GREMLIN Database
Q97ZX8 - Agmatinase (Agmatine ureohydrolase) (SpeB-1)
UniProt: Q97ZX8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (267)
Sequences: 5208 (3299)
Seq/√Len: 201.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_I110_I3.7451.00
220_V246_L3.7211.00
98_S126_R3.6211.00
94_S122_K3.1961.00
121_I158_I3.1591.00
48_S78_D3.0401.00
225_I279_L2.9711.00
94_S126_R2.7491.00
230_A276_T2.6891.00
222_M233_V2.4071.00
261_F287_T2.3671.00
179_E183_Q2.1411.00
130_C214_K2.0791.00
29_I100_F2.0581.00
243_P279_L2.0581.00
91_S95_S2.0281.00
222_M266_V2.0231.00
30_G51_R2.0041.00
21_K103_S1.9781.00
225_I246_L1.9721.00
97_I120_I1.9351.00
48_S52_E1.8791.00
167_E170_T1.8681.00
187_L205_R1.8671.00
27_V105_K1.8561.00
94_S123_G1.8531.00
199_V203_A1.8471.00
134_F224_G1.8311.00
187_L209_S1.8151.00
101_Q123_G1.8141.00
134_F249_I1.8071.00
88_E92_R1.7911.00
34_D44_R1.7621.00
97_I109_S1.7581.00
156_R160_E1.7411.00
31_I109_S1.7391.00
118_A122_K1.7141.00
197_L205_R1.7091.00
50_I280_A1.7071.00
110_I284_I1.7041.00
98_S102_E1.6711.00
118_A161_Y1.6641.00
195_R244_T1.6611.00
218_I258_V1.6561.00
263_I284_I1.6501.00
175_K179_E1.6481.00
31_I93_I1.6251.00
51_R78_D1.6251.00
224_G241_L1.6141.00
109_S120_I1.6011.00
197_L201_E1.6001.00
108_I261_F1.5921.00
204_R208_T1.5841.00
25_P72_G1.5651.00
166_I187_L1.5581.00
266_V280_A1.5391.00
217_Y260_G1.5281.00
26_F288_A1.5021.00
128_G215_S1.4501.00
30_G78_D1.4481.00
229_Y243_P1.4461.00
242_D245_N1.4371.00
170_T188_F1.4351.00
51_R77_G1.4281.00
116_I264_V1.4251.00
224_G246_L1.4221.00
27_V100_F1.4131.00
30_G77_G1.4031.00
201_E204_R1.4011.00
31_I89_N1.4011.00
222_M230_A1.3971.00
101_Q124_T1.3951.00
215_S257_R1.3881.00
85_N88_E1.3861.00
94_S98_S1.3801.00
124_T129_L1.3781.00
266_V276_T1.3681.00
195_R245_N1.3671.00
90_L115_T1.3671.00
180_Y184_K1.3581.00
164_K214_K1.3411.00
133_S167_E1.3371.00
151_H235_T1.3351.00
50_I266_V1.3331.00
251_N286_E1.3231.00
222_M263_I1.3221.00
204_R252_L1.3091.00
218_I261_F1.3081.00
51_R75_D1.3071.00
130_C213_C1.3021.00
49_S277_S1.3011.00
132_V253_I1.2961.00
27_V76_V1.2951.00
157_R160_E1.2671.00
198_G202_T1.2621.00
40_R270_Y1.2611.00
29_I97_I1.2601.00
207_I252_L1.2571.00
30_G75_D1.2501.00
29_I109_S1.2441.00
156_R180_Y1.2361.00
232_G276_T1.2351.00
201_E205_R1.2351.00
196_L248_D1.2331.00
114_H219_S1.2331.00
96_V99_Y1.2211.00
232_G271_D1.2191.00
93_I109_S1.2141.00
247_L286_E1.2111.00
100_F107_T1.2011.00
151_H234_A1.2011.00
166_I209_S1.1861.00
210_T213_C1.1831.00
45_F269_S1.1831.00
142_D157_R1.1811.00
190_T193_Q1.1611.00
37_S43_S1.1581.00
131_L155_M1.1431.00
90_L119_G1.1411.00
155_M167_E1.1311.00
49_S52_E1.1261.00
222_M280_A1.1241.00
108_I284_I1.1241.00
98_S123_G1.1221.00
138_L173_V1.1101.00
120_I262_D1.1051.00
41_P45_F1.1041.00
26_F106_I1.0911.00
197_L202_T1.0851.00
29_I96_V1.0771.00
200_K204_R1.0671.00
137_H223_D1.0651.00
122_K161_Y1.0551.00
81_L89_N1.0441.00
267_S270_Y1.0281.00
120_I217_Y1.0271.00
117_T121_I1.0231.00
89_N93_I1.0211.00
97_I107_T1.0211.00
215_S259_I1.0191.00
106_I261_F1.0191.00
95_S99_Y1.0171.00
246_L283_I1.0171.00
142_D156_R1.0111.00
203_A252_L0.9991.00
133_S219_S0.9821.00
135_D139_D0.9821.00
150_D153_C0.9811.00
191_P195_R0.9811.00
140_L181_A0.9781.00
276_T280_A0.9751.00
28_I110_I0.9751.00
31_I116_I0.9711.00
41_P44_R0.9590.99
198_G201_E0.9570.99
88_E91_S0.9520.99
121_I131_L0.9470.99
34_D42_G0.9420.99
124_T260_G0.9390.99
134_F241_L0.9370.99
195_R248_D0.9360.99
151_H233_V0.9350.99
49_S53_S0.9320.99
225_I243_P0.9270.99
272_T275_I0.9220.99
218_I250_I0.9210.99
252_L255_D0.9150.99
99_Y102_E0.9130.99
241_L249_I0.9060.99
130_C164_K0.9050.99
117_T262_D0.9050.99
206_I209_S0.9030.99
138_L170_T0.9020.99
97_I123_G0.8980.99
79_I92_R0.8970.99
138_L167_E0.8960.99
130_C166_I0.8880.99
155_M165_I0.8820.99
181_A186_I0.8800.99
171_R227_P0.8770.99
193_Q197_L0.8760.99
216_L257_R0.8750.99
129_L259_I0.8750.99
230_A279_L0.8740.99
91_S94_S0.8730.99
171_R226_D0.8720.99
233_V236_P0.8680.99
114_H151_H0.8670.99
34_D43_S0.8650.99
182_K188_F0.8620.99
131_L158_I0.8580.99
152_A235_T0.8510.99
140_L159_S0.8460.99
249_I252_L0.8430.99
205_R209_S0.8390.99
43_S267_S0.8330.98
33_M86_V0.8300.98
208_T211_Q0.8280.98
136_A171_R0.8280.98
132_V210_T0.8270.98
141_R177_E0.8200.98
189_F194_I0.8090.98
120_I260_G0.8030.98
227_P230_A0.8000.98
202_T206_I0.8000.98
151_H265_E0.7960.98
34_D40_R0.7950.98
76_V96_V0.7920.98
95_S98_S0.7920.98
275_I279_L0.7910.98
124_T259_I0.7890.98
114_H262_D0.7880.98
25_P105_K0.7810.98
53_S277_S0.7740.98
189_F209_S0.7740.98
192_Q251_N0.7730.98
34_D41_P0.7730.98
243_P247_L0.7730.98
114_H265_E0.7720.97
117_T154_V0.7710.97
241_L246_L0.7690.97
165_I186_I0.7680.97
108_I288_A0.7680.97
140_L180_Y0.7670.97
172_A237_E0.7670.97
100_F105_K0.7640.97
26_F71_I0.7620.97
206_I210_T0.7610.97
180_Y183_Q0.7600.97
250_I290_T0.7580.97
220_V283_I0.7560.97
247_L283_I0.7550.97
121_I129_L0.7520.97
138_L188_F0.7520.97
127_E215_S0.7500.97
205_R208_T0.7440.97
194_I245_N0.7390.97
29_I107_T0.7380.97
36_T113_E0.7380.97
266_V277_S0.7370.97
132_V166_I0.7360.97
225_I229_Y0.7290.96
168_V206_I0.7280.96
36_T86_V0.7270.96
192_Q248_D0.7260.96
200_K252_L0.7200.96
32_P78_D0.7110.96
46_A49_S0.7090.96
134_F168_V0.7020.96
142_D148_R0.6990.96
99_Y103_S0.6990.96
143_E157_R0.6960.95
135_D223_D0.6950.95
130_C210_T0.6930.95
189_F205_R0.6920.95
268_P271_D0.6860.95
21_K105_K0.6850.95
35_I89_N0.6850.95
132_V168_V0.6840.95
107_T124_T0.6830.95
76_V100_F0.6830.95
166_I206_I0.6820.95
132_V216_L0.6790.95
203_A249_I0.6740.95
46_A268_P0.6730.95
49_S268_P0.6730.95
46_A234_A0.6720.94
171_R237_E0.6710.94
217_Y262_D0.6690.94
75_D78_D0.6680.94
134_F218_I0.6660.94
28_I108_I0.6650.94
200_K248_D0.6650.94
233_V267_S0.6640.94
168_V241_L0.6620.94
159_S165_I0.6610.94
115_T149_Y0.6610.94
93_I119_G0.6610.94
244_T248_D0.6600.94
229_Y242_D0.6590.94
228_A243_P0.6580.94
117_T155_M0.6510.93
129_L215_S0.6500.93
139_D223_D0.6490.93
119_G123_G0.6480.93
230_A266_V0.6480.93
179_E182_K0.6470.93
33_M89_N0.6430.93
96_V100_F0.6340.93
46_A267_S0.6330.93
248_D252_L0.6300.92
85_N147_Y0.6300.92
218_I287_T0.6290.92
120_I124_T0.6220.92
219_S264_V0.6190.92
109_S116_I0.6180.92
216_L258_V0.6160.91
169_G224_G0.6160.91
239_D247_L0.6160.91
114_H217_Y0.6150.91
125_K129_L0.6140.91
232_G266_V0.6130.91
125_K164_K0.6130.91
31_I120_I0.6120.91
199_V249_I0.6120.91
53_S281_S0.6100.91
284_I287_T0.6100.91
24_S105_K0.6080.91
40_R236_P0.6040.91
194_I249_I0.6030.91
166_I189_F0.6030.91
191_P241_L0.6000.90
193_Q196_L0.5970.90
139_D265_E0.5960.90
159_S186_I0.5920.90
92_R95_S0.5920.90
133_S155_M0.5910.90
189_F193_Q0.5870.89
92_R96_V0.5850.89
128_G214_K0.5850.89
217_Y259_I0.5840.89
49_S274_G0.5790.89
271_D274_G0.5790.89
152_A223_D0.5780.89
229_Y279_L0.5780.89
286_E289_A0.5770.89
140_L184_K0.5770.89
21_K24_S0.5740.88
53_S274_G0.5740.88
38_S41_P0.5730.88
38_S151_H0.5710.88
125_K161_Y0.5690.88
122_K158_I0.5690.88
26_F108_I0.5680.88
117_T217_Y0.5640.88
207_I210_T0.5630.87
133_S235_T0.5620.87
114_H137_H0.5610.87
114_H264_V0.5600.87
86_V150_D0.5580.87
86_V90_L0.5580.87
48_S274_G0.5560.87
191_P226_D0.5540.87
214_K257_R0.5540.87
104_G107_T0.5540.87
117_T264_V0.5540.87
274_G277_S0.5530.86
82_H92_R0.5520.86
143_E148_R0.5510.86
213_C216_L0.5510.86
199_V248_D0.5510.86
219_S262_D0.5510.86
50_I281_S0.5500.86
79_I96_V0.5500.86
52_E274_G0.5490.86
138_L181_A0.5460.86
198_G245_N0.5460.86
35_I86_V0.5460.86
196_L200_K0.5410.85
203_A206_I0.5410.85
97_I124_T0.5400.85
203_A207_I0.5370.85
28_I73_F0.5350.85
118_A157_R0.5340.85
206_I249_I0.5330.84
27_V74_N0.5330.84
141_R152_A0.5320.84
261_F284_I0.5310.84
61_S286_E0.5310.84
131_L165_I0.5310.84
159_S180_Y0.5290.84
207_I255_D0.5290.84
176_E180_Y0.5280.84
263_I283_I0.5250.84
138_L141_R0.5240.83
239_D243_P0.5240.83
143_E146_G0.5240.83
89_N92_R0.5220.83
238_P279_L0.5200.83
159_S162_G0.5190.83
141_R235_T0.5190.83
81_L93_I0.5180.83
207_I256_K0.5180.83
168_V194_I0.5170.83
211_Q216_L0.5170.83
248_D251_N0.5120.82
97_I101_Q0.5110.82
93_I116_I0.5100.82
194_I198_G0.5090.82
153_C157_R0.5090.82
233_V265_E0.5080.82
133_S154_V0.5080.82
111_G116_I0.5070.81
155_M170_T0.5060.81
151_H177_E0.5050.81
42_G267_S0.5040.81
274_G278_V0.5040.81
166_I210_T0.5030.81
24_S74_N0.5010.81
97_I119_G0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nioA 5 0.9697 100 0.123 Contact Map
3niqA 5 0.9832 100 0.124 Contact Map
1gq6A 5 0.9764 100 0.127 Contact Map
3m1rA 5 0.9764 100 0.137 Contact Map
4mykA 3 0.9226 100 0.145 Contact Map
1wohA 5 0.9731 100 0.146 Contact Map
4dz4A 5 0.9562 100 0.154 Contact Map
3pzlA 5 0.9731 100 0.17 Contact Map
1xfkA 1 0.9697 100 0.195 Contact Map
3lhlA 3 0.9057 100 0.203 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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