GREMLIN Database
KAD6 - Putative adenylate kinase
UniProt: Q97ZW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (156)
Sequences: 6035 (3518)
Seq/√Len: 281.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_P121_G3.7331.00
23_A153_L3.1391.00
35_V58_V2.8891.00
45_D48_R2.8751.00
143_M151_K2.7391.00
91_R138_V2.7071.00
19_K149_L2.6061.00
118_E122_V2.4871.00
59_K76_I2.2811.00
38_N64_K2.2391.00
89_V138_V2.2211.00
111_V114_N2.1591.00
143_M147_Q2.0721.00
96_S99_N2.0361.00
119_I123_I1.9991.00
23_A149_L1.9981.00
90_L141_T1.9831.00
43_E46_E1.9801.00
65_I68_T1.8751.00
93_N142_E1.8681.00
46_E49_Q1.8651.00
39_K42_T1.8181.00
86_L137_E1.7831.00
96_S142_E1.7621.00
39_K43_E1.7561.00
121_G125_Q1.7331.00
137_E155_K1.7081.00
144_S147_Q1.6571.00
43_E60_E1.6441.00
125_Q129_E1.6341.00
24_L153_L1.6261.00
114_N117_A1.5641.00
27_N65_I1.5591.00
149_L153_L1.5521.00
11_V92_K1.5251.00
19_K146_E1.5171.00
5_V17_S1.4601.00
63_E67_S1.4461.00
16_A152_I1.4411.00
104_R107_A1.4341.00
6_T128_R1.3791.00
102_K115_V1.3551.00
103_G106_W1.3531.00
54_D57_K1.3511.00
19_K22_E1.3471.00
153_L157_C1.3401.00
24_L157_C1.3341.00
89_V128_R1.3321.00
18_K22_E1.3161.00
2_I82_S1.2941.00
38_N61_E1.2941.00
10_G101_L1.2691.00
129_E132_K1.2581.00
60_E63_E1.2541.00
104_R109_I1.2271.00
150_N154_N1.2151.00
92_K141_T1.2041.00
147_Q151_K1.2021.00
90_L152_I1.2001.00
110_K113_E1.1891.00
94_P118_E1.1411.00
43_E56_D1.1391.00
44_Y47_L1.1271.00
140_T143_M1.1231.00
4_I84_A1.1061.00
8_T120_L1.1041.00
55_E79_S1.1031.00
150_N153_L1.0871.00
105_G108_D1.0771.00
32_S36_I1.0651.00
104_R108_D1.0581.00
143_M148_I1.0551.00
34_F38_N1.0471.00
64_K68_T1.0461.00
95_F99_N1.0381.00
87_V136_C1.0311.00
120_L124_S1.0211.00
29_L65_I1.0171.00
5_V20_L1.0121.00
98_Y102_K0.9981.00
151_K154_N0.9781.00
14_T74_E0.9781.00
16_A149_L0.9711.00
130_A133_D0.9651.00
147_Q150_N0.9521.00
42_T45_D0.9471.00
103_G107_A0.9351.00
37_E65_I0.9311.00
21_S28_Y0.9231.00
40_L60_E0.9201.00
83_T135_V0.9131.00
140_T151_K0.9091.00
34_F61_E0.9071.00
42_T46_E0.8971.00
18_K28_Y0.8971.00
30_S33_Q0.8831.00
5_V72_V0.8771.00
8_T97_L0.8721.00
71_L84_A0.8651.00
59_K62_L0.8651.00
26_L70_H0.8511.00
57_K60_E0.8501.00
58_V62_L0.8431.00
44_Y60_E0.8401.00
6_T87_V0.8391.00
65_I70_H0.8351.00
38_N44_Y0.8311.00
2_I85_D0.8311.00
12_G15_V0.8311.00
3_I86_L0.8271.00
84_A135_V0.8251.00
119_I122_V0.8231.00
140_T148_I0.8211.00
32_S78_P0.8070.99
127_A131_F0.8040.99
7_G10_G0.8020.99
18_K21_S0.8010.99
33_Q37_E0.7980.99
145_T149_L0.7940.99
2_I71_L0.7930.99
38_N41_Y0.7920.99
55_E81_V0.7910.99
102_K114_N0.7890.99
64_K67_S0.7880.99
37_E68_T0.7810.99
80_L130_A0.7810.99
26_L71_L0.7780.99
91_R128_R0.7770.99
5_V90_L0.7740.99
25_N69_S0.7720.99
35_V62_L0.7660.99
35_V47_L0.7590.99
23_A157_C0.7530.99
56_D60_E0.7520.99
98_Y115_V0.7490.99
151_K155_K0.7470.99
127_A136_C0.7380.99
16_A19_K0.7360.99
88_V152_I0.7300.99
51_Y54_D0.7290.99
139_D148_I0.7250.99
29_L34_F0.7140.99
12_G100_E0.7110.99
124_S128_R0.7010.98
2_I6_T0.6960.98
5_V88_V0.6920.98
21_S72_V0.6920.98
2_I84_A0.6860.98
44_Y61_E0.6850.98
99_N103_G0.6800.98
17_S28_Y0.6790.98
7_G11_V0.6710.98
80_L127_A0.6700.98
94_P98_Y0.6680.98
139_D155_K0.6680.98
16_A141_T0.6670.98
16_A148_I0.6660.98
40_L64_K0.6650.98
118_E121_G0.6600.98
95_F98_Y0.6590.98
109_I114_N0.6590.98
20_L72_V0.6580.98
102_K109_I0.6570.98
9_P97_L0.6540.98
20_L149_L0.6520.98
120_L126_E0.6520.98
35_V44_Y0.6520.98
31_L62_L0.6480.97
48_R111_V0.6460.97
20_L152_I0.6450.97
27_N70_H0.6450.97
36_I78_P0.6450.97
86_L156_Q0.6420.97
89_V136_C0.6400.97
142_E151_K0.6360.97
66_I71_L0.6360.97
24_L149_L0.6360.97
22_E25_N0.6340.97
15_V100_E0.6240.97
19_K23_A0.6230.97
43_E57_K0.6230.97
120_L131_F0.6220.97
133_D136_C0.6170.97
16_A145_T0.6150.96
34_F65_I0.6140.96
92_K97_L0.6110.96
88_V137_E0.6100.96
124_S127_A0.6090.96
142_E148_I0.6050.96
4_I87_V0.5960.96
3_I156_Q0.5910.96
35_V38_N0.5850.95
65_I73_I0.5830.95
93_N96_S0.5720.95
146_E150_N0.5670.95
41_Y44_Y0.5650.94
141_T148_I0.5630.94
125_Q128_R0.5610.94
9_P117_A0.5610.94
53_I58_V0.5600.94
71_L82_S0.5560.94
8_T11_V0.5560.94
86_L155_K0.5540.94
38_N60_E0.5540.94
54_D58_V0.5530.94
8_T72_V0.5490.94
106_W109_I0.5490.94
113_E117_A0.5460.93
108_D111_V0.5430.93
6_T89_V0.5430.93
40_L57_K0.5430.93
47_L50_S0.5360.93
105_G109_I0.5350.93
5_V21_S0.5320.92
38_N65_I0.5320.92
101_L109_I0.5310.92
26_L65_I0.5280.92
154_N157_C0.5260.92
7_G12_G0.5260.92
59_K79_S0.5250.92
120_L127_A0.5250.92
50_S53_I0.5240.92
141_T152_I0.5240.92
59_K63_E0.5230.92
17_S21_S0.5220.92
52_I78_P0.5220.92
8_T124_S0.5210.92
51_Y119_I0.5190.92
87_V135_V0.5170.91
76_I92_K0.5160.91
40_L43_E0.5050.90
53_I75_T0.5040.90
53_I57_K0.5010.90
19_K150_N0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.861 99.9 0.447 Contact Map
2xb4A 4 0.8396 99.9 0.46 Contact Map
4jzkA 1 0.8396 99.9 0.468 Contact Map
3gmtA 1 0.7487 99.9 0.474 Contact Map
1ukzA 1 0.8556 99.9 0.482 Contact Map
1zd8A 1 0.861 99.9 0.484 Contact Map
4pzlA 2 0.8503 99.9 0.484 Contact Map
3tlxA 1 0.8449 99.9 0.485 Contact Map
4jl5A 1 0.8396 99.9 0.487 Contact Map
3cm0A 1 0.8396 99.9 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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