GREMLIN Database
Q97ZU7 - Histone acethyltransferase, putative
UniProt: Q97ZU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (452)
Sequences: 360 (209)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_E328_F5.4651.00
228_T232_D5.0421.00
278_Y325_E4.8681.00
464_E469_S4.4100.99
323_I328_F4.2270.99
428_L459_R4.1450.99
188_T191_D4.1300.99
430_E433_K3.9160.98
278_Y328_F3.6570.98
196_T208_Y3.5700.97
364_L377_L3.5250.97
184_N252_P3.4980.97
266_G269_T3.4910.97
203_G397_I3.0740.93
110_E129_A2.8160.90
355_E360_T2.7730.89
125_Y128_D2.7310.88
109_L450_I2.7230.88
351_K430_E2.6470.86
395_T445_S2.6400.86
81_P138_V2.5780.85
174_T179_I2.5520.84
315_K318_E2.5430.84
86_L108_A2.5270.84
233_P355_E2.5200.83
278_Y323_I2.5190.83
19_I108_A2.4890.83
351_K362_I2.4810.82
283_K352_E2.4670.82
200_K357_S2.4430.81
347_I423_Y2.3890.80
351_K364_L2.3870.80
17_V84_V2.3610.79
110_E114_R2.3250.78
213_G270_L2.3080.77
54_M57_I2.2720.76
10_M15_T2.2480.76
47_Y152_A2.2080.74
210_V229_I2.2070.74
22_H96_L2.1700.73
353_V362_I2.1610.72
36_G44_Q2.1410.72
85_E402_H2.1380.72
398_V428_L2.1370.72
158_D387_H2.1180.71
390_E465_G2.1160.71
396_A435_A2.1150.71
177_D190_K2.1110.71
193_I234_N2.0530.68
432_E470_K2.0090.67
351_K438_E1.9660.65
52_T66_Q1.9430.64
167_K200_K1.9030.62
449_G452_A1.9020.62
270_L303_N1.8970.62
71_L428_L1.8940.62
157_A198_I1.8740.61
202_S284_W1.8680.61
463_K468_M1.8430.60
85_E404_Y1.8410.60
113_N133_N1.8370.59
55_R70_R1.8250.59
233_P236_R1.8120.58
350_Y365_S1.8050.58
70_R293_D1.7870.57
9_R55_R1.7750.57
175_V229_I1.7340.55
9_R293_D1.7290.55
375_G403_V1.7230.54
114_R129_A1.7110.54
145_I165_A1.7050.54
265_Y270_L1.7030.53
353_V360_T1.7010.53
316_V323_I1.6830.53
55_R293_D1.6780.52
428_L446_V1.6700.52
103_W107_Y1.6580.51
106_T110_E1.6480.51
9_R70_R1.6310.50
19_I66_Q1.6290.50
249_E254_A1.6090.49
158_D388_R1.5940.48
77_N303_N1.5610.47
179_I265_Y1.5540.47
66_Q104_F1.5500.46
432_E461_Y1.5430.46
392_D395_T1.5370.46
32_V253_L1.5250.45
381_I441_M1.5080.45
8_T364_L1.5010.44
101_Q159_Q1.4890.44
88_I105_V1.4890.44
85_E225_A1.4820.43
152_A160_M1.4790.43
148_K214_L1.4760.43
350_Y367_E1.4620.43
63_P103_W1.4610.42
362_I438_E1.4610.42
108_A325_E1.4600.42
110_E117_S1.4590.42
86_L109_L1.4500.42
36_G48_G1.4380.41
107_Y110_E1.4320.41
391_I445_S1.4310.41
133_N136_A1.4290.41
134_E457_A1.4200.41
64_F114_R1.4190.41
445_S469_S1.4160.41
44_Q48_G1.4140.40
276_E319_K1.4090.40
434_I438_E1.3980.40
232_D421_R1.3960.40
33_F167_K1.3940.40
231_S236_R1.3840.39
36_G42_T1.3770.39
18_S47_Y1.3750.39
157_A204_F1.3560.38
246_L291_Q1.3530.38
401_L456_Y1.3320.37
85_E160_M1.3280.37
254_A300_L1.3250.37
307_N310_E1.3100.36
89_M169_E1.3010.36
18_S89_M1.2970.35
258_R261_L1.2930.35
274_I316_V1.2910.35
54_M273_L1.2850.35
430_E438_E1.2710.34
443_K464_E1.2670.34
315_K319_K1.2640.34
66_Q204_F1.2590.34
190_K194_E1.2580.34
148_K293_D1.2560.34
18_S169_E1.2520.34
349_L366_F1.2500.33
295_P449_G1.2460.33
126_L130_Q1.2430.33
44_Q47_Y1.2410.33
88_I321_I1.2390.33
15_T74_Y1.2370.33
19_I148_K1.2240.32
206_V397_I1.2230.32
36_G246_L1.2160.32
284_W352_E1.2120.32
126_L136_A1.2120.32
356_A446_V1.1980.31
353_V364_L1.1910.31
204_F447_L1.1780.31
97_P355_E1.1750.31
53_L94_L1.1740.30
29_G237_P1.1720.30
59_N69_S1.1700.30
219_P273_L1.1690.30
240_L245_T1.1690.30
174_T251_A1.1670.30
223_L276_E1.1630.30
8_T54_M1.1620.30
85_E307_N1.1620.30
461_Y470_K1.1610.30
54_M170_L1.1590.30
217_S225_A1.1490.30
59_N454_E1.1480.29
433_K438_E1.1440.29
388_R465_G1.1370.29
264_P301_D1.1310.29
51_P55_R1.1260.29
200_K284_W1.1260.29
89_M96_L1.1240.29
362_I430_E1.1240.29
199_L402_H1.1230.29
62_D274_I1.1230.29
96_L288_M1.1150.28
42_T61_Y1.1140.28
400_E404_Y1.1140.28
210_V277_M1.1100.28
394_K462_V1.1070.28
193_I232_D1.1060.28
152_A161_L1.1030.28
223_L273_L1.0960.28
189_V235_F1.0880.27
352_E365_S1.0860.27
20_M48_G1.0850.27
11_L333_M1.0850.27
112_M140_C1.0820.27
17_V170_L1.0770.27
48_G291_Q1.0760.27
10_M74_Y1.0740.27
41_D195_S1.0730.27
178_D221_K1.0680.27
44_Q96_L1.0580.26
33_F180_L1.0570.26
20_M246_L1.0560.26
113_N376_Y1.0560.26
270_L306_G1.0530.26
138_V143_M1.0520.26
74_Y308_L1.0510.26
56_A233_P1.0510.26
373_L402_H1.0450.26
165_A204_F1.0410.26
278_Y313_E1.0330.25
276_E410_I1.0310.25
203_G467_Y1.0250.25
179_I221_K1.0230.25
112_M138_V1.0230.25
425_S428_L1.0220.25
177_D245_T1.0140.25
139_R454_E1.0130.25
274_I425_S1.0110.25
172_V242_I1.0050.24
283_K349_L0.9990.24
130_Q163_L0.9970.24
47_Y298_V0.9890.24
167_K281_I0.9880.24
272_E315_K0.9840.24
73_Q246_L0.9820.24
425_S459_R0.9820.24
214_L222_D0.9820.24
103_W114_R0.9810.24
347_I374_I0.9740.23
95_S463_K0.9730.23
307_N404_Y0.9710.23
265_Y294_I0.9630.23
16_I179_I0.9620.23
56_A268_E0.9580.23
383_S386_A0.9580.23
36_G73_Q0.9560.23
113_N136_A0.9550.23
190_K369_E0.9530.23
167_K183_T0.9510.23
42_T245_T0.9500.23
377_L398_V0.9480.23
6_K375_G0.9470.23
181_K252_P0.9450.22
138_V145_I0.9450.22
74_Y349_L0.9430.22
54_M58_E0.9350.22
167_K239_M0.9320.22
229_I452_A0.9290.22
176_Y221_K0.9290.22
85_E435_A0.9280.22
21_T136_A0.9280.22
196_T357_S0.9270.22
263_K301_D0.9250.22
269_T358_E0.9240.22
195_S383_S0.9240.22
207_V288_M0.9200.22
365_S401_L0.9190.22
56_A214_L0.9160.22
74_Y82_S0.9120.21
86_L112_M0.9110.21
144_T449_G0.9100.21
19_I88_I0.9090.21
203_G433_K0.9060.21
115_F202_S0.9050.21
433_K437_E0.9030.21
86_L300_L0.8970.21
142_G422_G0.8950.21
196_T200_K0.8940.21
457_A462_V0.8930.21
396_A441_M0.8910.21
70_R148_K0.8900.21
44_Q291_Q0.8890.21
29_G33_F0.8880.21
175_V192_S0.8880.21
18_S270_L0.8870.21
428_L463_K0.8860.21
161_L291_Q0.8850.21
223_L272_E0.8840.21
160_M402_H0.8840.21
134_E139_R0.8810.20
66_Q82_S0.8810.20
177_D181_K0.8790.20
260_G446_V0.8750.20
95_S300_L0.8750.20
207_V239_M0.8750.20
352_E367_E0.8740.20
177_D188_T0.8700.20
163_L450_I0.8690.20
179_I190_K0.8680.20
17_V233_P0.8680.20
373_L404_Y0.8610.20
303_N306_G0.8610.20
444_I459_R0.8590.20
115_F281_I0.8580.20
52_T82_S0.8580.20
454_E457_A0.8560.20
48_G73_Q0.8550.20
148_K221_K0.8510.20
237_P282_P0.8500.20
143_M395_T0.8480.20
36_G291_Q0.8430.19
87_I235_F0.8430.19
177_D428_L0.8420.19
36_G96_L0.8420.19
320_G334_M0.8320.19
15_T407_E0.8320.19
424_G451_G0.8310.19
415_E437_E0.8310.19
313_E328_F0.8300.19
313_E325_E0.8300.19
215_P309_R0.8290.19
96_L291_Q0.8250.19
61_Y148_K0.8230.19
9_R21_T0.8230.19
239_M288_M0.8220.19
103_W163_L0.8220.19
362_I381_I0.8210.19
17_V274_I0.8210.19
20_M161_L0.8190.19
324_N371_E0.8190.19
81_P287_V0.8160.19
20_M73_Q0.8160.19
287_V309_R0.8130.19
351_K360_T0.8120.19
343_D346_K0.8100.18
18_S42_T0.8080.18
148_K468_M0.8080.18
20_M89_M0.8070.18
106_T157_A0.8060.18
104_F435_A0.8050.18
158_D390_E0.8030.18
141_V449_G0.8030.18
331_V372_I0.8020.18
20_M93_F0.8010.18
142_G160_M0.8010.18
180_L183_T0.7960.18
383_S397_I0.7940.18
158_D161_L0.7920.18
49_R54_M0.7910.18
114_R128_D0.7910.18
114_R404_Y0.7850.18
167_K441_M0.7810.18
455_Y467_Y0.7800.18
63_P107_Y0.7800.18
383_S388_R0.7800.18
200_K440_D0.7800.18
214_L456_Y0.7780.18
56_A107_Y0.7750.18
40_V74_Y0.7720.17
163_L195_S0.7700.17
44_Q290_I0.7690.17
32_V256_L0.7690.17
215_P256_L0.7670.17
73_Q89_M0.7670.17
56_A270_L0.7660.17
22_H288_M0.7660.17
283_K324_N0.7650.17
101_Q299_I0.7640.17
249_E253_L0.7630.17
190_K317_L0.7620.17
12_S63_P0.7620.17
353_V438_E0.7610.17
141_V395_T0.7610.17
275_S319_K0.7600.17
61_Y240_L0.7570.17
192_S287_V0.7570.17
247_V332_G0.7560.17
36_G245_T0.7530.17
14_V62_D0.7510.17
381_I397_I0.7510.17
188_T398_V0.7490.17
201_D242_I0.7490.17
429_S469_S0.7480.17
307_N402_H0.7470.17
48_G161_L0.7450.17
392_D445_S0.7440.17
167_K381_I0.7440.17
56_A96_L0.7420.17
212_L278_Y0.7420.17
55_R148_K0.7420.17
112_M407_E0.7400.17
246_L284_W0.7390.17
14_V326_I0.7370.17
283_K350_Y0.7370.17
193_I314_K0.7360.17
168_V202_S0.7330.16
256_L261_L0.7320.16
98_I231_S0.7310.16
213_G239_M0.7280.16
273_L295_P0.7260.16
145_I271_I0.7250.16
226_F242_I0.7240.16
229_I237_P0.7240.16
223_L271_I0.7210.16
19_I435_A0.7210.16
85_E199_L0.7210.16
71_L281_I0.7190.16
138_V287_V0.7180.16
127_E162_R0.7170.16
373_L461_Y0.7170.16
44_Q49_R0.7160.16
68_Q72_R0.7160.16
47_Y291_Q0.7140.16
48_G246_L0.7090.16
144_T380_R0.7090.16
161_L332_G0.7070.16
151_W167_K0.7070.16
44_Q61_Y0.7060.16
109_L143_M0.7050.16
236_R463_K0.7050.16
284_W331_V0.7040.16
266_G398_V0.7010.16
186_G332_G0.7000.16
75_V202_S0.7000.16
85_E141_V0.7000.16
175_V287_V0.6980.16
249_E305_K0.6980.16
10_M81_P0.6980.16
21_T55_R0.6970.16
10_M27_P0.6950.16
316_V319_K0.6940.15
97_P219_P0.6920.15
88_I133_N0.6900.15
93_F96_L0.6890.15
156_H160_M0.6860.15
42_T246_L0.6830.15
224_E227_K0.6830.15
242_I248_V0.6820.15
109_L331_V0.6810.15
272_E366_F0.6800.15
143_M351_K0.6800.15
148_K184_N0.6800.15
248_V254_A0.6790.15
224_E343_D0.6770.15
22_H77_N0.6760.15
155_W425_S0.6740.15
74_Y212_L0.6740.15
175_V221_K0.6730.15
169_E291_Q0.6730.15
16_I74_Y0.6710.15
159_Q373_L0.6700.15
148_K252_P0.6680.15
159_Q163_L0.6680.15
461_Y468_M0.6670.15
59_N373_L0.6630.15
332_G358_E0.6630.15
133_N376_Y0.6620.15
251_A254_A0.6610.15
133_N139_R0.6610.15
366_F472_L0.6580.15
23_P51_P0.6570.15
313_E364_L0.6560.15
75_V82_S0.6550.15
102_D162_R0.6540.15
178_D263_K0.6540.15
108_A278_Y0.6530.15
21_T113_N0.6530.15
74_Y142_G0.6520.15
283_K290_I0.6490.14
59_N148_K0.6490.14
423_Y450_I0.6480.14
143_M148_K0.6470.14
151_W457_A0.6430.14
204_F270_L0.6420.14
331_V458_K0.6420.14
408_V417_G0.6410.14
167_K207_V0.6410.14
24_H97_P0.6410.14
255_N271_I0.6410.14
202_S386_A0.6400.14
183_T215_P0.6400.14
300_L367_E0.6390.14
195_S199_L0.6380.14
110_E240_L0.6380.14
201_D383_S0.6370.14
433_K443_K0.6370.14
266_G450_I0.6370.14
7_P156_H0.6360.14
142_G367_E0.6360.14
20_M23_P0.6360.14
309_R313_E0.6360.14
74_Y77_N0.6340.14
25_S148_K0.6330.14
182_F216_K0.6330.14
39_D215_P0.6320.14
18_S96_L0.6310.14
67_V237_P0.6290.14
139_R163_L0.6280.14
220_D231_S0.6280.14
14_V126_L0.6270.14
273_L408_V0.6270.14
180_L192_S0.6250.14
82_S141_V0.6250.14
71_L237_P0.6240.14
10_M84_V0.6230.14
449_G461_Y0.6220.14
18_S73_Q0.6210.14
21_T180_L0.6200.14
67_V71_L0.6170.14
201_D390_E0.6160.14
97_P217_S0.6150.14
367_E401_L0.6140.14
109_L423_Y0.6130.14
85_E152_A0.6130.14
73_Q303_N0.6130.14
4_I320_G0.6120.14
19_I262_Y0.6120.14
106_T165_A0.6080.14
110_E404_Y0.6070.14
348_H436_R0.6060.14
186_G247_V0.6040.13
67_V86_L0.6030.13
413_W446_V0.6020.13
52_T333_M0.6010.13
231_S414_D0.6000.13
199_L229_I0.6000.13
316_V428_L0.6000.13
39_D42_T0.5980.13
195_S325_E0.5970.13
49_R298_V0.5970.13
154_E409_P0.5970.13
193_I272_E0.5960.13
223_L227_K0.5960.13
251_A303_N0.5950.13
281_I323_I0.5940.13
97_P125_Y0.5940.13
178_D218_D0.5940.13
113_N180_L0.5930.13
359_G380_R0.5930.13
275_S314_K0.5920.13
51_P70_R0.5920.13
296_A447_L0.5920.13
153_K191_D0.5900.13
307_N456_Y0.5900.13
375_G401_L0.5890.13
363_F403_V0.5880.13
6_K290_I0.5870.13
377_L428_L0.5860.13
260_G457_A0.5850.13
105_V255_N0.5840.13
247_V380_R0.5840.13
19_I204_F0.5830.13
210_V240_L0.5830.13
25_S195_S0.5820.13
265_Y271_I0.5820.13
6_K403_V0.5820.13
199_L396_A0.5820.13
227_K280_Y0.5810.13
464_E471_Q0.5810.13
174_T253_L0.5810.13
108_A328_F0.5810.13
184_N290_I0.5790.13
130_Q450_I0.5790.13
346_K369_E0.5790.13
179_I259_R0.5790.13
251_A299_I0.5790.13
31_C35_P0.5780.13
443_K469_S0.5780.13
31_C34_C0.5770.13
284_W403_V0.5770.13
348_H433_K0.5770.13
218_D221_K0.5770.13
138_V423_Y0.5760.13
32_V235_F0.5760.13
373_L449_G0.5750.13
131_V442_R0.5730.13
77_N202_S0.5700.13
9_R51_P0.5690.13
165_A265_Y0.5690.13
93_F152_A0.5670.13
144_T375_G0.5670.13
43_P325_E0.5660.13
9_R148_K0.5640.13
31_C45_S0.5640.13
53_L96_L0.5640.13
10_M323_I0.5610.13
161_L169_E0.5610.13
248_V377_L0.5600.13
245_T373_L0.5590.13
135_K454_E0.5590.13
148_K178_D0.5580.13
131_V347_I0.5580.13
237_P382_T0.5580.13
176_Y179_I0.5570.13
373_L463_K0.5570.13
31_C46_Y0.5570.13
99_D469_S0.5570.13
14_V453_R0.5570.13
277_M373_L0.5560.12
31_C50_E0.5560.12
115_F366_F0.5560.12
180_L262_Y0.5530.12
88_I224_E0.5520.12
73_Q112_M0.5520.12
444_I448_S0.5510.12
4_I154_E0.5510.12
85_E397_I0.5510.12
178_D224_E0.5500.12
443_K458_K0.5490.12
18_S303_N0.5490.12
262_Y428_L0.5490.12
74_Y81_P0.5490.12
47_Y161_L0.5480.12
34_C45_S0.5480.12
17_V82_S0.5480.12
21_T293_D0.5480.12
207_V287_V0.5470.12
451_G455_Y0.5460.12
262_Y295_P0.5460.12
42_T53_L0.5460.12
89_M144_T0.5450.12
407_E452_A0.5450.12
115_F135_K0.5440.12
230_F282_P0.5410.12
304_K430_E0.5410.12
84_V367_E0.5410.12
417_G428_L0.5390.12
59_N168_V0.5380.12
71_L218_D0.5380.12
447_L453_R0.5380.12
214_L307_N0.5370.12
131_V446_V0.5370.12
252_P259_R0.5370.12
32_V110_E0.5370.12
41_D96_L0.5350.12
364_L381_I0.5350.12
348_H414_D0.5350.12
220_D416_L0.5330.12
46_Y51_P0.5330.12
32_V183_T0.5330.12
354_Y363_F0.5310.12
161_L466_P0.5310.12
61_Y456_Y0.5290.12
138_V218_D0.5280.12
21_T70_R0.5280.12
220_D331_V0.5280.12
42_T291_Q0.5260.12
255_N434_I0.5260.12
43_P222_D0.5260.12
314_K318_E0.5260.12
53_L57_I0.5250.12
236_R280_Y0.5250.12
390_E468_M0.5240.12
248_V300_L0.5240.12
230_F323_I0.5240.12
137_E436_R0.5230.12
195_S328_F0.5230.12
47_Y94_L0.5230.12
29_G101_Q0.5230.12
16_I284_W0.5230.12
215_P380_R0.5230.12
33_F81_P0.5210.12
87_I448_S0.5190.12
222_D253_L0.5180.12
56_A266_G0.5180.12
448_S457_A0.5180.12
36_G89_M0.5180.12
204_F284_W0.5180.12
184_N207_V0.5170.12
17_V140_C0.5160.12
14_V127_E0.5140.12
21_T33_F0.5140.12
268_E332_G0.5140.12
75_V115_F0.5130.12
201_D388_R0.5130.12
245_T262_Y0.5130.12
270_L418_F0.5130.12
223_L428_L0.5120.12
19_I310_E0.5120.12
42_T47_Y0.5100.12
201_D380_R0.5100.12
374_I418_F0.5100.12
320_G425_S0.5100.12
5_R183_T0.5090.12
53_L267_T0.5080.12
455_Y461_Y0.5060.12
409_P417_G0.5050.12
210_V306_G0.5050.12
272_E318_E0.5050.12
36_G169_E0.5040.11
255_N394_K0.5040.11
109_L112_M0.5040.11
380_R461_Y0.5030.11
21_T216_K0.5020.11
118_Y429_S0.5000.11
200_K229_I0.5000.11
50_E376_Y0.5000.11
392_D440_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fhdA 1 0.5264 99.9 0.899 Contact Map
1oltA 1 0.7548 99.8 0.91 Contact Map
4wcxA 1 0.7336 99.8 0.917 Contact Map
4rtbA 2 0.6321 99.7 0.919 Contact Map
4jc0A 1 0.611 99.7 0.92 Contact Map
1r30A 2 0.5814 99.7 0.921 Contact Map
2qgqA 1 0.5307 99.7 0.923 Contact Map
3iixA 1 0.6068 99.7 0.924 Contact Map
3t7vA 1 0.5772 99.5 0.931 Contact Map
4r33A 2 0.6047 99.5 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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