GREMLIN Database
Q97ZW8 - Uncharacterized protein
UniProt: Q97ZW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (210)
Sequences: 2640 (1889)
Seq/√Len: 130.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_V246_L4.3701.00
225_K258_S4.3151.00
229_E262_M3.8961.00
67_S128_N3.0431.00
167_P178_L2.6151.00
78_A134_F2.5431.00
83_T134_F2.4211.00
41_Y257_L2.4121.00
151_K185_I2.3931.00
62_K66_L2.3821.00
57_E61_N2.3061.00
154_F187_V2.1051.00
164_G190_V2.0881.00
142_P171_W2.0281.00
174_N177_V1.9941.00
155_S185_I1.9721.00
114_M118_E1.9331.00
67_S74_L1.9091.00
43_D260_K1.8931.00
50_T60_L1.8901.00
110_T156_I1.8881.00
28_K43_D1.8841.00
75_T246_L1.8501.00
151_K184_Q1.8311.00
209_L245_V1.8311.00
258_S261_R1.7921.00
55_L60_L1.7551.00
232_K236_L1.7511.00
228_L262_M1.7381.00
151_K155_S1.7021.00
203_Q241_E1.6851.00
157_L163_Y1.6491.00
207_F231_L1.6161.00
204_I244_Y1.6101.00
249_N252_S1.5981.00
36_R66_L1.5981.00
28_K73_E1.5971.00
32_C246_L1.5921.00
31_T38_H1.5911.00
235_V245_V1.5821.00
134_F163_Y1.5451.00
38_H45_L1.5381.00
56_S59_R1.5031.00
78_A132_I1.4991.00
142_P178_L1.4821.00
136_T150_L1.4741.00
205_R243_I1.4631.00
73_E244_Y1.4371.00
165_W182_F1.4211.00
181_I185_I1.3911.00
61_N65_E1.3691.00
153_F157_L1.3651.00
222_K255_D1.3651.00
130_R244_Y1.3461.00
188_I204_I1.3231.00
73_E130_R1.3091.00
55_L119_I1.2981.00
224_T227_D1.2941.00
29_I260_K1.2871.00
235_V259_F1.2851.00
180_K184_Q1.2521.00
222_K254_D1.2511.00
62_K65_E1.2501.00
47_V59_R1.2481.00
86_Y90_T1.2461.00
188_I202_K1.2371.00
68_I128_N1.2371.00
164_G188_I1.2261.00
26_M242_L1.2161.00
64_K125_K1.2131.00
218_N221_Y1.2110.99
86_Y112_E1.2070.99
255_D258_S1.1980.99
111_K115_Q1.1960.99
152_D155_S1.1890.99
81_I112_E1.1800.99
75_T131_I1.1780.99
51_F84_H1.1650.99
58_E61_N1.1640.99
148_K152_D1.1630.99
29_I259_F1.1600.99
60_L123_E1.1470.99
64_K128_N1.1400.99
60_L120_T1.1350.99
131_I244_Y1.1290.99
210_H249_N1.1280.99
186_D203_Q1.1180.99
141_A169_G1.1160.99
179_L183_S1.1070.99
150_L154_F1.1070.99
82_I113_V1.0920.99
39_F67_S1.0820.99
151_K181_I1.0540.99
176_E180_K1.0540.99
50_T116_A1.0490.99
247_F259_F1.0480.99
47_V74_L1.0480.99
210_H255_D1.0330.98
37_K41_Y1.0290.98
58_E62_K1.0280.98
115_Q119_I1.0240.98
179_L189_H1.0240.98
34_F63_L1.0200.98
230_K234_Y1.0180.98
131_I204_I1.0090.98
150_L158_D1.0080.98
247_F255_D1.0070.98
72_V128_N1.0040.98
87_N139_S0.9980.98
64_K124_A0.9970.98
111_K114_M0.9970.98
223_Y247_F0.9850.98
162_I203_Q0.9840.98
232_K259_F0.9830.98
36_R40_N0.9800.98
34_F47_V0.9740.98
37_K40_N0.9730.98
129_S132_I0.9660.97
209_L248_N0.9560.97
81_I86_Y0.9540.97
149_N153_F0.9470.97
28_K242_L0.9460.97
150_L153_F0.9460.97
54_F119_I0.9360.97
78_A113_V0.9290.97
115_Q118_E0.9290.97
89_I149_N0.9280.97
84_H137_P0.9270.97
28_K244_Y0.9230.97
200_D205_R0.9210.97
90_T112_E0.9120.96
76_I120_T0.9050.96
117_L132_I0.9050.96
136_T153_F0.9010.96
60_L119_I0.8970.96
131_I206_Y0.8860.96
153_F158_D0.8840.96
212_L227_D0.8840.96
150_L165_W0.8760.96
75_T206_Y0.8750.96
110_T114_M0.8740.95
131_I164_G0.8730.95
124_A161_F0.8710.95
68_I72_V0.8670.95
112_E115_Q0.8640.95
53_N56_S0.8610.95
29_I256_A0.8570.95
79_N116_A0.8500.95
225_K262_M0.8480.95
210_H248_N0.8470.95
33_G206_Y0.8460.95
121_L125_K0.8430.95
205_R240_K0.8410.94
211_G219_Y0.8400.94
81_I85_E0.8400.94
29_I263_I0.8390.94
180_K183_S0.8390.94
193_P197_K0.8390.94
219_Y248_N0.8380.94
213_G218_N0.8380.94
210_H250_V0.8330.94
51_F137_P0.8260.94
57_E118_E0.8250.94
194_F198_S0.8230.94
192_D212_L0.8210.94
57_E119_I0.8100.93
115_Q120_T0.8090.93
76_I123_E0.8070.93
173_Q189_H0.8060.93
77_K135_Q0.8050.93
140_F150_L0.8010.93
54_F79_N0.7940.93
249_N255_D0.7940.93
165_W187_V0.7920.92
120_T124_A0.7920.92
210_H219_Y0.7890.92
28_K130_R0.7880.92
80_Q85_E0.7880.92
220_R251_Y0.7880.92
193_P199_V0.7860.92
205_R241_E0.7810.92
194_F211_G0.7800.92
121_L124_A0.7750.92
87_N90_T0.7710.91
134_F165_W0.7690.91
257_L260_K0.7630.91
57_E122_N0.7600.91
247_F256_A0.7600.91
231_L234_Y0.7570.91
47_V76_I0.7540.91
32_C48_Q0.7490.90
78_A83_T0.7460.90
225_K229_E0.7460.90
210_H223_Y0.7440.90
212_L221_Y0.7410.90
209_L231_L0.7370.90
80_Q90_T0.7330.89
120_T123_E0.7320.89
191_V207_F0.7320.89
60_L76_I0.7310.89
116_A120_T0.7300.89
211_G221_Y0.7300.89
70_N128_N0.7280.89
144_N148_K0.7280.89
154_F186_D0.7270.89
222_K258_S0.7250.89
170_E173_Q0.7250.89
211_G249_N0.7230.89
114_M124_A0.7230.89
133_I249_N0.7230.89
113_V117_L0.7180.88
162_I242_L0.7160.88
57_E121_L0.7130.88
85_E90_T0.7090.88
167_P179_L0.7040.87
172_N178_L0.6930.86
32_C248_N0.6900.86
213_G227_D0.6850.86
59_R62_K0.6850.86
207_F235_V0.6760.85
223_Y228_L0.6720.85
195_K199_V0.6710.85
77_K168_R0.6710.85
250_V255_D0.6690.84
204_I242_L0.6640.84
182_F187_V0.6610.84
194_F197_K0.6600.84
130_R242_L0.6600.84
212_L249_N0.6590.84
162_I204_I0.6570.83
38_H42_F0.6560.83
48_Q246_L0.6550.83
44_V244_Y0.6540.83
71_K128_N0.6520.83
87_N140_F0.6500.83
229_E232_K0.6480.83
125_K128_N0.6470.82
195_K198_S0.6450.82
152_D156_I0.6420.82
117_L161_F0.6400.82
136_T140_F0.6380.82
163_Y187_V0.6370.81
182_F189_H0.6370.81
37_K257_L0.6360.81
229_E237_S0.6350.81
165_W178_L0.6320.81
135_Q168_R0.6310.81
210_H247_F0.6270.80
83_T137_P0.6250.80
76_I116_A0.6250.80
67_S72_V0.6230.80
235_V243_I0.6190.80
142_P174_N0.6190.80
133_I190_V0.6190.80
45_L72_V0.6150.79
245_V259_F0.6140.79
150_L157_L0.6120.79
136_T149_N0.6100.79
234_Y237_S0.6060.78
50_T120_T0.6050.78
79_N82_I0.6050.78
26_M29_I0.6030.78
194_F212_L0.5890.76
34_F45_L0.5870.76
36_R41_Y0.5860.76
167_P172_N0.5850.76
61_N122_N0.5830.75
47_V50_T0.5820.75
68_I71_K0.5820.75
226_A230_K0.5810.75
245_V248_N0.5790.75
151_K156_I0.5790.75
78_A163_Y0.5760.75
229_E258_S0.5760.75
153_F163_Y0.5750.74
35_T49_E0.5750.74
118_E121_L0.5690.74
133_I140_F0.5660.73
28_K71_K0.5640.73
233_E237_S0.5620.73
140_F149_N0.5610.73
120_T129_S0.5600.73
43_D71_K0.5600.73
148_K155_S0.5540.72
217_V220_R0.5530.72
148_K151_K0.5530.72
38_H167_P0.5520.71
78_A157_L0.5500.71
154_F159_K0.5490.71
233_E236_L0.5450.71
31_T55_L0.5440.70
74_L128_N0.5430.70
154_F181_I0.5420.70
133_I252_S0.5410.70
35_T53_N0.5390.70
212_L224_T0.5380.70
31_T45_L0.5330.69
133_I210_H0.5330.69
140_F143_N0.5250.68
32_C49_E0.5240.68
193_P196_N0.5240.68
55_L62_K0.5230.67
39_F66_L0.5220.67
121_L160_S0.5190.67
46_E211_G0.5190.67
162_I188_I0.5150.66
46_E63_L0.5140.66
51_F136_T0.5130.66
155_S261_R0.5110.66
113_V153_F0.5100.66
138_P171_W0.5100.66
137_P140_F0.5090.65
28_K44_V0.5050.65
193_P207_F0.5050.65
38_H55_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpqA 2 0.8264 100 0.241 Contact Map
1vpyA 1 0.8528 100 0.251 Contact Map
4hnoA 1 0.8415 81.6 0.944 Contact Map
3aamA 1 0.8151 75.9 0.947 Contact Map
1qtwA 1 0.8415 74.6 0.947 Contact Map
3kwsA 2 0.8151 70.3 0.949 Contact Map
3wqoA 2 0.8377 64.8 0.951 Contact Map
4ovxA 1 0.8264 62.3 0.951 Contact Map
1k77A 1 0.8264 56.6 0.953 Contact Map
3dx5A 2 0.7887 50.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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