Q97ZV8 - SULSO - GREMLIN Contacts

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Q97ZV8 - Uncharacterized protein

UniProt:	Q97ZV8	Sequences: MFDLNLTIVLKSPLSIFDDIFITSIRVLEAKRLRELHMSQTRIANLLGVSQPAVKQYLDEDENSYIKRLQNLGLTREEIDDFLDKLTQLLINGDPKQVMQYISVFFLSNLSRLKFCKYHKMIDSEIPVDCDICKSLYKENEEEMMELALSMLQNESVAELIPEVLSNLAFAKANAKREEDVLAIPGRITKIRNLPTPASKPMWGGSKHLAKVLLSVMKNHPAVRSVMNIKYDEKVEMILKEIGYKFKKVGPQNDLGNERIAETIAAVFDEGTDVVIHLGGTGIEANTYVFGRDPLDVVKKIINISVKYKEIFSP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (267)
Sequences:	279 (209)
Seq/√Len:	12.8

HALSA - Q9HSG2 Q9HMC6
SULSO - Q97ZV8 Q97W49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
291_G	297_V	5.885	1.00
169_A	183_A	4.916	1.00
170_F	294_P	4.074	1.00
182_L	203_W	3.908	0.99
133_C	138_K	3.690	0.99
185_P	201_P	3.408	0.98
175_A	217_M	3.316	0.98
141_E	203_W	3.251	0.98
212_V	290_F	2.749	0.94
260_I	263_T	2.632	0.93
168_L	227_M	2.528	0.91
135_S	138_K	2.306	0.86
216_V	290_F	2.276	0.86
171_A	175_A	2.219	0.84
220_H	271_G	2.159	0.82
129_D	135_S	2.150	0.82
251_P	283_I	2.098	0.80
172_K	203_W	2.087	0.80
133_C	137_Y	2.060	0.79
128_V	133_C	2.034	0.78
181_V	193_N	1.984	0.76
141_E	182_L	1.971	0.76
255_L	283_I	1.971	0.76
282_G	285_A	1.932	0.74
183_A	205_G	1.913	0.74
212_V	277_H	1.897	0.73
289_V	297_V	1.873	0.72
172_K	182_L	1.869	0.72
169_A	213_L	1.835	0.70
133_C	136_L	1.774	0.68
86_L	275_V	1.771	0.68
164_V	167_N	1.763	0.67
238_I	274_V	1.736	0.66
148_A	298_V	1.729	0.66
225_S	297_V	1.720	0.65
145_M	297_V	1.709	0.65
209_L	250_G	1.670	0.63
293_D	296_D	1.657	0.62
48_G	175_A	1.650	0.62
195_P	304_I	1.633	0.61
167_N	208_H	1.622	0.61
89_L	165_L	1.611	0.60
168_L	294_P	1.605	0.60
52_P	119_H	1.592	0.59
248_K	278_L	1.566	0.58
132_I	135_S	1.562	0.58
273_D	300_K	1.544	0.57
142_E	203_W	1.537	0.56
53_A	56_Q	1.530	0.56
259_R	263_T	1.530	0.56
213_L	239_L	1.512	0.55
277_H	288_Y	1.508	0.55
141_E	172_K	1.507	0.55
183_A	206_S	1.504	0.55
171_A	184_I	1.485	0.54
231_Y	236_E	1.476	0.53
258_E	263_T	1.474	0.53
161_I	195_P	1.467	0.53
189_T	236_E	1.466	0.53
52_P	56_Q	1.459	0.52
251_P	254_D	1.450	0.52
53_A	119_H	1.442	0.51
145_M	168_L	1.441	0.51
34_R	37_H	1.430	0.51
258_E	262_E	1.429	0.51
166_S	195_P	1.428	0.51
112_R	201_P	1.425	0.50
231_Y	278_L	1.405	0.49
130_C	133_C	1.390	0.49
53_A	98_V	1.379	0.48
40_Q	51_Q	1.376	0.48
294_P	298_V	1.372	0.48
144_M	180_D	1.357	0.47
114_K	299_K	1.353	0.47
279_G	284_E	1.353	0.47
36_L	39_S	1.350	0.47
132_I	137_Y	1.345	0.46
255_L	263_T	1.322	0.45
256_G	301_I	1.315	0.45
145_M	170_F	1.313	0.45
160_L	235_V	1.291	0.44
92_N	95_P	1.291	0.44
145_M	294_P	1.282	0.43
128_V	138_K	1.282	0.43
251_P	255_L	1.278	0.43
128_V	135_S	1.264	0.42
249_V	277_H	1.244	0.41
251_P	286_N	1.242	0.41
51_Q	73_G	1.234	0.41
228_N	286_N	1.224	0.40
149_L	184_I	1.220	0.40
37_H	40_Q	1.220	0.40
144_M	170_F	1.220	0.40
213_L	217_M	1.203	0.39
164_V	187_R	1.203	0.39
145_M	291_G	1.193	0.39
171_A	217_M	1.191	0.39
95_P	99_M	1.165	0.37
204_G	210_A	1.164	0.37
130_C	137_Y	1.164	0.37
167_N	284_E	1.149	0.37
259_R	265_A	1.128	0.36
128_V	161_I	1.127	0.35
209_L	249_V	1.118	0.35
181_V	243_G	1.112	0.35
245_K	273_D	1.109	0.35
142_E	182_L	1.105	0.34
212_V	249_V	1.097	0.34
165_L	240_K	1.097	0.34
215_S	287_T	1.096	0.34
189_T	238_I	1.086	0.34
54_V	86_L	1.077	0.33
48_G	54_V	1.075	0.33
103_S	126_I	1.073	0.33
129_D	138_K	1.071	0.33
51_Q	57_Y	1.070	0.33
34_R	43_I	1.069	0.33
254_D	283_I	1.065	0.33
149_L	161_I	1.056	0.32
153_Q	197_P	1.048	0.32
72_L	230_K	1.044	0.32
141_E	170_F	1.043	0.32
249_V	288_Y	1.033	0.31
161_I	292_R	1.028	0.31
79_I	86_L	1.021	0.31
51_Q	116_C	1.020	0.31
164_V	249_V	1.020	0.31
235_V	238_I	1.015	0.30
49_V	195_P	1.014	0.30
236_E	271_G	1.014	0.30
206_S	285_A	1.012	0.30
208_H	284_E	1.004	0.30
222_A	292_R	1.002	0.30
289_V	301_I	0.999	0.30
159_E	193_N	0.998	0.30
225_S	294_P	0.993	0.29
144_M	152_L	0.989	0.29
255_L	262_E	0.986	0.29
161_I	289_V	0.984	0.29
140_N	230_K	0.981	0.29
289_V	300_K	0.980	0.29
128_V	132_I	0.974	0.29
243_G	291_G	0.974	0.29
227_M	297_V	0.967	0.28
220_H	290_F	0.967	0.28
157_V	166_S	0.967	0.28
44_A	52_P	0.964	0.28
161_I	166_S	0.963	0.28
65_Y	71_N	0.962	0.28
245_K	304_I	0.960	0.28
285_A	291_G	0.959	0.28
176_K	194_L	0.951	0.28
186_G	282_G	0.949	0.28
39_S	60_E	0.946	0.27
47_L	52_P	0.944	0.27
160_L	232_D	0.940	0.27
170_F	295_L	0.936	0.27
152_L	195_P	0.932	0.27
92_N	283_I	0.932	0.27
47_L	54_V	0.919	0.26
236_E	276_I	0.914	0.26
48_G	224_R	0.913	0.26
291_G	294_P	0.913	0.26
134_K	137_Y	0.904	0.26
259_R	262_E	0.902	0.26
178_E	213_L	0.891	0.25
111_S	179_E	0.889	0.25
177_R	241_E	0.887	0.25
244_Y	273_D	0.885	0.25
112_R	149_L	0.884	0.25
164_V	284_E	0.883	0.25
212_V	288_Y	0.881	0.25
200_K	226_V	0.879	0.25
209_L	226_V	0.872	0.24
279_G	285_A	0.872	0.24
119_H	133_C	0.866	0.24
212_V	280_G	0.858	0.24
167_N	228_N	0.857	0.24
255_L	264_I	0.857	0.24
151_M	304_I	0.853	0.24
246_F	301_I	0.853	0.24
102_I	108_S	0.846	0.23
96_K	101_Y	0.837	0.23
176_K	218_K	0.836	0.23
191_I	239_L	0.833	0.23
164_V	286_N	0.830	0.23
205_G	290_F	0.829	0.23
49_V	52_P	0.828	0.23
61_D	240_K	0.821	0.23
117_K	127_P	0.821	0.23
54_V	213_L	0.820	0.23
276_I	288_Y	0.818	0.22
128_V	137_Y	0.814	0.22
244_Y	300_K	0.810	0.22
162_P	187_R	0.809	0.22
142_E	241_E	0.808	0.22
152_L	302_I	0.808	0.22
247_K	264_I	0.807	0.22
76_R	146_E	0.805	0.22
148_A	223_V	0.805	0.22
157_V	182_L	0.804	0.22
208_H	254_D	0.803	0.22
166_S	180_D	0.803	0.22
181_V	273_D	0.802	0.22
45_N	142_E	0.802	0.22
188_I	257_N	0.794	0.22
187_R	228_N	0.792	0.22
144_M	294_P	0.791	0.22
189_T	199_S	0.789	0.21
272_T	275_V	0.783	0.21
263_T	288_Y	0.777	0.21
162_P	204_G	0.775	0.21
188_I	208_H	0.769	0.21
188_I	258_E	0.769	0.21
151_M	298_V	0.768	0.21
154_N	270_E	0.767	0.21
164_V	288_Y	0.766	0.21
295_L	299_K	0.765	0.21
225_S	300_K	0.765	0.21
92_N	115_F	0.758	0.20
239_L	265_A	0.756	0.20
228_N	279_G	0.751	0.20
51_Q	201_P	0.751	0.20
52_P	55_K	0.749	0.20
223_V	291_G	0.745	0.20
86_L	129_D	0.743	0.20
89_L	276_I	0.741	0.20
110_L	114_K	0.741	0.20
280_G	285_A	0.740	0.20
267_V	304_I	0.738	0.20
172_K	277_H	0.737	0.20
35_E	39_S	0.736	0.20
41_T	45_N	0.732	0.20
125_E	145_M	0.726	0.19
239_L	274_V	0.725	0.19
292_R	304_I	0.725	0.19
48_G	291_G	0.724	0.19
169_A	295_L	0.720	0.19
104_V	126_I	0.720	0.19
160_L	239_L	0.719	0.19
139_E	239_L	0.719	0.19
42_R	152_L	0.718	0.19
169_A	271_G	0.717	0.19
195_P	229_I	0.716	0.19
96_K	115_F	0.712	0.19
246_F	292_R	0.712	0.19
167_N	188_I	0.712	0.19
74_L	277_H	0.710	0.19
260_I	264_I	0.708	0.19
222_A	234_K	0.707	0.19
129_D	136_L	0.707	0.19
283_I	286_N	0.706	0.19
177_R	298_V	0.704	0.19
132_I	195_P	0.701	0.19
80_D	238_I	0.701	0.19
207_K	211_K	0.699	0.18
223_V	227_M	0.697	0.18
101_Y	106_F	0.696	0.18
37_H	51_Q	0.691	0.18
164_V	279_G	0.689	0.18
43_I	183_A	0.688	0.18
40_Q	116_C	0.687	0.18
138_K	214_L	0.687	0.18
44_A	193_N	0.685	0.18
291_G	295_L	0.681	0.18
188_I	245_K	0.679	0.18
171_A	180_D	0.676	0.18
263_T	286_N	0.674	0.18
257_N	261_A	0.673	0.18
95_P	109_N	0.671	0.18
43_I	147_L	0.670	0.18
176_K	270_E	0.668	0.18
168_L	280_G	0.665	0.17
167_N	277_H	0.664	0.17
267_V	271_G	0.660	0.17
111_S	114_K	0.659	0.17
145_M	165_L	0.659	0.17
219_N	234_K	0.658	0.17
39_S	43_I	0.657	0.17
177_R	245_K	0.656	0.17
120_K	123_D	0.656	0.17
168_L	302_I	0.654	0.17
129_D	133_C	0.653	0.17
231_Y	276_I	0.651	0.17
94_D	97_Q	0.649	0.17
102_I	174_N	0.649	0.17
180_D	204_G	0.646	0.17
251_P	275_V	0.645	0.17
258_E	265_A	0.644	0.17
43_I	169_A	0.641	0.17
97_Q	136_L	0.639	0.17
40_Q	119_H	0.636	0.17
40_Q	57_Y	0.636	0.17
206_S	209_L	0.635	0.17
118_Y	160_L	0.633	0.16
177_R	188_I	0.633	0.16
91_I	137_Y	0.633	0.16
47_L	152_L	0.631	0.16
97_Q	277_H	0.630	0.16
73_G	116_C	0.628	0.16
141_E	299_K	0.627	0.16
212_V	281_T	0.623	0.16
195_P	297_V	0.622	0.16
184_I	277_H	0.620	0.16
230_K	240_K	0.619	0.16
162_P	167_N	0.619	0.16
207_K	218_K	0.618	0.16
53_A	103_S	0.617	0.16
145_M	182_L	0.613	0.16
232_D	235_V	0.611	0.16
165_L	294_P	0.610	0.16
173_A	248_K	0.610	0.16
111_S	220_H	0.608	0.16
226_V	254_D	0.608	0.16
49_V	302_I	0.606	0.16
144_M	295_L	0.605	0.16
155_E	178_E	0.604	0.16
262_E	265_A	0.603	0.16
152_L	181_V	0.602	0.16
223_V	275_V	0.601	0.16
150_S	202_M	0.595	0.15
251_P	279_G	0.594	0.15
247_K	265_A	0.592	0.15
51_Q	55_K	0.591	0.15
164_V	277_H	0.589	0.15
268_F	290_F	0.587	0.15
157_V	203_W	0.585	0.15
267_V	270_E	0.584	0.15
182_L	294_P	0.582	0.15
40_Q	288_Y	0.578	0.15
229_I	237_M	0.577	0.15
260_I	265_A	0.576	0.15
85_K	125_E	0.576	0.15
104_V	152_L	0.574	0.15
110_L	292_R	0.573	0.15
243_G	268_F	0.573	0.15
247_K	268_F	0.571	0.15
79_I	232_D	0.571	0.15
289_V	299_K	0.570	0.15
144_M	293_D	0.570	0.15
227_M	305_S	0.569	0.15
103_S	244_Y	0.568	0.15
227_M	301_I	0.567	0.15
95_P	106_F	0.566	0.15
169_A	172_K	0.561	0.15
47_L	285_A	0.558	0.14
186_G	279_G	0.556	0.14
55_K	126_I	0.556	0.14
263_T	283_I	0.553	0.14
92_N	106_F	0.550	0.14
104_V	119_H	0.550	0.14
119_H	251_P	0.549	0.14
228_N	282_G	0.549	0.14
208_H	213_L	0.545	0.14
189_T	196_T	0.542	0.14
171_A	181_V	0.541	0.14
58_L	61_D	0.537	0.14
148_A	302_I	0.537	0.14
126_I	249_V	0.536	0.14
183_A	203_W	0.535	0.14
86_L	179_E	0.532	0.14
42_R	52_P	0.532	0.14
166_S	235_V	0.531	0.14
59_D	62_E	0.531	0.14
185_P	202_M	0.531	0.14
51_Q	288_Y	0.530	0.14
46_L	251_P	0.530	0.14
92_N	109_N	0.529	0.14
188_I	207_K	0.528	0.14
163_E	284_E	0.527	0.14
83_L	161_I	0.525	0.14
80_D	122_I	0.523	0.14
121_M	172_K	0.523	0.14
151_M	291_G	0.521	0.14
106_F	251_P	0.518	0.13
239_L	303_N	0.517	0.13
271_G	290_F	0.517	0.13
104_V	135_S	0.516	0.13
235_V	289_V	0.515	0.13
72_L	151_M	0.514	0.13
254_D	284_E	0.511	0.13
96_K	99_M	0.510	0.13
223_V	290_F	0.509	0.13
148_A	225_S	0.509	0.13
211_K	292_R	0.508	0.13
53_A	116_C	0.507	0.13
235_V	271_G	0.506	0.13
168_L	297_V	0.505	0.13
185_P	229_I	0.505	0.13
104_V	149_L	0.504	0.13
146_E	193_N	0.504	0.13
45_N	176_K	0.504	0.13
98_V	236_E	0.503	0.13
225_S	293_D	0.502	0.13
140_N	235_V	0.501	0.13
171_A	291_G	0.500	0.13
221_P	225_S	0.500	0.13
142_E	298_V	0.500	0.13
51_Q	112_R	0.500	0.13
270_E	275_V	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2phpA	3	0.5764	100	0.491	Contact Map
2pb9A	3	0.535	100	0.506	Contact Map
2ddmA	2	0.4331	98.1	0.916	Contact Map
2i5bA	2	0.4554	98.1	0.917	Contact Map
3bgkA	3	0.4395	98.1	0.918	Contact Map
3k5wA	4	0.4268	98	0.918	Contact Map
3rpzA	3	0.4395	97.9	0.92	Contact Map
4c5kA	2	0.4777	97.9	0.921	Contact Map
4yl5A	2	0.3408	97.9	0.921	Contact Map
3rssA	4	0.4363	97.9	0.921	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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