GREMLIN Database
Q97ZV6 - Uncharacterized protein
UniProt: Q97ZV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 582 (468)
Sequences: 1250 (1063)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_G510_L4.0551.00
66_L115_T3.9871.00
186_L493_L3.8931.00
261_H267_I3.6121.00
223_M416_I3.3331.00
199_L568_A3.2591.00
163_S569_E3.2101.00
514_F549_W3.0641.00
262_V266_D2.9961.00
547_G570_N2.9801.00
482_L492_S2.9721.00
202_L206_K2.9391.00
163_S173_S2.8201.00
279_E283_Q2.7621.00
264_P267_I2.6171.00
200_A495_S2.5901.00
259_R267_I2.5721.00
259_R263_I2.5381.00
261_H264_P2.5351.00
260_S263_I2.5331.00
199_L516_S2.5301.00
455_D501_Y2.5061.00
198_N547_G2.5061.00
498_R553_S2.4401.00
222_S495_S2.4241.00
458_Q499_L2.4081.00
461_I478_I2.4051.00
498_R523_D2.3931.00
255_R258_L2.3851.00
262_V267_I2.3681.00
166_N173_S2.3671.00
222_S484_H2.3581.00
263_I267_I2.3161.00
499_L509_Q2.2741.00
287_M291_Y2.2641.00
204_A218_I2.1861.00
199_L514_F2.1641.00
222_S487_K2.1591.00
206_K569_E2.1301.00
455_D495_S2.1251.00
193_G486_R2.1231.00
256_K259_R2.0951.00
222_S516_S2.0751.00
259_R262_V2.0671.00
220_D487_K2.0671.00
551_L566_F2.0531.00
260_S267_I2.0291.00
508_Q523_D2.0111.00
241_I246_V1.9930.99
451_L493_L1.9800.99
240_V243_L1.9670.99
433_I452_F1.9630.99
261_H265_D1.9540.99
498_R509_Q1.9520.99
501_Y505_N1.9310.99
272_D276_K1.9270.99
545_E548_Q1.9030.99
119_G485_G1.9020.99
263_I268_I1.8920.99
483_R501_Y1.8840.99
217_V415_F1.8350.99
479_E503_N1.8280.99
295_E298_T1.7930.99
176_I551_L1.7910.99
484_H508_Q1.7890.99
198_N571_N1.7810.99
377_F380_G1.7770.99
487_K497_Q1.7690.99
262_V265_D1.7400.99
488_Y509_Q1.7120.98
484_H487_K1.7110.98
195_G220_D1.7110.98
179_E496_T1.7020.98
508_Q553_S1.7020.98
185_H485_G1.6990.98
138_P461_I1.6850.98
185_H192_T1.6830.98
514_F551_L1.6740.98
283_Q291_Y1.6720.98
224_E487_K1.6650.98
205_R573_D1.6580.98
206_K209_D1.6550.98
347_I350_D1.6510.98
280_I283_Q1.6470.98
354_N358_E1.6180.98
509_Q523_D1.6140.98
283_Q286_K1.6040.98
297_F300_L1.6020.98
263_I269_D1.5960.98
270_I275_K1.5870.97
436_I490_L1.5870.97
358_E361_N1.5860.97
364_K367_H1.5810.97
295_E300_L1.5790.97
138_P563_P1.5600.97
498_R508_Q1.5550.97
256_K261_H1.5510.97
253_A257_F1.5510.97
185_H517_T1.5370.97
181_A184_Y1.5260.97
241_I245_R1.5240.97
295_E299_Y1.5210.97
221_V512_S1.5200.97
458_Q484_H1.5190.97
455_D480_K1.5090.96
185_H511_H1.5020.96
272_D281_L1.4990.96
260_S264_P1.4850.96
167_I174_L1.4850.96
459_E484_H1.4840.96
69_A74_M1.4810.96
308_L311_K1.4690.96
570_N574_L1.4550.96
119_G131_F1.4460.96
197_S487_K1.4370.95
188_I200_A1.4180.95
297_F301_T1.4130.95
298_T301_T1.4080.95
187_G455_D1.4050.95
483_R547_G1.4030.95
484_H553_S1.4010.95
345_D350_D1.3960.95
261_H268_I1.3850.94
303_A307_D1.3820.94
516_S549_W1.3800.94
153_A173_S1.3780.94
195_G457_A1.3710.94
187_G480_K1.3670.94
437_Y485_G1.3610.94
138_P224_E1.3610.94
270_I274_I1.3510.94
190_A501_Y1.3490.93
270_I273_K1.3400.93
220_D457_A1.3390.93
259_R264_P1.3360.93
85_I89_I1.3200.93
527_L541_T1.3150.93
305_L310_K1.3090.92
302_Y306_I1.3070.92
485_G496_T1.3040.92
307_D311_K1.2990.92
224_E483_R1.2960.92
271_R281_L1.2960.92
305_L309_V1.2800.92
484_H497_Q1.2710.91
260_S268_I1.2610.91
137_P521_P1.2540.91
499_L523_D1.2510.91
222_S548_Q1.2440.90
264_P269_D1.2440.90
272_D279_E1.2270.90
453_I493_L1.2270.90
487_K508_Q1.2260.90
483_R513_Y1.2250.90
266_D269_D1.2250.90
201_S571_N1.2250.90
309_V313_I1.2240.90
191_F519_P1.2210.90
224_E509_Q1.2190.89
400_L404_I1.2120.89
396_D400_L1.2100.89
362_L365_D1.2080.89
296_G300_L1.2060.89
282_H285_G1.1980.89
430_A474_S1.1980.89
259_R265_D1.1950.88
222_S496_T1.1920.88
240_V246_V1.1820.88
523_D553_S1.1820.88
498_R505_N1.1800.88
302_Y305_L1.1680.87
202_L521_P1.1650.87
220_D496_T1.1510.87
499_L508_Q1.1500.86
522_Y525_Q1.1480.86
253_A256_K1.1450.86
191_F496_T1.1440.86
487_K509_Q1.1430.86
223_M418_E1.1360.86
189_F514_F1.1350.86
261_H269_D1.1350.86
286_K289_Q1.1330.86
395_Y399_N1.1310.86
482_L506_A1.1300.86
303_A306_I1.1290.85
189_F510_L1.1290.85
240_V245_R1.1280.85
523_D563_P1.1260.85
130_Q150_K1.1260.85
208_L412_P1.1250.85
242_S245_R1.1200.85
131_F224_E1.1180.85
187_G553_S1.1150.85
131_F134_G1.1150.85
224_E518_L1.1110.85
145_K151_A1.1090.84
117_P546_P1.1040.84
350_D355_L1.1030.84
225_Y487_K1.1020.84
192_T511_H1.0990.84
460_F510_L1.0960.84
350_D354_N1.0950.84
309_V314_E1.0940.84
436_I450_V1.0930.84
243_L246_V1.0890.83
185_H489_H1.0880.83
66_L223_M1.0840.83
219_F512_S1.0810.83
547_G571_N1.0770.83
310_K313_I1.0770.83
437_Y455_D1.0770.83
273_K279_E1.0730.82
484_H509_Q1.0640.82
279_E282_H1.0640.82
305_L313_I1.0620.82
271_R279_E1.0540.81
283_Q287_M1.0530.81
437_Y520_R1.0500.81
199_L520_R1.0460.81
196_K456_E1.0430.81
548_Q567_A1.0400.80
495_S564_V1.0390.80
160_S177_N1.0360.80
185_H486_R1.0330.80
481_L498_R1.0290.80
506_A566_F1.0230.79
286_K292_V1.0230.79
433_I481_L1.0200.79
197_S220_D1.0170.79
509_Q553_S1.0110.78
274_I283_Q1.0100.78
276_K279_E1.0060.78
228_L455_D1.0050.78
399_N402_I1.0020.78
373_S376_T1.0020.78
181_A186_L0.9960.77
482_L487_K0.9960.77
238_S243_L0.9940.77
498_R517_T0.9930.77
272_D277_S0.9920.77
187_G498_R0.9870.77
455_D526_L0.9810.76
310_K314_E0.9800.76
458_Q483_R0.9760.76
205_R571_N0.9740.76
83_S512_S0.9710.76
288_K292_V0.9700.75
274_I279_E0.9670.75
191_F505_N0.9660.75
261_H266_D0.9650.75
497_Q509_Q0.9610.75
222_S455_D0.9600.75
200_A221_V0.9570.75
192_T457_A0.9510.74
152_Y165_G0.9510.74
458_Q509_Q0.9480.74
273_K283_Q0.9480.74
277_S283_Q0.9470.74
204_A287_M0.9470.74
198_N205_R0.9460.74
518_L527_L0.9450.74
273_K281_L0.9450.74
489_H509_Q0.9440.73
306_I309_V0.9440.73
155_F562_V0.9420.73
177_N180_K0.9420.73
500_A520_R0.9370.73
297_F302_Y0.9340.73
253_A259_R0.9330.73
343_T346_D0.9330.73
219_F429_V0.9320.73
306_I312_Q0.9310.72
138_P478_I0.9280.72
515_I546_P0.9280.72
222_S553_S0.9270.72
485_G498_R0.9270.72
451_L491_H0.9250.72
279_E291_Y0.9250.72
202_L569_E0.9220.72
505_N517_T0.9190.71
461_I510_L0.9190.71
278_A281_L0.9170.71
187_G487_K0.9160.71
367_H371_N0.9130.71
495_S516_S0.9120.71
430_A516_S0.9100.71
274_I281_L0.9080.71
494_I523_D0.9050.70
352_I355_L0.9010.70
70_D114_I0.9010.70
405_L409_R0.8980.70
494_I508_Q0.8980.70
184_Y448_P0.8970.70
225_Y455_D0.8970.70
535_D539_D0.8900.69
357_D360_E0.8880.69
191_F516_S0.8860.69
364_K369_K0.8850.69
224_E458_Q0.8830.68
345_D348_I0.8830.68
270_I276_K0.8820.68
290_L293_P0.8800.68
437_Y480_K0.8780.68
192_T491_H0.8760.68
276_K281_L0.8760.68
271_R274_I0.8740.68
481_L544_L0.8730.68
459_E483_R0.8730.68
306_I310_K0.8690.67
222_S458_Q0.8690.67
512_S555_K0.8680.67
286_K291_Y0.8660.67
258_L261_H0.8640.67
484_H523_D0.8630.67
221_V501_Y0.8630.67
302_Y311_K0.8630.67
378_I382_R0.8570.66
498_R520_R0.8550.66
484_H488_Y0.8530.66
455_D475_S0.8530.66
349_D360_E0.8510.66
185_H193_G0.8500.65
195_G458_Q0.8490.65
396_D399_N0.8460.65
166_N171_Q0.8450.65
264_P268_I0.8430.65
275_K283_Q0.8410.65
481_L553_S0.8410.65
195_G487_K0.8400.64
425_G433_I0.8380.64
474_S523_D0.8360.64
201_S498_R0.8300.64
197_S496_T0.8300.64
138_P487_K0.8290.63
222_S498_R0.8270.63
239_R244_D0.8260.63
302_Y309_V0.8260.63
277_S281_L0.8250.63
305_L308_L0.8210.63
222_S503_N0.8200.63
521_P526_L0.8190.63
296_G305_L0.8150.62
253_A260_S0.8100.62
494_I509_Q0.8090.62
488_Y498_R0.8070.61
138_P457_A0.8060.61
191_F460_F0.8040.61
361_N381_I0.8040.61
441_K495_S0.8030.61
262_V269_D0.7990.61
185_H544_L0.7990.61
301_T305_L0.7980.60
272_D275_K0.7970.60
191_F501_Y0.7950.60
549_W568_A0.7940.60
285_G289_Q0.7910.60
222_S509_Q0.7910.60
519_P533_I0.7900.60
119_G225_Y0.7900.60
199_L202_L0.7890.60
305_L314_E0.7860.59
304_D428_V0.7860.59
273_K277_S0.7840.59
342_L346_D0.7840.59
192_T458_Q0.7820.59
150_K173_S0.7800.59
417_L420_P0.7790.59
184_Y458_Q0.7790.59
483_R496_T0.7750.58
489_H523_D0.7750.58
258_L262_V0.7730.58
92_E95_K0.7720.58
487_K496_T0.7720.58
190_A488_Y0.7720.58
296_G299_Y0.7710.58
192_T518_L0.7710.58
401_A406_D0.7700.58
417_L555_K0.7690.58
524_R548_Q0.7680.58
184_Y507_L0.7680.58
140_L478_I0.7670.57
494_I498_R0.7650.57
343_T347_I0.7640.57
214_T509_Q0.7640.57
220_D483_R0.7610.57
363_G366_A0.7610.57
488_Y508_Q0.7590.57
460_F512_S0.7590.57
479_E505_N0.7580.57
195_G496_T0.7580.57
496_T555_K0.7570.56
194_S517_T0.7560.56
430_A434_N0.7550.56
402_I405_L0.7530.56
199_L549_W0.7530.56
458_Q501_Y0.7490.56
238_S242_S0.7470.55
221_V495_S0.7450.55
215_K501_Y0.7420.55
120_Y190_A0.7410.55
485_G517_T0.7410.55
237_P244_D0.7400.55
193_G523_D0.7400.55
437_Y500_A0.7380.55
273_K276_K0.7370.54
190_A521_P0.7370.54
189_F515_I0.7360.54
276_K280_I0.7350.54
189_F524_R0.7350.54
425_G459_E0.7340.54
191_F498_R0.7340.54
195_G225_Y0.7330.54
488_Y497_Q0.7320.54
461_I544_L0.7310.54
460_F519_P0.7270.53
140_L455_D0.7270.53
185_H512_S0.7250.53
314_E359_I0.7250.53
194_S458_Q0.7240.53
302_Y310_K0.7240.53
553_S563_P0.7230.53
331_S335_N0.7210.53
267_I271_R0.7210.53
198_N425_G0.7210.53
194_S516_S0.7190.53
220_D225_Y0.7180.53
263_I275_K0.7150.52
348_I352_I0.7130.52
505_N553_S0.7100.52
458_Q498_R0.7090.52
481_L549_W0.7080.52
236_V240_V0.7070.51
304_D307_D0.7060.51
504_T513_Y0.7040.51
396_D404_I0.7030.51
483_R512_S0.7030.51
426_R503_N0.7020.51
570_N573_D0.7020.51
182_I433_I0.7010.51
505_N520_R0.6990.51
302_Y307_D0.6970.50
224_E497_Q0.6970.50
430_A496_T0.6960.50
181_A563_P0.6940.50
232_K235_E0.6940.50
167_I413_R0.6940.50
426_R478_I0.6930.50
113_S429_V0.6900.50
392_T397_I0.6890.50
174_L564_V0.6870.49
190_A456_E0.6850.49
190_A196_K0.6850.49
331_S334_D0.6840.49
308_L313_I0.6840.49
69_A72_I0.6820.49
520_R553_S0.6810.49
484_H517_T0.6800.49
149_K171_Q0.6800.49
203_I500_A0.6800.49
404_I550_L0.6800.49
186_L455_D0.6790.49
205_R572_L0.6780.48
496_T526_L0.6770.48
461_I501_Y0.6760.48
223_M428_V0.6750.48
190_A455_D0.6730.48
516_S519_P0.6710.48
188_I193_G0.6710.48
274_I277_S0.6690.48
222_S500_A0.6670.47
424_E452_F0.6670.47
457_A498_R0.6660.47
255_R268_I0.6630.47
380_G387_L0.6620.47
189_F518_L0.6620.47
260_S266_D0.6610.47
517_T542_L0.6610.47
496_T553_S0.6600.47
279_E286_K0.6600.47
271_R276_K0.6560.46
349_D354_N0.6550.46
193_G563_P0.6540.46
403_E407_S0.6530.46
460_F501_Y0.6530.46
189_F487_K0.6530.46
486_R550_L0.6500.46
197_S534_S0.6480.45
193_G550_L0.6460.45
222_S459_E0.6440.45
263_I266_D0.6430.45
200_A453_I0.6420.45
517_T548_Q0.6410.45
309_V312_Q0.6410.45
305_L311_K0.6400.45
284_N423_E0.6380.44
502_L510_L0.6380.44
221_V459_E0.6370.44
119_G555_K0.6350.44
364_K368_L0.6350.44
276_K283_Q0.6350.44
440_R483_R0.6340.44
170_E173_S0.6320.44
253_A258_L0.6320.44
158_A161_N0.6310.44
188_I518_L0.6300.44
273_K280_I0.6300.44
298_T306_I0.6290.44
287_M292_V0.6270.43
304_D311_K0.6270.43
256_K265_D0.6270.43
201_S553_S0.6260.43
173_S352_I0.6260.43
197_S418_E0.6230.43
182_I491_H0.6220.43
196_K486_R0.6210.43
456_E486_R0.6210.43
478_I509_Q0.6200.43
215_K439_R0.6190.43
282_H290_L0.6190.43
169_H176_I0.6190.43
150_K153_A0.6180.42
380_G425_G0.6170.42
363_G368_L0.6170.42
484_H498_R0.6170.42
487_K553_S0.6160.42
256_K262_V0.6150.42
237_P246_V0.6150.42
187_G507_L0.6140.42
517_T523_D0.6140.42
299_Y304_D0.6130.42
343_T349_D0.6120.42
481_L508_Q0.6110.42
484_H520_R0.6110.42
116_Y157_C0.6090.42
286_K290_L0.6050.41
355_L360_E0.6050.41
454_I462_P0.6050.41
296_G399_N0.6050.41
399_N403_E0.6040.41
419_L478_I0.6040.41
165_G551_L0.6040.41
238_S245_R0.6020.41
482_L519_P0.6020.41
362_L366_A0.6020.41
225_Y452_F0.6020.41
274_I280_I0.6000.41
462_P478_I0.6000.41
353_N356_L0.5990.41
204_A453_I0.5990.41
515_I541_T0.5980.40
164_L176_I0.5970.40
439_R488_Y0.5960.40
305_L312_Q0.5960.40
223_M517_T0.5950.40
288_K291_Y0.5950.40
187_G496_T0.5930.40
173_S360_E0.5930.40
119_G510_L0.5920.40
301_T304_D0.5920.40
270_I279_E0.5920.40
301_T306_I0.5920.40
256_K260_S0.5910.40
454_I502_L0.5910.40
383_A389_I0.5890.40
304_D308_L0.5890.40
65_I69_A0.5880.39
458_Q517_T0.5880.39
498_R552_V0.5830.39
219_F454_I0.5830.39
197_S508_Q0.5830.39
301_T313_I0.5820.39
71_I74_M0.5820.39
267_I276_K0.5820.39
121_I172_L0.5810.39
440_R512_S0.5790.39
239_R243_L0.5790.39
498_R501_Y0.5780.39
422_L459_E0.5770.38
332_K335_N0.5770.38
271_R280_I0.5770.38
312_Q361_N0.5760.38
366_A370_E0.5750.38
95_K98_S0.5750.38
240_V414_L0.5740.38
224_E461_I0.5720.38
509_Q520_R0.5690.38
517_T553_S0.5690.38
275_K282_H0.5690.38
395_Y403_E0.5690.38
346_D359_I0.5670.37
117_P513_Y0.5670.37
194_S496_T0.5670.37
138_P460_F0.5650.37
489_H498_R0.5640.37
295_E301_T0.5630.37
120_Y135_Y0.5630.37
524_R542_L0.5620.37
137_P461_I0.5610.37
455_D484_H0.5610.37
481_L485_G0.5600.37
138_P509_Q0.5600.37
184_Y483_R0.5590.37
330_L335_N0.5590.37
88_E218_I0.5580.37
117_P120_Y0.5580.37
274_I516_S0.5580.37
347_I351_S0.5570.37
224_E512_S0.5550.36
188_I464_D0.5540.36
488_Y532_G0.5520.36
238_S241_I0.5520.36
164_L197_S0.5510.36
354_N572_L0.5510.36
239_R242_S0.5510.36
167_I172_L0.5500.36
289_Q292_V0.5490.36
531_F548_Q0.5470.36
215_K491_H0.5460.35
353_N357_D0.5420.35
224_E484_H0.5420.35
190_A194_S0.5410.35
183_K217_V0.5400.35
298_T302_Y0.5400.35
192_T516_S0.5390.35
174_L566_F0.5380.35
200_A513_Y0.5380.35
410_D491_H0.5360.35
120_Y134_G0.5360.35
268_I271_R0.5360.35
156_V381_I0.5340.34
137_P459_E0.5330.34
457_A494_I0.5330.34
417_L458_Q0.5330.34
122_L567_A0.5320.34
544_L553_S0.5320.34
193_G498_R0.5300.34
297_F303_A0.5300.34
201_S215_K0.5300.34
171_Q174_L0.5300.34
155_F504_T0.5290.34
458_Q494_I0.5290.34
217_V436_I0.5280.34
444_Y496_T0.5280.34
220_D485_G0.5280.34
487_K492_S0.5270.34
463_Y504_T0.5270.34
221_V550_L0.5250.34
436_I452_F0.5250.34
108_E203_I0.5250.34
497_Q508_Q0.5250.34
425_G501_Y0.5250.34
355_L394_D0.5240.33
111_I140_L0.5230.33
484_H499_L0.5220.33
270_I277_S0.5220.33
472_E512_S0.5210.33
307_D310_K0.5200.33
303_A308_L0.5190.33
177_N188_I0.5190.33
395_Y405_L0.5180.33
142_S509_Q0.5170.33
345_D352_I0.5170.33
380_G427_Q0.5170.33
498_R503_N0.5170.33
455_D537_L0.5170.33
330_L333_L0.5170.33
167_I524_R0.5170.33
242_S246_V0.5140.33
489_H517_T0.5130.32
308_L312_Q0.5130.32
119_G520_R0.5120.32
297_F307_D0.5120.32
289_Q293_P0.5120.32
462_P502_L0.5110.32
150_K209_D0.5110.32
426_R474_S0.5110.32
283_Q289_Q0.5100.32
459_E480_K0.5100.32
458_Q520_R0.5100.32
219_F432_V0.5090.32
442_R565_F0.5090.32
410_D448_P0.5080.32
307_D313_I0.5080.32
479_E513_Y0.5080.32
119_G512_S0.5080.32
392_T406_D0.5070.32
489_H553_S0.5070.32
276_K282_H0.5070.32
202_L518_L0.5070.32
193_G196_K0.5070.32
193_G456_E0.5070.32
275_K280_I0.5060.32
502_L571_N0.5060.32
499_L553_S0.5040.32
165_G456_E0.5040.32
165_G196_K0.5040.32
505_N516_S0.5030.32
475_S503_N0.5020.31
347_I352_I0.5010.31
237_P305_L0.5010.31
489_H544_L0.5010.31
282_H291_Y0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d2iA 3 0.7784 100 0.454 Contact Map
4ag6A 2 0.6151 100 0.598 Contact Map
1e9rA 3 0.6512 100 0.7 Contact Map
2iusA 1 0.634 99.7 0.836 Contact Map
2iutA 2 0.5979 99.3 0.873 Contact Map
4lyaA 1 0.4502 99.2 0.878 Contact Map
4nh0A 1 0.6357 98.9 0.892 Contact Map
2r2aA 1 0.2938 98 0.919 Contact Map
4kfuA 1 0.3522 97.7 0.925 Contact Map
4ww4A 2 0.634 96.5 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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