GREMLIN Database
Q97ZV8 - Uncharacterized protein
UniProt: Q97ZV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (267)
Sequences: 279 (209)
Seq/√Len: 12.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
291_G297_V5.8851.00
169_A183_A4.9161.00
170_F294_P4.0741.00
182_L203_W3.9080.99
133_C138_K3.6900.99
185_P201_P3.4080.98
175_A217_M3.3160.98
141_E203_W3.2510.98
212_V290_F2.7490.94
260_I263_T2.6320.93
168_L227_M2.5280.91
135_S138_K2.3060.86
216_V290_F2.2760.86
171_A175_A2.2190.84
220_H271_G2.1590.82
129_D135_S2.1500.82
251_P283_I2.0980.80
172_K203_W2.0870.80
133_C137_Y2.0600.79
128_V133_C2.0340.78
181_V193_N1.9840.76
141_E182_L1.9710.76
255_L283_I1.9710.76
282_G285_A1.9320.74
183_A205_G1.9130.74
212_V277_H1.8970.73
289_V297_V1.8730.72
172_K182_L1.8690.72
169_A213_L1.8350.70
133_C136_L1.7740.68
86_L275_V1.7710.68
164_V167_N1.7630.67
238_I274_V1.7360.66
148_A298_V1.7290.66
225_S297_V1.7200.65
145_M297_V1.7090.65
209_L250_G1.6700.63
293_D296_D1.6570.62
48_G175_A1.6500.62
195_P304_I1.6330.61
167_N208_H1.6220.61
89_L165_L1.6110.60
168_L294_P1.6050.60
52_P119_H1.5920.59
248_K278_L1.5660.58
132_I135_S1.5620.58
273_D300_K1.5440.57
142_E203_W1.5370.56
53_A56_Q1.5300.56
259_R263_T1.5300.56
213_L239_L1.5120.55
277_H288_Y1.5080.55
141_E172_K1.5070.55
183_A206_S1.5040.55
171_A184_I1.4850.54
231_Y236_E1.4760.53
258_E263_T1.4740.53
161_I195_P1.4670.53
189_T236_E1.4660.53
52_P56_Q1.4590.52
251_P254_D1.4500.52
53_A119_H1.4420.51
145_M168_L1.4410.51
34_R37_H1.4300.51
258_E262_E1.4290.51
166_S195_P1.4280.51
112_R201_P1.4250.50
231_Y278_L1.4050.49
130_C133_C1.3900.49
53_A98_V1.3790.48
40_Q51_Q1.3760.48
294_P298_V1.3720.48
144_M180_D1.3570.47
114_K299_K1.3530.47
279_G284_E1.3530.47
36_L39_S1.3500.47
132_I137_Y1.3450.46
255_L263_T1.3220.45
256_G301_I1.3150.45
145_M170_F1.3130.45
160_L235_V1.2910.44
92_N95_P1.2910.44
145_M294_P1.2820.43
128_V138_K1.2820.43
251_P255_L1.2780.43
128_V135_S1.2640.42
249_V277_H1.2440.41
251_P286_N1.2420.41
51_Q73_G1.2340.41
228_N286_N1.2240.40
149_L184_I1.2200.40
37_H40_Q1.2200.40
144_M170_F1.2200.40
213_L217_M1.2030.39
164_V187_R1.2030.39
145_M291_G1.1930.39
171_A217_M1.1910.39
95_P99_M1.1650.37
204_G210_A1.1640.37
130_C137_Y1.1640.37
167_N284_E1.1490.37
259_R265_A1.1280.36
128_V161_I1.1270.35
209_L249_V1.1180.35
181_V243_G1.1120.35
245_K273_D1.1090.35
142_E182_L1.1050.34
212_V249_V1.0970.34
165_L240_K1.0970.34
215_S287_T1.0960.34
189_T238_I1.0860.34
54_V86_L1.0770.33
48_G54_V1.0750.33
103_S126_I1.0730.33
129_D138_K1.0710.33
51_Q57_Y1.0700.33
34_R43_I1.0690.33
254_D283_I1.0650.33
149_L161_I1.0560.32
153_Q197_P1.0480.32
72_L230_K1.0440.32
141_E170_F1.0430.32
249_V288_Y1.0330.31
161_I292_R1.0280.31
79_I86_L1.0210.31
51_Q116_C1.0200.31
164_V249_V1.0200.31
235_V238_I1.0150.30
49_V195_P1.0140.30
236_E271_G1.0140.30
206_S285_A1.0120.30
208_H284_E1.0040.30
222_A292_R1.0020.30
289_V301_I0.9990.30
159_E193_N0.9980.30
225_S294_P0.9930.29
144_M152_L0.9890.29
255_L262_E0.9860.29
161_I289_V0.9840.29
140_N230_K0.9810.29
289_V300_K0.9800.29
128_V132_I0.9740.29
243_G291_G0.9740.29
227_M297_V0.9670.28
220_H290_F0.9670.28
157_V166_S0.9670.28
44_A52_P0.9640.28
161_I166_S0.9630.28
65_Y71_N0.9620.28
245_K304_I0.9600.28
285_A291_G0.9590.28
176_K194_L0.9510.28
186_G282_G0.9490.28
39_S60_E0.9460.27
47_L52_P0.9440.27
160_L232_D0.9400.27
170_F295_L0.9360.27
152_L195_P0.9320.27
92_N283_I0.9320.27
47_L54_V0.9190.26
236_E276_I0.9140.26
48_G224_R0.9130.26
291_G294_P0.9130.26
134_K137_Y0.9040.26
259_R262_E0.9020.26
178_E213_L0.8910.25
111_S179_E0.8890.25
177_R241_E0.8870.25
244_Y273_D0.8850.25
112_R149_L0.8840.25
164_V284_E0.8830.25
212_V288_Y0.8810.25
200_K226_V0.8790.25
209_L226_V0.8720.24
279_G285_A0.8720.24
119_H133_C0.8660.24
212_V280_G0.8580.24
167_N228_N0.8570.24
255_L264_I0.8570.24
151_M304_I0.8530.24
246_F301_I0.8530.24
102_I108_S0.8460.23
96_K101_Y0.8370.23
176_K218_K0.8360.23
191_I239_L0.8330.23
164_V286_N0.8300.23
205_G290_F0.8290.23
49_V52_P0.8280.23
61_D240_K0.8210.23
117_K127_P0.8210.23
54_V213_L0.8200.23
276_I288_Y0.8180.22
128_V137_Y0.8140.22
244_Y300_K0.8100.22
162_P187_R0.8090.22
142_E241_E0.8080.22
152_L302_I0.8080.22
247_K264_I0.8070.22
76_R146_E0.8050.22
148_A223_V0.8050.22
157_V182_L0.8040.22
208_H254_D0.8030.22
166_S180_D0.8030.22
181_V273_D0.8020.22
45_N142_E0.8020.22
188_I257_N0.7940.22
187_R228_N0.7920.22
144_M294_P0.7910.22
189_T199_S0.7890.21
272_T275_V0.7830.21
263_T288_Y0.7770.21
162_P204_G0.7750.21
188_I208_H0.7690.21
188_I258_E0.7690.21
151_M298_V0.7680.21
154_N270_E0.7670.21
164_V288_Y0.7660.21
295_L299_K0.7650.21
225_S300_K0.7650.21
92_N115_F0.7580.20
239_L265_A0.7560.20
228_N279_G0.7510.20
51_Q201_P0.7510.20
52_P55_K0.7490.20
223_V291_G0.7450.20
86_L129_D0.7430.20
89_L276_I0.7410.20
110_L114_K0.7410.20
280_G285_A0.7400.20
267_V304_I0.7380.20
172_K277_H0.7370.20
35_E39_S0.7360.20
41_T45_N0.7320.20
125_E145_M0.7260.19
239_L274_V0.7250.19
292_R304_I0.7250.19
48_G291_G0.7240.19
169_A295_L0.7200.19
104_V126_I0.7200.19
160_L239_L0.7190.19
139_E239_L0.7190.19
42_R152_L0.7180.19
169_A271_G0.7170.19
195_P229_I0.7160.19
96_K115_F0.7120.19
246_F292_R0.7120.19
167_N188_I0.7120.19
74_L277_H0.7100.19
260_I264_I0.7080.19
222_A234_K0.7070.19
129_D136_L0.7070.19
283_I286_N0.7060.19
177_R298_V0.7040.19
132_I195_P0.7010.19
80_D238_I0.7010.19
207_K211_K0.6990.18
223_V227_M0.6970.18
101_Y106_F0.6960.18
37_H51_Q0.6910.18
164_V279_G0.6890.18
43_I183_A0.6880.18
40_Q116_C0.6870.18
138_K214_L0.6870.18
44_A193_N0.6850.18
291_G295_L0.6810.18
188_I245_K0.6790.18
171_A180_D0.6760.18
263_T286_N0.6740.18
257_N261_A0.6730.18
95_P109_N0.6710.18
43_I147_L0.6700.18
176_K270_E0.6680.18
168_L280_G0.6650.17
167_N277_H0.6640.17
267_V271_G0.6600.17
111_S114_K0.6590.17
145_M165_L0.6590.17
219_N234_K0.6580.17
39_S43_I0.6570.17
177_R245_K0.6560.17
120_K123_D0.6560.17
168_L302_I0.6540.17
129_D133_C0.6530.17
231_Y276_I0.6510.17
94_D97_Q0.6490.17
102_I174_N0.6490.17
180_D204_G0.6460.17
251_P275_V0.6450.17
258_E265_A0.6440.17
43_I169_A0.6410.17
97_Q136_L0.6390.17
40_Q119_H0.6360.17
40_Q57_Y0.6360.17
206_S209_L0.6350.17
118_Y160_L0.6330.16
177_R188_I0.6330.16
91_I137_Y0.6330.16
47_L152_L0.6310.16
97_Q277_H0.6300.16
73_G116_C0.6280.16
141_E299_K0.6270.16
212_V281_T0.6230.16
195_P297_V0.6220.16
184_I277_H0.6200.16
230_K240_K0.6190.16
162_P167_N0.6190.16
207_K218_K0.6180.16
53_A103_S0.6170.16
145_M182_L0.6130.16
232_D235_V0.6110.16
165_L294_P0.6100.16
173_A248_K0.6100.16
111_S220_H0.6080.16
226_V254_D0.6080.16
49_V302_I0.6060.16
144_M295_L0.6050.16
155_E178_E0.6040.16
262_E265_A0.6030.16
152_L181_V0.6020.16
223_V275_V0.6010.16
150_S202_M0.5950.15
251_P279_G0.5940.15
247_K265_A0.5920.15
51_Q55_K0.5910.15
164_V277_H0.5890.15
268_F290_F0.5870.15
157_V203_W0.5850.15
267_V270_E0.5840.15
182_L294_P0.5820.15
40_Q288_Y0.5780.15
229_I237_M0.5770.15
260_I265_A0.5760.15
85_K125_E0.5760.15
104_V152_L0.5740.15
110_L292_R0.5730.15
243_G268_F0.5730.15
247_K268_F0.5710.15
79_I232_D0.5710.15
289_V299_K0.5700.15
144_M293_D0.5700.15
227_M305_S0.5690.15
103_S244_Y0.5680.15
227_M301_I0.5670.15
95_P106_F0.5660.15
169_A172_K0.5610.15
47_L285_A0.5580.14
186_G279_G0.5560.14
55_K126_I0.5560.14
263_T283_I0.5530.14
92_N106_F0.5500.14
104_V119_H0.5500.14
119_H251_P0.5490.14
228_N282_G0.5490.14
208_H213_L0.5450.14
189_T196_T0.5420.14
171_A181_V0.5410.14
58_L61_D0.5370.14
148_A302_I0.5370.14
126_I249_V0.5360.14
183_A203_W0.5350.14
86_L179_E0.5320.14
42_R52_P0.5320.14
166_S235_V0.5310.14
59_D62_E0.5310.14
185_P202_M0.5310.14
51_Q288_Y0.5300.14
46_L251_P0.5300.14
92_N109_N0.5290.14
188_I207_K0.5280.14
163_E284_E0.5270.14
83_L161_I0.5250.14
80_D122_I0.5230.14
121_M172_K0.5230.14
151_M291_G0.5210.14
106_F251_P0.5180.13
239_L303_N0.5170.13
271_G290_F0.5170.13
104_V135_S0.5160.13
235_V289_V0.5150.13
72_L151_M0.5140.13
254_D284_E0.5110.13
96_K99_M0.5100.13
223_V290_F0.5090.13
148_A225_S0.5090.13
211_K292_R0.5080.13
53_A116_C0.5070.13
235_V271_G0.5060.13
168_L297_V0.5050.13
185_P229_I0.5050.13
104_V149_L0.5040.13
146_E193_N0.5040.13
45_N176_K0.5040.13
98_V236_E0.5030.13
225_S293_D0.5020.13
140_N235_V0.5010.13
171_A291_G0.5000.13
221_P225_S0.5000.13
142_E298_V0.5000.13
51_Q112_R0.5000.13
270_E275_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2phpA 3 0.5764 100 0.491 Contact Map
2pb9A 3 0.535 100 0.506 Contact Map
2ddmA 2 0.4331 98.1 0.916 Contact Map
2i5bA 2 0.4554 98.1 0.917 Contact Map
3bgkA 3 0.4395 98.1 0.918 Contact Map
3k5wA 4 0.4268 98 0.918 Contact Map
3rpzA 3 0.4395 97.9 0.92 Contact Map
4c5kA 2 0.4777 97.9 0.921 Contact Map
4yl5A 2 0.3408 97.9 0.921 Contact Map
3rssA 4 0.4363 97.9 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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