GREMLIN Database
Q97ZV0 - Uncharacterized protein
UniProt: Q97ZV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 541 (419)
Sequences: 6041 (3587)
Seq/√Len: 175.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_V260_V4.1231.00
264_M305_V4.0311.00
350_S403_D3.9081.00
351_E368_R3.6311.00
415_I460_K3.5101.00
350_S406_Q3.3761.00
301_M335_D3.3741.00
471_P509_G3.2951.00
352_K403_D3.1751.00
469_M509_G3.1091.00
511_Y523_T3.1061.00
474_T497_I2.9671.00
326_K376_D2.9581.00
330_E380_I2.8301.00
513_Y523_T2.7621.00
298_T334_Y2.6891.00
446_K450_R2.6801.00
299_E302_N2.6751.00
412_Q457_I2.6751.00
469_M511_Y2.5701.00
352_K356_K2.5651.00
371_K413_S2.5591.00
409_D413_S2.4751.00
408_I454_V2.4261.00
258_K261_E2.3871.00
261_E265_R2.3701.00
330_E334_Y2.3271.00
340_A490_I2.2921.00
188_D191_R2.2871.00
264_M303_M2.2651.00
375_L413_S2.2611.00
260_V271_V2.1911.00
466_T515_F2.1331.00
372_D375_L2.1301.00
260_V300_T2.1301.00
371_K414_I2.1151.00
400_T403_D2.0801.00
122_V125_K2.0651.00
409_D412_Q2.0571.00
333_R380_I2.0261.00
115_D194_K1.9811.00
440_P443_V1.9731.00
363_F406_Q1.9581.00
301_M336_E1.9371.00
346_L410_L1.9351.00
292_A327_A1.9341.00
269_K306_D1.9181.00
292_A295_K1.9151.00
253_L299_E1.9141.00
461_Y464_Q1.9111.00
375_L379_A1.9051.00
503_Q506_E1.9021.00
405_D409_D1.8971.00
443_V446_K1.8821.00
95_P105_K1.8741.00
301_M337_D1.8621.00
404_V450_R1.8511.00
425_P438_N1.8481.00
401_N443_V1.8021.00
459_W463_L1.7981.00
363_F409_D1.7811.00
471_P507_T1.7691.00
348_S407_S1.7471.00
405_D450_R1.7331.00
195_S200_Q1.7331.00
331_I335_D1.6931.00
412_Q454_V1.6871.00
363_F371_K1.6721.00
298_T335_D1.6461.00
378_T382_N1.6401.00
160_I179_V1.6351.00
471_P490_I1.6221.00
425_P432_G1.5911.00
408_I450_R1.5841.00
353_I356_K1.5811.00
252_P255_V1.5761.00
298_T331_I1.5751.00
166_S180_I1.5741.00
369_E372_D1.5731.00
474_T508_Q1.5721.00
130_F160_I1.5641.00
472_I487_Q1.5621.00
417_H461_Y1.5491.00
306_D471_P1.5411.00
422_W448_P1.5381.00
295_K299_E1.5311.00
301_M331_I1.5301.00
443_V447_M1.5271.00
181_F192_V1.5251.00
326_K330_E1.5201.00
257_K299_E1.4991.00
403_D406_Q1.4731.00
415_I461_Y1.4611.00
406_Q409_D1.4181.00
441_F444_L1.4141.00
162_G181_F1.3941.00
401_N405_D1.3921.00
351_E363_F1.3861.00
90_V118_G1.3851.00
262_V266_A1.3701.00
495_Y512_A1.3661.00
449_T453_D1.3551.00
340_A385_Y1.3541.00
108_V162_G1.3481.00
465_I468_E1.3461.00
228_V256_V1.3451.00
258_K262_V1.3351.00
411_V451_Y1.3281.00
295_K327_A1.3271.00
372_D376_D1.3181.00
362_P369_E1.3121.00
335_D338_R1.3071.00
392_M411_V1.3071.00
257_K261_E1.3051.00
237_G245_P1.3031.00
91_V119_L1.3001.00
484_R498_E1.2961.00
465_I470_I1.2961.00
237_G247_T1.2951.00
342_P377_A1.2821.00
291_E295_K1.2791.00
368_R372_D1.2711.00
173_N177_A1.2631.00
445_E449_T1.2631.00
463_L466_T1.2611.00
298_T327_A1.2591.00
332_A338_R1.2571.00
356_K403_D1.2541.00
402_E406_Q1.2541.00
356_K398_E1.2511.00
377_A386_I1.2471.00
376_D380_I1.2461.00
93_I105_K1.2381.00
441_F445_E1.2291.00
422_W441_F1.2221.00
297_F338_R1.2111.00
294_T331_I1.2111.00
261_E299_E1.2101.00
514_T521_N1.2011.00
239_Q358_M1.1891.00
308_I337_D1.1891.00
262_V265_R1.1881.00
363_F410_L1.1871.00
376_D379_A1.1811.00
217_P220_I1.1801.00
373_V376_D1.1731.00
129_I157_F1.1711.00
179_V196_I1.1671.00
493_I497_I1.1641.00
374_I378_T1.1631.00
306_D337_D1.1621.00
329_S380_I1.1611.00
239_Q396_Y1.1601.00
239_Q430_P1.1491.00
301_M338_R1.1461.00
307_G310_F1.1451.00
251_I259_E1.1431.00
510_K522_N1.1411.00
291_E299_E1.1391.00
402_E405_D1.1351.00
261_E303_M1.1301.00
150_K153_S1.1201.00
138_A142_E1.1201.00
342_P386_I1.1141.00
401_N450_R1.1141.00
297_F335_D1.1121.00
260_V303_M1.0961.00
351_E362_P1.0941.00
457_I460_K1.0871.00
401_N446_K1.0851.00
466_T514_T1.0811.00
351_E406_Q1.0791.00
405_D408_I1.0771.00
398_E437_R1.0761.00
253_L257_K1.0751.00
332_A381_M1.0731.00
331_I338_R1.0721.00
251_I255_V1.0711.00
492_K495_Y1.0681.00
112_T193_V1.0681.00
194_K198_D1.0571.00
490_I493_I1.0551.00
492_K497_I1.0531.00
269_K507_T1.0511.00
420_K452_W1.0461.00
356_K435_Y1.0420.99
411_V419_L1.0400.99
302_N335_D1.0380.99
377_A381_M1.0340.99
453_D457_I1.0340.99
368_R371_K1.0330.99
149_S152_K1.0320.99
493_I496_S1.0320.99
502_K506_E1.0270.99
242_P245_P1.0230.99
491_D497_I1.0220.99
329_S377_A1.0090.99
488_Y494_F1.0090.99
358_M430_P1.0080.99
392_M419_L1.0070.99
185_A188_D1.0070.99
111_L190_P1.0060.99
430_P433_V1.0060.99
135_T141_F1.0050.99
455_L458_S1.0040.99
251_I256_V1.0030.99
271_V305_V1.0030.99
158_K196_I1.0010.99
179_V192_V0.9990.99
332_A342_P0.9990.99
374_I388_P0.9970.99
512_A520_L0.9900.99
362_P368_R0.9830.99
161_V177_A0.9830.99
92_V123_S0.9820.99
373_V378_T0.9820.99
94_P147_K0.9790.99
228_V271_V0.9780.99
278_V310_F0.9760.99
373_V382_N0.9760.99
142_E146_E0.9750.99
128_M158_K0.9670.99
477_I485_T0.9660.99
93_I130_F0.9620.99
235_P247_T0.9610.99
422_W445_E0.9590.99
195_S199_G0.9580.99
330_E333_R0.9540.99
273_F300_T0.9490.99
226_G263_N0.9490.99
341_A492_K0.9480.99
477_I501_F0.9450.99
394_I404_V0.9440.99
411_V416_D0.9440.99
298_T302_N0.9420.99
218_P221_N0.9420.99
404_V451_Y0.9410.99
491_D495_Y0.9410.99
453_D456_Y0.9390.99
90_V120_N0.9390.99
369_E373_V0.9350.99
390_Y419_L0.9270.99
167_W182_I0.9270.99
257_K300_T0.9260.99
341_A389_C0.9220.99
496_S519_N0.9090.99
117_F128_M0.9080.99
158_K197_I0.9050.99
90_V125_K0.9050.99
254_D299_E0.9050.99
462_D493_I0.9020.99
485_T499_W0.9010.99
109_V119_L0.8960.98
326_K380_I0.8930.98
269_K506_E0.8880.98
346_L392_M0.8840.98
306_D507_T0.8840.98
448_P452_W0.8830.98
152_K178_D0.8810.98
410_L414_I0.8800.98
191_R195_S0.8790.98
224_R475_G0.8790.98
293_I297_F0.8780.98
333_R381_M0.8760.98
405_D412_Q0.8750.98
398_E438_N0.8750.98
342_P388_P0.8740.98
371_K375_L0.8720.98
169_L172_E0.8720.98
112_T130_F0.8720.98
329_S381_M0.8660.98
374_I382_N0.8650.98
215_E255_V0.8640.98
416_D419_L0.8630.98
148_I161_V0.8630.98
408_I412_Q0.8610.98
231_T248_F0.8610.98
478_K481_F0.8590.98
327_A331_I0.8590.98
105_K109_V0.8580.98
459_W462_D0.8570.98
463_L515_F0.8550.98
454_V457_I0.8550.98
294_T327_A0.8540.98
350_S353_I0.8540.98
328_M331_I0.8540.98
218_P222_P0.8530.98
326_K373_V0.8520.98
108_V189_L0.8520.98
327_A330_E0.8520.98
129_I151_L0.8510.98
326_K329_S0.8510.98
444_L447_M0.8510.98
96_H147_K0.8490.98
95_P132_G0.8470.98
459_W515_F0.8460.98
248_F280_L0.8430.98
352_K402_E0.8400.98
160_I181_F0.8360.98
390_Y416_D0.8340.98
491_D494_F0.8330.98
294_T325_V0.8270.97
490_I495_Y0.8250.97
280_L323_Q0.8240.97
438_N444_L0.8230.97
113_V119_L0.8230.97
352_K355_S0.8200.97
476_G486_V0.8180.97
93_I109_V0.8150.97
499_W503_Q0.8140.97
158_K193_V0.8130.97
324_T328_M0.8120.97
456_Y518_I0.8110.97
516_A521_N0.8100.97
394_I451_Y0.8100.97
470_I489_M0.8100.97
133_G161_V0.8080.97
356_K437_R0.8040.97
254_D258_K0.8030.97
374_I414_I0.8020.97
411_V455_L0.8010.97
387_Y491_D0.8000.97
465_I491_D0.8000.97
196_I199_G0.7990.97
129_I156_N0.7970.97
352_K400_T0.7960.97
490_I494_F0.7960.97
460_K463_L0.7950.97
285_K288_V0.7930.97
91_V113_V0.7910.97
389_C418_K0.7910.97
253_L295_K0.7910.97
264_M304_G0.7900.97
491_D496_S0.7890.97
91_V109_V0.7890.97
310_F332_A0.7890.97
325_V328_M0.7880.97
370_W374_I0.7870.97
485_T502_K0.7870.97
170_T173_N0.7850.96
328_M332_A0.7840.96
152_K157_F0.7800.96
107_K110_G0.7790.96
237_G358_M0.7790.96
353_I403_D0.7760.96
411_V415_I0.7740.96
245_P430_P0.7740.96
152_K159_V0.7730.96
106_T110_G0.7720.96
255_V258_K0.7710.96
103_N229_Q0.7710.96
271_V300_T0.7690.96
236_R280_L0.7670.96
474_T510_K0.7620.96
452_W455_L0.7610.96
331_I337_D0.7590.96
240_F361_K0.7590.96
499_W502_K0.7570.96
300_T308_I0.7560.96
329_S376_D0.7560.96
373_V377_A0.7550.96
148_I152_K0.7540.96
194_K197_I0.7530.96
293_I328_M0.7510.95
227_E272_E0.7500.95
385_Y468_E0.7500.95
498_E523_T0.7500.95
378_T381_M0.7480.95
148_I151_L0.7480.95
420_K448_P0.7480.95
394_I448_P0.7450.95
301_M308_I0.7430.95
295_K298_T0.7400.95
356_K396_Y0.7400.95
150_K154_K0.7400.95
458_S462_D0.7390.95
492_K496_S0.7380.95
253_L296_L0.7380.95
120_N126_L0.7380.95
392_M451_Y0.7370.95
465_I469_M0.7350.95
236_R277_D0.7340.95
214_N218_P0.7320.95
115_D190_P0.7310.95
461_Y465_I0.7300.95
478_K483_Q0.7290.95
226_G268_V0.7270.95
349_G406_Q0.7270.95
474_T485_T0.7260.95
99_E274_I0.7240.95
239_Q356_K0.7200.94
136_W242_P0.7190.94
404_V408_I0.7190.94
485_T500_V0.7180.94
253_L281_Y0.7160.94
459_W517_S0.7160.94
263_N268_V0.7120.94
297_F328_M0.7100.94
297_F300_T0.7090.94
472_I510_K0.7080.94
349_G370_W0.7080.94
115_D191_R0.7070.94
211_P216_I0.7050.94
322_P360_A0.7030.94
349_G407_S0.7030.94
245_P428_V0.7020.94
264_M306_D0.7010.94
294_T328_M0.6980.93
352_K406_Q0.6970.93
131_G148_I0.6960.93
435_Y438_N0.6960.93
92_V120_N0.6960.93
419_L455_L0.6940.93
183_G186_E0.6920.93
288_V291_E0.6890.93
120_N125_K0.6880.93
135_T168_E0.6880.93
432_G438_N0.6880.93
280_L322_P0.6840.93
470_I512_A0.6830.93
324_T373_V0.6830.93
398_E436_I0.6820.93
370_W416_D0.6800.92
144_F161_V0.6790.92
91_V117_F0.6780.92
123_S129_I0.6770.92
415_I464_Q0.6760.92
213_V217_P0.6730.92
381_M386_I0.6720.92
331_I334_Y0.6720.92
211_P215_E0.6690.92
177_A180_I0.6690.92
342_P385_Y0.6680.92
213_V216_I0.6660.92
231_T275_T0.6660.92
289_N295_K0.6640.92
214_N220_I0.6640.92
204_K207_Y0.6620.91
167_W170_T0.6620.91
494_F497_I0.6580.91
122_V151_L0.6580.91
228_V300_T0.6550.91
143_E146_E0.6550.91
225_L272_E0.6520.91
158_K179_V0.6490.91
477_I482_A0.6480.91
352_K398_E0.6460.90
109_V113_V0.6440.90
210_N214_N0.6440.90
100_K276_D0.6430.90
466_T469_M0.6430.90
405_D446_K0.6420.90
394_I422_W0.6420.90
394_I444_L0.6410.90
463_L514_T0.6370.90
224_R268_V0.6350.90
363_F368_R0.6340.90
131_G151_L0.6330.90
219_I222_P0.6320.89
450_R454_V0.6310.89
417_H493_I0.6290.89
340_A381_M0.6280.89
378_T415_I0.6270.89
191_R194_K0.6270.89
458_S517_S0.6260.89
264_M308_I0.6250.89
228_V263_N0.6240.89
120_N123_S0.6240.89
236_R322_P0.6240.89
300_T305_V0.6220.89
305_V507_T0.6210.89
385_Y388_P0.6200.89
235_P283_S0.6190.88
196_I200_Q0.6180.88
473_L487_Q0.6160.88
478_K496_S0.6160.88
285_K289_N0.6160.88
92_V129_I0.6150.88
385_Y464_Q0.6130.88
141_F169_L0.6120.88
490_I496_S0.6110.88
497_I510_K0.6090.88
473_L507_T0.6080.88
257_K303_M0.6080.88
351_E372_D0.6060.87
189_L193_V0.6020.87
212_K215_E0.6020.87
181_F185_A0.6010.87
210_N215_E0.6000.87
139_K142_E0.5990.87
282_G285_K0.5980.87
305_V308_I0.5970.87
117_F197_I0.5950.86
477_I483_Q0.5940.86
160_I192_V0.5940.86
91_V120_N0.5930.86
332_A335_D0.5920.86
253_L291_E0.5920.86
418_K458_S0.5910.86
128_M160_I0.5880.86
190_P193_V0.5880.86
477_I481_F0.5870.86
288_V292_A0.5870.86
225_L267_G0.5860.86
184_E240_F0.5850.86
306_D336_E0.5840.85
303_M306_D0.5840.85
433_V436_I0.5830.85
373_V381_M0.5820.85
401_N447_M0.5800.85
465_I493_I0.5780.85
480_K483_Q0.5770.85
256_V296_L0.5740.84
254_D261_E0.5740.84
396_Y431_M0.5720.84
407_S451_Y0.5720.84
449_T456_Y0.5710.84
139_K146_E0.5710.84
174_K177_A0.5700.84
303_M337_D0.5700.84
299_E303_M0.5690.84
481_F484_R0.5690.84
396_Y435_Y0.5690.84
478_K482_A0.5680.84
141_F172_E0.5680.84
202_V206_V0.5670.84
480_K486_V0.5670.84
240_F358_M0.5650.84
209_K212_K0.5640.83
351_E361_K0.5640.83
95_P102_I0.5640.83
216_I220_I0.5640.83
258_K265_R0.5620.83
202_V207_Y0.5620.83
217_P221_N0.5610.83
445_E448_P0.5600.83
100_K103_N0.5600.83
304_G307_G0.5580.83
422_W444_L0.5580.83
139_K143_E0.5560.83
500_V523_T0.5560.83
485_T503_Q0.5550.82
375_L378_T0.5550.82
442_P447_M0.5540.82
148_I176_W0.5540.82
377_A380_I0.5520.82
375_L382_N0.5510.82
264_M337_D0.5510.82
201_E204_K0.5510.82
96_H131_G0.5500.82
215_E258_K0.5490.82
381_M385_Y0.5490.82
339_A490_I0.5480.82
113_V118_G0.5480.82
280_L344_V0.5460.81
279_L318_V0.5440.81
210_N213_V0.5430.81
298_T301_M0.5420.81
349_G414_I0.5420.81
236_R360_A0.5410.81
209_K214_N0.5390.81
290_H295_K0.5390.81
201_E206_V0.5390.81
129_I159_V0.5370.80
496_S521_N0.5370.80
253_L292_A0.5360.80
305_V337_D0.5350.80
452_W458_S0.5350.80
229_Q232_R0.5330.80
265_R304_G0.5330.80
277_D293_I0.5320.80
211_P214_N0.5320.80
203_P206_V0.5320.80
349_G410_L0.5310.80
149_S174_K0.5300.80
391_T426_L0.5300.80
324_T329_S0.5290.79
387_Y417_H0.5290.79
479_N482_A0.5290.79
209_K213_V0.5280.79
304_G309_W0.5260.79
374_I381_M0.5260.79
374_I377_A0.5250.79
461_Y493_I0.5250.79
437_R444_L0.5240.79
284_Q288_V0.5230.79
501_F506_E0.5230.79
411_V454_V0.5220.79
478_K484_R0.5220.79
353_I396_Y0.5210.78
329_S333_R0.5210.78
477_I480_K0.5200.78
483_Q498_E0.5180.78
442_P446_K0.5180.78
404_V411_V0.5170.78
190_P194_K0.5170.78
236_R323_Q0.5160.78
317_A346_L0.5160.78
215_E220_I0.5160.78
420_K455_L0.5160.78
136_W423_I0.5150.78
497_I508_Q0.5150.78
297_F301_M0.5150.78
106_T109_V0.5140.77
458_S515_F0.5140.77
210_N219_I0.5130.77
472_I522_N0.5130.77
485_T504_L0.5120.77
193_V197_I0.5110.77
242_P361_K0.5100.77
96_H144_F0.5100.77
130_F179_V0.5090.77
412_Q415_I0.5080.77
297_F308_I0.5080.77
168_E427_P0.5080.77
223_A266_A0.5070.77
344_V373_V0.5070.77
343_V426_L0.5050.76
344_V358_M0.5040.76
503_Q508_Q0.5040.76
261_E304_G0.5030.76
498_E501_F0.5030.76
213_V219_I0.5020.76
264_M271_V0.5020.76
95_P98_L0.5010.76
489_M495_Y0.5000.76
317_A321_S0.5000.76
254_D257_K0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.7523 100 0.516 Contact Map
2qgqA 1 0.488 100 0.671 Contact Map
1oltA 1 0.6137 99.9 0.82 Contact Map
4u0oB 1 0.4898 99.9 0.842 Contact Map
4wcxA 1 0.658 99.8 0.856 Contact Map
3iixA 1 0.6026 99.8 0.857 Contact Map
3t7vA 1 0.5656 99.8 0.857 Contact Map
4r33A 2 0.6063 99.8 0.86 Contact Map
4rtbA 2 0.597 99.8 0.861 Contact Map
1r30A 2 0.5342 99.8 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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