GREMLIN Database
Q97ZW4 - MRP protein homolog, conserved ATPase (Mrp)
UniProt: Q97ZW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (233)
Sequences: 14391 (9022)
Seq/√Len: 591.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_P280_E4.1851.00
116_K154_L3.9011.00
62_S158_I3.6911.00
72_S286_D3.5191.00
61_V281_F3.0701.00
74_R156_Y3.0221.00
267_P270_L2.9141.00
48_G179_I2.7781.00
77_G154_L2.7671.00
69_I156_Y2.7111.00
45_Y181_G2.6161.00
217_M254_L2.4021.00
187_I217_M2.3771.00
71_A282_L2.3561.00
78_I88_V2.3501.00
63_S88_V2.2001.00
61_V214_V2.1871.00
91_M191_V2.1531.00
68_A269_F2.1181.00
68_A285_A2.1001.00
214_V284_I2.0811.00
238_K242_E2.0781.00
62_S78_I2.0571.00
257_S260_E2.0341.00
66_A78_I2.0301.00
72_S282_L1.9821.00
49_V65_L1.9551.00
181_G211_L1.9101.00
250_G287_K1.8411.00
219_H254_L1.8161.00
69_I158_I1.7911.00
75_K155_D1.7441.00
63_S91_M1.6991.00
70_A115_I1.6871.00
66_A158_I1.6661.00
90_K194_L1.6051.00
250_G284_I1.5921.00
46_K159_I1.5831.00
240_M244_M1.5791.00
65_L288_V1.5781.00
49_V183_V1.5311.00
48_G161_M1.5111.00
239_K243_E1.5051.00
255_D277_T1.5021.00
74_R289_I1.4791.00
182_F203_A1.4651.00
99_L102_D1.4591.00
74_R155_D1.4411.00
238_K251_Q1.4121.00
65_L285_A1.3981.00
215_E237_G1.3901.00
45_Y180_T1.3771.00
102_D105_G1.3701.00
183_V214_V1.3701.00
66_A88_V1.3651.00
87_S195_A1.3641.00
104_K108_P1.3561.00
237_G241_A1.3561.00
81_V159_I1.3551.00
218_S251_Q1.3481.00
212_G249_L1.3401.00
140_S143_K1.3331.00
70_A114_G1.3321.00
239_K242_E1.3321.00
92_L115_I1.3181.00
128_D132_V1.2991.00
181_G209_K1.2951.00
63_S92_L1.2901.00
257_S272_H1.2881.00
105_G108_P1.2831.00
50_V199_S1.2781.00
275_S278_S1.2741.00
94_V117_V1.2681.00
57_G216_N1.2651.00
140_S144_Q1.2651.00
188_P215_E1.2641.00
49_V62_S1.2101.00
258_I277_T1.2081.00
104_K109_V1.2061.00
104_K107_N1.2041.00
256_P260_E1.1861.00
181_G212_G1.1751.00
72_S289_I1.1691.00
77_G157_L1.1651.00
50_V161_M1.1521.00
102_D108_P1.1471.00
189_S192_S1.1461.00
266_E271_K1.1431.00
279_K282_L1.1381.00
61_V65_L1.1301.00
102_D107_N1.1221.00
107_N110_I1.1201.00
255_D275_S1.1181.00
122_F198_K1.1111.00
92_L117_V1.1051.00
142_I145_F1.0991.00
99_L109_V1.0931.00
252_V277_T1.0901.00
117_V122_F1.0891.00
128_D131_V1.0881.00
61_V216_N1.0871.00
260_E264_A1.0831.00
68_A72_S1.0761.00
59_S88_V1.0761.00
75_K153_E1.0711.00
59_S91_M1.0681.00
248_L251_Q1.0511.00
143_K147_G1.0491.00
189_S259_A1.0481.00
216_N281_F1.0471.00
276_P279_K1.0381.00
66_A115_I1.0381.00
129_T132_V1.0351.00
141_A145_F1.0331.00
235_G238_K1.0311.00
286_D290_K1.0261.00
101_A105_G1.0221.00
131_V134_R1.0211.00
64_N67_M1.0131.00
64_N269_F1.0131.00
156_Y289_I1.0001.00
172_I175_L0.9981.00
282_L286_D0.9931.00
67_M71_A0.9921.00
49_V61_V0.9861.00
266_E270_L0.9821.00
186_T237_G0.9821.00
86_P89_P0.9811.00
273_P278_S0.9811.00
280_E283_N0.9801.00
284_I288_V0.9761.00
283_N286_D0.9751.00
46_K150_N0.9701.00
69_I76_V0.9691.00
47_I288_V0.9661.00
116_K152_G0.9651.00
87_S191_V0.9631.00
112_P270_L0.9591.00
197_K243_E0.9431.00
99_L105_G0.9431.00
269_F282_L0.9421.00
191_V262_N0.9341.00
60_F258_I0.9331.00
81_V174_Q0.9231.00
60_F262_N0.9221.00
68_A282_L0.9201.00
220_F223_P0.9161.00
201_N204_R0.9161.00
116_K119_S0.9151.00
130_P133_W0.8971.00
127_D131_V0.8951.00
79_V159_I0.8871.00
84_H166_G0.8861.00
79_V157_L0.8861.00
283_N287_K0.8831.00
184_I196_V0.8821.00
252_V280_E0.8801.00
169_A172_I0.8781.00
184_I200_I0.8741.00
52_G202_F0.8731.00
46_K157_L0.8711.00
49_V158_I0.8661.00
235_G239_K0.8661.00
44_K150_N0.8661.00
264_A271_K0.8651.00
102_D109_V0.8561.00
110_I116_K0.8551.00
272_H275_S0.8531.00
105_G109_V0.8511.00
111_G114_G0.8501.00
255_D276_P0.8491.00
69_I285_A0.8441.00
204_R207_N0.8411.00
236_K241_A0.8341.00
185_V216_N0.8331.00
268_F278_S0.8301.00
71_A270_L0.8261.00
58_K163_P0.8251.00
127_D130_P0.8231.00
47_I156_Y0.8221.00
86_P120_I0.8171.00
154_L157_L0.8161.00
106_I109_V0.8041.00
134_R138_K0.8011.00
56_V192_S0.7971.00
161_M174_Q0.7921.00
47_I181_G0.7921.00
137_I140_S0.7911.00
99_L107_N0.7841.00
79_V146_L0.7761.00
277_T280_E0.7681.00
188_P218_S0.7681.00
212_G247_D0.7661.00
44_K157_L0.7611.00
71_A269_F0.7611.00
269_F278_S0.7601.00
100_T105_G0.7591.00
130_P134_R0.7561.00
222_C233_G0.7551.00
238_K241_A0.7541.00
111_G116_K0.7541.00
100_T103_D0.7511.00
61_V185_V0.7501.00
64_N267_P0.7471.00
171_S175_L0.7431.00
249_L287_K0.7421.00
68_A71_A0.7401.00
53_K58_K0.7391.00
145_F148_D0.7381.00
215_E218_S0.7381.00
106_I118_V0.7331.00
197_K201_N0.7291.00
67_M269_F0.7281.00
171_S174_Q0.7251.00
75_K116_K0.7201.00
144_Q148_D0.7191.00
149_V152_G0.7161.00
85_G89_P0.7131.00
187_I192_S0.7131.00
222_C256_P0.7121.00
261_A268_F0.7091.00
137_I144_Q0.7031.00
105_G110_I0.6991.00
65_L284_I0.6981.00
90_K190_E0.6981.00
89_P121_D0.6951.00
142_I146_L0.6851.00
45_Y211_L0.6851.00
53_K191_V0.6841.00
98_M102_D0.6831.00
62_S88_V0.6791.00
141_A146_L0.6791.00
68_A281_F0.6741.00
76_V158_I0.6711.00
44_K153_E0.6701.00
279_K283_N0.6701.00
276_P280_E0.6681.00
234_E238_K0.6671.00
211_L249_L0.6671.00
101_A107_N0.6661.00
85_G163_P0.6651.00
247_D287_K0.6651.00
87_S194_L0.6631.00
253_P276_P0.6591.00
98_M101_A0.6561.00
134_R137_I0.6481.00
232_F235_G0.6481.00
45_Y156_Y0.6441.00
236_K244_M0.6441.00
78_I92_L0.6431.00
236_K239_K0.6341.00
86_P121_D0.6341.00
182_F208_T0.6321.00
102_D110_I0.6301.00
258_I262_N0.6301.00
76_V155_D0.6301.00
46_K180_T0.6241.00
150_N180_T0.6231.00
107_N150_N0.6211.00
73_G114_G0.6181.00
111_G115_I0.6161.00
76_V115_I0.6131.00
133_W137_I0.6101.00
51_S56_V0.6081.00
120_I123_L0.6061.00
215_E251_Q0.6051.00
268_F277_T0.6041.00
107_N148_D0.6031.00
98_M104_K0.6031.00
169_A173_A0.6001.00
274_D279_K0.5991.00
100_T104_K0.5991.00
48_G182_F0.5971.00
84_H170_L0.5901.00
81_V170_L0.5891.00
76_V156_Y0.5881.00
287_K290_K0.5861.00
68_A278_S0.5861.00
88_V117_V0.5851.00
99_L108_P0.5821.00
129_T133_W0.5801.00
61_V252_V0.5791.00
64_N281_F0.5791.00
158_I288_V0.5781.00
133_W138_K0.5771.00
67_M270_L0.5761.00
91_M262_N0.5761.00
219_H256_P0.5761.00
145_F149_V0.5751.00
50_V171_S0.5741.00
260_E271_K0.5741.00
256_P259_A0.5731.00
104_K110_I0.5721.00
173_A176_V0.5721.00
278_S282_L0.5701.00
103_D107_N0.5681.00
215_E240_M0.5681.00
67_M115_I0.5661.00
241_A251_Q0.5631.00
147_G150_N0.5600.99
45_Y74_R0.5600.99
170_L173_A0.5590.99
118_V149_V0.5540.99
77_G110_I0.5520.99
237_G251_Q0.5510.99
186_T213_V0.5490.99
184_I199_S0.5470.99
112_P115_I0.5460.99
81_V142_I0.5460.99
170_L174_Q0.5450.99
135_G141_A0.5440.99
179_I208_T0.5430.99
129_T134_R0.5410.99
197_K244_M0.5410.99
190_E194_L0.5400.99
75_K154_L0.5400.99
47_I211_L0.5390.99
51_S195_A0.5390.99
215_E248_L0.5330.99
98_M103_D0.5310.99
95_R127_D0.5300.99
116_K153_E0.5280.99
46_K146_L0.5280.99
67_M267_P0.5250.99
127_D132_V0.5240.99
128_D133_W0.5240.99
240_M243_E0.5220.99
102_D106_I0.5210.99
70_A112_P0.5210.99
107_N153_E0.5190.99
184_I210_I0.5180.99
273_P279_K0.5170.99
188_P233_G0.5100.99
144_Q147_G0.5090.99
192_S195_A0.5090.99
150_N153_E0.5090.99
48_G159_I0.5080.99
135_G139_H0.5080.99
101_A104_K0.5070.99
89_P119_S0.5070.99
261_A271_K0.5050.99
135_G138_K0.5040.99
259_A262_N0.5040.99
44_K75_K0.5040.99
84_H87_S0.5030.99
59_S87_S0.5020.99
139_H169_A0.5020.99
281_F284_I0.5010.99
119_S122_F0.5000.99
236_K240_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.7466 100 0.387 Contact Map
3pg5A 2 0.7264 100 0.39 Contact Map
1g3qA 1 0.7736 100 0.411 Contact Map
1wcv1 2 0.7838 100 0.413 Contact Map
3kjhA 2 0.7703 100 0.418 Contact Map
3ea0A 2 0.7635 100 0.418 Contact Map
1hyqA 1 0.7601 100 0.419 Contact Map
3ez9A 2 0.8176 100 0.423 Contact Map
4rz3A 2 0.7905 100 0.424 Contact Map
3ez2A 2 0.9493 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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