y51_K1.8740.66
143_R221_G1.8700.65
83_K102_G1.8670.65
217_K259_D1.8300.64
41_S225_T1.8290.64
61_R131_T1.8270.64
69_I112_M1.8080.63
95_R110_E1.8080.63
19_K26_Y1.7890.62
189_I201_S1.7830.62
250_K254_G1.7820.61
78_K105_V1.7300.59
35_I42_G1.7240.59
90_R101_E1.7100.58
81_I246_V1.6920.57
34_V147_V1.6910.57
172_V223_Y1.6720.56
144_V260_L1.6490.55
184_V187_R1.6090.53
42_G174_A1.6030.53
38_A135_V1.6020.53
9_D167_S1.5950.53
24_D125_K1.5940.53
252_V256_I1.5840.52
75_L151_W1.5770.52
98_E102_G1.5720.52
211_T230_T1.5630.51
90_R96_L1.5480.50
98_E101_E1.5470.50
31_S34_V1.5460.50
60_E73_A1.5080.49
64_S156_M1.4670.47
229_V235_L1.4080.44
35_I58_V1.3900.43
114_K118_A1.3720.42
138_R145_A1.3540.41
159_L204_S1.3440.41
173_D222_L1.3420.41
27_Q260_L1.3280.40
210_L236_P1.3260.40
14_S47_Y1.3210.40
62_R127_I1.3170.40
98_E105_V1.3110.39
218_V225_T1.3070.39
172_V252_V1.2760.38
47_Y114_K1.2750.38
33_V50_A1.2740.38
144_V185_A1.2680.37
152_T156_M1.2660.37
86_D96_L1.2590.37
45_A252_V1.2560.37
28_F57_L1.2490.37
85_A186_A1.2460.36
76_F151_W1.2420.36
35_I117_T1.2350.36
138_R190_P1.2220.35
57_L127_I1.2100.35
13_I92_V1.2060.35
76_F164_I1.2050.35
190_P194_I1.2000.34
13_I201_S1.1920.34
47_Y121_D1.1920.34
211_T221_G1.1810.34
118_A121_D1.1770.33
54_L252_V1.1700.33
13_I145_A1.1630.33
207_A247_L1.1630.33
135_V147_V1.1580.33
129_G153_A1.1340.32
70_G128_H1.1280.31
137_F185_A1.1260.31
170_A223_Y1.1110.31
255_E258_K1.1100.31
19_K23_E1.1050.30
187_R209_E1.1030.30
192_L195_V1.0990.30
136_I145_A1.0950.30
9_D188_K1.0890.30
211_T251_A1.0830.29
216_G229_V1.0800.29
31_S57_L1.0790.29
70_G148_A1.0740.29
164_I185_A1.0720.29
38_A205_E1.0690.29
224_A261_L1.0640.29
128_H148_A1.0600.29
241_I244_A1.0480.28
135_V182_I1.0480.28
173_D179_A1.0470.28
71_G160_H1.0460.28
47_Y92_V1.0410.28
20_E105_V1.0350.28
46_A50_A1.0330.28
48_Y91_E1.0260.27
65_F112_M1.0200.27
251_A254_G1.0170.27
170_A252_V1.0140.27
224_A244_A1.0090.27
65_F126_I1.0050.26
185_A189_I1.0050.26
172_V256_I1.0030.26
143_R172_V1.0020.26
77_H121_D1.0000.26
21_T128_H0.9940.26
224_A228_A0.9870.26
35_I46_A0.9840.26
27_Q170_A0.9840.26
111_F118_A0.9820.26
128_H150_E0.9780.25
191_E194_I0.9760.25
36_V171_V0.9750.25
199_E231_E0.9690.25
135_V185_A0.9670.25
61_R180_E0.9630.25
62_R153_A0.9610.25
70_G150_E0.9610.25
49_L260_L0.9580.25
63_L71_G0.9570.25
12_K27_Q0.9560.25
31_S213_I0.9510.25
70_G112_M0.9430.24
15_R26_Y0.9400.24
8_V79_L0.9400.24
216_G235_L0.9370.24
36_V207_A0.9300.24
35_I41_S0.9290.24
21_T77_H0.9240.24
150_E202_A0.9220.24
84_P209_E0.9220.24
170_A256_I0.9210.23
79_L88_I0.9160.23
214_N235_L0.9100.23
175_T181_V0.9080.23
221_G256_I0.9050.23
77_H202_A0.9040.23
64_S80_I0.8950.23
62_R160_H0.8880.22
41_S201_S0.8870.22
69_I246_V0.8870.22
57_L76_F0.8850.22
34_V166_I0.8800.22
70_G202_A0.8740.22
10_E36_V0.8640.22
29_V38_A0.8620.21
41_S223_Y0.8590.21
45_A171_V0.8550.21
71_G241_I0.8500.21
28_F125_K0.8480.21
78_K125_K0.8480.21
95_R121_D0.8470.21
47_Y118_A0.8420.21
61_R201_S0.8360.21
209_E213_I0.8350.21
38_A152_T0.8260.20
10_E232_V0.8250.20
251_A255_E0.8170.20
44_S116_A0.8150.20
21_T25_W0.8150.20
60_E160_H0.8140.20
61_R152_T0.8140.20
213_I257_T0.8100.20
239_G245_M0.8050.20
23_E101_E0.8000.20
81_I147_V0.7970.19
216_G233_K0.7940.19
223_Y255_E0.7870.19
44_S174_A0.7810.19
173_D182_I0.7750.19
86_D90_R0.7740.19
48_Y171_V0.7700.19
80_I103_V0.7700.19
71_G74_M0.7690.19
34_V83_K0.7650.19
85_A118_A0.7640.18
90_R93_N0.7620.18
25_W138_R0.7590.18
50_A144_V0.7560.18
34_V59_F0.7530.18
76_F94_I0.7510.18
229_V252_V0.7500.18
135_V188_K0.7480.18
55_K132_V0.7470.18
55_K169_K0.7470.18
120_I174_A0.7460.18
17_I40_P0.7450.18
73_A138_R0.7450.18
189_I200_K0.7450.18
63_L69_I0.7420.18
69_I159_L0.7410.18
174_A225_T0.7400.18
167_S213_I0.7370.18
84_P241_I0.7370.18
34_V57_L0.7350.18
14_S147_V0.7340.18
91_E147_V0.7330.18
188_K201_S0.7270.17
114_K127_I0.7250.17
41_S107_D0.7230.17
13_I202_A0.7210.17
110_E164_I0.7170.17
25_W139_E0.7170.17
111_F246_V0.7140.17
160_H199_E0.7130.17
14_S25_W0.7120.17
110_E120_I0.7120.17
18_I22_M0.7100.17
80_I204_S0.7090.17
29_V211_T0.7030.17
172_V196_I0.7020.17
62_R240_P0.6930.17
36_V175_T0.6900.16
44_S119_A0.6890.16
24_D29_V0.6860.16
207_A219_A0.6850.16
12_K100_E0.6840.16
82_E164_I0.6830.16
8_V69_I0.6820.16
14_S73_A0.6800.16
30_E88_I0.6790.16
43_L126_I0.6790.16
148_A202_A0.6780.16
27_Q55_K0.6770.16
45_A251_A0.6750.16
10_E204_S0.6750.16
136_I167_S0.6720.16
157_A174_A0.6710.16
70_G116_A0.6700.16
51_K117_T0.6690.16
93_N118_A0.6660.16
77_H128_H0.6660.16
29_V98_E0.6630.16
130_V204_S0.6620.16
15_R100_E0.6620.16
16_Y154_T0.6560.16
41_S139_E0.6560.16
73_A137_F0.6540.16
128_H202_A0.6540.16
84_P244_A0.6480.15
20_E31_S0.6460.15
59_F166_I0.6430.15
12_K144_V0.6410.15
245_M249_G0.6410.15
19_K99_V0.6400.15
71_G199_E0.6400.15
16_Y99_V0.6390.15
61_R96_L0.6360.15
240_P246_V0.6340.15
34_V153_A0.6330.15
168_A218_V0.6310.15
82_E241_I0.6310.15
211_T240_P0.6260.15
144_V261_L0.6250.15
27_Q181_V0.6220.15
57_L126_I0.6210.15
62_R154_T0.6190.15
182_I185_A0.6190.15
127_I133_D0.6130.15
95_R169_K0.6120.14
30_E100_E0.6100.14
103_V207_A0.6090.14
219_A230_T0.6060.14
102_G123_G0.6040.14
131_T218_V0.6020.14
225_T254_G0.6010.14
59_F71_G0.6010.14
88_I186_A0.5990.14
57_L207_A0.5980.14
77_H108_S0.5960.14
15_R143_R0.5940.14
10_E108_S0.5940.14
44_S120_I0.5920.14
217_K243_G0.5910.14
24_D149_V0.5900.14
8_V100_E0.5860.14
117_T127_I0.5860.14
59_F130_V0.5860.14
207_A235_L0.5860.14
91_E96_L0.5850.14
15_R55_K0.5830.14
249_G253_A0.5800.14
138_R203_Y0.5790.14
113_A236_P0.5790.14
50_A250_K0.5760.14
93_N100_E0.5750.14
55_K225_T0.5720.14
64_S159_L0.5710.14
105_V108_S0.5700.14
47_Y151_W0.5690.14
28_F31_S0.5680.13
98_E169_K0.5680.13
65_F181_V0.5650.13
160_H241_I0.5580.13
152_T174_A0.5560.13
108_S159_L0.5560.13
51_K91_E0.5530.13
94_I165_F0.5520.13
172_V225_T0.5520.13
168_A221_G0.5510.13
64_S70_G0.5500.13
132_V160_H0.5500.13
122_A135_V0.5470.13
149_V166_I0.5450.13
94_I191_E0.5440.13
44_S157_A0.5430.13
85_A171_V0.5400.13
82_E160_H0.5400.13
103_V147_V0.5390.13
14_S29_V0.5380.13
88_I246_V0.5370.13
227_M239_G0.5370.13
211_T235_L0.5350.13
252_V257_T0.5350.13
74_M164_I0.5320.13
64_S119_A0.5310.13
21_T47_Y0.5310.13
46_A93_N0.5310.13
91_E171_V0.5310.13
54_L260_L0.5310.13
180_E252_V0.5290.13
172_V205_E0.5290.13
24_D107_D0.5290.13
38_A69_I0.5280.13
229_V236_P0.5270.13
54_L223_Y0.5260.13
183_S186_A0.5240.13
24_D232_V0.5220.12
43_L193_G0.5210.12
165_F222_L0.5210.12
184_V188_K0.5200.12
71_G159_L0.5180.12
25_W175_T0.5160.12
237_R242_F0.5150.12
103_V112_M0.5140.12
241_I258_K0.5140.12
25_W151_W0.5130.12
182_I218_V0.5120.12
33_V256_I0.5120.12
56_T165_F0.5120.12
23_E27_Q0.5110.12
93_N225_T0.5100.12
77_H112_M0.5100.12
30_E115_L0.5100.12
20_E78_K0.5090.12
58_V65_F0.5090.12
152_T159_L0.5080.12
89_L137_F0.5040.12
133_D148_A0.5020.12
92_V151_W0.5020.12
13_I147_V0.5010.12
19_K136_I0.5010.12
53_G158_S0.5010.12
30_E57_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fpzA 6 0.9775 100 0.673 Contact Map
3jskA 6 0.9963 100 0.678 Contact Map
1rp0A 5 0.9925 100 0.697 Contact Map
2culA 1 0.7341 99.8 0.841 Contact Map
2bs2A 2 0.8764 99.8 0.849 Contact Map
2e5vA 1 0.8315 99.7 0.849 Contact Map
1qo8A 2 0.9513 99.7 0.851 Contact Map
3nlcA 1 0.9139 99.7 0.852 Contact Map
2i0zA 1 0.8127 99.7 0.852 Contact Map
2wdqA 1 0.8839 99.7 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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