GREMLIN Database
Q97ZU8 - Uncharacterized protein
UniProt: Q97ZU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (152)
Sequences: 11109 (8036)
Seq/√Len: 651.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_L60_Q2.7761.00
17_K36_L2.7231.00
68_F73_V2.5801.00
96_Q155_F2.5551.00
40_L61_A2.5201.00
61_A67_P2.1401.00
76_L95_A2.1371.00
22_G81_S2.1191.00
94_E97_R2.1071.00
44_L48_N2.0611.00
23_C39_C2.0281.00
95_A105_I2.0051.00
30_D54_G1.9831.00
76_L99_L1.9601.00
89_S152_S1.9451.00
19_I73_V1.9331.00
21_V95_A1.9301.00
87_D90_Q1.8891.00
21_V63_M1.7981.00
47_L60_Q1.7971.00
23_C29_C1.7861.00
29_C37_V1.7821.00
88_P149_I1.7731.00
36_L57_N1.7531.00
85_L91_A1.7151.00
59_V68_F1.7011.00
147_K151_E1.6891.00
99_L105_I1.6811.00
38_I73_V1.6771.00
47_L58_L1.6471.00
142_Y145_E1.6361.00
50_A58_L1.6361.00
54_G58_L1.6231.00
18_I32_F1.6211.00
49_Q52_K1.6051.00
99_L103_G1.5891.00
74_D100_K1.5851.00
17_K38_I1.5601.00
30_D53_K1.5201.00
81_S85_L1.5161.00
69_R72_S1.4921.00
94_E98_V1.4841.00
18_I75_S1.4561.00
42_L62_D1.4371.00
70_D97_R1.4311.00
99_L155_F1.4091.00
89_S93_G1.3981.00
66_L98_V1.3951.00
17_K73_V1.3811.00
16_D75_S1.3731.00
38_I59_V1.3541.00
89_S149_I1.3221.00
29_C39_C1.2981.00
90_Q93_G1.2841.00
22_G78_Y1.2701.00
17_K100_K1.2281.00
32_F77_A1.1971.00
148_R152_S1.1951.00
48_N51_R1.1891.00
29_C58_L1.1721.00
39_C58_L1.1581.00
38_I68_F1.1431.00
17_K72_S1.1371.00
62_D65_Y1.1251.00
13_I16_D1.1181.00
63_M85_L1.1051.00
92_L150_M1.0891.00
39_C50_A1.0791.00
66_L94_E1.0751.00
63_M81_S1.0751.00
25_S46_Q1.0721.00
16_D35_R1.0671.00
116_F120_R1.0661.00
41_D47_L1.0661.00
26_G50_A1.0611.00
84_H109_V1.0441.00
15_G35_R1.0391.00
148_R151_E1.0281.00
19_I76_L1.0271.00
80_A83_H1.0181.00
91_A95_A1.0151.00
76_L98_V1.0071.00
71_S101_D0.9841.00
65_Y90_Q0.9781.00
19_I98_V0.9761.00
64_E85_L0.9761.00
147_K160_Y0.9741.00
121_R125_K0.9671.00
43_S46_Q0.9641.00
38_I57_N0.9571.00
105_I150_M0.9511.00
83_H109_V0.9451.00
89_S153_K0.9381.00
45_N48_N0.9341.00
82_L85_L0.9311.00
20_D23_C0.9161.00
40_L59_V0.9111.00
40_L66_L0.9081.00
78_Y81_S0.9071.00
12_L16_D0.9051.00
124_I127_S0.9031.00
26_G58_L0.8981.00
112_V142_Y0.8941.00
79_I108_T0.8871.00
93_G153_K0.8801.00
122_Y125_K0.8781.00
21_V76_L0.8641.00
117_F120_R0.8631.00
80_A84_H0.8541.00
27_Q53_K0.8451.00
23_C50_A0.8391.00
95_A99_L0.8341.00
80_A108_T0.8241.00
28_N79_I0.8201.00
78_Y85_L0.8191.00
9_Y12_L0.8171.00
145_E148_R0.8171.00
51_R55_C0.8151.00
107_V150_M0.8121.00
18_I37_V0.8101.00
134_V137_F0.7941.00
92_L153_K0.7901.00
68_F98_V0.7891.00
64_E87_D0.7831.00
48_N52_K0.7801.00
22_G85_L0.7771.00
82_L92_L0.7751.00
52_K56_Q0.7751.00
41_D46_Q0.7691.00
70_D94_E0.7671.00
25_S53_K0.7671.00
10_V75_S0.7651.00
78_Y107_V0.7631.00
126_R129_I0.7631.00
92_L146_L0.7581.00
83_H110_W0.7301.00
30_D55_C0.7231.00
125_K128_L0.7211.00
124_I128_L0.7191.00
49_Q53_K0.7171.00
45_N49_Q0.7101.00
123_I126_R0.7031.00
64_E91_A0.7031.00
123_I127_S0.7011.00
21_V40_L0.6981.00
80_A110_W0.6951.00
64_E86_R0.6941.00
82_L107_V0.6931.00
122_Y127_S0.6841.00
20_D40_L0.6831.00
15_G34_G0.6671.00
65_Y94_E0.6611.00
16_D104_E0.6611.00
51_R54_G0.6611.00
25_S49_Q0.6611.00
151_E158_K0.6521.00
17_K74_D0.6511.00
122_Y126_R0.6501.00
67_P94_E0.6471.00
82_L146_L0.6471.00
44_L51_R0.6441.00
110_W137_F0.6421.00
14_N34_G0.6421.00
28_N77_A0.6411.00
118_F122_Y0.6411.00
68_F72_S0.6411.00
47_L51_R0.6401.00
84_H110_W0.6401.00
130_N133_E0.6341.00
20_D37_V0.6341.00
131_G134_V0.6321.00
64_E90_Q0.6291.00
23_C47_L0.6261.00
71_S100_K0.6251.00
52_K55_C0.6221.00
118_F121_R0.6171.00
96_Q153_K0.6101.00
90_Q94_E0.6101.00
125_K129_I0.6041.00
135_R138_Y0.6021.00
19_I68_F0.6021.00
42_L64_E0.5991.00
21_V91_A0.5971.00
16_D74_D0.5951.00
93_G152_S0.5921.00
132_K136_R0.5881.00
81_S84_H0.5841.00
109_V146_L0.5831.00
105_I155_F0.5781.00
22_G42_L0.5781.00
133_E137_F0.5731.00
116_F119_L0.5731.00
17_K35_R0.5671.00
150_M155_F0.5621.00
121_R124_I0.5591.00
42_L60_Q0.5591.00
92_L149_I0.5581.00
75_S103_G0.5581.00
144_W147_K0.5571.00
134_V138_Y0.5561.00
79_I83_H0.5481.00
63_M91_A0.5471.00
9_Y159_I0.5461.00
28_N31_Q0.5461.00
20_D77_A0.5451.00
28_N80_A0.5431.00
96_Q99_L0.5381.00
144_W160_Y0.5381.00
136_R139_R0.5371.00
20_D39_C0.5361.00
130_N134_V0.5351.00
122_Y128_L0.5341.00
40_L68_F0.5330.99
27_Q31_Q0.5300.99
151_E157_T0.5270.99
120_R123_I0.5200.99
27_Q30_D0.5190.99
124_I129_I0.5170.99
38_I72_S0.5140.99
23_C58_L0.5130.99
53_K56_Q0.5110.99
119_L123_I0.5100.99
12_L35_R0.5090.99
82_L91_A0.5050.99
46_Q80_A0.5040.99
111_L114_L0.5020.99
18_I77_A0.5000.99
131_G135_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.956 100 0.402 Contact Map
4pneA 2 0.9505 100 0.404 Contact Map
4ineA 2 0.956 100 0.409 Contact Map
2o57A 2 0.9615 100 0.412 Contact Map
3ujcA 1 0.9615 100 0.412 Contact Map
4kriA 1 0.956 100 0.414 Contact Map
4kdcA 1 0.9396 100 0.414 Contact Map
3e8sA 2 0.989 100 0.416 Contact Map
3bkxA 2 0.9945 100 0.418 Contact Map
3busA 1 0.978 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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