GREMLIN Database
Q97ZV2 - DNA repair protein rad25
UniProt: Q97ZV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (366)
Sequences: 23579 (16403)
Seq/√Len: 857.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_I111_T3.8011.00
176_V198_G3.6951.00
81_L106_L3.5311.00
101_L128_I3.4381.00
341_S345_L3.2351.00
245_N427_K3.0921.00
363_E367_S3.0011.00
74_Q78_N2.9451.00
100_G199_L2.9311.00
135_E148_G2.7701.00
347_P370_Y2.7301.00
225_T228_N2.6571.00
325_E389_S2.6441.00
391_G410_I2.6351.00
125_Y129_R2.6151.00
360_E364_K2.6111.00
185_S189_Q2.6061.00
314_K317_D2.5151.00
80_W103_A2.5031.00
357_E360_E2.4821.00
109_L169_G2.3941.00
347_P364_K2.3941.00
364_K369_K2.3881.00
76_A99_I2.3871.00
366_R387_D2.3101.00
111_T170_L2.2921.00
100_G172_I2.2821.00
341_S348_A2.2501.00
123_Q384_D2.2421.00
125_Y138_R2.1671.00
359_I363_E2.1641.00
354_N357_E2.1591.00
238_E418_K2.1051.00
331_T337_V1.9541.00
128_I149_I1.9431.00
393_V407_L1.9421.00
397_Y400_S1.9301.00
184_Y187_I1.9291.00
338_Y348_A1.9161.00
69_L102_K1.9061.00
236_S418_K1.8751.00
80_W86_G1.8701.00
77_L102_K1.8651.00
186_I190_G1.8641.00
340_I394_L1.8521.00
269_N273_K1.8111.00
114_I152_I1.7951.00
347_P361_I1.7851.00
379_L383_I1.7461.00
341_S346_I1.7431.00
120_L382_G1.7431.00
326_K330_F1.7271.00
155_D158_Y1.7221.00
407_L421_L1.7151.00
334_T352_K1.7061.00
243_Y427_K1.7031.00
125_Y151_V1.6901.00
397_Y402_Q1.6791.00
187_I191_L1.6791.00
240_Q420_R1.6501.00
251_E255_R1.6481.00
397_Y401_R1.6401.00
390_I422_I1.6291.00
126_E363_E1.6271.00
178_H381_E1.5981.00
322_L390_I1.5881.00
316_K343_L1.5841.00
185_S188_A1.5791.00
234_L237_F1.5761.00
333_N336_M1.5641.00
246_L426_T1.5571.00
184_Y188_A1.5441.00
353_T361_I1.5421.00
226_V229_L1.5021.00
247_T250_E1.4861.00
334_T337_V1.4531.00
316_K320_K1.4521.00
110_A169_G1.4411.00
154_Y173_F1.4381.00
80_W197_L1.4341.00
121_L151_V1.4181.00
368_G387_D1.4111.00
170_L197_L1.3951.00
258_R261_L1.3911.00
319_L327_I1.3651.00
327_I392_I1.3611.00
281_L284_L1.3511.00
426_T429_T1.3461.00
101_L132_L1.3461.00
357_E361_I1.3431.00
186_I189_Q1.3371.00
392_I424_I1.3351.00
337_V341_S1.3321.00
220_L223_R1.3191.00
223_R226_V1.3161.00
254_Y257_Y1.3131.00
389_S417_K1.2991.00
128_I136_A1.2951.00
393_V406_R1.2931.00
224_I229_L1.2871.00
100_G197_L1.2821.00
92_T201_A1.2801.00
255_R259_G1.2761.00
350_T353_T1.2741.00
364_K368_G1.2741.00
156_S159_T1.2701.00
314_K318_L1.2691.00
390_I420_R1.2601.00
112_L168_F1.2431.00
269_N274_S1.2411.00
334_T338_Y1.2391.00
171_V193_A1.2391.00
173_F188_A1.2371.00
336_M339_E1.2341.00
311_K319_L1.2331.00
277_D281_L1.2331.00
122_Q359_I1.2321.00
150_T168_F1.2291.00
212_L215_S1.2261.00
214_P218_G1.2251.00
323_N326_K1.2071.00
193_A196_R1.2061.00
126_E130_E1.2041.00
67_I131_L1.1941.00
177_H381_E1.1901.00
219_P224_I1.1811.00
102_K105_A1.1801.00
105_A132_L1.1791.00
325_E390_I1.1781.00
365_F388_A1.1771.00
328_I410_I1.1691.00
169_G194_P1.1691.00
120_L123_Q1.1681.00
326_K387_D1.1671.00
270_L273_K1.1591.00
336_M394_L1.1561.00
224_I228_N1.1541.00
275_L279_N1.1521.00
184_Y189_Q1.1441.00
329_I372_V1.1441.00
318_L422_I1.1421.00
65_D98_V1.1421.00
242_I422_I1.1391.00
171_V191_L1.1311.00
122_Q126_E1.1211.00
127_N130_E1.1191.00
318_L322_L1.1181.00
315_L394_L1.1181.00
70_R413_K1.1171.00
68_K74_Q1.1051.00
277_D280_R1.0981.00
215_S218_G1.0931.00
339_E343_L1.0931.00
375_T379_L1.0921.00
237_F408_G1.0921.00
103_A170_L1.0891.00
173_F179_L1.0781.00
104_I172_I1.0771.00
104_I128_I1.0741.00
333_N337_V1.0731.00
337_V348_A1.0721.00
360_E363_E1.0681.00
270_L274_S1.0641.00
327_I330_F1.0631.00
349_V353_T1.0601.00
220_L225_T1.0571.00
152_I156_S1.0531.00
188_A191_L1.0491.00
242_I314_K1.0471.00
269_N272_L1.0461.00
86_G197_L1.0431.00
71_E75_E1.0411.00
362_L366_R1.0391.00
127_N384_D1.0391.00
276_N280_R1.0381.00
318_L392_I1.0341.00
211_K215_S1.0321.00
280_R284_L1.0291.00
225_T229_L1.0261.00
113_I124_W1.0261.00
201_A408_G1.0231.00
115_V121_L1.0221.00
104_I170_L1.0211.00
114_I157_A1.0201.00
364_K370_Y1.0161.00
212_L216_L1.0131.00
399_T402_Q1.0121.00
112_L171_V1.0111.00
315_L392_I1.0091.00
77_L103_A1.0071.00
220_L224_I1.0051.00
90_I94_G1.0041.00
67_I98_V1.0011.00
214_P217_V1.0011.00
221_V224_I0.9981.00
319_L322_L0.9981.00
327_I390_I0.9951.00
152_I157_A0.9871.00
126_E359_I0.9791.00
238_E420_R0.9761.00
312_L316_K0.9761.00
223_R228_N0.9731.00
167_K192_A0.9721.00
98_V127_N0.9691.00
219_P225_T0.9691.00
267_Q271_K0.9691.00
361_I364_K0.9681.00
185_S190_G0.9651.00
170_L195_Y0.9641.00
339_E342_R0.9641.00
71_E74_Q0.9601.00
212_L218_G0.9581.00
332_R336_M0.9531.00
217_V221_V0.9501.00
111_T169_G0.9501.00
315_L319_L0.9501.00
380_D402_Q0.9491.00
156_S160_Q0.9471.00
331_T340_I0.9461.00
90_I99_I0.9451.00
220_L226_V0.9411.00
398_G401_R0.9411.00
107_I170_L0.9361.00
222_Y226_V0.9311.00
167_K194_P0.9311.00
301_A305_A0.9291.00
279_N283_R0.9281.00
212_L217_V0.9231.00
77_L81_L0.9231.00
185_S191_L0.9151.00
324_G327_I0.9131.00
338_Y342_R0.9131.00
410_I419_A0.9091.00
187_I190_G0.9061.00
244_V310_A0.9051.00
75_E78_N0.9001.00
255_R258_R0.8991.00
363_E366_R0.8981.00
79_A86_G0.8891.00
137_G150_T0.8871.00
217_V225_T0.8851.00
222_Y228_N0.8841.00
315_L329_I0.8771.00
107_I169_G0.8771.00
349_V379_L0.8751.00
161_L190_G0.8751.00
210_H214_P0.8721.00
326_K368_G0.8711.00
69_L77_L0.8691.00
331_T334_T0.8661.00
240_Q243_Y0.8581.00
284_L287_K0.8571.00
304_I307_N0.8541.00
144_D147_K0.8501.00
366_R386_P0.8501.00
349_V378_V0.8491.00
117_T155_D0.8491.00
77_L106_L0.8471.00
136_A151_V0.8461.00
248_E252_K0.8381.00
332_R337_V0.8381.00
134_V148_G0.8381.00
77_L99_I0.8361.00
280_R283_R0.8361.00
176_V200_T0.8351.00
263_K267_Q0.8351.00
89_V208_G0.8341.00
172_I199_L0.8321.00
375_T378_V0.8311.00
223_R229_L0.8311.00
365_F373_I0.8281.00
61_P64_V0.8261.00
85_L196_R0.8231.00
116_P120_L0.8211.00
218_G222_Y0.8211.00
368_G371_N0.8201.00
115_V124_W0.8201.00
245_N251_E0.8171.00
76_A88_I0.8151.00
342_R345_L0.8131.00
278_F282_L0.8041.00
356_Q360_E0.8031.00
211_K216_L0.8031.00
214_P219_P0.8031.00
211_K214_P0.8011.00
276_N289_K0.8011.00
126_E366_R0.8001.00
377_S402_Q0.8001.00
286_V289_K0.7981.00
311_K316_K0.7971.00
78_N81_L0.7971.00
338_Y352_K0.7941.00
303_K306_V0.7921.00
325_E417_K0.7901.00
219_P223_R0.7891.00
217_V220_L0.7861.00
275_L282_L0.7841.00
311_K314_K0.7831.00
266_S269_N0.7831.00
254_Y261_L0.7821.00
256_H260_I0.7821.00
336_M340_I0.7801.00
316_K319_L0.7781.00
347_P371_N0.7771.00
277_D284_L0.7761.00
344_F374_V0.7741.00
253_L257_Y0.7721.00
222_Y229_L0.7681.00
246_L254_Y0.7671.00
213_Y216_L0.7661.00
224_I230_V0.7651.00
244_V426_T0.7651.00
165_G190_G0.7641.00
244_V314_K0.7631.00
120_L383_I0.7631.00
219_P222_Y0.7581.00
101_L127_N0.7561.00
308_S311_K0.7521.00
171_V196_R0.7521.00
221_V225_T0.7511.00
213_Y217_V0.7491.00
279_N288_D0.7471.00
219_P226_V0.7471.00
403_F423_E0.7461.00
324_G329_I0.7451.00
110_A148_G0.7431.00
84_K195_Y0.7421.00
275_L278_F0.7381.00
125_Y136_A0.7371.00
112_L152_I0.7351.00
279_N285_A0.7351.00
338_Y341_S0.7351.00
154_Y158_Y0.7341.00
224_I227_S0.7331.00
210_H216_L0.7291.00
267_Q270_L0.7291.00
324_G371_N0.7271.00
139_V160_Q0.7261.00
234_L241_R0.7251.00
330_F333_N0.7241.00
387_D415_E0.7231.00
126_E129_R0.7231.00
221_V226_V0.7201.00
328_I331_T0.7191.00
397_Y403_F0.7161.00
92_T408_G0.7161.00
117_T153_T0.7151.00
153_T156_S0.7151.00
384_D413_K0.7121.00
283_R287_K0.7111.00
287_K290_E0.7091.00
220_L228_N0.7091.00
221_V229_L0.7091.00
218_G221_V0.7071.00
143_Y146_L0.7061.00
140_G144_D0.7061.00
227_S230_V0.7061.00
327_I331_T0.7061.00
268_R273_K0.7041.00
158_Y184_Y0.7031.00
113_I128_I0.7031.00
283_R286_V0.7011.00
313_E316_K0.7011.00
362_L383_I0.6991.00
330_F406_R0.6991.00
289_K311_K0.6971.00
121_L138_R0.6961.00
139_V144_D0.6911.00
222_Y225_T0.6911.00
253_L256_H0.6901.00
299_H302_L0.6841.00
337_V350_T0.6821.00
276_N279_N0.6811.00
257_Y285_A0.6761.00
60_F63_I0.6741.00
310_A313_E0.6721.00
329_I374_V0.6701.00
139_V145_E0.6701.00
335_S339_E0.6701.00
59_P62_L0.6691.00
107_I195_Y0.6691.00
108_R169_G0.6691.00
301_A304_I0.6691.00
221_V228_N0.6661.00
256_H259_G0.6661.00
257_Y261_L0.6651.00
142_G145_E0.6631.00
408_G411_L0.6631.00
325_E328_I0.6621.00
216_L219_P0.6601.00
341_S374_V0.6591.00
98_V131_L0.6581.00
246_L250_E0.6551.00
299_H303_K0.6551.00
210_H213_Y0.6531.00
88_I197_L0.6521.00
282_L286_V0.6521.00
286_V290_E0.6511.00
109_L167_K0.6481.00
278_F283_R0.6481.00
275_L286_V0.6461.00
133_G136_A0.6461.00
279_N282_L0.6451.00
283_R288_D0.6451.00
317_D321_E0.6441.00
251_E428_G0.6441.00
65_D105_A0.6431.00
249_D252_K0.6431.00
313_E343_L0.6391.00
226_V230_V0.6391.00
110_A167_K0.6361.00
252_K256_H0.6351.00
76_A90_I0.6331.00
217_V226_V0.6291.00
157_A188_A0.6291.00
215_S219_P0.6281.00
263_K266_S0.6281.00
233_Y237_F0.6261.00
122_Q125_Y0.6251.00
287_K336_M0.6251.00
388_A410_I0.6251.00
254_Y264_F0.6241.00
258_R262_K0.6241.00
282_L288_D0.6231.00
240_Q244_V0.6201.00
90_I224_I0.6181.00
239_I244_V0.6161.00
398_G402_Q0.6161.00
380_D406_R0.6141.00
322_L325_E0.6121.00
216_L220_L0.6101.00
331_T336_M0.6091.00
353_T357_E0.6091.00
393_V396_G0.6081.00
337_V344_F0.6071.00
268_R271_K0.6061.00
102_K106_L0.6051.00
88_I99_I0.6051.00
388_A392_I0.6041.00
389_S415_E0.6031.00
172_I197_L0.6031.00
358_R362_L0.6021.00
279_N289_K0.6011.00
307_N311_K0.6001.00
376_S406_R0.5991.00
141_G145_E0.5991.00
177_H200_T0.5981.00
327_I372_V0.5961.00
259_G263_K0.5961.00
115_V151_V0.5911.00
80_W88_I0.5891.00
311_K315_L0.5871.00
353_T358_R0.5861.00
155_D178_H0.5851.00
123_Q383_I0.5851.00
88_I199_L0.5851.00
271_K274_S0.5851.00
119_D383_I0.5841.00
278_F288_D0.5831.00
265_L268_R0.5831.00
261_L264_F0.5821.00
127_N131_L0.5811.00
244_V247_T0.5811.00
393_V423_E0.5791.00
183_G186_I0.5781.00
277_D282_L0.5771.00
210_H215_S0.5761.00
268_R272_L0.5741.00
225_T230_V0.5741.00
246_L251_E0.5701.00
218_G223_R0.5701.00
123_Q127_N0.5681.00
288_D291_A0.5681.00
236_S239_I0.5671.00
64_V67_I0.5651.00
184_Y191_L0.5641.00
241_R423_E0.5631.00
267_Q272_L0.5621.00
81_L103_A0.5601.00
334_T341_S0.5601.00
214_P220_L0.5601.00
241_R425_I0.5601.00
279_N430_S0.5591.00
365_F370_Y0.5571.00
104_I113_I0.5571.00
311_K318_L0.5561.00
282_L285_A0.5511.00
254_Y258_R0.5501.00
355_K359_I0.5501.00
318_L424_I0.5471.00
250_E310_A0.5461.00
324_G328_I0.5461.00
232_K235_S0.5461.00
312_L340_I0.5451.00
115_V153_T0.5441.00
391_G421_L0.5441.00
318_L321_E0.5441.00
79_A222_Y0.5401.00
226_V408_G0.5391.00
348_A352_K0.5391.00
325_E329_I0.5381.00
235_S241_R0.5381.00
151_V154_Y0.5361.00
200_T203_P0.5351.00
282_L287_K0.5351.00
309_K319_L0.5341.00
104_I149_I0.5331.00
85_L195_Y0.5331.00
139_V146_L0.5301.00
265_L274_S0.5291.00
219_P228_N0.5281.00
276_N286_V0.5271.00
314_K321_E0.5261.00
67_I102_K0.5261.00
277_D289_K0.5261.00
216_L224_I0.5231.00
358_R378_V0.5231.00
159_T162_E0.5221.00
277_D288_D0.5221.00
184_Y190_G0.5221.00
101_L131_L0.5211.00
157_A161_L0.5201.00
218_G225_T0.5191.00
340_I344_F0.5171.00
128_I151_V0.5161.00
240_Q422_I0.5161.00
280_R286_V0.5151.00
239_I242_I0.5151.00
119_D378_V0.5131.00
266_S273_K0.5121.00
202_T405_Q0.5121.00
266_S270_L0.5101.00
239_I245_N0.5101.00
344_F372_V0.5081.00
245_N248_E0.5071.00
361_I370_Y0.5051.00
276_N283_R0.5051.00
284_L289_K0.5051.00
217_V224_I0.5051.00
366_R384_D0.5041.00
264_F269_N0.5031.00
160_Q163_K0.5031.00
278_F281_L0.5031.00
409_R412_R0.5031.00
310_A314_K0.5021.00
335_S338_Y0.5011.00
213_Y219_P0.5011.00
338_Y350_T0.5001.00
390_I393_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.9707 100 0.27 Contact Map
2fwrA 1 0.9775 100 0.284 Contact Map
1z63A 1 0.8468 100 0.297 Contact Map
1z3iX 4 0.9617 100 0.299 Contact Map
1wp9A 1 0.8423 100 0.384 Contact Map
3dmqA 1 0.964 100 0.391 Contact Map
4a2qA 1 0.786 100 0.396 Contact Map
2ocaA 1 0.8784 100 0.397 Contact Map
4a2wA 1 0.7928 100 0.397 Contact Map
4qu4A 1 0.8221 100 0.407 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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