GREMLIN Database
Q97ZW9 - Uncharacterized protein
UniProt: Q97ZW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (132)
Sequences: 282 (264)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L133_L3.1821.00
38_L85_L3.1461.00
37_M84_I3.0611.00
27_L122_L2.9711.00
37_M132_H2.9340.99
43_V90_L2.6390.99
18_L26_Q2.5940.99
74_L122_L2.5390.98
90_L138_L2.4360.98
84_I132_H2.4010.98
109_Y118_I2.3270.97
10_V105_I2.3240.97
57_I105_I2.1450.96
81_V129_V2.1330.95
57_I81_V2.1330.95
10_V57_I2.0370.94
76_I124_I2.0350.94
42_K89_N1.9590.93
38_L133_L1.9200.92
60_M108_E1.8790.91
67_A115_I1.8420.90
57_I64_G1.7620.88
71_S119_A1.6920.86
66_S120_K1.6910.86
18_L114_S1.6870.86
54_I102_I1.6280.84
131_Y135_K1.6150.83
74_L81_V1.4570.76
64_G112_G1.4540.76
89_N137_G1.4340.75
84_I88_Y1.4310.75
130_V134_K1.4090.74
49_V124_I1.3950.73
54_I84_I1.3620.71
20_I67_A1.3270.69
56_K60_M1.3120.68
9_K12_K1.2680.65
113_N117_R1.2490.64
49_V97_L1.2250.63
23_I85_L1.2160.62
115_I133_L1.2030.61
108_E121_E1.2010.61
9_K13_M1.1720.59
106_R129_V1.1460.57
67_A85_L1.1420.57
70_I74_L1.1350.57
70_I118_I1.1310.56
20_I115_I1.1180.56
47_G129_V1.1040.55
60_M73_E1.1010.54
65_Y123_N1.0870.53
60_M137_G1.0870.53
43_V138_L1.0840.53
41_A136_M1.0830.53
118_I129_V1.0820.53
29_L37_M1.0770.53
61_G109_Y1.0740.53
101_E124_I1.0510.51
34_V81_V1.0440.50
14_Y85_L1.0350.50
14_Y61_G1.0330.50
19_S25_N1.0330.50
13_M108_E1.0230.49
29_L32_S1.0180.49
43_V89_N1.0180.49
27_L34_V1.0170.49
17_G83_R1.0000.47
16_E63_Q0.9910.47
14_Y109_Y0.9690.45
97_L124_I0.9680.45
56_K59_E0.9660.45
66_S110_I0.9630.45
57_I88_Y0.9500.44
65_Y91_G0.9420.43
104_K108_E0.9420.43
58_I62_K0.9290.42
127_N130_V0.9200.42
20_I38_L0.9190.42
41_A88_Y0.9190.42
30_S70_I0.9130.41
44_N74_L0.9040.41
65_Y73_E0.9030.41
55_Q87_K0.8970.40
71_S114_S0.8960.40
14_Y38_L0.8940.40
132_H136_M0.8800.39
19_S94_R0.8790.39
97_L101_E0.8770.39
37_M88_Y0.8650.38
22_E81_V0.8550.38
10_V43_V0.8550.38
34_V129_V0.8510.37
43_V46_R0.8490.37
21_R86_K0.8440.37
20_I85_L0.8350.36
23_I70_I0.8260.36
115_I129_V0.8210.35
54_I57_I0.8200.35
25_N69_R0.8190.35
42_K137_G0.8190.35
52_D111_K0.8060.34
131_Y140_R0.8010.34
29_L124_I0.7990.34
11_K57_I0.7830.33
63_Q86_K0.7810.33
106_R109_Y0.7760.33
49_V53_K0.7730.32
27_L74_L0.7710.32
19_S83_R0.7660.32
33_K128_L0.7640.32
67_A133_L0.7620.32
28_G123_N0.7590.32
32_S70_I0.7390.30
14_Y23_I0.7370.30
99_A103_E0.7320.30
30_S129_V0.7310.30
9_K56_K0.7300.30
63_Q125_S0.7270.30
31_Y125_S0.7250.30
58_I105_I0.7180.29
29_L61_G0.7150.29
49_V88_Y0.7110.29
68_N81_V0.7030.28
115_I130_V0.6930.28
21_R35_R0.6870.27
103_E106_R0.6640.26
61_G100_K0.6610.26
13_M18_L0.6500.25
69_R81_V0.6500.25
38_L67_A0.6470.25
77_N85_L0.6470.25
52_D57_I0.6460.25
12_K28_G0.6360.25
90_L94_R0.6310.24
48_K69_R0.6280.24
88_Y136_M0.6280.24
10_V101_E0.6260.24
85_L89_N0.6260.24
25_N48_K0.6240.24
53_K58_I0.6220.24
23_I106_R0.6210.24
24_A27_L0.6190.24
66_S90_L0.6180.24
34_V44_N0.6150.24
80_T87_K0.6130.24
59_E97_L0.6100.23
87_K100_K0.6070.23
81_V138_L0.6040.23
40_K72_R0.6030.23
124_I131_Y0.5990.23
44_N87_K0.5990.23
86_K95_R0.5980.23
44_N124_I0.5970.23
30_S75_N0.5920.22
32_S123_N0.5920.22
91_G118_I0.5890.22
9_K120_K0.5880.22
116_Y127_N0.5880.22
35_R127_N0.5850.22
61_G70_I0.5850.22
109_Y129_V0.5800.22
40_K77_N0.5800.22
75_N87_K0.5760.22
48_K124_I0.5740.22
92_K95_R0.5730.22
50_P105_I0.5720.22
66_S104_K0.5690.21
117_R123_N0.5690.21
19_S114_S0.5680.21
114_S130_V0.5670.21
19_S44_N0.5650.21
53_K76_I0.5560.21
26_Q123_N0.5550.21
9_K19_S0.5540.21
9_K52_D0.5540.21
36_R110_I0.5540.21
32_S81_V0.5520.21
17_G112_G0.5510.21
23_I59_E0.5470.20
49_V80_T0.5400.20
38_L108_E0.5400.20
21_R29_L0.5390.20
100_K139_Y0.5390.20
37_M106_R0.5370.20
24_A122_L0.5370.20
104_K117_R0.5330.20
73_E80_T0.5280.20
12_K16_E0.5270.19
23_I57_I0.5260.19
81_V101_E0.5220.19
92_K104_K0.5210.19
12_K75_N0.5200.19
26_Q59_E0.5180.19
19_S134_K0.5120.19
69_R90_L0.5110.19
11_K15_E0.5060.19
47_G104_K0.5030.18
65_Y70_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u78A 1 0.6267 99 0.627 Contact Map
1k78A 1 0.5867 98.9 0.645 Contact Map
1pdnC 1 0.5667 98.8 0.648 Contact Map
2k27A 1 0.8467 98.7 0.665 Contact Map
2lvsA 1 0.6333 98.6 0.674 Contact Map
4u7bA 2 0.6933 98.3 0.701 Contact Map
1h89C 1 0.7133 98.1 0.72 Contact Map
1hlvA 1 0.5933 97.7 0.745 Contact Map
4fcyA 4 0.7867 97.7 0.745 Contact Map
1h8aC 1 0.6467 97.6 0.747 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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