GREMLIN Database
Q97ZW7 - Uncharacterized protein
UniProt: Q97ZW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (175)
Sequences: 12125 (8541)
Seq/√Len: 645.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_T100_Y5.1601.00
83_S171_V3.6011.00
84_Y88_R3.3941.00
6_L135_G3.0291.00
161_Y164_V2.9911.00
69_N72_Y2.8631.00
80_L174_G2.5821.00
160_K164_V2.3631.00
51_I104_L2.3131.00
87_I164_V2.2231.00
73_I77_I2.1991.00
81_Y85_L2.1771.00
76_G178_L2.0601.00
87_I167_S2.0031.00
26_M41_I1.9831.00
30_E33_K1.8951.00
168_V172_I1.8771.00
85_L88_R1.8681.00
31_S38_G1.8661.00
155_G159_V1.8441.00
10_I139_G1.7941.00
90_K164_V1.7921.00
48_A108_L1.7701.00
12_L120_V1.7611.00
80_L171_V1.7501.00
83_S167_S1.7431.00
37_H99_N1.7291.00
23_V45_A1.7171.00
76_G174_G1.6881.00
24_N147_F1.6741.00
38_G148_P1.6231.00
68_R72_Y1.6221.00
101_F105_S1.5741.00
17_A139_G1.5641.00
69_N73_I1.5571.00
91_M164_V1.4951.00
18_A143_W1.4711.00
30_E41_I1.4691.00
10_I135_G1.4691.00
61_G65_T1.4671.00
80_L84_Y1.4661.00
50_L137_F1.4661.00
43_A100_Y1.4381.00
28_A151_V1.4111.00
42_G148_P1.3731.00
38_G42_G1.3691.00
41_I103_G1.3661.00
53_F133_I1.3451.00
100_Y104_L1.3401.00
31_S148_P1.3381.00
161_Y165_I1.2981.00
70_A74_I1.2811.00
73_I76_G1.2741.00
143_W147_F1.2611.00
140_I144_I1.2601.00
78_F82_L1.2541.00
33_K37_H1.2471.00
54_I58_F1.2141.00
39_S149_K1.2131.00
104_L108_L1.2081.00
36_L40_S1.2031.00
171_V175_V1.1991.00
30_E102_I1.1951.00
8_L11_I1.1901.00
5_Y8_L1.1631.00
9_G13_G1.1491.00
51_I108_L1.1481.00
9_G132_I1.1461.00
88_R91_M1.1321.00
26_M106_M1.1251.00
46_M141_L1.1241.00
35_W149_K1.1231.00
44_G100_Y1.1231.00
117_W136_F1.1211.00
7_G11_I1.1211.00
26_M30_E1.0991.00
23_V107_G1.0871.00
35_W152_N1.0831.00
167_S171_V1.0821.00
146_A150_A1.0761.00
13_G136_F1.0761.00
153_M156_S1.0741.00
83_S174_G1.0561.00
172_I176_Y1.0491.00
27_I144_I1.0481.00
73_I178_L1.0481.00
46_M137_F1.0451.00
17_A140_I1.0411.00
89_A163_K1.0291.00
24_N144_I1.0271.00
39_S145_I1.0221.00
27_I31_S1.0171.00
8_L12_L1.0121.00
40_S99_N1.0021.00
23_V140_I0.9941.00
164_V168_V0.9931.00
153_M157_K0.9891.00
49_D107_G0.9651.00
32_M151_V0.9571.00
78_F81_Y0.9561.00
49_D113_Q0.9391.00
91_M94_K0.9341.00
23_V106_M0.9341.00
35_W145_I0.9141.00
12_L15_S0.9121.00
25_A29_N0.9101.00
10_I14_L0.9061.00
14_L139_G0.9001.00
52_F114_I0.8981.00
47_T104_L0.8961.00
6_L138_V0.8901.00
23_V49_D0.8891.00
165_I168_V0.8891.00
37_H40_S0.8811.00
175_V179_Y0.8721.00
48_A104_L0.8671.00
119_T123_S0.8551.00
105_S109_T0.8521.00
130_I133_I0.8491.00
27_I148_P0.8371.00
99_N102_I0.8361.00
25_A166_S0.8331.00
35_W148_P0.8331.00
49_D52_F0.8271.00
24_N143_W0.8261.00
33_K99_N0.8221.00
145_I149_K0.8181.00
13_G17_A0.8181.00
52_F108_L0.8171.00
176_Y179_Y0.8171.00
162_V166_S0.8161.00
150_A153_M0.8101.00
76_G80_L0.8091.00
91_M160_K0.8071.00
85_L89_A0.8061.00
24_N28_A0.8061.00
77_I80_L0.8031.00
44_G104_L0.8021.00
57_Y129_S0.7931.00
141_L145_I0.7811.00
88_R92_P0.7751.00
67_I70_A0.7641.00
47_T51_I0.7641.00
61_G64_P0.7621.00
11_I15_S0.7591.00
86_T167_S0.7561.00
15_S19_P0.7531.00
34_S37_H0.7521.00
53_F117_W0.7491.00
171_V174_G0.7451.00
60_Q64_P0.7431.00
109_T118_I0.7371.00
31_S151_V0.7341.00
84_Y171_V0.7311.00
58_F61_G0.7301.00
74_I77_I0.7271.00
81_Y84_Y0.7241.00
87_I171_V0.7211.00
42_G46_M0.7201.00
77_I81_Y0.7191.00
7_G10_I0.7101.00
53_F144_I0.7011.00
144_I147_F0.7001.00
23_V144_I0.6971.00
66_P69_N0.6971.00
52_F113_Q0.6961.00
39_S148_P0.6911.00
45_A49_D0.6871.00
165_I169_I0.6851.00
6_L10_I0.6841.00
42_G145_I0.6821.00
149_K153_M0.6821.00
51_I54_I0.6761.00
74_I109_T0.6761.00
41_I99_N0.6741.00
154_L157_K0.6741.00
24_N106_M0.6681.00
27_I45_A0.6631.00
46_M140_I0.6591.00
28_A147_F0.6591.00
90_K160_K0.6571.00
52_F118_I0.6561.00
93_S96_I0.6561.00
49_D137_F0.6561.00
107_G113_Q0.6501.00
130_I134_P0.6491.00
43_A46_M0.6351.00
17_A24_N0.6341.00
48_A107_G0.6341.00
114_I118_I0.6311.00
102_I106_M0.6311.00
56_V60_Q0.6301.00
94_K97_K0.6291.00
131_L135_G0.6271.00
53_F137_F0.6261.00
70_A73_I0.6221.00
39_S42_G0.6191.00
49_D140_I0.6151.00
52_F56_V0.6131.00
83_S87_I0.6101.00
75_G115_S0.6071.00
138_V142_I0.6071.00
151_V154_L0.6061.00
45_A107_G0.6041.00
49_D117_W0.6011.00
27_I41_I0.5981.00
143_W146_A0.5971.00
56_V117_W0.5941.00
17_A144_I0.5921.00
17_A143_W0.5901.00
20_P112_Y0.5891.00
19_P24_N0.5851.00
134_P138_V0.5841.00
49_D136_F0.5841.00
52_F107_G0.5831.00
12_L16_M0.5811.00
46_M144_I0.5761.00
54_I133_I0.5751.00
57_Y133_I0.5751.00
41_I106_M0.5731.00
148_P152_N0.5731.00
22_P110_N0.5701.00
107_G144_I0.5701.00
143_W148_P0.5661.00
14_L18_A0.5651.00
147_F151_V0.5621.00
17_A49_D0.5611.00
93_S97_K0.5611.00
29_N163_K0.5591.00
168_V171_V0.5541.00
76_G171_V0.5541.00
156_S159_V0.5511.00
38_G41_I0.5511.00
94_K98_G0.5471.00
87_I168_V0.5471.00
91_M163_K0.5411.00
125_I129_S0.5391.00
137_F141_L0.5381.00
35_W153_M0.5371.00
166_S170_L0.5340.99
63_I71_L0.5290.99
9_G122_I0.5290.99
117_W140_I0.5260.99
22_P86_T0.5240.99
136_F140_I0.5230.99
50_L54_I0.5220.99
150_A154_L0.5210.99
172_I175_V0.5180.99
56_V125_I0.5180.99
66_P71_L0.5160.99
19_P163_K0.5150.99
56_V114_I0.5100.99
142_I146_A0.5070.99
23_V113_Q0.5070.99
44_G103_G0.5060.99
142_I145_I0.5040.99
87_I91_M0.5020.99
16_M116_W0.5010.99
113_Q140_I0.5010.99
146_A149_K0.5010.99
45_A113_Q0.5000.99
95_S98_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.5161 19.3 0.926 Contact Map
2cfqA 1 0.957 8.1 0.938 Contact Map
4uvmA 1 0.4839 7.4 0.939 Contact Map
4m64A 1 0.9785 7.1 0.939 Contact Map
2gfpA 2 0.9462 6.7 0.94 Contact Map
3wdoA 1 0.5054 5.8 0.942 Contact Map
4p6vD 1 0.4355 4.4 0.945 Contact Map
4q65A 1 0.4785 4.2 0.945 Contact Map
3h90A 3 0.4677 3 0.949 Contact Map
4g1uA 2 0.414 2.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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