GREMLIN Database
Q97ZU9 - Uncharacterized protein
UniProt: Q97ZU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (357)
Sequences: 4395 (2881)
Seq/√Len: 152.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_G255_T4.2911.00
247_E250_G4.1951.00
301_G329_G4.1941.00
224_N245_K3.8741.00
214_K218_E3.7961.00
300_R330_Q3.6081.00
303_Y335_F3.4891.00
180_R375_V3.4761.00
349_D372_R3.3551.00
329_G334_F3.3481.00
291_S294_E3.3271.00
349_D374_K3.2681.00
210_K213_E3.1601.00
299_S328_I3.0981.00
301_G327_K2.7651.00
327_K334_F2.6201.00
129_R132_K2.5371.00
10_K100_N2.4571.00
290_W294_E2.4411.00
113_S235_V2.3521.00
291_S353_R2.3071.00
214_K346_V2.2691.00
220_T247_E2.2451.00
295_L370_Y2.2331.00
222_Y286_K2.2161.00
354_E370_Y2.1931.00
162_A165_S2.1731.00
85_V90_N2.1721.00
222_Y245_K2.1141.00
218_E251_D2.0321.00
64_R67_S2.0221.00
58_I62_G1.9911.00
149_N152_D1.9791.00
297_D332_Q1.9741.00
161_R165_S1.9581.00
200_N203_N1.9431.00
102_K110_K1.9231.00
214_K253_I1.8821.00
220_T251_D1.8791.00
53_V56_K1.8521.00
75_E79_D1.8371.00
296_I328_I1.8261.00
184_I299_S1.8121.00
234_S243_T1.7881.00
344_E373_M1.7801.00
216_S345_L1.7361.00
295_L350_A1.7341.00
347_T374_K1.7331.00
51_A56_K1.7181.00
165_S169_S1.7151.00
87_A90_N1.6961.00
246_K270_N1.6881.00
259_G263_S1.6881.00
328_I334_F1.6751.00
290_W350_A1.6501.00
292_L296_I1.6151.00
246_K256_N1.6141.00
34_V49_S1.6121.00
347_T375_V1.6091.00
244_K266_G1.5981.00
343_Q347_T1.5861.00
298_E350_A1.5801.00
299_S372_R1.5771.00
64_R68_S1.5671.00
104_N110_K1.5661.00
111_V236_F1.5561.00
139_Y143_N1.5351.00
18_Q23_Y1.5201.00
100_N112_I1.5131.00
304_I328_I1.5121.00
160_L164_Q1.5091.00
302_A328_I1.4991.00
326_V333_I1.4821.00
202_L248_I1.4791.00
290_W298_E1.4781.00
292_L370_Y1.4751.00
100_N114_K1.4631.00
287_Q355_N1.4521.00
55_G59_V1.4511.00
298_E372_R1.4461.00
128_C167_L1.4451.00
245_K284_E1.4401.00
186_D304_I1.4301.00
222_Y247_E1.4221.00
154_P158_E1.4001.00
190_V371_V1.3891.00
284_E367_V1.3791.00
212_N255_T1.3691.00
234_S281_F1.3661.00
59_V62_G1.3601.00
216_S219_I1.3601.00
248_I258_L1.3531.00
84_S90_N1.3351.00
184_I295_L1.3341.00
293_N332_Q1.3341.00
352_T370_Y1.3281.00
86_K90_N1.3271.00
85_V88_W1.3201.00
84_S130_E1.3091.00
38_S64_R1.3071.00
77_C80_F1.3041.00
241_V267_E1.3031.00
130_E172_R1.2901.00
143_N162_A1.2871.00
182_T374_K1.2821.00
351_V371_V1.2761.00
226_L243_T1.2661.00
198_L283_L1.2651.00
10_K32_F1.2641.00
182_T372_R1.2461.00
241_V261_L1.2441.00
292_L295_L1.2361.00
40_I69_Q1.2261.00
158_E162_A1.2141.00
56_K60_Y1.2131.00
303_Y338_I1.2101.00
251_D255_T1.2081.00
220_T286_K1.2071.00
176_T181_L1.2051.00
174_V327_K1.2001.00
304_I333_I1.1991.00
143_N146_Y1.1971.00
184_I372_R1.1901.00
128_C168_T1.1901.00
63_N67_S1.1721.00
149_N229_F1.1721.00
217_S351_V1.1671.00
98_F114_K1.1651.00
61_D65_L1.1631.00
199_R203_N1.1631.00
322_P325_V1.1541.00
62_G66_E1.1541.00
220_T250_G1.1521.00
343_Q346_V1.1471.00
16_M23_Y1.1461.00
126_K164_Q1.1361.00
77_C81_Y1.1351.00
47_T60_Y1.1351.00
293_N297_D1.1311.00
245_K286_K1.1301.00
164_Q168_T1.1281.00
84_S87_A1.1241.00
182_T375_V1.1231.00
241_V269_G1.1190.99
105_E109_L1.1160.99
299_S302_A1.1130.99
296_I304_I1.1080.99
219_I351_V1.1010.99
264_K267_E1.0990.99
40_I68_S1.0980.99
82_H86_K1.0970.99
219_I285_V1.0960.99
247_E255_T1.0950.99
45_S64_R1.0950.99
259_G267_E1.0930.99
184_I292_L1.0890.99
344_E376_R1.0880.99
65_L68_S1.0840.99
199_R204_G1.0820.99
335_F338_I1.0740.99
85_V91_K1.0700.99
233_F282_S1.0680.99
219_I348_I1.0600.99
49_S60_Y1.0600.99
357_G367_V1.0590.99
305_A340_I1.0580.99
141_D146_Y1.0540.99
194_F285_V1.0540.99
85_V128_C1.0520.99
204_G259_G1.0490.99
294_E297_D1.0470.99
272_R279_D1.0420.99
40_I65_L1.0400.99
247_E251_D1.0370.99
152_D229_F1.0360.99
163_S167_L1.0310.99
14_I96_R1.0300.99
128_C132_K1.0270.99
181_L327_K1.0240.99
225_P234_S1.0240.99
284_E355_N1.0200.99
156_I160_L1.0140.99
295_L352_T1.0120.99
76_I80_F1.0030.99
221_I249_I1.0020.99
94_Y120_I0.9980.99
292_L353_R0.9900.99
157_V161_R0.9870.99
184_I328_I0.9810.99
190_V368_T0.9800.99
128_C164_Q0.9790.99
55_G58_I0.9770.99
177_E301_G0.9730.99
126_K167_L0.9710.99
143_N147_A0.9630.98
74_F77_C0.9590.98
128_C171_S0.9560.98
102_K112_I0.9540.98
56_K59_V0.9520.98
73_E157_V0.9490.98
260_T278_P0.9480.98
185_L305_A0.9400.98
144_F147_A0.9330.98
67_S71_I0.9320.98
368_T371_V0.9300.98
225_P243_T0.9250.98
246_K268_A0.9220.98
296_I299_S0.9220.98
49_S56_K0.9190.98
39_L44_R0.9170.98
225_P281_F0.9170.98
84_S88_W0.9140.98
227_N230_S0.9130.98
179_G301_G0.9130.98
72_K75_E0.9110.98
43_K73_E0.9030.98
313_L320_I0.9000.98
292_L304_I0.8940.98
10_K30_A0.8910.97
148_G151_K0.8910.97
221_I283_L0.8880.97
314_I317_S0.8840.97
17_L25_E0.8770.97
82_H91_K0.8770.97
271_A278_P0.8750.97
74_F78_E0.8730.97
8_A34_V0.8710.97
256_N268_A0.8690.97
194_F221_I0.8690.97
299_S349_D0.8670.97
132_K137_V0.8630.97
12_N30_A0.8620.97
239_E261_L0.8610.97
142_L145_S0.8600.97
33_S46_Y0.8580.97
82_H85_V0.8570.97
73_E76_I0.8560.97
201_F204_G0.8530.97
225_P246_K0.8510.97
74_F79_D0.8510.97
74_F81_Y0.8430.96
318_I344_E0.8410.96
103_L111_V0.8400.96
211_L257_Y0.8390.96
260_T263_S0.8370.96
19_Q24_S0.8340.96
263_S278_P0.8340.96
216_S249_I0.8330.96
9_Y99_T0.8300.96
350_A372_R0.8300.96
32_F52_L0.8280.96
139_Y144_F0.8250.96
128_C137_V0.8230.96
270_N281_F0.8200.96
202_L205_N0.8200.96
290_W353_R0.8190.96
312_E320_I0.8190.96
145_S154_P0.8180.96
302_A333_I0.8170.96
140_N144_F0.8160.96
195_H200_N0.8150.96
325_V335_F0.8120.96
290_W295_L0.8060.95
292_L354_E0.8060.95
34_V57_W0.8050.95
130_E137_V0.7990.95
184_I304_I0.7980.95
42_Y73_E0.7980.95
328_I333_I0.7970.95
86_K89_P0.7960.95
83_E88_W0.7950.95
86_K91_K0.7940.95
138_E141_D0.7910.95
63_N68_S0.7900.95
175_L337_E0.7900.95
308_V312_E0.7830.95
176_T303_Y0.7830.95
78_E81_Y0.7810.95
209_L213_E0.7810.95
225_P233_F0.7800.95
227_N284_E0.7770.94
65_L69_Q0.7760.94
259_G264_K0.7750.94
83_E86_K0.7750.94
196_Y200_N0.7750.94
174_V329_G0.7740.94
295_L299_S0.7720.94
158_E161_R0.7720.94
181_L303_Y0.7720.94
161_R164_Q0.7720.94
180_R377_A0.7690.94
293_N296_I0.7610.94
147_A150_P0.7610.94
215_I346_V0.7610.94
173_Q336_R0.7600.94
141_D145_S0.7570.94
190_V285_V0.7550.94
128_C131_E0.7530.94
36_G60_Y0.7530.94
123_H126_K0.7510.93
189_I192_S0.7510.93
82_H87_A0.7510.93
223_D246_K0.7470.93
15_K27_V0.7450.93
166_Q186_D0.7420.93
243_T281_F0.7410.93
182_T301_G0.7370.93
296_I301_G0.7370.93
198_L345_L0.7360.93
224_N284_E0.7340.93
99_T115_K0.7300.92
284_E357_G0.7300.92
145_S153_I0.7280.92
37_Y239_E0.7280.92
280_Y283_L0.7260.92
107_D261_L0.7250.92
139_Y142_L0.7220.92
64_R71_I0.7220.92
73_E77_C0.7220.92
174_V334_F0.7210.92
101_I113_S0.7200.92
216_S348_I0.7160.92
84_S89_P0.7150.92
168_T171_S0.7120.91
251_D266_G0.7120.91
88_W91_K0.7100.91
63_N66_E0.7090.91
200_N205_N0.7090.91
47_T64_R0.7080.91
196_Y320_I0.7080.91
45_S67_S0.7070.91
348_I371_V0.7070.91
82_H168_T0.7070.91
355_N367_V0.7060.91
244_K256_N0.7030.91
201_F342_L0.7030.91
72_K80_F0.7020.91
306_M326_V0.6990.91
214_K251_D0.6990.91
303_Y327_K0.6980.91
194_F219_I0.6980.91
145_S159_Y0.6970.91
206_S342_L0.6960.91
137_V140_N0.6960.91
76_I79_D0.6960.91
288_G369_P0.6960.91
311_S314_I0.6950.91
197_V216_S0.6940.90
13_N95_S0.6910.90
199_R202_L0.6910.90
69_Q72_K0.6910.90
74_F80_F0.6890.90
181_L335_F0.6880.90
83_E87_A0.6870.90
311_S320_I0.6850.90
196_Y199_R0.6840.90
96_R118_K0.6820.90
169_S326_V0.6810.90
182_T299_S0.6800.90
310_K319_R0.6800.90
82_H88_W0.6790.89
230_S233_F0.6780.89
141_D144_F0.6750.89
142_L147_A0.6710.89
66_E69_Q0.6680.89
12_N98_F0.6660.89
68_S71_I0.6660.89
86_K129_R0.6650.88
126_K132_K0.6640.88
294_E298_E0.6630.88
296_I333_I0.6600.88
308_V311_S0.6590.88
186_D306_M0.6580.88
297_D300_R0.6570.88
260_T271_A0.6560.88
45_S68_S0.6500.87
321_T337_E0.6470.87
147_A153_I0.6430.87
34_V56_K0.6420.87
189_I308_V0.6410.87
41_D73_E0.6390.86
195_H279_D0.6370.86
185_L308_V0.6360.86
322_P340_I0.6340.86
33_S274_I0.6340.86
227_N233_F0.6300.86
11_L97_L0.6290.86
74_F120_I0.6280.85
84_S91_K0.6280.85
261_L265_Y0.6270.85
139_Y336_R0.6260.85
226_L245_K0.6250.85
213_E253_I0.6250.85
260_T277_K0.6220.85
85_V89_P0.6190.85
203_N280_Y0.6140.84
33_S48_L0.6130.84
87_A91_K0.6130.84
304_I370_Y0.6110.84
192_S196_Y0.6100.84
217_S251_D0.6080.84
260_T311_S0.6080.84
223_D248_I0.6060.83
328_I372_R0.6050.83
184_I296_I0.6050.83
248_I283_L0.6040.83
195_H280_Y0.6020.83
287_Q353_R0.6010.83
160_L163_S0.5960.82
77_C161_R0.5950.82
176_T179_G0.5940.82
168_T172_R0.5940.82
308_V320_I0.5940.82
233_F281_F0.5900.82
193_I308_V0.5900.82
211_L256_N0.5900.82
207_P215_I0.5890.82
189_I305_A0.5890.82
137_V142_L0.5880.82
199_R205_N0.5880.82
194_F371_V0.5880.82
202_L254_I0.5870.81
319_R341_P0.5860.81
162_A166_Q0.5860.81
62_G161_R0.5860.81
142_L148_G0.5830.81
127_E139_Y0.5830.81
157_V160_L0.5810.81
211_L255_T0.5800.81
309_K339_A0.5790.81
59_V63_N0.5790.81
207_P210_K0.5770.80
182_T300_R0.5770.80
75_E78_E0.5760.80
38_S45_S0.5750.80
321_T339_A0.5750.80
322_P338_I0.5750.80
164_Q167_L0.5740.80
199_R279_D0.5740.80
295_L333_I0.5720.80
139_Y159_Y0.5720.80
307_G324_S0.5710.80
288_G353_R0.5710.80
312_E319_R0.5700.80
310_K339_A0.5700.80
315_R319_R0.5700.80
11_L99_T0.5660.79
183_F376_R0.5660.79
13_N97_L0.5650.79
301_G330_Q0.5650.79
289_D353_R0.5640.79
259_G278_P0.5620.79
204_G263_S0.5610.78
302_A326_V0.5590.78
187_S193_I0.5580.78
298_E330_Q0.5570.78
185_L190_V0.5570.78
330_Q334_F0.5570.78
196_Y203_N0.5560.78
203_N279_D0.5540.78
206_S211_L0.5530.78
154_P162_A0.5530.78
29_E213_E0.5520.77
140_N143_N0.5510.77
267_E271_A0.5510.77
46_Y276_P0.5510.77
186_D190_V0.5510.77
316_N319_R0.5500.77
297_D301_G0.5490.77
189_I321_T0.5490.77
310_K316_N0.5490.77
142_L146_Y0.5490.77
138_E142_L0.5480.77
283_L368_T0.5470.77
149_N153_I0.5450.76
238_D272_R0.5410.76
305_A308_V0.5410.76
246_K258_L0.5410.76
52_L56_K0.5390.76
182_T349_D0.5380.76
200_N279_D0.5370.75
143_N154_P0.5370.75
347_T376_R0.5360.75
13_N31_E0.5350.75
310_K318_I0.5350.75
248_I256_N0.5350.75
138_E143_N0.5350.75
160_L167_L0.5330.75
298_E349_D0.5310.75
95_S119_S0.5310.75
103_L109_L0.5310.75
232_S365_G0.5280.74
196_Y318_I0.5270.74
12_N28_I0.5260.74
143_N149_N0.5260.74
230_S236_F0.5260.74
54_N57_W0.5260.74
72_K76_I0.5260.74
76_I81_Y0.5260.74
222_Y284_E0.5260.74
309_K324_S0.5250.74
189_I221_I0.5250.74
122_I163_S0.5240.74
179_G303_Y0.5240.74
267_E272_R0.5240.74
319_R339_A0.5210.73
306_M333_I0.5210.73
109_L261_L0.5200.73
299_S304_I0.5200.73
310_K322_P0.5190.73
302_A327_K0.5190.73
67_S70_K0.5180.73
172_R332_Q0.5180.73
206_S209_L0.5170.73
46_Y49_S0.5170.73
345_L348_I0.5160.73
250_G253_I0.5160.73
221_I285_V0.5150.72
197_V320_I0.5140.72
126_K129_R0.5130.72
83_E90_N0.5120.72
156_I164_Q0.5110.72
105_E261_L0.5110.72
144_F148_G0.5110.72
71_I79_D0.5090.72
216_S254_I0.5070.71
224_N227_N0.5070.71
59_V66_E0.5060.71
292_L299_S0.5050.71
174_V332_Q0.5030.71
238_D271_A0.5030.71
38_S61_D0.5010.70
67_S79_D0.5010.70
310_K313_L0.5000.70
8_A32_F0.5000.70
81_Y164_Q0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tv9A 2 0.9368 100 0.23 Contact Map
3qtdA 2 0.9474 100 0.238 Contact Map
1vl4A 2 0.9342 100 0.242 Contact Map
1vpbA 2 0.9289 100 0.254 Contact Map
3e8vA 1 0.1632 5.4 0.974 Contact Map
3pegA 2 0.1842 5.4 0.974 Contact Map
2m5oA 1 0.2053 4.5 0.975 Contact Map
2gkpA 1 0.1737 4.1 0.976 Contact Map
1droA 1 0.1816 4 0.976 Contact Map
4bpeB 1 0.2421 4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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