Q97ZV5 - SULSO - GREMLIN Contacts

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Q97ZV5 - Uncharacterized protein

UniProt:	Q97ZV5	Sequences: MYYGSIITVLSSDKNKLTGIAEKLGKLHETAKTKIYYRKKGEYIRSILLTTEYPEKIIDLAEALSLSSTAILYIPETLTWMDGELALLIDSLNTHNKIVISNLDQGKINNILGSLSSFTKFDLYNDIPDLSETEEEDKGIVYVDRVFTVKGVGTVVTGFSFTNVEVHEKLVALPYNKEVEIKSIQVLDEDQKSVSTGVRIGFALKNVKEEEIEDLLYLVKPNVKVVKEIEGQITNYKWSTINQGQNHIIVKGHGIAANIKVDNQKAKIMSSVPIPIVDNRILVLNVNVRQGKPRVAGYISL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (266)
Sequences:	14720 (7459)
Seq/√Len:	457.3

ECOLI - SELB CYSN EFTU2 EFTU1 TYPA LEPA RF3 EFG
BACSU - EFTU TYPA LEPA EFG
HALSA - EF1A IF2G Q9HPE4 EF2 IF2P
SULSO - Q97ZV5 EF1A Q97W17 IF2G EF2 IF2P

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
194_V	200_I	5.090	1.00
165_E	193_S	4.300	1.00
163_N	193_S	3.735	1.00
169_K	178_E	3.673	1.00
183_S	190_D	3.009	1.00
107_K	110_N	2.901	1.00
107_K	111_I	2.770	1.00
166_V	192_K	2.470	1.00
118_F	121_F	2.348	1.00
165_E	168_E	2.334	1.00
139_G	160_S	2.257	1.00
107_K	112_L	2.180	1.00
112_L	116_S	2.163	1.00
8_T	67_S	2.152	1.00
168_E	220_K	2.115	1.00
158_G	202_F	2.094	1.00
110_N	114_S	2.075	1.00
139_G	164_V	1.973	1.00
112_L	115_L	1.962	1.00
169_K	180_E	1.945	1.00
39_K	44_I	1.940	1.00
173_L	219_V	1.936	1.00
171_V	178_E	1.933	1.00
108_I	111_I	1.928	1.00
141_V	158_G	1.925	1.00
137_D	162_T	1.921	1.00
21_A	47_I	1.913	1.00
125_N	129_D	1.901	1.00
109_N	112_L	1.891	1.00
195_S	198_V	1.883	1.00
177_K	211_E	1.867	1.00
231_G	234_T	1.829	1.00
155_V	201_G	1.827	1.00
76_E	79_T	1.817	1.00
140_I	162_T	1.802	1.00
111_I	114_S	1.802	1.00
160_S	194_V	1.784	1.00
134_E	137_D	1.759	1.00
109_N	113_G	1.739	1.00
164_V	181_I	1.723	1.00
166_V	190_D	1.720	1.00
226_V	234_T	1.698	1.00
163_N	195_S	1.688	1.00
9_V	21_A	1.687	1.00
139_G	170_L	1.678	1.00
143_V	156_V	1.671	1.00
128_P	131_S	1.662	1.00
266_A	270_S	1.652	1.00
74_I	82_D	1.651	1.00
108_I	116_S	1.648	1.00
125_N	128_P	1.643	1.00
107_K	114_S	1.596	1.00
160_S	200_I	1.587	1.00
111_I	116_S	1.582	1.00
171_V	221_P	1.555	1.00
228_E	233_I	1.539	1.00
107_K	116_S	1.517	1.00
111_I	118_F	1.508	1.00
272_V	275_P	1.506	1.00
70_A	89_I	1.484	1.00
170_L	181_I	1.480	1.00
249_I	257_A	1.475	1.00
10_L	72_L	1.465	1.00
229_I	233_I	1.462	1.00
20_I	73_Y	1.461	1.00
86_A	115_L	1.447	1.00
111_I	115_L	1.440	1.00
115_L	118_F	1.425	1.00
107_K	115_L	1.413	1.00
159_F	199_R	1.413	1.00
262_D	265_K	1.351	1.00
156_V	212_I	1.337	1.00
111_I	117_S	1.334	1.00
119_T	122_D	1.334	1.00
186_V	189_E	1.332	1.00
266_A	269_M	1.315	1.00
191_Q	194_V	1.299	1.00
10_L	89_I	1.295	1.00
178_E	221_P	1.289	1.00
117_S	122_D	1.286	1.00
184_I	202_F	1.286	1.00
135_E	195_S	1.272	1.00
61_A	88_L	1.265	1.00
127_I	131_S	1.251	1.00
38_R	47_I	1.244	1.00
118_F	123_L	1.239	1.00
175_Y	216_L	1.234	1.00
48_L	67_S	1.233	1.00
37_Y	44_I	1.233	1.00
226_V	233_I	1.231	1.00
107_K	117_S	1.219	1.00
126_D	129_D	1.212	1.00
85_L	88_L	1.211	1.00
164_V	202_F	1.204	1.00
108_I	112_L	1.204	1.00
115_L	121_F	1.200	1.00
38_R	45_R	1.188	1.00
270_S	274_I	1.176	1.00
108_I	114_S	1.163	1.00
39_K	42_E	1.150	1.00
250_V	254_G	1.148	1.00
183_S	203_A	1.147	1.00
147_F	157_T	1.145	1.00
172_A	179_V	1.143	1.00
213_E	216_L	1.138	1.00
10_L	70_A	1.136	1.00
230_E	233_I	1.133	1.00
166_V	184_I	1.119	1.00
113_G	116_S	1.116	1.00
273_P	276_I	1.109	1.00
227_K	233_I	1.108	1.00
117_S	120_K	1.103	1.00
107_K	118_F	1.102	1.00
73_Y	101_S	1.099	1.00
124_Y	128_P	1.095	1.00
124_Y	127_I	1.095	1.00
171_V	176_N	1.088	1.00
271_S	274_I	1.078	1.00
238_W	249_I	1.077	1.00
112_L	118_F	1.070	1.00
266_A	275_P	1.064	1.00
226_V	231_G	1.063	1.00
78_L	82_D	1.059	1.00
174_P	216_L	1.059	1.00
226_V	229_I	1.053	1.00
108_I	115_L	1.053	1.00
240_T	243_Q	1.050	1.00
11_S	15_N	1.045	1.00
228_E	231_G	1.037	1.00
262_D	266_A	1.032	1.00
109_N	116_S	1.024	1.00
227_K	234_T	1.022	1.00
175_Y	213_E	1.021	1.00
264_Q	270_S	1.020	1.00
266_A	273_P	1.018	1.00
33_T	48_L	1.014	1.00
179_V	207_V	1.002	1.00
72_L	82_D	0.994	1.00
229_I	234_T	0.989	1.00
194_V	198_V	0.986	1.00
19_G	24_L	0.984	1.00
72_L	98_I	0.977	1.00
172_A	218_L	0.965	1.00
248_I	254_G	0.958	1.00
89_I	96_N	0.955	1.00
228_E	234_T	0.949	1.00
141_V	160_S	0.944	1.00
7_I	45_R	0.943	1.00
116_S	119_T	0.943	1.00
236_Y	248_I	0.941	1.00
20_I	24_L	0.941	1.00
109_N	120_K	0.932	1.00
207_V	212_I	0.930	1.00
219_V	223_V	0.922	1.00
17_L	24_L	0.919	1.00
118_F	122_D	0.915	1.00
158_G	200_I	0.914	1.00
114_S	117_S	0.912	1.00
248_I	258_N	0.912	1.00
186_V	191_Q	0.911	1.00
149_V	152_V	0.911	1.00
170_L	218_L	0.909	1.00
70_A	94_T	0.908	1.00
263_N	266_A	0.904	1.00
269_M	273_P	0.901	1.00
269_M	272_V	0.900	1.00
110_N	113_G	0.898	1.00
185_Q	190_D	0.897	1.00
165_E	192_K	0.894	1.00
9_V	71_I	0.894	1.00
69_T	130_L	0.893	1.00
164_V	170_L	0.892	1.00
109_N	119_T	0.891	1.00
127_I	132_E	0.882	1.00
166_V	183_S	0.881	1.00
120_K	123_L	0.878	1.00
135_E	138_K	0.878	1.00
169_K	221_P	0.873	1.00
115_L	123_L	0.872	1.00
75_P	105_Q	0.867	1.00
170_L	179_V	0.859	1.00
108_I	118_F	0.856	1.00
27_L	31_A	0.852	1.00
257_A	260_K	0.849	1.00
264_Q	268_I	0.847	1.00
270_S	273_P	0.837	1.00
240_T	245_Q	0.837	1.00
267_K	273_P	0.837	1.00
24_L	38_R	0.837	1.00
263_N	271_S	0.836	1.00
135_E	163_N	0.835	1.00
138_K	220_K	0.830	1.00
32_K	59_D	0.828	1.00
116_S	122_D	0.824	1.00
265_K	275_P	0.823	1.00
12_S	15_N	0.818	1.00
267_K	275_P	0.816	1.00
265_K	269_M	0.815	1.00
90_D	96_N	0.809	1.00
185_Q	188_D	0.809	1.00
43_Y	128_P	0.805	1.00
117_S	121_F	0.799	1.00
227_K	231_G	0.797	1.00
13_D	53_Y	0.796	1.00
268_I	275_P	0.795	1.00
242_N	246_N	0.795	1.00
250_V	253_H	0.793	1.00
141_V	202_F	0.792	1.00
223_V	230_E	0.791	1.00
76_E	105_Q	0.789	1.00
115_L	122_D	0.789	1.00
229_I	232_Q	0.788	1.00
141_V	144_D	0.787	1.00
115_L	119_T	0.786	1.00
171_V	222_N	0.786	1.00
226_V	230_E	0.781	1.00
227_K	230_E	0.780	1.00
74_I	98_I	0.778	1.00
113_G	118_F	0.776	1.00
109_N	118_F	0.769	1.00
13_D	29_E	0.768	1.00
19_G	25_G	0.767	1.00
263_N	269_M	0.766	1.00
242_N	245_Q	0.766	1.00
72_L	85_L	0.765	1.00
17_L	25_G	0.764	1.00
172_A	212_I	0.762	1.00
264_Q	275_P	0.762	1.00
241_I	244_G	0.759	1.00
11_S	21_A	0.755	1.00
116_S	120_K	0.754	1.00
240_T	244_G	0.751	1.00
240_T	247_H	0.747	1.00
143_V	212_I	0.741	1.00
271_S	276_I	0.740	1.00
248_I	256_A	0.739	1.00
112_L	120_K	0.736	1.00
228_E	232_Q	0.731	1.00
41_G	125_N	0.730	1.00
22_E	25_G	0.728	1.00
108_I	122_D	0.724	1.00
117_S	123_L	0.722	1.00
164_V	194_V	0.719	1.00
15_N	22_E	0.717	1.00
265_K	273_P	0.714	1.00
202_F	218_L	0.713	1.00
14_K	53_Y	0.712	1.00
112_L	117_S	0.712	1.00
135_E	196_T	0.711	1.00
162_T	224_K	0.710	1.00
230_E	234_T	0.710	1.00
71_I	100_I	0.705	1.00
244_G	247_H	0.704	1.00
33_T	63_A	0.700	1.00
251_K	254_G	0.699	1.00
139_G	181_I	0.697	1.00
224_K	232_Q	0.696	1.00
61_A	91_S	0.695	1.00
230_E	267_K	0.695	1.00
8_T	50_T	0.694	1.00
133_T	196_T	0.691	1.00
54_P	80_W	0.691	1.00
271_S	275_P	0.690	1.00
10_L	64_L	0.690	1.00
166_V	182_K	0.689	1.00
116_S	123_L	0.689	1.00
119_T	123_L	0.687	1.00
269_M	275_P	0.680	1.00
226_V	232_Q	0.678	1.00
264_Q	273_P	0.678	1.00
262_D	267_K	0.676	1.00
264_Q	274_I	0.673	1.00
223_V	226_V	0.673	1.00
124_Y	131_S	0.673	1.00
164_V	184_I	0.669	1.00
114_S	119_T	0.665	1.00
133_T	137_D	0.665	1.00
253_H	257_A	0.664	1.00
224_K	227_K	0.663	1.00
228_E	267_K	0.663	1.00
245_Q	248_I	0.662	1.00
20_I	23_K	0.661	1.00
18_T	22_E	0.657	1.00
264_Q	269_M	0.656	1.00
136_E	163_N	0.655	1.00
272_V	276_I	0.654	1.00
241_I	247_H	0.653	1.00
72_L	86_A	0.648	1.00
228_E	269_M	0.648	1.00
254_G	258_N	0.647	1.00
21_A	24_L	0.646	1.00
258_N	261_V	0.644	1.00
223_V	233_I	0.643	1.00
263_N	272_V	0.642	1.00
261_V	266_A	0.642	1.00
252_G	255_I	0.641	1.00
14_K	29_E	0.640	1.00
17_L	20_I	0.639	0.99
127_I	130_L	0.638	0.99
114_S	120_K	0.637	0.99
151_G	154_T	0.634	0.99
108_I	113_G	0.634	0.99
227_K	232_Q	0.632	0.99
264_Q	267_K	0.632	0.99
173_L	225_V	0.631	0.99
108_I	117_S	0.630	0.99
184_I	194_V	0.629	0.99
112_L	119_T	0.629	0.99
149_V	155_V	0.626	0.99
265_K	270_S	0.624	0.99
266_A	274_I	0.622	0.99
133_T	162_T	0.622	0.99
60_L	64_L	0.618	0.99
263_N	273_P	0.616	0.99
110_N	115_L	0.615	0.99
115_L	120_K	0.614	0.99
114_S	118_F	0.613	0.99
83_G	87_L	0.613	0.99
160_S	164_V	0.612	0.99
265_K	271_S	0.611	0.99
270_S	275_P	0.611	0.99
243_Q	246_N	0.607	0.99
241_I	246_N	0.605	0.99
232_Q	265_K	0.605	0.99
246_N	249_I	0.605	0.99
249_I	255_I	0.604	0.99
247_H	257_A	0.603	0.99
267_K	276_I	0.603	0.99
108_I	119_T	0.601	0.99
75_P	102_N	0.601	0.99
263_N	270_S	0.600	0.99
15_N	76_E	0.600	0.99
32_K	36_Y	0.597	0.99
248_I	251_K	0.596	0.99
186_V	198_V	0.595	0.99
266_A	271_S	0.594	0.99
238_W	247_H	0.594	0.99
250_V	255_I	0.594	0.99
248_I	252_G	0.590	0.99
233_I	237_K	0.587	0.99
124_Y	132_E	0.584	0.99
65_S	161_F	0.584	0.99
254_G	257_A	0.579	0.99
171_V	219_V	0.576	0.99
87_L	90_D	0.575	0.99
247_H	252_G	0.574	0.99
267_K	270_S	0.573	0.99
111_I	122_D	0.571	0.99
60_L	85_L	0.568	0.99
157_T	201_G	0.568	0.99
266_A	276_I	0.567	0.99
82_D	98_I	0.566	0.99
243_Q	260_K	0.566	0.99
142_Y	145_R	0.565	0.99
36_Y	187_L	0.564	0.99
225_V	231_G	0.564	0.99
267_K	272_V	0.563	0.99
270_S	276_I	0.563	0.99
64_L	92_L	0.559	0.99
263_N	275_P	0.558	0.99
191_Q	198_V	0.558	0.99
50_T	60_L	0.558	0.99
263_N	268_I	0.557	0.99
266_A	272_V	0.556	0.99
254_G	261_V	0.555	0.99
116_S	121_F	0.551	0.99
223_V	227_K	0.549	0.98
54_P	84_E	0.547	0.98
12_S	79_T	0.546	0.98
126_D	131_S	0.544	0.98
21_A	25_G	0.542	0.98
239_S	244_G	0.540	0.98
148_T	154_T	0.538	0.98
251_K	255_I	0.536	0.98
224_K	234_T	0.535	0.98
256_A	259_I	0.534	0.98
211_E	215_L	0.531	0.98
41_G	128_P	0.530	0.98
8_T	64_L	0.528	0.98
61_A	85_L	0.527	0.98
71_I	97_K	0.527	0.98
44_I	198_V	0.523	0.98
224_K	230_E	0.522	0.98
171_V	175_Y	0.521	0.98
179_V	212_I	0.519	0.98
83_G	114_S	0.517	0.98
86_A	90_D	0.517	0.98
71_I	99_V	0.515	0.98
231_G	266_A	0.513	0.98
247_H	250_V	0.513	0.98
107_K	119_T	0.512	0.98
114_S	122_D	0.510	0.98
13_D	30_T	0.510	0.98
29_E	53_Y	0.509	0.98
188_D	201_G	0.506	0.97
81_M	85_L	0.504	0.97
182_K	203_A	0.504	0.97
14_K	28_H	0.501	0.97
149_V	153_G	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wndA	1	0.9834	100	0.33	Contact Map
1d2eA	3	0.9967	100	0.337	Contact Map
3mcaA	1	0.9003	100	0.338	Contact Map
2c78A	1	0.9967	100	0.343	Contact Map
1jnyA	1	0.9635	100	0.347	Contact Map
3wy9A	1	0.9967	100	0.352	Contact Map
3avxA	1	0.9834	100	0.354	Contact Map
1f60A	1	1	100	0.357	Contact Map
4crnP	1	0.9934	100	0.362	Contact Map
1r5bA	1	0.9236	100	0.369	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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