Q97ZU9 - SULSO - GREMLIN Contacts

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Q97ZU9 - Uncharacterized protein

UniProt:	Q97ZU9	Sequences: MRKLKREAYKLNNIKMLQQDVKYSEEVIEAEFSVEGYSLIDYKRSYTLSRALVNGKWIVYDGNRLESSQKIKEFEICEDFYHESVKAWPNKEKYSRLFTNIKLNEDDQLKVISKKISKSILIHDVKECREEKVVNYVEYNDLNFSYAGNPKDIPSIVEYLRASQSQLTSPSRQVLTESGRLTFILDSEIVASIFHYVLRNFLNGNSPKLKLNEKISSEITIYDNPLNSFSSSFSVFDDEGVKTKKKEIIGDGIITNYLGTLTSKYGEAGNARGILPKPDYFSLEVKQGDWSLNELIDESRGAYIAMGVKKSELIRNSIRITPRSVVKIGQGQIFFREIAIPLQELVTIDAVTRENRGVFIDEEHGGVTPYVRMKVRAILY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (357)
Sequences:	4395 (2881)
Seq/√Len:	152.5

ECOLI - TLDD PMBA
SULSO - Q97ZU9 TLDD Q97YZ8 Q7LXP5 Q97YZ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
250_G	255_T	4.291	1.00
247_E	250_G	4.195	1.00
301_G	329_G	4.194	1.00
224_N	245_K	3.874	1.00
214_K	218_E	3.796	1.00
300_R	330_Q	3.608	1.00
303_Y	335_F	3.489	1.00
180_R	375_V	3.476	1.00
349_D	372_R	3.355	1.00
329_G	334_F	3.348	1.00
291_S	294_E	3.327	1.00
349_D	374_K	3.268	1.00
210_K	213_E	3.160	1.00
299_S	328_I	3.098	1.00
301_G	327_K	2.765	1.00
327_K	334_F	2.620	1.00
129_R	132_K	2.537	1.00
10_K	100_N	2.457	1.00
290_W	294_E	2.441	1.00
113_S	235_V	2.352	1.00
291_S	353_R	2.307	1.00
214_K	346_V	2.269	1.00
220_T	247_E	2.245	1.00
295_L	370_Y	2.233	1.00
222_Y	286_K	2.216	1.00
354_E	370_Y	2.193	1.00
162_A	165_S	2.173	1.00
85_V	90_N	2.172	1.00
222_Y	245_K	2.114	1.00
218_E	251_D	2.032	1.00
64_R	67_S	2.022	1.00
58_I	62_G	1.991	1.00
149_N	152_D	1.979	1.00
297_D	332_Q	1.974	1.00
161_R	165_S	1.958	1.00
200_N	203_N	1.943	1.00
102_K	110_K	1.923	1.00
214_K	253_I	1.882	1.00
220_T	251_D	1.879	1.00
53_V	56_K	1.852	1.00
75_E	79_D	1.837	1.00
296_I	328_I	1.826	1.00
184_I	299_S	1.812	1.00
234_S	243_T	1.788	1.00
344_E	373_M	1.780	1.00
216_S	345_L	1.736	1.00
295_L	350_A	1.734	1.00
347_T	374_K	1.733	1.00
51_A	56_K	1.718	1.00
165_S	169_S	1.715	1.00
87_A	90_N	1.696	1.00
246_K	270_N	1.688	1.00
259_G	263_S	1.688	1.00
328_I	334_F	1.675	1.00
290_W	350_A	1.650	1.00
292_L	296_I	1.615	1.00
246_K	256_N	1.614	1.00
34_V	49_S	1.612	1.00
347_T	375_V	1.609	1.00
244_K	266_G	1.598	1.00
343_Q	347_T	1.586	1.00
298_E	350_A	1.580	1.00
299_S	372_R	1.577	1.00
64_R	68_S	1.567	1.00
104_N	110_K	1.566	1.00
111_V	236_F	1.556	1.00
139_Y	143_N	1.535	1.00
18_Q	23_Y	1.520	1.00
100_N	112_I	1.513	1.00
304_I	328_I	1.512	1.00
160_L	164_Q	1.509	1.00
302_A	328_I	1.499	1.00
326_V	333_I	1.482	1.00
202_L	248_I	1.479	1.00
290_W	298_E	1.478	1.00
292_L	370_Y	1.475	1.00
100_N	114_K	1.463	1.00
287_Q	355_N	1.452	1.00
55_G	59_V	1.451	1.00
298_E	372_R	1.446	1.00
128_C	167_L	1.445	1.00
245_K	284_E	1.440	1.00
186_D	304_I	1.430	1.00
222_Y	247_E	1.422	1.00
154_P	158_E	1.400	1.00
190_V	371_V	1.389	1.00
284_E	367_V	1.379	1.00
212_N	255_T	1.369	1.00
234_S	281_F	1.366	1.00
59_V	62_G	1.360	1.00
216_S	219_I	1.360	1.00
248_I	258_L	1.353	1.00
84_S	90_N	1.335	1.00
184_I	295_L	1.334	1.00
293_N	332_Q	1.334	1.00
352_T	370_Y	1.328	1.00
86_K	90_N	1.327	1.00
85_V	88_W	1.320	1.00
84_S	130_E	1.309	1.00
38_S	64_R	1.307	1.00
77_C	80_F	1.304	1.00
241_V	267_E	1.303	1.00
130_E	172_R	1.290	1.00
143_N	162_A	1.287	1.00
182_T	374_K	1.282	1.00
351_V	371_V	1.276	1.00
226_L	243_T	1.266	1.00
198_L	283_L	1.265	1.00
10_K	32_F	1.264	1.00
182_T	372_R	1.246	1.00
241_V	261_L	1.244	1.00
292_L	295_L	1.236	1.00
40_I	69_Q	1.226	1.00
158_E	162_A	1.214	1.00
56_K	60_Y	1.213	1.00
303_Y	338_I	1.210	1.00
251_D	255_T	1.208	1.00
220_T	286_K	1.207	1.00
176_T	181_L	1.205	1.00
174_V	327_K	1.200	1.00
304_I	333_I	1.199	1.00
143_N	146_Y	1.197	1.00
184_I	372_R	1.190	1.00
128_C	168_T	1.190	1.00
63_N	67_S	1.172	1.00
149_N	229_F	1.172	1.00
217_S	351_V	1.167	1.00
98_F	114_K	1.165	1.00
61_D	65_L	1.163	1.00
199_R	203_N	1.163	1.00
322_P	325_V	1.154	1.00
62_G	66_E	1.154	1.00
220_T	250_G	1.152	1.00
343_Q	346_V	1.147	1.00
16_M	23_Y	1.146	1.00
126_K	164_Q	1.136	1.00
77_C	81_Y	1.135	1.00
47_T	60_Y	1.135	1.00
293_N	297_D	1.131	1.00
245_K	286_K	1.130	1.00
164_Q	168_T	1.128	1.00
84_S	87_A	1.124	1.00
182_T	375_V	1.123	1.00
241_V	269_G	1.119	0.99
105_E	109_L	1.116	0.99
299_S	302_A	1.113	0.99
296_I	304_I	1.108	0.99
219_I	351_V	1.101	0.99
264_K	267_E	1.099	0.99
40_I	68_S	1.098	0.99
82_H	86_K	1.097	0.99
219_I	285_V	1.096	0.99
247_E	255_T	1.095	0.99
45_S	64_R	1.095	0.99
259_G	267_E	1.093	0.99
184_I	292_L	1.089	0.99
344_E	376_R	1.088	0.99
65_L	68_S	1.084	0.99
199_R	204_G	1.082	0.99
335_F	338_I	1.074	0.99
85_V	91_K	1.070	0.99
233_F	282_S	1.068	0.99
219_I	348_I	1.060	0.99
49_S	60_Y	1.060	0.99
357_G	367_V	1.059	0.99
305_A	340_I	1.058	0.99
141_D	146_Y	1.054	0.99
194_F	285_V	1.054	0.99
85_V	128_C	1.052	0.99
204_G	259_G	1.049	0.99
294_E	297_D	1.047	0.99
272_R	279_D	1.042	0.99
40_I	65_L	1.040	0.99
247_E	251_D	1.037	0.99
152_D	229_F	1.036	0.99
163_S	167_L	1.031	0.99
14_I	96_R	1.030	0.99
128_C	132_K	1.027	0.99
181_L	327_K	1.024	0.99
225_P	234_S	1.024	0.99
284_E	355_N	1.020	0.99
156_I	160_L	1.014	0.99
295_L	352_T	1.012	0.99
76_I	80_F	1.003	0.99
221_I	249_I	1.002	0.99
94_Y	120_I	0.998	0.99
292_L	353_R	0.990	0.99
157_V	161_R	0.987	0.99
184_I	328_I	0.981	0.99
190_V	368_T	0.980	0.99
128_C	164_Q	0.979	0.99
55_G	58_I	0.977	0.99
177_E	301_G	0.973	0.99
126_K	167_L	0.971	0.99
143_N	147_A	0.963	0.98
74_F	77_C	0.959	0.98
128_C	171_S	0.956	0.98
102_K	112_I	0.954	0.98
56_K	59_V	0.952	0.98
73_E	157_V	0.949	0.98
260_T	278_P	0.948	0.98
185_L	305_A	0.940	0.98
144_F	147_A	0.933	0.98
67_S	71_I	0.932	0.98
368_T	371_V	0.930	0.98
225_P	243_T	0.925	0.98
246_K	268_A	0.922	0.98
296_I	299_S	0.922	0.98
49_S	56_K	0.919	0.98
39_L	44_R	0.917	0.98
225_P	281_F	0.917	0.98
84_S	88_W	0.914	0.98
227_N	230_S	0.913	0.98
179_G	301_G	0.913	0.98
72_K	75_E	0.911	0.98
43_K	73_E	0.903	0.98
313_L	320_I	0.900	0.98
292_L	304_I	0.894	0.98
10_K	30_A	0.891	0.97
148_G	151_K	0.891	0.97
221_I	283_L	0.888	0.97
314_I	317_S	0.884	0.97
17_L	25_E	0.877	0.97
82_H	91_K	0.877	0.97
271_A	278_P	0.875	0.97
74_F	78_E	0.873	0.97
8_A	34_V	0.871	0.97
256_N	268_A	0.869	0.97
194_F	221_I	0.869	0.97
299_S	349_D	0.867	0.97
132_K	137_V	0.863	0.97
12_N	30_A	0.862	0.97
239_E	261_L	0.861	0.97
142_L	145_S	0.860	0.97
33_S	46_Y	0.858	0.97
82_H	85_V	0.857	0.97
73_E	76_I	0.856	0.97
201_F	204_G	0.853	0.97
225_P	246_K	0.851	0.97
74_F	79_D	0.851	0.97
74_F	81_Y	0.843	0.96
318_I	344_E	0.841	0.96
103_L	111_V	0.840	0.96
211_L	257_Y	0.839	0.96
260_T	263_S	0.837	0.96
19_Q	24_S	0.834	0.96
263_S	278_P	0.834	0.96
216_S	249_I	0.833	0.96
9_Y	99_T	0.830	0.96
350_A	372_R	0.830	0.96
32_F	52_L	0.828	0.96
139_Y	144_F	0.825	0.96
128_C	137_V	0.823	0.96
270_N	281_F	0.820	0.96
202_L	205_N	0.820	0.96
290_W	353_R	0.819	0.96
312_E	320_I	0.819	0.96
145_S	154_P	0.818	0.96
302_A	333_I	0.817	0.96
140_N	144_F	0.816	0.96
195_H	200_N	0.815	0.96
325_V	335_F	0.812	0.96
290_W	295_L	0.806	0.95
292_L	354_E	0.806	0.95
34_V	57_W	0.805	0.95
130_E	137_V	0.799	0.95
184_I	304_I	0.798	0.95
42_Y	73_E	0.798	0.95
328_I	333_I	0.797	0.95
86_K	89_P	0.796	0.95
83_E	88_W	0.795	0.95
86_K	91_K	0.794	0.95
138_E	141_D	0.791	0.95
63_N	68_S	0.790	0.95
175_L	337_E	0.790	0.95
308_V	312_E	0.783	0.95
176_T	303_Y	0.783	0.95
78_E	81_Y	0.781	0.95
209_L	213_E	0.781	0.95
225_P	233_F	0.780	0.95
227_N	284_E	0.777	0.94
65_L	69_Q	0.776	0.94
259_G	264_K	0.775	0.94
83_E	86_K	0.775	0.94
196_Y	200_N	0.775	0.94
174_V	329_G	0.774	0.94
295_L	299_S	0.772	0.94
158_E	161_R	0.772	0.94
181_L	303_Y	0.772	0.94
161_R	164_Q	0.772	0.94
180_R	377_A	0.769	0.94
293_N	296_I	0.761	0.94
147_A	150_P	0.761	0.94
215_I	346_V	0.761	0.94
173_Q	336_R	0.760	0.94
141_D	145_S	0.757	0.94
190_V	285_V	0.755	0.94
128_C	131_E	0.753	0.94
36_G	60_Y	0.753	0.94
123_H	126_K	0.751	0.93
189_I	192_S	0.751	0.93
82_H	87_A	0.751	0.93
223_D	246_K	0.747	0.93
15_K	27_V	0.745	0.93
166_Q	186_D	0.742	0.93
243_T	281_F	0.741	0.93
182_T	301_G	0.737	0.93
296_I	301_G	0.737	0.93
198_L	345_L	0.736	0.93
224_N	284_E	0.734	0.93
99_T	115_K	0.730	0.92
284_E	357_G	0.730	0.92
145_S	153_I	0.728	0.92
37_Y	239_E	0.728	0.92
280_Y	283_L	0.726	0.92
107_D	261_L	0.725	0.92
139_Y	142_L	0.722	0.92
64_R	71_I	0.722	0.92
73_E	77_C	0.722	0.92
174_V	334_F	0.721	0.92
101_I	113_S	0.720	0.92
216_S	348_I	0.716	0.92
84_S	89_P	0.715	0.92
168_T	171_S	0.712	0.91
251_D	266_G	0.712	0.91
88_W	91_K	0.710	0.91
63_N	66_E	0.709	0.91
200_N	205_N	0.709	0.91
47_T	64_R	0.708	0.91
196_Y	320_I	0.708	0.91
45_S	67_S	0.707	0.91
348_I	371_V	0.707	0.91
82_H	168_T	0.707	0.91
355_N	367_V	0.706	0.91
244_K	256_N	0.703	0.91
201_F	342_L	0.703	0.91
72_K	80_F	0.702	0.91
306_M	326_V	0.699	0.91
214_K	251_D	0.699	0.91
303_Y	327_K	0.698	0.91
194_F	219_I	0.698	0.91
145_S	159_Y	0.697	0.91
206_S	342_L	0.696	0.91
137_V	140_N	0.696	0.91
76_I	79_D	0.696	0.91
288_G	369_P	0.696	0.91
311_S	314_I	0.695	0.91
197_V	216_S	0.694	0.90
13_N	95_S	0.691	0.90
199_R	202_L	0.691	0.90
69_Q	72_K	0.691	0.90
74_F	80_F	0.689	0.90
181_L	335_F	0.688	0.90
83_E	87_A	0.687	0.90
311_S	320_I	0.685	0.90
196_Y	199_R	0.684	0.90
96_R	118_K	0.682	0.90
169_S	326_V	0.681	0.90
182_T	299_S	0.680	0.90
310_K	319_R	0.680	0.90
82_H	88_W	0.679	0.89
230_S	233_F	0.678	0.89
141_D	144_F	0.675	0.89
142_L	147_A	0.671	0.89
66_E	69_Q	0.668	0.89
12_N	98_F	0.666	0.89
68_S	71_I	0.666	0.89
86_K	129_R	0.665	0.88
126_K	132_K	0.664	0.88
294_E	298_E	0.663	0.88
296_I	333_I	0.660	0.88
308_V	311_S	0.659	0.88
186_D	306_M	0.658	0.88
297_D	300_R	0.657	0.88
260_T	271_A	0.656	0.88
45_S	68_S	0.650	0.87
321_T	337_E	0.647	0.87
147_A	153_I	0.643	0.87
34_V	56_K	0.642	0.87
189_I	308_V	0.641	0.87
41_D	73_E	0.639	0.86
195_H	279_D	0.637	0.86
185_L	308_V	0.636	0.86
322_P	340_I	0.634	0.86
33_S	274_I	0.634	0.86
227_N	233_F	0.630	0.86
11_L	97_L	0.629	0.86
74_F	120_I	0.628	0.85
84_S	91_K	0.628	0.85
261_L	265_Y	0.627	0.85
139_Y	336_R	0.626	0.85
226_L	245_K	0.625	0.85
213_E	253_I	0.625	0.85
260_T	277_K	0.622	0.85
85_V	89_P	0.619	0.85
203_N	280_Y	0.614	0.84
33_S	48_L	0.613	0.84
87_A	91_K	0.613	0.84
304_I	370_Y	0.611	0.84
192_S	196_Y	0.610	0.84
217_S	251_D	0.608	0.84
260_T	311_S	0.608	0.84
223_D	248_I	0.606	0.83
328_I	372_R	0.605	0.83
184_I	296_I	0.605	0.83
248_I	283_L	0.604	0.83
195_H	280_Y	0.602	0.83
287_Q	353_R	0.601	0.83
160_L	163_S	0.596	0.82
77_C	161_R	0.595	0.82
176_T	179_G	0.594	0.82
168_T	172_R	0.594	0.82
308_V	320_I	0.594	0.82
233_F	281_F	0.590	0.82
193_I	308_V	0.590	0.82
211_L	256_N	0.590	0.82
207_P	215_I	0.589	0.82
189_I	305_A	0.589	0.82
137_V	142_L	0.588	0.82
199_R	205_N	0.588	0.82
194_F	371_V	0.588	0.82
202_L	254_I	0.587	0.81
319_R	341_P	0.586	0.81
162_A	166_Q	0.586	0.81
62_G	161_R	0.586	0.81
142_L	148_G	0.583	0.81
127_E	139_Y	0.583	0.81
157_V	160_L	0.581	0.81
211_L	255_T	0.580	0.81
309_K	339_A	0.579	0.81
59_V	63_N	0.579	0.81
207_P	210_K	0.577	0.80
182_T	300_R	0.577	0.80
75_E	78_E	0.576	0.80
38_S	45_S	0.575	0.80
321_T	339_A	0.575	0.80
322_P	338_I	0.575	0.80
164_Q	167_L	0.574	0.80
199_R	279_D	0.574	0.80
295_L	333_I	0.572	0.80
139_Y	159_Y	0.572	0.80
307_G	324_S	0.571	0.80
288_G	353_R	0.571	0.80
312_E	319_R	0.570	0.80
310_K	339_A	0.570	0.80
315_R	319_R	0.570	0.80
11_L	99_T	0.566	0.79
183_F	376_R	0.566	0.79
13_N	97_L	0.565	0.79
301_G	330_Q	0.565	0.79
289_D	353_R	0.564	0.79
259_G	278_P	0.562	0.79
204_G	263_S	0.561	0.78
302_A	326_V	0.559	0.78
187_S	193_I	0.558	0.78
298_E	330_Q	0.557	0.78
185_L	190_V	0.557	0.78
330_Q	334_F	0.557	0.78
196_Y	203_N	0.556	0.78
203_N	279_D	0.554	0.78
206_S	211_L	0.553	0.78
154_P	162_A	0.553	0.78
29_E	213_E	0.552	0.77
140_N	143_N	0.551	0.77
267_E	271_A	0.551	0.77
46_Y	276_P	0.551	0.77
186_D	190_V	0.551	0.77
316_N	319_R	0.550	0.77
297_D	301_G	0.549	0.77
189_I	321_T	0.549	0.77
310_K	316_N	0.549	0.77
142_L	146_Y	0.549	0.77
138_E	142_L	0.548	0.77
283_L	368_T	0.547	0.77
149_N	153_I	0.545	0.76
238_D	272_R	0.541	0.76
305_A	308_V	0.541	0.76
246_K	258_L	0.541	0.76
52_L	56_K	0.539	0.76
182_T	349_D	0.538	0.76
200_N	279_D	0.537	0.75
143_N	154_P	0.537	0.75
347_T	376_R	0.536	0.75
13_N	31_E	0.535	0.75
310_K	318_I	0.535	0.75
248_I	256_N	0.535	0.75
138_E	143_N	0.535	0.75
160_L	167_L	0.533	0.75
298_E	349_D	0.531	0.75
95_S	119_S	0.531	0.75
103_L	109_L	0.531	0.75
232_S	365_G	0.528	0.74
196_Y	318_I	0.527	0.74
12_N	28_I	0.526	0.74
143_N	149_N	0.526	0.74
230_S	236_F	0.526	0.74
54_N	57_W	0.526	0.74
72_K	76_I	0.526	0.74
76_I	81_Y	0.526	0.74
222_Y	284_E	0.526	0.74
309_K	324_S	0.525	0.74
189_I	221_I	0.525	0.74
122_I	163_S	0.524	0.74
179_G	303_Y	0.524	0.74
267_E	272_R	0.524	0.74
319_R	339_A	0.521	0.73
306_M	333_I	0.521	0.73
109_L	261_L	0.520	0.73
299_S	304_I	0.520	0.73
310_K	322_P	0.519	0.73
302_A	327_K	0.519	0.73
67_S	70_K	0.518	0.73
172_R	332_Q	0.518	0.73
206_S	209_L	0.517	0.73
46_Y	49_S	0.517	0.73
345_L	348_I	0.516	0.73
250_G	253_I	0.516	0.73
221_I	285_V	0.515	0.72
197_V	320_I	0.514	0.72
126_K	129_R	0.513	0.72
83_E	90_N	0.512	0.72
156_I	164_Q	0.511	0.72
105_E	261_L	0.511	0.72
144_F	148_G	0.511	0.72
71_I	79_D	0.509	0.72
216_S	254_I	0.507	0.71
224_N	227_N	0.507	0.71
59_V	66_E	0.506	0.71
292_L	299_S	0.505	0.71
174_V	332_Q	0.503	0.71
238_D	271_A	0.503	0.71
38_S	61_D	0.501	0.70
67_S	79_D	0.501	0.70
310_K	313_L	0.500	0.70
8_A	32_F	0.500	0.70
81_Y	164_Q	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tv9A	2	0.9368	100	0.23	Contact Map
3qtdA	2	0.9474	100	0.238	Contact Map
1vl4A	2	0.9342	100	0.242	Contact Map
1vpbA	2	0.9289	100	0.254	Contact Map
3e8vA	1	0.1632	5.4	0.974	Contact Map
3pegA	2	0.1842	5.4	0.974	Contact Map
2m5oA	1	0.2053	4.5	0.975	Contact Map
2gkpA	1	0.1737	4.1	0.976	Contact Map
1droA	1	0.1816	4	0.976	Contact Map
4bpeB	1	0.2421	4	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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