GREMLIN Database
ALAXM - Alanyl-tRNA editing protein AlaX-M
UniProt: Q97ZX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (212)
Sequences: 5496 (3627)
Seq/√Len: 249.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_D208_N3.8261.00
56_I73_I3.1391.00
29_L87_G3.0471.00
164_P167_E2.8171.00
102_T193_I2.7821.00
43_N61_V2.7731.00
100_L234_V2.6271.00
151_I154_K2.3741.00
19_V22_I2.3401.00
50_N54_E2.2951.00
113_R147_E2.2721.00
93_R97_M2.2191.00
57_S74_D2.2061.00
19_V25_N2.2001.00
49_V88_T2.1011.00
155_D210_K2.0931.00
45_T93_R2.0701.00
148_A215_I2.0381.00
165_R169_L2.0281.00
33_A87_G1.9941.00
207_K211_E1.9051.00
109_A113_R1.9011.00
80_N83_E1.8581.00
162_F187_I1.8441.00
26_Y70_L1.7731.00
57_S75_Q1.7491.00
167_E170_M1.7471.00
142_I146_N1.7241.00
137_N140_T1.7151.00
47_F55_R1.7071.00
118_L135_V1.6981.00
159_K192_E1.6971.00
114_K147_E1.6931.00
161_Y192_E1.6781.00
48_L85_V1.6531.00
158_L193_I1.6491.00
206_V212_I1.6391.00
55_R76_N1.5961.00
49_V55_R1.5911.00
161_Y171_I1.5741.00
48_L87_G1.5621.00
143_E146_N1.5491.00
24_G74_D1.5421.00
34_F87_G1.5351.00
166_E170_M1.5261.00
62_K72_K1.5221.00
42_D97_M1.5211.00
95_Y98_M1.5191.00
192_E198_I1.5021.00
59_T74_D1.4871.00
147_E150_E1.4851.00
27_V48_L1.4781.00
160_I191_V1.4691.00
99_R153_K1.4681.00
93_R126_P1.4661.00
26_Y72_K1.4411.00
150_E154_K1.4351.00
157_E208_N1.4251.00
224_G227_R1.4031.00
37_G62_K1.4021.00
47_F88_T1.3871.00
120_T134_N1.3831.00
91_W95_Y1.3621.00
32_T71_H1.3591.00
171_I198_I1.3591.00
41_L204_P1.3421.00
43_N60_E1.3371.00
49_V86_I1.3311.00
50_N53_G1.3301.00
24_G59_T1.3171.00
146_N150_E1.3151.00
140_T143_E1.2881.00
163_L171_I1.2851.00
25_N73_I1.2691.00
106_I148_A1.2641.00
27_V73_I1.2581.00
38_G63_R1.2551.00
25_N56_I1.2481.00
155_D211_E1.2381.00
125_S128_Q1.2331.00
151_I196_I1.2311.00
192_E195_G1.2241.00
151_I156_I1.2181.00
164_P187_I1.2151.00
29_L85_V1.2101.00
56_I79_L1.2081.00
143_E147_E1.1971.00
37_G43_N1.1961.00
54_E79_L1.1951.00
145_I216_V1.1941.00
58_V73_I1.1891.00
111_A144_L1.1821.00
166_E169_L1.1801.00
29_L48_L1.1501.00
50_N85_V1.1481.00
158_L206_V1.1361.00
102_T206_V1.1321.00
220_V228_K1.1261.00
28_I70_L1.1231.00
55_R75_Q1.1191.00
42_D125_S1.1021.00
128_Q231_Y1.0901.00
221_E231_Y1.0731.00
104_S122_G1.0721.00
163_L167_E1.0641.00
95_Y99_R1.0631.00
112_Y174_I1.0631.00
129_A232_Y1.0621.00
59_T73_I1.0471.00
96_R235_K1.0401.00
102_T158_L1.0391.00
132_D229_R1.0351.00
91_W98_M1.0351.00
90_D93_R1.0321.00
152_I215_I1.0301.00
118_L134_N1.0211.00
54_E85_V1.0081.00
114_K143_E1.0061.00
47_F57_S1.0031.00
141_L217_L0.9991.00
24_G72_K0.9981.00
79_L85_V0.9981.00
104_S129_A0.9941.00
138_K142_I0.9851.00
98_M204_P0.9831.00
147_E151_I0.9821.00
97_M126_P0.9681.00
111_A133_F0.9661.00
106_I151_I0.9641.00
121_G132_D0.9601.00
95_Y211_E0.9591.00
110_L147_E0.9571.00
22_I25_N0.9501.00
50_N83_E0.9491.00
34_F58_V0.9461.00
218_L233_T0.9321.00
190_I198_I0.9251.00
36_P69_I0.9201.00
108_A174_I0.9201.00
109_A196_I0.9061.00
139_D143_E0.8991.00
106_I212_I0.8901.00
161_Y167_E0.8881.00
103_A215_I0.8771.00
208_N211_E0.8761.00
60_E72_K0.8700.99
135_V140_T0.8600.99
163_L190_I0.8550.99
34_F46_G0.8520.99
110_L144_L0.8490.99
206_V211_E0.8450.99
193_I209_T0.8380.99
100_L129_A0.8310.99
59_T72_K0.8290.99
28_I68_E0.8260.99
63_R69_I0.8260.99
71_H87_G0.8250.99
156_I194_P0.8250.99
104_S119_I0.8240.99
149_N214_E0.8180.99
27_V79_L0.8160.99
96_R100_L0.8120.99
103_A234_V0.8080.99
156_I209_T0.8060.99
113_R151_I0.8010.99
65_E68_E0.7980.99
96_R99_R0.7950.99
107_V215_I0.7910.99
114_K140_T0.7840.99
107_V217_L0.7710.99
153_K214_E0.7700.99
88_T91_W0.7700.99
147_E196_I0.7660.99
173_A177_L0.7550.99
124_I129_A0.7550.99
57_S90_D0.7540.99
157_E207_K0.7520.99
158_L191_V0.7470.98
38_G69_I0.7450.98
109_A174_I0.7400.98
20_V23_E0.7390.98
42_D126_P0.7310.98
157_E194_P0.7310.98
54_E77_G0.7220.98
165_R185_I0.7210.98
21_R76_N0.7200.98
118_L136_E0.7140.98
49_V54_E0.7070.98
45_T90_D0.7060.98
94_R204_P0.7060.98
27_V56_I0.7050.98
38_G98_M0.7040.98
79_L83_E0.7040.98
122_G129_A0.7030.98
160_I189_R0.7010.98
113_R196_I0.7010.98
103_A212_I0.6970.98
98_M160_I0.6880.97
173_A176_K0.6880.97
171_I192_E0.6870.97
35_Y202_G0.6860.97
20_V28_I0.6790.97
89_I98_M0.6770.97
172_P175_V0.6760.97
107_V111_A0.6750.97
49_V53_G0.6730.97
172_P177_L0.6720.97
155_D209_T0.6720.97
48_L58_V0.6720.97
45_T59_T0.6710.97
109_A156_I0.6700.97
110_L114_K0.6680.97
43_N62_K0.6630.97
108_A119_I0.6620.97
159_K194_P0.6600.97
34_F89_I0.6530.96
52_K83_E0.6420.96
99_R211_E0.6420.96
67_G185_I0.6350.96
36_P63_R0.6350.96
104_S232_Y0.6330.96
177_L183_P0.6330.96
108_A176_K0.6330.96
62_K70_L0.6320.96
42_D123_H0.6290.96
154_K157_E0.6220.95
99_R213_G0.6220.95
37_G60_E0.6200.95
120_T227_R0.6170.95
53_G83_E0.6140.95
152_I212_I0.6110.95
104_S108_A0.6090.95
121_G229_R0.6090.95
103_A232_Y0.6060.95
158_L209_T0.6060.95
109_A151_I0.6040.95
98_M206_V0.6030.94
26_Y65_E0.6000.94
21_R28_I0.5980.94
104_S199_Q0.5980.94
112_Y119_I0.5970.94
45_T57_S0.5960.94
220_V230_V0.5950.94
171_I190_I0.5950.94
201_D205_H0.5940.94
106_I209_T0.5910.94
141_L220_V0.5910.94
92_D96_R0.5890.94
33_A89_I0.5860.94
73_I77_G0.5850.94
65_E70_L0.5840.93
98_M207_K0.5830.93
61_V71_H0.5830.93
74_D77_G0.5800.93
152_I214_E0.5800.93
216_V233_T0.5790.93
50_N79_L0.5790.93
50_N56_I0.5740.93
111_A230_V0.5740.93
210_K213_G0.5730.93
54_E78_S0.5730.93
153_K210_K0.5720.93
222_N226_G0.5680.93
167_E171_I0.5670.92
172_P176_K0.5650.92
112_Y117_A0.5620.92
156_I193_I0.5610.92
26_Y73_I0.5590.92
54_E75_Q0.5580.92
52_K86_I0.5550.92
88_T92_D0.5540.92
45_T61_V0.5540.92
66_N70_L0.5530.92
36_P43_N0.5530.92
92_D150_E0.5510.91
107_V129_A0.5490.91
104_S124_I0.5480.91
160_I207_K0.5430.91
159_K162_F0.5420.91
35_Y203_G0.5420.91
108_A199_Q0.5410.91
163_L168_A0.5400.91
63_R66_N0.5390.90
35_Y204_P0.5370.90
149_N206_V0.5340.90
108_A197_D0.5320.90
119_I135_V0.5320.90
142_I145_I0.5310.90
27_V58_V0.5310.90
148_A151_I0.5310.90
160_I204_P0.5280.90
21_R81_V0.5280.90
100_L233_T0.5270.89
119_I134_N0.5260.89
97_M125_S0.5250.89
36_P61_V0.5230.89
99_R206_V0.5210.89
63_R67_G0.5180.89
168_A173_A0.5170.89
103_A129_A0.5170.89
180_R183_P0.5160.88
117_A135_V0.5150.88
165_R200_A0.5140.88
111_A131_D0.5140.88
176_K180_R0.5130.88
153_K235_K0.5100.88
112_Y198_I0.5100.88
116_G135_V0.5070.88
151_I194_P0.5070.88
121_G130_K0.5070.88
38_G42_D0.5060.88
119_I199_Q0.5050.87
113_R143_E0.5050.87
128_Q233_T0.5050.87
125_S129_A0.5030.87
174_I198_I0.5020.87
165_R186_P0.5010.87
219_K231_Y0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zzeA 1 0.9237 100 0.154 Contact Map
3wqyA 2 0.9788 100 0.154 Contact Map
2ztgA 1 0.9788 100 0.167 Contact Map
3kewA 1 0.9364 100 0.176 Contact Map
2e1bA 1 0.8814 100 0.202 Contact Map
1nyrA 2 0.8729 100 0.594 Contact Map
1v4pA 2 0.6102 100 0.612 Contact Map
4ce4c 1 0.8475 100 0.616 Contact Map
1tkeA 1 0.8686 100 0.624 Contact Map
1qf6A 1 0.8602 99.9 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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