GREMLIN Database
Q97ZV5 - Uncharacterized protein
UniProt: Q97ZV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (266)
Sequences: 14720 (7459)
Seq/√Len: 457.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_V200_I5.0901.00
165_E193_S4.3001.00
163_N193_S3.7351.00
169_K178_E3.6731.00
183_S190_D3.0091.00
107_K110_N2.9011.00
107_K111_I2.7701.00
166_V192_K2.4701.00
118_F121_F2.3481.00
165_E168_E2.3341.00
139_G160_S2.2571.00
107_K112_L2.1801.00
112_L116_S2.1631.00
8_T67_S2.1521.00
168_E220_K2.1151.00
158_G202_F2.0941.00
110_N114_S2.0751.00
139_G164_V1.9731.00
112_L115_L1.9621.00
169_K180_E1.9451.00
39_K44_I1.9401.00
173_L219_V1.9361.00
171_V178_E1.9331.00
108_I111_I1.9281.00
141_V158_G1.9251.00
137_D162_T1.9211.00
21_A47_I1.9131.00
125_N129_D1.9011.00
109_N112_L1.8911.00
195_S198_V1.8831.00
177_K211_E1.8671.00
231_G234_T1.8291.00
155_V201_G1.8271.00
76_E79_T1.8171.00
140_I162_T1.8021.00
111_I114_S1.8021.00
160_S194_V1.7841.00
134_E137_D1.7591.00
109_N113_G1.7391.00
164_V181_I1.7231.00
166_V190_D1.7201.00
226_V234_T1.6981.00
163_N195_S1.6881.00
9_V21_A1.6871.00
139_G170_L1.6781.00
143_V156_V1.6711.00
128_P131_S1.6621.00
266_A270_S1.6521.00
74_I82_D1.6511.00
108_I116_S1.6481.00
125_N128_P1.6431.00
107_K114_S1.5961.00
160_S200_I1.5871.00
111_I116_S1.5821.00
171_V221_P1.5551.00
228_E233_I1.5391.00
107_K116_S1.5171.00
111_I118_F1.5081.00
272_V275_P1.5061.00
70_A89_I1.4841.00
170_L181_I1.4801.00
249_I257_A1.4751.00
10_L72_L1.4651.00
229_I233_I1.4621.00
20_I73_Y1.4611.00
86_A115_L1.4471.00
111_I115_L1.4401.00
115_L118_F1.4251.00
107_K115_L1.4131.00
159_F199_R1.4131.00
262_D265_K1.3511.00
156_V212_I1.3371.00
111_I117_S1.3341.00
119_T122_D1.3341.00
186_V189_E1.3321.00
266_A269_M1.3151.00
191_Q194_V1.2991.00
10_L89_I1.2951.00
178_E221_P1.2891.00
117_S122_D1.2861.00
184_I202_F1.2861.00
135_E195_S1.2721.00
61_A88_L1.2651.00
127_I131_S1.2511.00
38_R47_I1.2441.00
118_F123_L1.2391.00
175_Y216_L1.2341.00
48_L67_S1.2331.00
37_Y44_I1.2331.00
226_V233_I1.2311.00
107_K117_S1.2191.00
126_D129_D1.2121.00
85_L88_L1.2111.00
164_V202_F1.2041.00
108_I112_L1.2041.00
115_L121_F1.2001.00
38_R45_R1.1881.00
270_S274_I1.1761.00
108_I114_S1.1631.00
39_K42_E1.1501.00
250_V254_G1.1481.00
183_S203_A1.1471.00
147_F157_T1.1451.00
172_A179_V1.1431.00
213_E216_L1.1381.00
10_L70_A1.1361.00
230_E233_I1.1331.00
166_V184_I1.1191.00
113_G116_S1.1161.00
273_P276_I1.1091.00
227_K233_I1.1081.00
117_S120_K1.1031.00
107_K118_F1.1021.00
73_Y101_S1.0991.00
124_Y128_P1.0951.00
124_Y127_I1.0951.00
171_V176_N1.0881.00
271_S274_I1.0781.00
238_W249_I1.0771.00
112_L118_F1.0701.00
266_A275_P1.0641.00
226_V231_G1.0631.00
78_L82_D1.0591.00
174_P216_L1.0591.00
226_V229_I1.0531.00
108_I115_L1.0531.00
240_T243_Q1.0501.00
11_S15_N1.0451.00
228_E231_G1.0371.00
262_D266_A1.0321.00
109_N116_S1.0241.00
227_K234_T1.0221.00
175_Y213_E1.0211.00
264_Q270_S1.0201.00
266_A273_P1.0181.00
33_T48_L1.0141.00
179_V207_V1.0021.00
72_L82_D0.9941.00
229_I234_T0.9891.00
194_V198_V0.9861.00
19_G24_L0.9841.00
72_L98_I0.9771.00
172_A218_L0.9651.00
248_I254_G0.9581.00
89_I96_N0.9551.00
228_E234_T0.9491.00
141_V160_S0.9441.00
7_I45_R0.9431.00
116_S119_T0.9431.00
236_Y248_I0.9411.00
20_I24_L0.9411.00
109_N120_K0.9321.00
207_V212_I0.9301.00
219_V223_V0.9221.00
17_L24_L0.9191.00
118_F122_D0.9151.00
158_G200_I0.9141.00
114_S117_S0.9121.00
248_I258_N0.9121.00
186_V191_Q0.9111.00
149_V152_V0.9111.00
170_L218_L0.9091.00
70_A94_T0.9081.00
263_N266_A0.9041.00
269_M273_P0.9011.00
269_M272_V0.9001.00
110_N113_G0.8981.00
185_Q190_D0.8971.00
165_E192_K0.8941.00
9_V71_I0.8941.00
69_T130_L0.8931.00
164_V170_L0.8921.00
109_N119_T0.8911.00
127_I132_E0.8821.00
166_V183_S0.8811.00
120_K123_L0.8781.00
135_E138_K0.8781.00
169_K221_P0.8731.00
115_L123_L0.8721.00
75_P105_Q0.8671.00
170_L179_V0.8591.00
108_I118_F0.8561.00
27_L31_A0.8521.00
257_A260_K0.8491.00
264_Q268_I0.8471.00
270_S273_P0.8371.00
240_T245_Q0.8371.00
267_K273_P0.8371.00
24_L38_R0.8371.00
263_N271_S0.8361.00
135_E163_N0.8351.00
138_K220_K0.8301.00
32_K59_D0.8281.00
116_S122_D0.8241.00
265_K275_P0.8231.00
12_S15_N0.8181.00
267_K275_P0.8161.00
265_K269_M0.8151.00
90_D96_N0.8091.00
185_Q188_D0.8091.00
43_Y128_P0.8051.00
117_S121_F0.7991.00
227_K231_G0.7971.00
13_D53_Y0.7961.00
268_I275_P0.7951.00
242_N246_N0.7951.00
250_V253_H0.7931.00
141_V202_F0.7921.00
223_V230_E0.7911.00
76_E105_Q0.7891.00
115_L122_D0.7891.00
229_I232_Q0.7881.00
141_V144_D0.7871.00
115_L119_T0.7861.00
171_V222_N0.7861.00
226_V230_E0.7811.00
227_K230_E0.7801.00
74_I98_I0.7781.00
113_G118_F0.7761.00
109_N118_F0.7691.00
13_D29_E0.7681.00
19_G25_G0.7671.00
263_N269_M0.7661.00
242_N245_Q0.7661.00
72_L85_L0.7651.00
17_L25_G0.7641.00
172_A212_I0.7621.00
264_Q275_P0.7621.00
241_I244_G0.7591.00
11_S21_A0.7551.00
116_S120_K0.7541.00
240_T244_G0.7511.00
240_T247_H0.7471.00
143_V212_I0.7411.00
271_S276_I0.7401.00
248_I256_A0.7391.00
112_L120_K0.7361.00
228_E232_Q0.7311.00
41_G125_N0.7301.00
22_E25_G0.7281.00
108_I122_D0.7241.00
117_S123_L0.7221.00
164_V194_V0.7191.00
15_N22_E0.7171.00
265_K273_P0.7141.00
202_F218_L0.7131.00
14_K53_Y0.7121.00
112_L117_S0.7121.00
135_E196_T0.7111.00
162_T224_K0.7101.00
230_E234_T0.7101.00
71_I100_I0.7051.00
244_G247_H0.7041.00
33_T63_A0.7001.00
251_K254_G0.6991.00
139_G181_I0.6971.00
224_K232_Q0.6961.00
61_A91_S0.6951.00
230_E267_K0.6951.00
8_T50_T0.6941.00
133_T196_T0.6911.00
54_P80_W0.6911.00
271_S275_P0.6901.00
10_L64_L0.6901.00
166_V182_K0.6891.00
116_S123_L0.6891.00
119_T123_L0.6871.00
269_M275_P0.6801.00
226_V232_Q0.6781.00
264_Q273_P0.6781.00
262_D267_K0.6761.00
264_Q274_I0.6731.00
223_V226_V0.6731.00
124_Y131_S0.6731.00
164_V184_I0.6691.00
114_S119_T0.6651.00
133_T137_D0.6651.00
253_H257_A0.6641.00
224_K227_K0.6631.00
228_E267_K0.6631.00
245_Q248_I0.6621.00
20_I23_K0.6611.00
18_T22_E0.6571.00
264_Q269_M0.6561.00
136_E163_N0.6551.00
272_V276_I0.6541.00
241_I247_H0.6531.00
72_L86_A0.6481.00
228_E269_M0.6481.00
254_G258_N0.6471.00
21_A24_L0.6461.00
258_N261_V0.6441.00
223_V233_I0.6431.00
263_N272_V0.6421.00
261_V266_A0.6421.00
252_G255_I0.6411.00
14_K29_E0.6401.00
17_L20_I0.6390.99
127_I130_L0.6380.99
114_S120_K0.6370.99
151_G154_T0.6340.99
108_I113_G0.6340.99
227_K232_Q0.6320.99
264_Q267_K0.6320.99
173_L225_V0.6310.99
108_I117_S0.6300.99
184_I194_V0.6290.99
112_L119_T0.6290.99
149_V155_V0.6260.99
265_K270_S0.6240.99
266_A274_I0.6220.99
133_T162_T0.6220.99
60_L64_L0.6180.99
263_N273_P0.6160.99
110_N115_L0.6150.99
115_L120_K0.6140.99
114_S118_F0.6130.99
83_G87_L0.6130.99
160_S164_V0.6120.99
265_K271_S0.6110.99
270_S275_P0.6110.99
243_Q246_N0.6070.99
241_I246_N0.6050.99
232_Q265_K0.6050.99
246_N249_I0.6050.99
249_I255_I0.6040.99
247_H257_A0.6030.99
267_K276_I0.6030.99
108_I119_T0.6010.99
75_P102_N0.6010.99
263_N270_S0.6000.99
15_N76_E0.6000.99
32_K36_Y0.5970.99
248_I251_K0.5960.99
186_V198_V0.5950.99
266_A271_S0.5940.99
238_W247_H0.5940.99
250_V255_I0.5940.99
248_I252_G0.5900.99
233_I237_K0.5870.99
124_Y132_E0.5840.99
65_S161_F0.5840.99
254_G257_A0.5790.99
171_V219_V0.5760.99
87_L90_D0.5750.99
247_H252_G0.5740.99
267_K270_S0.5730.99
111_I122_D0.5710.99
60_L85_L0.5680.99
157_T201_G0.5680.99
266_A276_I0.5670.99
82_D98_I0.5660.99
243_Q260_K0.5660.99
142_Y145_R0.5650.99
36_Y187_L0.5640.99
225_V231_G0.5640.99
267_K272_V0.5630.99
270_S276_I0.5630.99
64_L92_L0.5590.99
263_N275_P0.5580.99
191_Q198_V0.5580.99
50_T60_L0.5580.99
263_N268_I0.5570.99
266_A272_V0.5560.99
254_G261_V0.5550.99
116_S121_F0.5510.99
223_V227_K0.5490.98
54_P84_E0.5470.98
12_S79_T0.5460.98
126_D131_S0.5440.98
21_A25_G0.5420.98
239_S244_G0.5400.98
148_T154_T0.5380.98
251_K255_I0.5360.98
224_K234_T0.5350.98
256_A259_I0.5340.98
211_E215_L0.5310.98
41_G128_P0.5300.98
8_T64_L0.5280.98
61_A85_L0.5270.98
71_I97_K0.5270.98
44_I198_V0.5230.98
224_K230_E0.5220.98
171_V175_Y0.5210.98
179_V212_I0.5190.98
83_G114_S0.5170.98
86_A90_D0.5170.98
71_I99_V0.5150.98
231_G266_A0.5130.98
247_H250_V0.5130.98
107_K119_T0.5120.98
114_S122_D0.5100.98
13_D30_T0.5100.98
29_E53_Y0.5090.98
188_D201_G0.5060.97
81_M85_L0.5040.97
182_K203_A0.5040.97
14_K28_H0.5010.97
149_V153_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wndA 1 0.9834 100 0.33 Contact Map
1d2eA 3 0.9967 100 0.337 Contact Map
3mcaA 1 0.9003 100 0.338 Contact Map
2c78A 1 0.9967 100 0.343 Contact Map
1jnyA 1 0.9635 100 0.347 Contact Map
3wy9A 1 0.9967 100 0.352 Contact Map
3avxA 1 0.9834 100 0.354 Contact Map
1f60A 1 1 100 0.357 Contact Map
4crnP 1 0.9934 100 0.362 Contact Map
1r5bA 1 0.9236 100 0.369 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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