GREMLIN Database
Q97ZY2 - Uncharacterized protein
UniProt: Q97ZY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (190)
Sequences: 1401 (1016)
Seq/√Len: 73.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_N156_K3.9451.00
161_I197_E3.7071.00
53_K57_E3.1491.00
63_L84_L3.0671.00
20_K56_I3.0351.00
56_I91_S2.8041.00
20_K55_D2.7671.00
49_V98_T2.6671.00
51_G54_N2.6201.00
57_E88_E2.6081.00
158_E198_D2.6071.00
105_L174_E2.5671.00
53_K88_E2.3511.00
23_D55_D2.3511.00
24_E91_S2.3071.00
125_K160_E2.3011.00
158_E162_D2.2151.00
160_E163_E2.0821.00
16_Q62_R2.0361.00
41_N44_Q2.0281.00
162_D198_D1.9481.00
171_A175_K1.9261.00
134_I137_L1.8071.00
47_S51_G1.8051.00
27_V48_K1.7661.00
155_I201_K1.7611.00
48_K51_G1.7591.00
61_Y152_R1.7351.00
15_Q138_R1.7251.00
154_V204_A1.6871.00
33_S120_I1.6421.00
61_Y155_I1.6411.00
29_Y124_E1.5570.99
71_R76_D1.5530.99
99_Y166_R1.5370.99
22_L131_T1.4950.99
90_V130_I1.4860.99
25_T94_L1.4660.99
133_F207_I1.4560.99
118_L171_A1.4530.99
166_R187_K1.4500.99
132_Y153_N1.4480.99
10_I80_Y1.4430.99
20_K52_I1.4420.99
51_G55_D1.4370.99
20_K23_D1.4220.99
53_K92_Q1.3690.98
125_K128_T1.3660.98
89_K92_Q1.3590.98
14_L80_Y1.3520.98
149_E153_N1.3150.98
132_Y135_E1.3000.98
146_N149_E1.2870.97
67_I80_Y1.2500.97
168_L190_A1.2460.97
57_E92_Q1.2430.97
199_L202_S1.2350.97
129_S157_L1.2340.97
138_R141_S1.2150.96
41_N45_I1.2140.96
97_A193_L1.2120.96
126_I133_F1.2020.96
62_R66_Y1.1990.96
50_N95_D1.1950.96
118_L121_V1.1860.96
19_L23_D1.1780.96
27_V49_V1.1730.96
10_I73_G1.1710.95
123_C127_I1.1560.95
119_L126_I1.1520.95
16_Q19_L1.1410.95
186_L190_A1.1200.94
35_T101_L1.1140.94
126_I193_L1.1020.94
123_C136_A1.1010.94
104_I185_L1.1010.94
90_V203_S1.1010.94
194_E198_D1.0980.94
126_I136_A1.0960.94
27_V45_I1.0920.93
88_E92_Q1.0900.93
21_L91_S1.0850.93
10_I71_R1.0810.93
35_T42_A1.0680.93
22_L26_R1.0670.93
31_F42_A1.0660.93
83_I203_S1.0630.92
172_L189_I1.0620.92
126_I197_E1.0550.92
166_R173_F1.0460.92
61_Y208_T1.0440.92
162_D194_E1.0440.92
127_I133_F1.0410.92
125_K157_L1.0340.91
179_D182_Y1.0220.91
27_V52_I1.0190.91
17_I56_I1.0170.91
48_K55_D1.0130.91
30_E48_K1.0090.90
53_K56_I1.0050.90
120_I127_I1.0020.90
28_L94_L0.9950.90
31_F98_T0.9870.89
129_S132_Y0.9820.89
127_I137_L0.9790.89
153_N157_L0.9760.89
152_R159_Q0.9640.88
14_L75_L0.9590.88
32_L123_C0.9560.88
126_I137_L0.9460.87
134_I138_R0.9430.87
70_I73_G0.9410.87
71_R77_K0.9350.87
64_G206_N0.9290.86
61_Y201_K0.9280.86
121_V160_E0.9210.86
173_F187_K0.9210.86
182_Y185_L0.9190.86
122_I164_L0.9130.85
130_I134_I0.9100.85
28_L32_L0.9070.85
97_A196_S0.9060.85
96_A100_R0.9030.85
133_F137_L0.9020.85
131_T135_E0.8910.84
18_S22_L0.8870.84
71_R74_L0.8860.84
176_K183_I0.8840.83
165_Y191_D0.8820.83
17_I84_L0.8760.83
165_Y194_E0.8710.83
75_L78_D0.8680.82
129_S136_A0.8640.82
172_L190_A0.8590.82
54_N58_V0.8450.81
73_G80_Y0.8360.80
30_E33_S0.8350.80
44_Q48_K0.8180.78
22_L130_I0.8120.78
136_A140_L0.8100.78
123_C133_F0.8100.78
86_N89_K0.8050.77
27_V30_E0.8010.77
17_I20_K0.8000.77
17_I196_S0.7970.77
118_L167_S0.7950.76
44_Q47_S0.7900.76
23_D33_S0.7880.76
55_D147_S0.7850.76
71_R80_Y0.7780.75
126_I130_I0.7780.75
129_S154_V0.7770.75
102_S170_L0.7710.74
93_N199_L0.7670.74
31_F49_V0.7670.74
159_Q163_E0.7650.74
11_E201_K0.7640.74
73_G76_D0.7630.73
168_L200_L0.7620.73
10_I13_Q0.7570.73
152_R155_I0.7550.73
26_R30_E0.7490.72
148_Y151_A0.7480.72
52_I55_D0.7470.72
164_L168_L0.7420.71
34_N41_N0.7380.71
123_C130_I0.7360.71
120_I126_I0.7350.71
152_R201_K0.7310.70
103_V195_D0.7300.70
93_N195_D0.7270.70
123_C126_I0.7230.69
71_R75_L0.7220.69
23_D30_E0.7220.69
127_I136_A0.7210.69
124_E127_I0.7200.69
132_Y150_N0.7200.69
74_L77_K0.7160.69
155_I205_D0.7100.68
90_V200_L0.7100.68
197_E209_Y0.7060.68
120_I124_E0.7040.67
175_K178_A0.6920.66
107_K128_T0.6910.66
130_I136_A0.6910.66
202_S205_D0.6870.65
29_Y33_S0.6860.65
125_K136_A0.6820.65
26_R131_T0.6770.64
70_I75_L0.6760.64
71_R194_E0.6730.64
66_Y69_K0.6700.63
24_E52_I0.6690.63
57_E201_K0.6680.63
186_L210_I0.6640.63
187_K191_D0.6640.63
157_L161_I0.6630.63
75_L207_I0.6610.62
117_R121_V0.6600.62
130_I137_L0.6510.61
157_L197_E0.6510.61
128_T135_E0.6490.61
63_L80_Y0.6490.61
55_D58_V0.6480.61
133_F150_N0.6450.61
13_Q59_S0.6350.59
121_V124_E0.6280.59
65_E208_T0.6270.58
137_L140_L0.6270.58
84_L87_L0.6250.58
90_V150_N0.6210.58
43_M169_E0.6210.58
41_N48_K0.6200.58
120_I133_F0.6120.57
125_K130_I0.6090.56
12_E16_Q0.6080.56
21_L24_E0.6050.56
203_S206_N0.5990.55
88_E158_E0.5970.55
172_L186_L0.5970.55
128_T131_T0.5960.55
52_I98_T0.5960.55
42_A210_I0.5960.55
46_Y166_R0.5920.54
126_I134_I0.5910.54
158_E194_E0.5890.54
103_V169_E0.5870.53
23_D128_T0.5840.53
143_N147_S0.5810.53
100_R192_R0.5790.52
178_A183_I0.5780.52
59_S66_Y0.5760.52
72_E75_L0.5760.52
23_D51_G0.5750.52
12_E147_S0.5750.52
43_M47_S0.5750.52
119_L168_L0.5730.52
127_I131_T0.5730.52
67_I74_L0.5690.51
28_L101_L0.5660.51
14_L122_I0.5650.51
45_I180_F0.5640.51
126_I140_L0.5620.50
49_V52_I0.5600.50
103_V166_R0.5590.50
53_K201_K0.5590.50
167_S171_A0.5590.50
92_Q158_E0.5570.50
18_S87_L0.5550.50
97_A192_R0.5530.49
18_S21_L0.5530.49
133_F136_A0.5520.49
60_K63_L0.5460.48
95_D159_Q0.5430.48
60_K84_L0.5370.47
50_N54_N0.5370.47
49_V94_L0.5360.47
106_S204_A0.5360.47
191_D195_D0.5350.47
57_E74_L0.5350.47
132_Y154_V0.5340.47
34_N45_I0.5310.47
30_E34_N0.5310.47
17_I21_L0.5300.46
206_N210_I0.5290.46
92_Q201_K0.5270.46
151_A208_T0.5270.46
14_L18_S0.5240.46
125_K137_L0.5230.46
120_I140_L0.5230.46
94_L194_E0.5190.45
14_L210_I0.5180.45
96_A192_R0.5160.45
30_E45_I0.5140.44
14_L104_I0.5130.44
188_D191_D0.5110.44
16_Q121_V0.5100.44
155_I159_Q0.5090.44
33_S117_R0.5090.44
135_E138_R0.5080.44
61_Y159_Q0.5070.44
43_M102_S0.5040.43
146_N174_E0.5020.43
126_I129_S0.5010.43
32_L97_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l39A 3 0.9488 100 0.273 Contact Map
2oltA 5 0.9581 100 0.459 Contact Map
1t72A 5 0.9349 98.5 0.797 Contact Map
2i0mA 2 0.8837 98.4 0.802 Contact Map
1xwmA 2 0.907 98.3 0.807 Contact Map
4q25A 2 0.9256 98.2 0.81 Contact Map
1sumB 2 0.9163 98.2 0.813 Contact Map
3vkgA 2 0.9116 18.8 0.94 Contact Map
4n78F 1 0.3767 15 0.943 Contact Map
3g67A 2 0.9116 12 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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