GREMLIN Database
ENDA - tRNA-splicing endonuclease
UniProt: Q97ZY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (162)
Sequences: 837 (618)
Seq/√Len: 48.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_A131_V3.9391.00
59_K97_E3.7791.00
74_E77_K3.3711.00
26_G100_R3.2511.00
127_H151_R3.0461.00
11_V54_S2.8491.00
131_V153_S2.7791.00
20_R24_S2.7491.00
15_S18_E2.7121.00
132_V163_A2.6141.00
98_D102_K2.3181.00
95_V134_A2.3011.00
95_V163_A2.1911.00
119_Y127_H2.0951.00
60_K101_E2.0291.00
13_V22_L2.0000.99
27_F96_Y1.9830.99
78_L82_S1.9010.99
28_Y96_Y1.7870.99
49_L53_E1.7560.99
56_Y117_A1.7540.99
102_K145_E1.7370.99
119_Y151_R1.6520.98
113_G127_H1.6430.98
118_V132_V1.5710.97
76_K80_E1.5690.97
77_K80_E1.5410.97
80_E84_M1.5390.97
127_H156_T1.5150.96
93_Y97_E1.5020.96
99_L118_V1.4940.96
117_A128_A1.4740.96
50_S108_S1.4710.96
55_V89_F1.4690.96
29_G53_E1.4640.96
54_S63_I1.4430.95
58_T63_I1.3990.94
40_P43_I1.3990.94
31_P34_I1.3950.94
122_G125_L1.3900.94
154_H157_K1.3890.94
113_G119_Y1.3680.94
96_Y100_R1.3670.94
79_Y82_S1.3520.93
85_K88_K1.3140.92
55_V93_Y1.3030.92
107_R111_K1.3000.92
112_Y127_H1.2900.92
97_E101_E1.2810.91
109_G112_Y1.2610.91
70_G73_L1.2500.90
57_L96_Y1.2430.90
127_H158_K1.2270.89
149_F160_L1.2190.89
113_G151_R1.2090.89
39_G44_V1.1920.88
75_Y78_L1.1910.88
22_L109_G1.1870.88
77_K84_M1.1650.87
56_Y100_R1.1600.87
116_F134_A1.1590.87
55_V90_E1.1560.86
64_N67_D1.1400.86
39_G42_D1.1350.85
65_V81_Y1.1090.84
152_V156_T1.1060.84
27_F122_G1.1040.84
23_Y122_G1.0920.83
79_Y84_M1.0890.83
38_K42_D1.0830.83
51_L89_F1.0780.82
19_S45_R1.0710.82
104_F118_V1.0700.82
95_V116_F1.0670.82
30_K111_K1.0620.81
110_V147_L1.0580.81
48_E156_T1.0290.79
147_L150_G1.0240.79
151_R156_T0.9990.77
30_K48_E0.9990.77
150_G160_L0.9950.77
115_D133_I0.9940.77
26_G128_A0.9860.76
111_K127_H0.9850.76
33_G99_L0.9820.76
37_P44_V0.9740.75
95_V165_V0.9740.75
88_K115_D0.9680.75
100_R105_I0.9660.75
125_L152_V0.9650.75
107_R117_A0.9600.74
128_A158_K0.9560.74
98_D168_K0.9440.73
64_N72_L0.9430.73
106_V159_R0.9270.72
52_I161_V0.9220.71
70_G74_E0.9220.71
81_Y84_M0.9200.71
122_G126_E0.9100.70
100_R117_A0.8880.68
153_S163_A0.8850.68
23_Y31_P0.8780.67
38_K44_V0.8760.67
67_D73_L0.8740.67
70_G80_E0.8640.66
131_V134_A0.8630.66
80_E83_A0.8610.66
71_D77_K0.8570.66
17_D84_M0.8520.65
31_P101_E0.8520.65
83_A90_E0.8510.65
37_P150_G0.8490.65
109_G151_R0.8460.65
33_G46_P0.8400.64
126_E129_P0.8360.64
29_G47_L0.8290.63
33_G45_R0.8270.63
81_Y85_K0.8220.62
151_R158_K0.8200.62
119_Y158_K0.8140.62
125_L129_P0.8120.61
53_E57_L0.8100.61
106_V153_S0.8030.61
122_G152_V0.8010.60
72_L77_K0.7980.60
93_Y100_R0.7950.60
112_Y151_R0.7950.60
94_K165_V0.7930.60
148_S152_V0.7920.59
91_I128_A0.7860.59
22_L65_V0.7840.59
96_Y142_T0.7800.58
34_I45_R0.7790.58
133_I148_S0.7790.58
22_L140_E0.7750.58
14_P152_V0.7740.58
138_D157_K0.7680.57
37_P42_D0.7500.55
23_Y27_F0.7480.55
26_G105_I0.7370.54
109_G127_H0.7340.54
26_G47_L0.7300.53
56_Y101_E0.7290.53
35_S45_R0.7270.53
56_Y130_Y0.7260.53
127_H152_V0.7230.53
58_T61_G0.7190.52
46_P124_G0.7150.52
112_Y119_Y0.7050.51
91_I94_K0.7020.50
111_K129_P0.7000.50
149_F156_T0.6990.50
91_I134_A0.6970.50
86_I89_F0.6880.49
89_F93_Y0.6810.48
65_V89_F0.6800.48
118_V130_Y0.6790.48
71_D84_M0.6780.48
31_P45_R0.6760.48
36_K39_G0.6740.48
93_Y114_A0.6730.48
119_Y156_T0.6700.47
114_A155_S0.6690.47
109_G128_A0.6680.47
59_K93_Y0.6630.47
122_G129_P0.6630.47
39_G43_I0.6620.46
74_E79_Y0.6600.46
48_E143_P0.6500.45
29_G100_R0.6480.45
146_L152_V0.6460.45
11_V63_I0.6450.45
92_L95_V0.6430.45
11_V110_V0.6420.44
73_L81_Y0.6330.44
115_D134_A0.6310.43
96_Y105_I0.6290.43
9_S108_S0.6290.43
41_K44_V0.6260.43
91_I157_K0.6230.43
25_N100_R0.6230.43
47_L53_E0.6210.42
77_K81_Y0.6200.42
55_V134_A0.6140.42
150_G157_K0.6120.41
57_L63_I0.6110.41
56_Y62_L0.6100.41
13_V49_L0.6080.41
87_N169_S0.6070.41
79_Y166_D0.6040.41
62_L165_V0.6030.41
112_Y120_T0.5990.40
71_D76_K0.5990.40
115_D146_L0.5940.40
82_S146_L0.5930.40
13_V19_S0.5920.40
124_G128_A0.5880.39
129_P154_H0.5880.39
133_I161_V0.5870.39
23_Y121_L0.5860.39
28_Y97_E0.5790.38
130_Y149_F0.5770.38
102_K115_D0.5760.38
17_D20_R0.5740.38
8_G65_V0.5700.37
24_S77_K0.5690.37
10_K48_E0.5680.37
89_F100_R0.5670.37
61_G99_L0.5670.37
116_F130_Y0.5670.37
101_E104_F0.5660.37
125_L164_L0.5640.37
50_S106_V0.5620.37
60_K97_E0.5610.37
120_T129_P0.5600.36
98_D101_E0.5550.36
12_L32_I0.5540.36
100_R165_V0.5540.36
16_I52_I0.5540.36
80_E157_K0.5530.36
16_I84_M0.5520.36
32_I155_S0.5490.35
48_E123_P0.5440.35
7_V19_S0.5440.35
132_V135_V0.5430.35
26_G93_Y0.5430.35
53_E56_Y0.5420.35
106_V118_V0.5390.35
47_L70_G0.5380.34
51_L82_S0.5340.34
146_L150_G0.5290.34
98_D104_F0.5280.34
23_Y129_P0.5200.33
59_K79_Y0.5200.33
11_V116_F0.5150.32
88_K136_D0.5140.32
10_K153_S0.5110.32
161_V164_L0.5100.32
8_G116_F0.5080.32
71_D75_Y0.5080.32
14_P111_K0.5070.32
78_L81_Y0.5040.31
49_L115_D0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zyzB 2 0.9945 100 0.141 Contact Map
2cv8A 3 0.989 100 0.153 Contact Map
3ajvB 2 0.978 100 0.156 Contact Map
1a79A 4 0.9231 100 0.216 Contact Map
1r0vA 2 0.8516 100 0.246 Contact Map
4fz2A 2 0.9341 100 0.275 Contact Map
3ieyA 2 0.7637 100 0.29 Contact Map
3ajvA 1 0.8626 100 0.316 Contact Map
3ieyB 1 0.8187 100 0.32 Contact Map
2ohcA 2 0.7308 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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