GREMLIN Database
Q97ZW6 - Uncharacterized protein
UniProt: Q97ZW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (231)
Sequences: 378 (249)
Seq/√Len: 16.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_D198_S6.7041.00
50_F74_H4.3191.00
138_I199_R3.8911.00
195_A200_L3.8471.00
49_E202_R3.8241.00
175_D199_R3.6811.00
67_V130_V3.5271.00
64_Q172_T3.4240.99
59_N64_Q3.3720.99
13_R28_Y3.0930.99
71_A78_V3.0840.99
175_D197_P2.4840.95
58_V81_P2.4400.94
56_I71_A2.3050.92
70_I74_H2.1760.90
179_V182_I2.1100.88
26_P33_N2.1020.88
173_V178_I2.0900.88
107_R110_G2.0590.87
194_I201_I2.0550.87
218_L222_K1.9950.85
44_L170_A1.9800.85
8_R12_W1.9360.84
5_Q9_E1.8530.81
5_Q149_Y1.8310.80
48_K52_N1.7860.78
19_N27_V1.7680.77
47_C193_I1.7300.76
41_A59_N1.6910.74
45_V70_I1.6800.74
80_V111_F1.6760.73
33_N63_P1.6570.73
21_A24_P1.6560.73
16_E21_A1.6470.72
131_A189_V1.6170.71
90_F115_G1.5840.69
41_A53_A1.5630.68
4_K8_R1.5580.68
224_D230_R1.5530.67
30_R33_N1.5300.66
106_S110_G1.5200.66
62_S108_I1.4850.64
3_S198_S1.4830.64
56_I213_I1.4660.63
201_I223_I1.4520.62
36_G135_A1.4290.61
67_V195_A1.4220.60
170_A193_I1.4090.60
39_E42_L1.3990.59
141_N182_I1.3990.59
154_F158_R1.3940.59
169_I209_K1.3690.57
69_E73_R1.3590.57
51_E126_V1.3360.56
59_N84_R1.3350.55
41_A67_V1.3350.55
215_L232_Y1.3110.54
46_K49_E1.3060.54
157_L183_P1.2960.53
61_D132_G1.2910.53
63_P147_E1.2880.53
31_I145_K1.2880.53
203_V206_K1.2800.52
137_D141_N1.2730.52
144_G148_G1.2640.51
42_L121_E1.2540.51
20_I176_V1.2510.51
43_N197_P1.2500.50
142_R188_D1.2470.50
228_L232_Y1.2440.50
50_F80_V1.2300.49
137_D182_I1.2150.48
40_A171_T1.2090.48
43_N200_L1.2080.48
48_K214_Y1.2070.48
77_K91_L1.2000.48
154_F169_I1.1990.47
41_A66_K1.1950.47
9_E13_R1.1930.47
78_V92_L1.1880.47
14_K18_G1.1830.47
54_E180_D1.1780.46
145_K153_E1.1740.46
142_R153_E1.1680.46
107_R113_K1.1540.45
47_C170_A1.1530.45
88_D150_S1.1390.44
16_E26_P1.1180.43
41_A172_T1.1090.42
57_K129_M1.1080.42
154_F208_E1.1080.42
79_L82_T1.1000.42
30_R63_P1.0900.41
56_I126_V1.0830.41
26_P63_P1.0810.41
27_V171_T1.0810.41
21_A27_V1.0790.41
43_N199_R1.0730.40
47_C200_L1.0720.40
89_F115_G1.0660.40
14_K178_I1.0660.40
87_G220_K1.0580.39
156_I194_I1.0550.39
30_R62_S1.0450.39
58_V191_V1.0350.38
193_I202_R1.0240.38
14_K176_V1.0220.37
151_E182_I1.0170.37
170_A203_V1.0160.37
11_I202_R1.0120.37
31_I142_R1.0070.37
52_N56_I0.9920.36
23_F169_I0.9920.36
88_D231_E0.9780.35
33_N37_A0.9760.35
63_P84_R0.9730.35
146_G218_L0.9710.35
135_A145_K0.9700.35
129_M176_V0.9670.34
221_Q225_N0.9620.34
60_P68_R0.9570.34
38_E73_R0.9540.34
50_F70_I0.9490.33
33_N62_S0.9470.33
97_I102_I0.9440.33
84_R147_E0.9430.33
50_F81_P0.9420.33
49_E200_L0.9290.32
59_N172_T0.9270.32
42_L156_I0.9270.32
41_A146_G0.9230.32
193_I200_L0.9120.32
31_I153_E0.9080.31
55_I126_V0.9050.31
21_A26_P0.9020.31
7_I47_C0.9010.31
86_R223_I0.9010.31
146_G151_E0.8920.31
180_D193_I0.8910.31
56_I78_V0.8900.30
24_P33_N0.8870.30
213_I216_E0.8860.30
170_A200_L0.8830.30
33_N154_F0.8790.30
90_F112_E0.8710.30
152_L218_L0.8690.29
60_P83_P0.8640.29
158_R209_K0.8580.29
44_L130_V0.8570.29
151_E215_L0.8550.29
105_A115_G0.8520.29
220_K230_R0.8520.29
53_A168_P0.8510.29
164_D168_P0.8490.28
59_N66_K0.8460.28
56_I224_D0.8450.28
178_I214_Y0.8400.28
86_R162_K0.8400.28
213_I232_Y0.8390.28
25_R151_E0.8380.28
186_P214_Y0.8380.28
37_A59_N0.8370.28
181_E208_E0.8300.28
92_L165_E0.8260.27
141_N218_L0.8140.27
16_E110_G0.8130.27
222_K226_T0.8120.27
115_G126_V0.8110.27
133_S147_E0.8040.26
51_E116_I0.7920.26
89_F105_A0.7890.26
145_K149_Y0.7880.26
49_E193_I0.7850.26
48_K216_E0.7780.25
213_I218_L0.7780.25
208_E223_I0.7760.25
200_L211_K0.7710.25
141_N184_S0.7680.25
125_R164_D0.7660.25
66_K69_E0.7600.24
86_R209_K0.7580.24
184_S190_P0.7570.24
63_P83_P0.7570.24
129_M194_I0.7560.24
69_E110_G0.7550.24
41_A44_L0.7530.24
153_E188_D0.7520.24
137_D179_V0.7490.24
3_S6_E0.7450.24
59_N63_P0.7400.24
54_E163_V0.7400.24
16_E24_P0.7390.24
57_K161_G0.7370.23
185_E217_Y0.7340.23
213_I233_L0.7340.23
35_K168_P0.7320.23
61_D174_H0.7290.23
37_A64_Q0.7250.23
67_V146_G0.7240.23
137_D216_E0.7230.23
87_G117_R0.7220.23
15_L29_G0.7140.22
33_N171_T0.7130.22
57_K147_E0.7100.22
144_G151_E0.7090.22
79_L120_L0.7090.22
151_E227_P0.7040.22
43_N46_K0.7020.22
71_A76_K0.7020.22
11_I179_V0.6980.22
154_F184_S0.6960.22
45_V74_H0.6950.22
83_P150_S0.6920.22
104_R113_K0.6880.21
19_N103_P0.6870.21
170_A220_K0.6870.21
41_A64_Q0.6770.21
43_N71_A0.6770.21
7_I35_K0.6760.21
130_V230_R0.6750.21
59_N62_S0.6740.21
151_E188_D0.6740.21
218_L223_I0.6740.21
130_V170_A0.6730.21
47_C130_V0.6720.21
55_I69_E0.6680.21
110_G115_G0.6680.21
131_A143_V0.6680.21
87_G228_L0.6630.20
91_L106_S0.6620.20
57_K145_K0.6620.20
61_D149_Y0.6610.20
108_I112_E0.6570.20
11_I70_I0.6570.20
136_V171_T0.6560.20
55_I64_Q0.6550.20
120_L231_E0.6540.20
50_F86_R0.6540.20
130_V199_R0.6530.20
113_K157_L0.6520.20
87_G122_D0.6520.20
211_K216_E0.6490.20
82_T231_E0.6490.20
16_E25_R0.6480.20
52_N122_D0.6470.20
57_K149_Y0.6470.20
132_G174_H0.6460.20
39_E52_N0.6390.20
54_E204_N0.6380.20
111_F117_R0.6370.19
69_E103_P0.6340.19
32_P179_V0.6330.19
82_T97_I0.6330.19
38_E66_K0.6320.19
88_D98_S0.6310.19
79_L156_I0.6310.19
98_S112_E0.6300.19
4_K12_W0.6260.19
84_R189_V0.6260.19
220_K234_K0.6250.19
154_F189_V0.6240.19
142_R151_E0.6230.19
113_K137_D0.6210.19
156_I160_L0.6180.19
82_T168_P0.6180.19
14_K20_I0.6170.19
153_E187_F0.6170.19
127_D136_V0.6160.19
94_P119_S0.6150.19
79_L90_F0.6140.19
29_G80_V0.6100.19
92_L95_S0.6100.19
126_V179_V0.6090.18
215_L233_L0.6070.18
31_I188_D0.6020.18
44_L67_V0.5940.18
6_E143_V0.5890.18
22_L149_Y0.5870.18
8_R144_G0.5870.18
42_L95_S0.5860.18
91_L200_L0.5850.18
10_L14_K0.5840.18
58_V82_T0.5830.18
50_F193_I0.5810.18
141_N222_K0.5760.17
98_S181_E0.5740.17
37_A56_I0.5720.17
61_D145_K0.5710.17
73_R200_L0.5700.17
129_M221_Q0.5700.17
37_A43_N0.5690.17
154_F190_P0.5680.17
154_F181_E0.5680.17
223_I232_Y0.5660.17
63_P154_F0.5640.17
131_A150_S0.5640.17
141_N156_I0.5630.17
8_R142_R0.5620.17
40_A172_T0.5610.17
22_L69_E0.5580.17
106_S111_F0.5560.17
4_K142_R0.5560.17
65_Y69_E0.5550.17
15_L48_K0.5540.17
74_H105_A0.5490.16
16_E27_V0.5490.16
30_R171_T0.5490.16
11_I14_K0.5480.16
169_I189_V0.5480.16
81_P218_L0.5460.16
126_V205_R0.5460.16
136_V187_F0.5440.16
27_V214_Y0.5430.16
20_I125_R0.5420.16
149_Y194_I0.5400.16
43_N201_I0.5400.16
66_K172_T0.5370.16
39_E202_R0.5360.16
81_P209_K0.5340.16
50_F58_V0.5310.16
60_P85_L0.5300.16
57_K188_D0.5290.16
75_K92_L0.5280.16
194_I219_S0.5270.16
48_K51_E0.5260.16
30_R83_P0.5260.16
24_P63_P0.5250.16
63_P203_V0.5240.16
63_P115_G0.5230.16
142_R177_Q0.5210.16
148_G151_E0.5200.16
37_A66_K0.5190.16
85_L107_R0.5150.15
198_S214_Y0.5140.15
81_P162_K0.5140.15
223_I233_L0.5130.15
67_V89_F0.5110.15
23_F26_P0.5070.15
71_A118_I0.5060.15
136_V191_V0.5050.15
144_G188_D0.5020.15
92_L97_I0.5010.15
134_V171_T0.5010.15
57_K64_Q0.5010.15
20_I35_K0.5010.15
90_F110_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wkcA 1 0.6888 100 0.679 Contact Map
1ydmA 3 0.7137 100 0.702 Contact Map
1souA 1 0.7759 100 0.705 Contact Map
3hy3A 2 0.7344 100 0.706 Contact Map
2jcbA 1 0.7344 100 0.718 Contact Map
1sbqA 1 0.6307 99.9 0.744 Contact Map
2cfmA 1 0.7967 24.4 0.969 Contact Map
2hivA 1 0.8133 18.4 0.971 Contact Map
1jcuA 1 0.6722 14.3 0.972 Contact Map
1x9nA 1 0.805 10.1 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.