GREMLIN Database
Q97ZW2 - Uncharacterized protein
UniProt: Q97ZW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (176)
Sequences: 6449 (4831)
Seq/√Len: 364.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_I121_G5.7131.00
120_A147_G5.1801.00
123_L196_G3.9321.00
81_S125_N3.3751.00
86_N139_S3.2961.00
74_Y77_E3.2541.00
121_G144_G3.2201.00
128_T186_N2.9751.00
43_T91_F2.7021.00
35_T114_Y2.6661.00
127_L192_G2.5781.00
88_F92_I2.5251.00
150_S194_I2.3791.00
39_M95_F2.3631.00
42_V117_F2.3511.00
128_T138_S2.2861.00
138_S186_N2.0671.00
39_M99_Y2.0291.00
66_L69_L2.0261.00
42_V95_F2.0251.00
64_E137_L1.7601.00
154_F198_I1.7321.00
96_I100_V1.7221.00
116_I120_A1.6951.00
34_S115_G1.6821.00
34_S111_K1.6301.00
179_D187_V1.6291.00
116_I151_Y1.6001.00
93_F97_S1.5941.00
35_T106_G1.5351.00
124_G143_G1.5101.00
117_F144_G1.4941.00
151_Y201_A1.4911.00
175_F179_D1.4671.00
39_M42_V1.4491.00
58_T62_Y1.4381.00
65_Q70_V1.4171.00
154_F201_A1.3601.00
98_L145_I1.3501.00
79_F122_I1.3431.00
143_G189_A1.3391.00
38_L42_V1.3191.00
98_L102_Y1.2861.00
188_V192_G1.2851.00
109_A116_I1.2711.00
33_I111_K1.2701.00
81_S138_S1.2651.00
103_L107_S1.2511.00
131_F188_V1.2091.00
65_Q129_V1.1991.00
65_Q125_N1.1751.00
85_T90_D1.1731.00
146_F175_F1.1661.00
71_I129_V1.1521.00
59_S63_L1.1511.00
64_E139_S1.1491.00
196_G200_Y1.1431.00
70_V73_G1.1421.00
94_N142_S1.1151.00
117_F141_A1.1151.00
46_F91_F1.1141.00
82_I144_G1.1081.00
36_F40_F1.1051.00
60_L64_E1.0901.00
186_N189_A1.0881.00
173_S177_V1.0851.00
39_M43_T1.0851.00
177_V181_I1.0851.00
120_A196_G1.0731.00
37_F41_L1.0641.00
90_D142_S1.0611.00
97_S145_I1.0481.00
94_N190_H1.0431.00
124_G192_G1.0391.00
78_L125_N1.0331.00
142_S190_H1.0301.00
57_S61_Y1.0121.00
58_T61_Y1.0051.00
42_V83_F1.0041.00
76_S80_T0.9991.00
172_V175_F0.9961.00
153_T172_V0.9921.00
95_F98_L0.9751.00
84_I139_S0.9751.00
62_Y66_L0.9721.00
97_S100_V0.9651.00
157_F161_D0.9581.00
169_V173_S0.9491.00
43_T95_F0.9471.00
124_G147_G0.9441.00
154_F202_V0.9391.00
92_I96_I0.9371.00
33_I36_F0.9341.00
78_L129_V0.9341.00
82_I122_I0.9141.00
102_Y106_G0.9101.00
47_M51_L0.9071.00
87_S139_S0.9041.00
40_F44_L0.9001.00
79_F82_I0.8811.00
170_F174_V0.8811.00
125_N143_G0.8791.00
61_Y64_E0.8791.00
150_S198_I0.8761.00
46_F49_G0.8641.00
176_G191_I0.8631.00
123_L127_L0.8611.00
127_L131_F0.8601.00
200_Y204_Y0.8571.00
202_V205_Y0.8571.00
119_L200_Y0.8511.00
90_D94_N0.8421.00
83_F118_I0.8421.00
32_G36_F0.8411.00
114_Y117_F0.8361.00
77_E80_T0.8321.00
46_F50_L0.8291.00
125_N138_S0.8291.00
45_G84_I0.8231.00
38_L115_G0.8211.00
44_L48_V0.8201.00
198_I202_V0.8171.00
170_F173_S0.8171.00
150_S201_A0.8161.00
123_L192_G0.8081.00
106_G110_G0.8081.00
167_G175_F0.8071.00
82_I125_N0.8061.00
79_F83_F0.8041.00
90_D190_H0.8021.00
42_V46_F0.8001.00
127_L188_V0.8001.00
31_I36_F0.7981.00
119_L196_G0.7891.00
36_F99_Y0.7891.00
118_I122_I0.7871.00
141_A144_G0.7851.00
38_L117_F0.7821.00
174_V177_V0.7821.00
45_G49_G0.7791.00
38_L98_L0.7701.00
167_G170_F0.7681.00
49_G62_Y0.7641.00
89_V93_F0.7631.00
107_S111_K0.7611.00
33_I37_F0.7601.00
60_L63_L0.7581.00
63_L66_L0.7541.00
105_F151_Y0.7521.00
108_R156_D0.7441.00
49_G84_I0.7401.00
115_G118_I0.7381.00
171_L175_F0.7321.00
198_I201_A0.7311.00
63_L84_I0.7271.00
169_V172_V0.7261.00
160_K166_Y0.7251.00
116_I201_A0.7241.00
34_S37_F0.7241.00
162_N166_Y0.7211.00
110_G113_E0.7140.99
89_V92_I0.7130.99
176_G194_I0.7110.99
122_I126_L0.7070.99
39_M98_L0.7040.99
41_L45_G0.7000.99
162_N165_V0.6990.99
152_Y168_L0.6980.99
43_T88_F0.6980.99
82_I117_F0.6950.99
75_Y79_F0.6920.99
146_F179_D0.6900.99
34_S114_Y0.6850.99
78_L122_I0.6810.99
202_V206_L0.6810.99
43_T47_M0.6790.99
46_F87_S0.6770.99
170_F177_V0.6760.99
161_D164_G0.6740.99
42_V49_G0.6640.99
62_Y76_S0.6640.99
106_G111_K0.6630.99
50_L53_T0.6580.99
120_A124_G0.6550.99
91_F95_F0.6530.99
64_E68_Y0.6520.99
49_G52_A0.6510.99
64_E67_N0.6510.99
192_G196_G0.6510.99
117_F148_L0.6500.99
65_Q186_N0.6490.99
179_D194_I0.6460.99
175_F178_S0.6440.99
98_L117_F0.6420.99
119_L123_L0.6320.99
104_I107_S0.6300.99
138_S188_V0.6290.99
62_Y69_L0.6250.99
105_F109_A0.6210.99
81_S143_G0.6200.99
97_S149_L0.6160.98
75_Y78_L0.6140.98
79_F118_I0.6140.98
199_M202_V0.6140.98
128_T132_Y0.6120.98
94_N141_A0.6100.98
109_A114_Y0.6100.98
158_L169_V0.6080.98
63_L67_N0.6060.98
120_A201_A0.6040.98
49_G53_T0.5950.98
93_F100_V0.5920.98
122_I125_N0.5920.98
151_Y155_Y0.5920.98
104_I152_Y0.5910.98
138_S189_A0.5900.98
163_L166_Y0.5870.98
124_G127_L0.5860.98
121_G124_G0.5800.98
109_A155_Y0.5710.98
109_A151_Y0.5690.97
72_K75_Y0.5690.97
83_F117_F0.5640.97
116_I200_Y0.5640.97
123_L147_G0.5630.97
191_I195_L0.5610.97
149_L168_L0.5590.97
70_V129_V0.5560.97
119_L124_G0.5550.97
49_G60_L0.5530.97
78_L81_S0.5500.97
61_Y67_N0.5450.97
61_Y66_L0.5380.96
158_L167_G0.5370.96
154_F199_M0.5360.96
157_F160_K0.5350.96
101_I152_Y0.5340.96
118_I121_G0.5340.96
68_Y72_K0.5330.96
104_I159_K0.5320.96
97_S101_I0.5310.96
97_S197_G0.5300.96
101_I148_L0.5290.96
199_M203_V0.5270.96
36_F39_M0.5270.96
42_V82_I0.5270.96
128_T188_V0.5260.96
37_F40_F0.5260.96
132_Y136_T0.5230.96
89_V178_S0.5220.96
102_Y114_Y0.5210.96
42_V45_G0.5200.96
46_F86_N0.5160.96
176_G179_D0.5130.95
112_H115_G0.5100.95
95_F117_F0.5100.95
68_Y71_I0.5080.95
147_G196_G0.5060.95
174_V178_S0.5050.95
59_S62_Y0.5020.95
43_T46_F0.5020.95
89_V96_I0.5010.95
85_T142_S0.5010.95
142_S193_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4njnA 4 0.8178 100 0.346 Contact Map
2nr9A 2 0.8598 100 0.349 Contact Map
2xovA 1 0.8131 100 0.382 Contact Map
4j05A 3 0.7664 56.8 0.922 Contact Map
4ytpC 1 0.5748 50 0.925 Contact Map
3o7qA 1 0.8925 35 0.931 Contact Map
4oh3A 2 0.8925 27.6 0.935 Contact Map
2cfqA 1 0.9393 26.1 0.935 Contact Map
2kogA 1 0.2477 25 0.936 Contact Map
4zw9A 1 0.8505 21.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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