Q97ZX8 - SULSO - GREMLIN Contacts

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Q97ZX8 - Agmatinase (Agmatine ureohydrolase) (SpeB-1)

UniProt:	Q97ZX8	Sequences: MSDGRLLYLNENSRKFAGFNKEKSPFVIIGIPMDITSSYRPGSRFAPSSIRESAQYIEFYSIRNDVDMGEIGFNDVGDIILHPSNVEENLSRISSVISYFQESGKITISIGGEHTITAGIIKGTKREGLCLVSFDAHLDLRDEYMGYRYDHACVMRRISEYGVKIIEVGTRAVSKEEIEYAKQKGILFFTPQQIRLLGVKETARRIITSTQECKSLYISVDMDGIDPAYAPGVATPEPDGLDPTNLLDIINLIADKRVIGFDIVEVSPSYDTSGITSVLASRIILETAATVYKARSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (267)
Sequences:	5208 (3299)
Seq/√Len:	201.9

ECOLI - SPEB
BACSU - SPEB HUTG ARGI
HALSA - HUTG Q9HP79
SULSO - Q97ZX8 Q97VA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_I	110_I	3.745	1.00
220_V	246_L	3.721	1.00
98_S	126_R	3.621	1.00
94_S	122_K	3.196	1.00
121_I	158_I	3.159	1.00
48_S	78_D	3.040	1.00
225_I	279_L	2.971	1.00
94_S	126_R	2.749	1.00
230_A	276_T	2.689	1.00
222_M	233_V	2.407	1.00
261_F	287_T	2.367	1.00
179_E	183_Q	2.141	1.00
130_C	214_K	2.079	1.00
29_I	100_F	2.058	1.00
243_P	279_L	2.058	1.00
91_S	95_S	2.028	1.00
222_M	266_V	2.023	1.00
30_G	51_R	2.004	1.00
21_K	103_S	1.978	1.00
225_I	246_L	1.972	1.00
97_I	120_I	1.935	1.00
48_S	52_E	1.879	1.00
167_E	170_T	1.868	1.00
187_L	205_R	1.867	1.00
27_V	105_K	1.856	1.00
94_S	123_G	1.853	1.00
199_V	203_A	1.847	1.00
134_F	224_G	1.831	1.00
187_L	209_S	1.815	1.00
101_Q	123_G	1.814	1.00
134_F	249_I	1.807	1.00
88_E	92_R	1.791	1.00
34_D	44_R	1.762	1.00
97_I	109_S	1.758	1.00
156_R	160_E	1.741	1.00
31_I	109_S	1.739	1.00
118_A	122_K	1.714	1.00
197_L	205_R	1.709	1.00
50_I	280_A	1.707	1.00
110_I	284_I	1.704	1.00
98_S	102_E	1.671	1.00
118_A	161_Y	1.664	1.00
195_R	244_T	1.661	1.00
218_I	258_V	1.656	1.00
263_I	284_I	1.650	1.00
175_K	179_E	1.648	1.00
31_I	93_I	1.625	1.00
51_R	78_D	1.625	1.00
224_G	241_L	1.614	1.00
109_S	120_I	1.601	1.00
197_L	201_E	1.600	1.00
108_I	261_F	1.592	1.00
204_R	208_T	1.584	1.00
25_P	72_G	1.565	1.00
166_I	187_L	1.558	1.00
266_V	280_A	1.539	1.00
217_Y	260_G	1.528	1.00
26_F	288_A	1.502	1.00
128_G	215_S	1.450	1.00
30_G	78_D	1.448	1.00
229_Y	243_P	1.446	1.00
242_D	245_N	1.437	1.00
170_T	188_F	1.435	1.00
51_R	77_G	1.428	1.00
116_I	264_V	1.425	1.00
224_G	246_L	1.422	1.00
27_V	100_F	1.413	1.00
30_G	77_G	1.403	1.00
201_E	204_R	1.401	1.00
31_I	89_N	1.401	1.00
222_M	230_A	1.397	1.00
101_Q	124_T	1.395	1.00
215_S	257_R	1.388	1.00
85_N	88_E	1.386	1.00
94_S	98_S	1.380	1.00
124_T	129_L	1.378	1.00
266_V	276_T	1.368	1.00
195_R	245_N	1.367	1.00
90_L	115_T	1.367	1.00
180_Y	184_K	1.358	1.00
164_K	214_K	1.341	1.00
133_S	167_E	1.337	1.00
151_H	235_T	1.335	1.00
50_I	266_V	1.333	1.00
251_N	286_E	1.323	1.00
222_M	263_I	1.322	1.00
204_R	252_L	1.309	1.00
218_I	261_F	1.308	1.00
51_R	75_D	1.307	1.00
130_C	213_C	1.302	1.00
49_S	277_S	1.301	1.00
132_V	253_I	1.296	1.00
27_V	76_V	1.295	1.00
157_R	160_E	1.267	1.00
198_G	202_T	1.262	1.00
40_R	270_Y	1.261	1.00
29_I	97_I	1.260	1.00
207_I	252_L	1.257	1.00
30_G	75_D	1.250	1.00
29_I	109_S	1.244	1.00
156_R	180_Y	1.236	1.00
232_G	276_T	1.235	1.00
201_E	205_R	1.235	1.00
196_L	248_D	1.233	1.00
114_H	219_S	1.233	1.00
96_V	99_Y	1.221	1.00
232_G	271_D	1.219	1.00
93_I	109_S	1.214	1.00
247_L	286_E	1.211	1.00
100_F	107_T	1.201	1.00
151_H	234_A	1.201	1.00
166_I	209_S	1.186	1.00
210_T	213_C	1.183	1.00
45_F	269_S	1.183	1.00
142_D	157_R	1.181	1.00
190_T	193_Q	1.161	1.00
37_S	43_S	1.158	1.00
131_L	155_M	1.143	1.00
90_L	119_G	1.141	1.00
155_M	167_E	1.131	1.00
49_S	52_E	1.126	1.00
222_M	280_A	1.124	1.00
108_I	284_I	1.124	1.00
98_S	123_G	1.122	1.00
138_L	173_V	1.110	1.00
120_I	262_D	1.105	1.00
41_P	45_F	1.104	1.00
26_F	106_I	1.091	1.00
197_L	202_T	1.085	1.00
29_I	96_V	1.077	1.00
200_K	204_R	1.067	1.00
137_H	223_D	1.065	1.00
122_K	161_Y	1.055	1.00
81_L	89_N	1.044	1.00
267_S	270_Y	1.028	1.00
120_I	217_Y	1.027	1.00
117_T	121_I	1.023	1.00
89_N	93_I	1.021	1.00
97_I	107_T	1.021	1.00
215_S	259_I	1.019	1.00
106_I	261_F	1.019	1.00
95_S	99_Y	1.017	1.00
246_L	283_I	1.017	1.00
142_D	156_R	1.011	1.00
203_A	252_L	0.999	1.00
133_S	219_S	0.982	1.00
135_D	139_D	0.982	1.00
150_D	153_C	0.981	1.00
191_P	195_R	0.981	1.00
140_L	181_A	0.978	1.00
276_T	280_A	0.975	1.00
28_I	110_I	0.975	1.00
31_I	116_I	0.971	1.00
41_P	44_R	0.959	0.99
198_G	201_E	0.957	0.99
88_E	91_S	0.952	0.99
121_I	131_L	0.947	0.99
34_D	42_G	0.942	0.99
124_T	260_G	0.939	0.99
134_F	241_L	0.937	0.99
195_R	248_D	0.936	0.99
151_H	233_V	0.935	0.99
49_S	53_S	0.932	0.99
225_I	243_P	0.927	0.99
272_T	275_I	0.922	0.99
218_I	250_I	0.921	0.99
252_L	255_D	0.915	0.99
99_Y	102_E	0.913	0.99
241_L	249_I	0.906	0.99
130_C	164_K	0.905	0.99
117_T	262_D	0.905	0.99
206_I	209_S	0.903	0.99
138_L	170_T	0.902	0.99
97_I	123_G	0.898	0.99
79_I	92_R	0.897	0.99
138_L	167_E	0.896	0.99
130_C	166_I	0.888	0.99
155_M	165_I	0.882	0.99
181_A	186_I	0.880	0.99
171_R	227_P	0.877	0.99
193_Q	197_L	0.876	0.99
216_L	257_R	0.875	0.99
129_L	259_I	0.875	0.99
230_A	279_L	0.874	0.99
91_S	94_S	0.873	0.99
171_R	226_D	0.872	0.99
233_V	236_P	0.868	0.99
114_H	151_H	0.867	0.99
34_D	43_S	0.865	0.99
182_K	188_F	0.862	0.99
131_L	158_I	0.858	0.99
152_A	235_T	0.851	0.99
140_L	159_S	0.846	0.99
249_I	252_L	0.843	0.99
205_R	209_S	0.839	0.99
43_S	267_S	0.833	0.98
33_M	86_V	0.830	0.98
208_T	211_Q	0.828	0.98
136_A	171_R	0.828	0.98
132_V	210_T	0.827	0.98
141_R	177_E	0.820	0.98
189_F	194_I	0.809	0.98
120_I	260_G	0.803	0.98
227_P	230_A	0.800	0.98
202_T	206_I	0.800	0.98
151_H	265_E	0.796	0.98
34_D	40_R	0.795	0.98
76_V	96_V	0.792	0.98
95_S	98_S	0.792	0.98
275_I	279_L	0.791	0.98
124_T	259_I	0.789	0.98
114_H	262_D	0.788	0.98
25_P	105_K	0.781	0.98
53_S	277_S	0.774	0.98
189_F	209_S	0.774	0.98
192_Q	251_N	0.773	0.98
34_D	41_P	0.773	0.98
243_P	247_L	0.773	0.98
114_H	265_E	0.772	0.97
117_T	154_V	0.771	0.97
241_L	246_L	0.769	0.97
165_I	186_I	0.768	0.97
108_I	288_A	0.768	0.97
140_L	180_Y	0.767	0.97
172_A	237_E	0.767	0.97
100_F	105_K	0.764	0.97
26_F	71_I	0.762	0.97
206_I	210_T	0.761	0.97
180_Y	183_Q	0.760	0.97
250_I	290_T	0.758	0.97
220_V	283_I	0.756	0.97
247_L	283_I	0.755	0.97
121_I	129_L	0.752	0.97
138_L	188_F	0.752	0.97
127_E	215_S	0.750	0.97
205_R	208_T	0.744	0.97
194_I	245_N	0.739	0.97
29_I	107_T	0.738	0.97
36_T	113_E	0.738	0.97
266_V	277_S	0.737	0.97
132_V	166_I	0.736	0.97
225_I	229_Y	0.729	0.96
168_V	206_I	0.728	0.96
36_T	86_V	0.727	0.96
192_Q	248_D	0.726	0.96
200_K	252_L	0.720	0.96
32_P	78_D	0.711	0.96
46_A	49_S	0.709	0.96
134_F	168_V	0.702	0.96
142_D	148_R	0.699	0.96
99_Y	103_S	0.699	0.96
143_E	157_R	0.696	0.95
135_D	223_D	0.695	0.95
130_C	210_T	0.693	0.95
189_F	205_R	0.692	0.95
268_P	271_D	0.686	0.95
21_K	105_K	0.685	0.95
35_I	89_N	0.685	0.95
132_V	168_V	0.684	0.95
107_T	124_T	0.683	0.95
76_V	100_F	0.683	0.95
166_I	206_I	0.682	0.95
132_V	216_L	0.679	0.95
203_A	249_I	0.674	0.95
46_A	268_P	0.673	0.95
49_S	268_P	0.673	0.95
46_A	234_A	0.672	0.94
171_R	237_E	0.671	0.94
217_Y	262_D	0.669	0.94
75_D	78_D	0.668	0.94
134_F	218_I	0.666	0.94
28_I	108_I	0.665	0.94
200_K	248_D	0.665	0.94
233_V	267_S	0.664	0.94
168_V	241_L	0.662	0.94
159_S	165_I	0.661	0.94
115_T	149_Y	0.661	0.94
93_I	119_G	0.661	0.94
244_T	248_D	0.660	0.94
229_Y	242_D	0.659	0.94
228_A	243_P	0.658	0.94
117_T	155_M	0.651	0.93
129_L	215_S	0.650	0.93
139_D	223_D	0.649	0.93
119_G	123_G	0.648	0.93
230_A	266_V	0.648	0.93
179_E	182_K	0.647	0.93
33_M	89_N	0.643	0.93
96_V	100_F	0.634	0.93
46_A	267_S	0.633	0.93
248_D	252_L	0.630	0.92
85_N	147_Y	0.630	0.92
218_I	287_T	0.629	0.92
120_I	124_T	0.622	0.92
219_S	264_V	0.619	0.92
109_S	116_I	0.618	0.92
216_L	258_V	0.616	0.91
169_G	224_G	0.616	0.91
239_D	247_L	0.616	0.91
114_H	217_Y	0.615	0.91
125_K	129_L	0.614	0.91
232_G	266_V	0.613	0.91
125_K	164_K	0.613	0.91
31_I	120_I	0.612	0.91
199_V	249_I	0.612	0.91
53_S	281_S	0.610	0.91
284_I	287_T	0.610	0.91
24_S	105_K	0.608	0.91
40_R	236_P	0.604	0.91
194_I	249_I	0.603	0.91
166_I	189_F	0.603	0.91
191_P	241_L	0.600	0.90
193_Q	196_L	0.597	0.90
139_D	265_E	0.596	0.90
159_S	186_I	0.592	0.90
92_R	95_S	0.592	0.90
133_S	155_M	0.591	0.90
189_F	193_Q	0.587	0.89
92_R	96_V	0.585	0.89
128_G	214_K	0.585	0.89
217_Y	259_I	0.584	0.89
49_S	274_G	0.579	0.89
271_D	274_G	0.579	0.89
152_A	223_D	0.578	0.89
229_Y	279_L	0.578	0.89
286_E	289_A	0.577	0.89
140_L	184_K	0.577	0.89
21_K	24_S	0.574	0.88
53_S	274_G	0.574	0.88
38_S	41_P	0.573	0.88
38_S	151_H	0.571	0.88
125_K	161_Y	0.569	0.88
122_K	158_I	0.569	0.88
26_F	108_I	0.568	0.88
117_T	217_Y	0.564	0.88
207_I	210_T	0.563	0.87
133_S	235_T	0.562	0.87
114_H	137_H	0.561	0.87
114_H	264_V	0.560	0.87
86_V	150_D	0.558	0.87
86_V	90_L	0.558	0.87
48_S	274_G	0.556	0.87
191_P	226_D	0.554	0.87
214_K	257_R	0.554	0.87
104_G	107_T	0.554	0.87
117_T	264_V	0.554	0.87
274_G	277_S	0.553	0.86
82_H	92_R	0.552	0.86
143_E	148_R	0.551	0.86
213_C	216_L	0.551	0.86
199_V	248_D	0.551	0.86
219_S	262_D	0.551	0.86
50_I	281_S	0.550	0.86
79_I	96_V	0.550	0.86
52_E	274_G	0.549	0.86
138_L	181_A	0.546	0.86
198_G	245_N	0.546	0.86
35_I	86_V	0.546	0.86
196_L	200_K	0.541	0.85
203_A	206_I	0.541	0.85
97_I	124_T	0.540	0.85
203_A	207_I	0.537	0.85
28_I	73_F	0.535	0.85
118_A	157_R	0.534	0.85
206_I	249_I	0.533	0.84
27_V	74_N	0.533	0.84
141_R	152_A	0.532	0.84
261_F	284_I	0.531	0.84
61_S	286_E	0.531	0.84
131_L	165_I	0.531	0.84
159_S	180_Y	0.529	0.84
207_I	255_D	0.529	0.84
176_E	180_Y	0.528	0.84
263_I	283_I	0.525	0.84
138_L	141_R	0.524	0.83
239_D	243_P	0.524	0.83
143_E	146_G	0.524	0.83
89_N	92_R	0.522	0.83
238_P	279_L	0.520	0.83
159_S	162_G	0.519	0.83
141_R	235_T	0.519	0.83
81_L	93_I	0.518	0.83
207_I	256_K	0.518	0.83
168_V	194_I	0.517	0.83
211_Q	216_L	0.517	0.83
248_D	251_N	0.512	0.82
97_I	101_Q	0.511	0.82
93_I	116_I	0.510	0.82
194_I	198_G	0.509	0.82
153_C	157_R	0.509	0.82
233_V	265_E	0.508	0.82
133_S	154_V	0.508	0.82
111_G	116_I	0.507	0.81
155_M	170_T	0.506	0.81
151_H	177_E	0.505	0.81
42_G	267_S	0.504	0.81
274_G	278_V	0.504	0.81
166_I	210_T	0.503	0.81
24_S	74_N	0.501	0.81
97_I	119_G	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nioA	5	0.9697	100	0.123	Contact Map
3niqA	5	0.9832	100	0.124	Contact Map
1gq6A	5	0.9764	100	0.127	Contact Map
3m1rA	5	0.9764	100	0.137	Contact Map
4mykA	3	0.9226	100	0.145	Contact Map
1wohA	5	0.9731	100	0.146	Contact Map
4dz4A	5	0.9562	100	0.154	Contact Map
3pzlA	5	0.9731	100	0.17	Contact Map
1xfkA	1	0.9697	100	0.195	Contact Map
3lhlA	3	0.9057	100	0.203	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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