KAD6 - SULSO - GREMLIN Contacts

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KAD6 - Putative adenylate kinase

UniProt:	Q97ZW3	Sequences: MIIIVTGTPGVGKTVASKKLSEALNLNYLSLSQFVIENKLYTEYDELRQSYIIDEDKVKEELEKIISTSHLVIETIYPSLVSTADLVVVLRKNPFSLYNELKGRGWADIKVAENVEAEILGVISQEAREAFKDKVCEVDTTEMSTEQILNKILNKQCDGPIEWLVDTKVQRFLEELDKIISSYENDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	187 (156)
Sequences:	6035 (3518)
Seq/√Len:	281.7

ECOLI - KAD AROL AROK
BACSU - KAD AROK YQAC
HALSA - KAD6 KCY KAD Y2452
SULSO - KAD6 KCY Y1041

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
94_P	121_G	3.733	1.00
23_A	153_L	3.139	1.00
35_V	58_V	2.889	1.00
45_D	48_R	2.875	1.00
143_M	151_K	2.739	1.00
91_R	138_V	2.707	1.00
19_K	149_L	2.606	1.00
118_E	122_V	2.487	1.00
59_K	76_I	2.281	1.00
38_N	64_K	2.239	1.00
89_V	138_V	2.221	1.00
111_V	114_N	2.159	1.00
143_M	147_Q	2.072	1.00
96_S	99_N	2.036	1.00
119_I	123_I	1.999	1.00
23_A	149_L	1.998	1.00
90_L	141_T	1.983	1.00
43_E	46_E	1.980	1.00
65_I	68_T	1.875	1.00
93_N	142_E	1.868	1.00
46_E	49_Q	1.865	1.00
39_K	42_T	1.818	1.00
86_L	137_E	1.783	1.00
96_S	142_E	1.762	1.00
39_K	43_E	1.756	1.00
121_G	125_Q	1.733	1.00
137_E	155_K	1.708	1.00
144_S	147_Q	1.657	1.00
43_E	60_E	1.644	1.00
125_Q	129_E	1.634	1.00
24_L	153_L	1.626	1.00
114_N	117_A	1.564	1.00
27_N	65_I	1.559	1.00
149_L	153_L	1.552	1.00
11_V	92_K	1.525	1.00
19_K	146_E	1.517	1.00
5_V	17_S	1.460	1.00
63_E	67_S	1.446	1.00
16_A	152_I	1.441	1.00
104_R	107_A	1.434	1.00
6_T	128_R	1.379	1.00
102_K	115_V	1.355	1.00
103_G	106_W	1.353	1.00
54_D	57_K	1.351	1.00
19_K	22_E	1.347	1.00
153_L	157_C	1.340	1.00
24_L	157_C	1.334	1.00
89_V	128_R	1.332	1.00
18_K	22_E	1.316	1.00
2_I	82_S	1.294	1.00
38_N	61_E	1.294	1.00
10_G	101_L	1.269	1.00
129_E	132_K	1.258	1.00
60_E	63_E	1.254	1.00
104_R	109_I	1.227	1.00
150_N	154_N	1.215	1.00
92_K	141_T	1.204	1.00
147_Q	151_K	1.202	1.00
90_L	152_I	1.200	1.00
110_K	113_E	1.189	1.00
94_P	118_E	1.141	1.00
43_E	56_D	1.139	1.00
44_Y	47_L	1.127	1.00
140_T	143_M	1.123	1.00
4_I	84_A	1.106	1.00
8_T	120_L	1.104	1.00
55_E	79_S	1.103	1.00
150_N	153_L	1.087	1.00
105_G	108_D	1.077	1.00
32_S	36_I	1.065	1.00
104_R	108_D	1.058	1.00
143_M	148_I	1.055	1.00
34_F	38_N	1.047	1.00
64_K	68_T	1.046	1.00
95_F	99_N	1.038	1.00
87_V	136_C	1.031	1.00
120_L	124_S	1.021	1.00
29_L	65_I	1.017	1.00
5_V	20_L	1.012	1.00
98_Y	102_K	0.998	1.00
151_K	154_N	0.978	1.00
14_T	74_E	0.978	1.00
16_A	149_L	0.971	1.00
130_A	133_D	0.965	1.00
147_Q	150_N	0.952	1.00
42_T	45_D	0.947	1.00
103_G	107_A	0.935	1.00
37_E	65_I	0.931	1.00
21_S	28_Y	0.923	1.00
40_L	60_E	0.920	1.00
83_T	135_V	0.913	1.00
140_T	151_K	0.909	1.00
34_F	61_E	0.907	1.00
42_T	46_E	0.897	1.00
18_K	28_Y	0.897	1.00
30_S	33_Q	0.883	1.00
5_V	72_V	0.877	1.00
8_T	97_L	0.872	1.00
71_L	84_A	0.865	1.00
59_K	62_L	0.865	1.00
26_L	70_H	0.851	1.00
57_K	60_E	0.850	1.00
58_V	62_L	0.843	1.00
44_Y	60_E	0.840	1.00
6_T	87_V	0.839	1.00
65_I	70_H	0.835	1.00
38_N	44_Y	0.831	1.00
2_I	85_D	0.831	1.00
12_G	15_V	0.831	1.00
3_I	86_L	0.827	1.00
84_A	135_V	0.825	1.00
119_I	122_V	0.823	1.00
140_T	148_I	0.821	1.00
32_S	78_P	0.807	0.99
127_A	131_F	0.804	0.99
7_G	10_G	0.802	0.99
18_K	21_S	0.801	0.99
33_Q	37_E	0.798	0.99
145_T	149_L	0.794	0.99
2_I	71_L	0.793	0.99
38_N	41_Y	0.792	0.99
55_E	81_V	0.791	0.99
102_K	114_N	0.789	0.99
64_K	67_S	0.788	0.99
37_E	68_T	0.781	0.99
80_L	130_A	0.781	0.99
26_L	71_L	0.778	0.99
91_R	128_R	0.777	0.99
5_V	90_L	0.774	0.99
25_N	69_S	0.772	0.99
35_V	62_L	0.766	0.99
35_V	47_L	0.759	0.99
23_A	157_C	0.753	0.99
56_D	60_E	0.752	0.99
98_Y	115_V	0.749	0.99
151_K	155_K	0.747	0.99
127_A	136_C	0.738	0.99
16_A	19_K	0.736	0.99
88_V	152_I	0.730	0.99
51_Y	54_D	0.729	0.99
139_D	148_I	0.725	0.99
29_L	34_F	0.714	0.99
12_G	100_E	0.711	0.99
124_S	128_R	0.701	0.98
2_I	6_T	0.696	0.98
5_V	88_V	0.692	0.98
21_S	72_V	0.692	0.98
2_I	84_A	0.686	0.98
44_Y	61_E	0.685	0.98
99_N	103_G	0.680	0.98
17_S	28_Y	0.679	0.98
7_G	11_V	0.671	0.98
80_L	127_A	0.670	0.98
94_P	98_Y	0.668	0.98
139_D	155_K	0.668	0.98
16_A	141_T	0.667	0.98
16_A	148_I	0.666	0.98
40_L	64_K	0.665	0.98
118_E	121_G	0.660	0.98
95_F	98_Y	0.659	0.98
109_I	114_N	0.659	0.98
20_L	72_V	0.658	0.98
102_K	109_I	0.657	0.98
9_P	97_L	0.654	0.98
20_L	149_L	0.652	0.98
120_L	126_E	0.652	0.98
35_V	44_Y	0.652	0.98
31_L	62_L	0.648	0.97
48_R	111_V	0.646	0.97
20_L	152_I	0.645	0.97
27_N	70_H	0.645	0.97
36_I	78_P	0.645	0.97
86_L	156_Q	0.642	0.97
89_V	136_C	0.640	0.97
142_E	151_K	0.636	0.97
66_I	71_L	0.636	0.97
24_L	149_L	0.636	0.97
22_E	25_N	0.634	0.97
15_V	100_E	0.624	0.97
19_K	23_A	0.623	0.97
43_E	57_K	0.623	0.97
120_L	131_F	0.622	0.97
133_D	136_C	0.617	0.97
16_A	145_T	0.615	0.96
34_F	65_I	0.614	0.96
92_K	97_L	0.611	0.96
88_V	137_E	0.610	0.96
124_S	127_A	0.609	0.96
142_E	148_I	0.605	0.96
4_I	87_V	0.596	0.96
3_I	156_Q	0.591	0.96
35_V	38_N	0.585	0.95
65_I	73_I	0.583	0.95
93_N	96_S	0.572	0.95
146_E	150_N	0.567	0.95
41_Y	44_Y	0.565	0.94
141_T	148_I	0.563	0.94
125_Q	128_R	0.561	0.94
9_P	117_A	0.561	0.94
53_I	58_V	0.560	0.94
71_L	82_S	0.556	0.94
8_T	11_V	0.556	0.94
86_L	155_K	0.554	0.94
38_N	60_E	0.554	0.94
54_D	58_V	0.553	0.94
8_T	72_V	0.549	0.94
106_W	109_I	0.549	0.94
113_E	117_A	0.546	0.93
108_D	111_V	0.543	0.93
6_T	89_V	0.543	0.93
40_L	57_K	0.543	0.93
47_L	50_S	0.536	0.93
105_G	109_I	0.535	0.93
5_V	21_S	0.532	0.92
38_N	65_I	0.532	0.92
101_L	109_I	0.531	0.92
26_L	65_I	0.528	0.92
154_N	157_C	0.526	0.92
7_G	12_G	0.526	0.92
59_K	79_S	0.525	0.92
120_L	127_A	0.525	0.92
50_S	53_I	0.524	0.92
141_T	152_I	0.524	0.92
59_K	63_E	0.523	0.92
17_S	21_S	0.522	0.92
52_I	78_P	0.522	0.92
8_T	124_S	0.521	0.92
51_Y	119_I	0.519	0.92
87_V	135_V	0.517	0.91
76_I	92_K	0.516	0.91
40_L	43_E	0.505	0.90
53_I	75_T	0.504	0.90
53_I	57_K	0.501	0.90
19_K	150_N	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qbgB	1	0.861	99.9	0.447	Contact Map
2xb4A	4	0.8396	99.9	0.46	Contact Map
4jzkA	1	0.8396	99.9	0.468	Contact Map
3gmtA	1	0.7487	99.9	0.474	Contact Map
1ukzA	1	0.8556	99.9	0.482	Contact Map
1zd8A	1	0.861	99.9	0.484	Contact Map
4pzlA	2	0.8503	99.9	0.484	Contact Map
3tlxA	1	0.8449	99.9	0.485	Contact Map
4jl5A	1	0.8396	99.9	0.487	Contact Map
3cm0A	1	0.8396	99.9	0.487	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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