GREMLIN Database
Q97ZW1 - Uncharacterized protein
UniProt: Q97ZW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (157)
Sequences: 1721 (1237)
Seq/√Len: 98.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_I164_A5.4871.00
137_G156_L4.6181.00
59_P129_T3.1721.00
68_A112_G2.8371.00
67_A121_K2.5691.00
74_F111_C2.5571.00
95_S98_G2.4141.00
190_L194_A2.3521.00
124_L179_I2.1441.00
60_H64_H2.1191.00
62_I66_Q2.1191.00
66_Q70_R2.1061.00
109_I112_G2.0671.00
86_T91_N2.0421.00
134_G161_F2.0241.00
71_Y118_V1.9691.00
62_I79_L1.9531.00
172_W177_L1.9421.00
62_I65_R1.9131.00
71_Y121_K1.9131.00
124_L128_L1.8741.00
91_N95_S1.8081.00
117_D121_K1.7981.00
63_G129_T1.7931.00
188_A191_I1.6741.00
114_L117_D1.6611.00
58_I62_I1.6571.00
183_N186_V1.6391.00
52_V56_A1.6371.00
76_R106_Y1.6311.00
107_T119_E1.6281.00
61_E64_H1.5771.00
178_K185_I1.5621.00
93_I97_V1.5551.00
129_T133_V1.5141.00
66_Q69_R1.5121.00
52_V156_L1.4621.00
120_G124_L1.4041.00
168_L179_I1.4001.00
112_G122_T1.3900.99
123_A178_K1.3850.99
128_L132_I1.3710.99
65_R79_L1.3610.99
115_N118_V1.3610.99
60_H175_D1.3270.99
189_V192_I1.3170.99
119_E123_A1.2680.99
84_F88_L1.2650.99
52_V152_F1.2290.99
88_L93_I1.2110.99
71_Y120_G1.2010.98
56_A133_V1.1850.98
189_V193_I1.1840.98
158_R162_W1.1830.98
137_G157_A1.1760.98
69_R74_F1.1670.98
60_H126_G1.1540.98
185_I188_A1.1510.98
64_H126_G1.1470.98
61_E175_D1.1410.98
93_I98_G1.1380.98
159_F163_V1.1380.98
133_V156_L1.1360.98
114_L118_V1.1350.98
61_E167_N1.1320.98
64_H167_N1.1310.98
65_R69_R1.1290.98
120_G123_A1.1210.98
49_P155_E1.1210.98
133_V137_G1.1120.97
161_F165_F1.1000.97
120_G127_P1.0970.97
152_F156_L1.0910.97
137_G153_F1.0880.97
64_H102_F1.0730.97
138_L157_A1.0700.97
89_I93_I1.0270.96
64_H175_D1.0230.96
119_E178_K1.0160.96
184_M191_I1.0090.95
167_N175_D0.9970.95
60_H167_N0.9930.95
153_F156_L0.9820.95
47_I51_I0.9810.95
86_T95_S0.9800.95
64_H125_A0.9780.95
54_L58_I0.9760.95
56_A160_N0.9640.94
89_I94_G0.9610.94
48_I155_E0.9590.94
107_T112_G0.9430.94
90_L101_V0.9400.93
60_H105_G0.9180.93
61_E130_N0.9000.92
94_G101_V0.8890.91
59_P133_V0.8750.91
87_T103_F0.8750.91
177_L181_R0.8740.91
67_A70_R0.8740.91
52_V137_G0.8700.90
73_C83_G0.8640.90
44_G47_I0.8530.90
154_F158_R0.8520.90
80_S83_G0.8480.89
68_A111_C0.8410.89
188_A195_F0.8380.89
188_A192_I0.8340.89
64_H130_N0.8300.88
141_A150_G0.8270.88
134_G157_A0.8250.88
184_M188_A0.8230.88
48_I148_L0.8230.88
64_H105_G0.8200.88
85_W90_L0.8190.88
120_G178_K0.8170.88
73_C100_L0.8140.87
193_I196_A0.8140.87
130_N160_N0.8020.87
43_I47_I0.7910.86
60_H102_F0.7910.86
73_C82_S0.7900.86
49_P159_F0.7860.85
65_R106_Y0.7860.85
132_I136_V0.7700.84
78_T163_V0.7690.84
115_N119_E0.7690.84
42_P46_I0.7640.84
151_L154_F0.7630.84
58_I65_R0.7630.84
126_G175_D0.7600.83
135_F139_I0.7590.83
42_P45_S0.7540.83
73_C85_W0.7440.82
67_A125_A0.7440.82
53_A159_F0.7410.82
140_G151_L0.7400.82
166_F174_L0.7380.82
145_P148_L0.7380.82
78_T85_W0.7370.82
182_W186_V0.7290.81
147_S151_L0.7190.80
61_E102_F0.7170.80
130_N167_N0.7160.80
89_I101_V0.7120.79
91_N98_G0.7100.79
48_I151_L0.7080.79
70_R117_D0.7050.79
59_P81_F0.7000.78
131_I168_L0.7000.78
73_C81_F0.6960.78
87_T100_L0.6910.77
164_A168_L0.6870.77
51_I54_L0.6770.76
144_V148_L0.6730.75
172_W184_M0.6710.75
78_T90_L0.6690.75
86_T92_I0.6680.75
172_W181_R0.6680.75
90_L100_L0.6580.74
184_M189_V0.6560.74
148_L152_F0.6550.73
174_L178_K0.6500.73
64_H174_L0.6370.71
186_V189_V0.6360.71
59_P67_A0.6340.71
126_G167_N0.6340.71
132_I139_I0.6300.70
117_D124_L0.6290.70
179_I183_N0.6210.69
143_L150_G0.6150.69
65_R73_C0.6140.69
118_V122_T0.6100.68
92_I95_S0.6090.68
53_A86_T0.6060.68
57_I95_S0.6060.68
186_V191_I0.6050.67
77_F80_S0.6020.67
73_C77_F0.6010.67
145_P151_L0.5970.66
187_W191_I0.5960.66
63_G67_A0.5890.65
192_I196_A0.5890.65
187_W192_I0.5870.65
73_C90_L0.5860.65
86_T102_F0.5850.65
146_F150_G0.5850.65
182_W191_I0.5850.65
171_F188_A0.5850.65
71_Y127_P0.5830.65
161_F197_L0.5820.64
142_S146_F0.5810.64
141_A147_S0.5780.64
130_N166_F0.5730.63
44_G171_F0.5660.62
185_I191_I0.5660.62
85_W100_L0.5650.62
155_E159_F0.5640.62
62_I80_S0.5600.61
148_L151_L0.5600.61
61_E126_G0.5580.61
144_V147_S0.5580.61
182_W185_I0.5570.61
193_I197_L0.5460.60
88_L187_W0.5460.60
117_D120_G0.5420.59
66_Q120_G0.5400.59
78_T87_T0.5380.58
111_C114_L0.5370.58
52_V155_E0.5340.58
76_R79_L0.5300.57
115_N127_P0.5270.57
147_S197_L0.5270.57
89_I150_G0.5250.57
124_L127_P0.5240.56
51_I148_L0.5240.56
62_I98_G0.5210.56
108_S111_C0.5200.56
101_V108_S0.5190.56
127_P179_I0.5170.55
129_T168_L0.5130.55
45_S49_P0.5130.55
110_S149_V0.5100.54
152_F155_E0.5100.54
51_I151_L0.5090.54
93_I96_F0.5080.54
141_A154_F0.5070.54
138_L142_S0.5040.54
55_L59_P0.5040.54
57_I94_G0.5030.53
99_I162_W0.5030.53
90_L105_G0.5020.53
51_I155_E0.5020.53
87_T90_L0.5020.53
59_P63_G0.5010.53
82_S100_L0.5000.53
118_V194_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.85 99.9 0.593 Contact Map
4b03D 5 0.28 5.7 0.959 Contact Map
3rceA 1 0.875 3.3 0.964 Contact Map
4av3A 2 0.82 2.9 0.965 Contact Map
4czbA 2 0.38 2.6 0.965 Contact Map
3ovuB 1 0.265 2.3 0.966 Contact Map
2wwbC 1 0.18 2.2 0.967 Contact Map
3j01B 1 0.23 1.8 0.969 Contact Map
3g2mA 2 0.265 1.7 0.969 Contact Map
4bptA 1 0.215 1.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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