GREMLIN Database
Q97ZX3 - Uncharacterized protein
UniProt: Q97ZX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (118)
Sequences: 282 (221)
Seq/√Len: 20.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E124_N3.8581.00
139_S143_V3.5841.00
87_V131_G2.8530.99
43_E74_H2.7460.99
24_T44_I2.6830.98
50_F69_R2.6410.98
127_G131_G2.5360.98
91_L126_I2.5260.98
16_L48_F2.3410.96
54_D69_R2.3250.96
21_N38_L2.1840.94
35_G89_L2.1250.93
38_L124_N2.1010.93
83_V134_V2.0610.92
73_F139_S2.0390.92
25_Y120_L2.0310.92
7_L135_R1.9500.90
29_S120_L1.8470.87
25_Y41_A1.7830.85
21_N41_A1.7760.85
41_A124_N1.7700.85
49_N73_F1.6590.81
25_Y124_N1.6300.80
75_G79_L1.5300.75
50_F76_S1.4610.72
132_F137_I1.4040.69
9_K123_T1.3880.68
87_V92_L1.3740.67
6_R54_D1.3650.66
38_L88_A1.3520.66
25_Y88_A1.2980.62
15_G19_I1.2640.60
70_L126_I1.2530.59
15_G48_F1.2440.59
6_R60_D1.2340.58
18_T132_F1.2300.58
49_N139_S1.2240.58
12_L24_T1.2200.57
24_T79_L1.2090.57
35_G39_A1.1940.56
6_R43_E1.1940.56
47_I70_L1.1920.56
94_Y130_S1.1670.54
88_A120_L1.1380.52
28_A32_I1.1160.51
53_N57_T1.1100.50
28_A40_I1.0970.49
122_L133_V1.0830.48
71_L86_I1.0720.48
23_V27_L1.0680.47
83_V131_G1.0530.47
19_I41_A1.0450.46
7_L93_V1.0390.46
67_L122_L1.0310.45
17_G49_N1.0300.45
81_N84_Q1.0230.45
73_F136_F1.0230.45
20_V41_A1.0180.44
23_V44_I0.9970.43
78_Y137_I0.9900.42
6_R69_R0.9860.42
27_L32_I0.9780.42
16_L139_S0.9540.40
47_I130_S0.9520.40
77_S139_S0.9510.40
80_G83_V0.9460.40
23_V70_L0.9390.39
87_V127_G0.9380.39
56_W126_I0.9380.39
45_S127_G0.9370.39
5_I9_K0.9370.39
40_I68_N0.9340.39
73_F77_S0.9260.38
41_A70_L0.9230.38
68_N136_F0.9210.38
76_S143_V0.9180.38
47_I74_H0.9080.37
47_I50_F0.8800.36
25_Y44_I0.8780.35
44_I87_V0.8770.35
53_N56_W0.8670.35
8_A67_L0.8550.34
50_F143_V0.8550.34
20_V49_N0.8500.34
93_V135_R0.8500.34
5_I23_V0.8480.34
42_I46_L0.8440.33
12_L65_S0.8240.32
53_N58_F0.8100.32
28_A37_S0.8020.31
24_T28_A0.7720.29
20_V44_I0.7690.29
76_S139_S0.7640.29
46_L77_S0.7500.28
32_I37_S0.7460.28
34_I40_I0.7430.28
9_K56_W0.7430.28
49_N77_S0.7390.28
43_E54_D0.7250.27
46_L58_F0.7240.27
21_N45_S0.7220.27
21_N124_N0.7210.27
52_L73_F0.7110.26
51_V66_Y0.7100.26
8_A62_R0.6940.25
42_I45_S0.6900.25
40_I88_A0.6890.25
29_S124_N0.6790.25
25_Y78_Y0.6720.24
52_L139_S0.6680.24
71_L75_G0.6640.24
88_A124_N0.6630.24
11_A93_V0.6610.24
75_G86_I0.6600.24
75_G78_Y0.6550.23
31_T55_I0.6540.23
84_Q88_A0.6500.23
35_G93_V0.6410.23
38_L41_A0.6410.23
12_L59_K0.6400.23
7_L67_L0.6390.23
30_K136_F0.6380.23
48_F52_L0.6350.23
77_S142_Y0.6350.23
73_F140_L0.6320.22
86_I130_S0.6270.22
7_L132_F0.6230.22
136_F140_L0.6210.22
43_E69_R0.6180.22
24_T27_L0.6150.22
80_G134_V0.6120.22
69_R74_H0.6050.21
21_N28_A0.5970.21
8_A61_K0.5900.21
10_F45_S0.5870.20
54_D74_H0.5860.20
37_S124_N0.5840.20
127_G132_F0.5840.20
7_L137_I0.5830.20
91_L130_S0.5800.20
68_N130_S0.5790.20
54_D136_F0.5770.20
130_S133_V0.5770.20
55_I59_K0.5750.20
76_S84_Q0.5710.20
81_N123_T0.5700.20
54_D140_L0.5690.20
77_S140_L0.5670.20
19_I68_N0.5650.20
44_I124_N0.5540.19
9_K63_N0.5520.19
20_V73_F0.5520.19
79_L83_V0.5520.19
43_E46_L0.5500.19
16_L49_N0.5490.19
12_L97_H0.5480.19
43_E47_I0.5460.19
37_S46_L0.5450.19
89_L92_L0.5450.19
15_G39_A0.5410.19
27_L30_K0.5410.19
51_V55_I0.5400.19
29_S33_P0.5340.18
77_S143_V0.5330.18
16_L19_I0.5320.18
21_N76_S0.5310.18
23_V55_I0.5270.18
21_N48_F0.5270.18
120_L124_N0.5210.18
118_F126_I0.5190.18
22_E134_V0.5170.18
6_R72_K0.5160.18
84_Q123_T0.5140.18
39_A51_V0.5060.17
6_R140_L0.5010.17
53_N121_V0.5000.17
27_L51_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfF 1 0.3724 4 0.952 Contact Map
1sa3A 1 0.4759 2.1 0.958 Contact Map
4wgvA 2 0.8345 2 0.959 Contact Map
2khvA 1 0.2345 1.7 0.961 Contact Map
2kkpA 1 0.269 1.6 0.961 Contact Map
4lz6A 1 0.4552 1.6 0.961 Contact Map
3mktA 1 0.9103 1.5 0.962 Contact Map
3mp7B 1 0.2069 1.4 0.963 Contact Map
2ww9B 1 0.2207 1.2 0.964 Contact Map
3w4tA 1 0.4207 1.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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