GREMLIN Database
Q97ZU6 - Uncharacterized protein
UniProt: Q97ZU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (198)
Sequences: 27825 (21904)
Seq/√Len: 1556.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K153_E4.2731.00
132_L136_N2.9281.00
142_E146_R2.8781.00
115_K120_E2.8561.00
167_Y174_E2.6841.00
107_R111_V2.6531.00
4_A149_V2.4851.00
158_G163_D2.4321.00
86_M90_N2.3281.00
142_E145_K2.3001.00
102_V139_P2.1881.00
132_L138_M2.1721.00
7_F99_I2.1621.00
144_I154_S2.1351.00
98_P122_D2.1081.00
107_R129_D2.0971.00
164_V174_E2.0651.00
168_Y194_A2.0571.00
198_D202_E2.0511.00
30_K66_V2.0191.00
103_T110_A1.9781.00
173_R194_A1.9621.00
165_M169_S1.9371.00
123_V146_R1.9241.00
100_A123_V1.9221.00
91_R95_V1.9051.00
150_D153_E1.8571.00
26_I70_I1.8541.00
5_V97_I1.8421.00
156_G167_Y1.7801.00
155_V175_I1.7251.00
144_I172_I1.7201.00
85_V200_L1.6541.00
93_R122_D1.6391.00
6_I143_A1.6171.00
6_I156_G1.6041.00
4_A147_L1.6001.00
149_V154_S1.5741.00
178_V198_D1.5621.00
144_I151_P1.5301.00
6_I102_V1.5261.00
111_V120_E1.5161.00
31_L66_V1.4761.00
175_I197_L1.4401.00
5_V157_V1.4151.00
100_A147_L1.4111.00
82_K179_R1.3951.00
5_V92_L1.3941.00
70_I73_E1.3791.00
185_N189_A1.3771.00
178_V196_I1.3661.00
30_K70_I1.3521.00
13_L85_V1.3491.00
12_T157_V1.3451.00
88_L200_L1.3361.00
161_I165_M1.3261.00
9_L110_A1.3241.00
175_I195_K1.3021.00
9_L14_A1.2931.00
91_R94_D1.2901.00
26_I30_K1.2791.00
49_D52_K1.2731.00
59_H62_K1.2561.00
199_S202_E1.2521.00
140_V156_G1.2501.00
111_V115_K1.2361.00
66_V70_I1.2341.00
26_I74_L1.2331.00
74_L77_T1.2301.00
9_L101_V1.2211.00
137_P141_I1.2211.00
140_V166_A1.2121.00
84_C87_E1.1981.00
6_I154_S1.1911.00
66_V69_E1.1831.00
81_P119_V1.1771.00
27_A31_L1.1731.00
87_E201_C1.1501.00
93_R99_I1.1481.00
62_K66_V1.1461.00
70_I74_L1.1251.00
10_D16_T1.1161.00
140_V172_I1.1121.00
154_S172_I1.1111.00
22_L78_L1.1041.00
4_A98_P1.0891.00
102_V143_A1.0871.00
4_A154_S1.0751.00
65_S69_E1.0701.00
22_L74_L1.0641.00
76_K112_Q1.0631.00
118_N121_P1.0611.00
138_M142_E1.0401.00
22_L26_I1.0301.00
112_Q116_V1.0261.00
9_L105_S1.0181.00
125_I146_R1.0171.00
29_R34_D1.0111.00
25_E29_R1.0101.00
110_A126_T0.9911.00
90_N94_D0.9901.00
69_E73_E0.9871.00
141_I170_A0.9851.00
168_Y174_E0.9841.00
186_V190_R0.9831.00
156_G172_I0.9791.00
140_V158_G0.9701.00
141_I145_K0.9661.00
155_V173_R0.9641.00
26_I29_R0.9581.00
164_V193_D0.9521.00
173_R195_K0.9521.00
87_E90_N0.9481.00
84_C199_S0.9411.00
168_Y192_Y0.9361.00
81_P86_M0.9351.00
10_D105_S0.9311.00
90_N121_P0.9271.00
45_R49_D0.9201.00
162_Y165_M0.9191.00
122_D128_D0.9131.00
141_I151_P0.9101.00
143_A147_L0.9091.00
4_A100_A0.9021.00
138_M141_I0.8941.00
47_T51_A0.8931.00
174_E194_A0.8901.00
107_R126_T0.8871.00
28_L33_Y0.8841.00
82_K177_V0.8841.00
151_P172_I0.8781.00
92_L99_I0.8771.00
48_I52_K0.8691.00
185_N198_D0.8691.00
112_Q115_K0.8661.00
49_D53_I0.8641.00
123_V147_L0.8631.00
92_L97_I0.8631.00
52_K60_A0.8621.00
25_E37_V0.8621.00
107_R128_D0.8621.00
6_I147_L0.8561.00
22_L25_E0.8521.00
47_T50_I0.8501.00
131_K138_M0.8411.00
64_A68_T0.8371.00
40_R43_L0.8371.00
67_K71_Y0.8371.00
9_L113_V0.8331.00
157_V175_I0.8321.00
3_K97_I0.8251.00
197_L203_I0.8221.00
53_I56_G0.8201.00
84_C201_C0.8171.00
10_D103_T0.8131.00
46_K49_D0.8081.00
110_A113_V0.8041.00
179_R200_L0.8021.00
14_A113_V0.8011.00
5_V155_V0.7991.00
45_R53_I0.7931.00
52_K56_G0.7921.00
6_I172_I0.7911.00
21_K25_E0.7911.00
164_V176_I0.7901.00
125_I143_A0.7881.00
157_V203_I0.7861.00
14_A117_I0.7741.00
139_P143_A0.7721.00
38_D41_Y0.7701.00
149_V153_E0.7681.00
103_T126_T0.7661.00
100_A143_A0.7621.00
19_V79_A0.7571.00
71_Y75_V0.7571.00
82_K85_V0.7541.00
175_I203_I0.7541.00
166_A170_A0.7541.00
86_M118_N0.7411.00
140_V163_D0.7361.00
51_A55_I0.7341.00
90_N93_R0.7321.00
176_I196_I0.7251.00
74_L78_L0.7251.00
99_I122_D0.7251.00
130_V142_E0.7231.00
188_E192_Y0.7231.00
10_D159_D0.7221.00
63_L66_V0.7101.00
18_E80_K0.7041.00
81_P117_I0.6991.00
188_E191_K0.6981.00
20_H24_W0.6981.00
61_E65_S0.6981.00
114_L120_E0.6951.00
105_S110_A0.6941.00
6_I100_A0.6901.00
86_M121_P0.6861.00
87_E91_R0.6861.00
187_E190_R0.6851.00
126_T129_D0.6841.00
139_P166_A0.6831.00
11_G17_D0.6821.00
55_I58_S0.6811.00
165_M168_Y0.6801.00
23_A27_A0.6801.00
129_D146_R0.6791.00
98_P149_V0.6741.00
3_K98_P0.6731.00
68_T72_N0.6721.00
31_L62_K0.6711.00
65_S68_T0.6711.00
84_C88_L0.6711.00
104_S133_G0.6701.00
62_K65_S0.6631.00
186_V189_A0.6591.00
122_D126_T0.6551.00
3_K149_V0.6501.00
125_I142_E0.6461.00
15_N80_K0.6441.00
60_A63_L0.6381.00
23_A70_I0.6381.00
88_L157_V0.6301.00
156_G166_A0.6291.00
125_I139_P0.6281.00
48_I61_E0.6271.00
110_A114_L0.6251.00
53_I57_E0.6241.00
15_N18_E0.6211.00
12_T177_V0.6181.00
177_V200_L0.6131.00
156_G163_D0.6131.00
10_D113_V0.6101.00
111_V124_L0.6091.00
151_P154_S0.6081.00
102_V156_G0.6061.00
63_L67_K0.6051.00
197_L200_L0.6051.00
20_H105_S0.6041.00
20_H67_K0.5981.00
7_F88_L0.5981.00
73_E77_T0.5981.00
114_L121_P0.5971.00
130_V139_P0.5971.00
137_P169_S0.5931.00
16_T105_S0.5871.00
14_A79_A0.5791.00
144_I149_V0.5761.00
115_K121_P0.5751.00
72_N108_N0.5741.00
83_P201_C0.5741.00
21_K37_V0.5721.00
165_M191_K0.5641.00
108_N112_Q0.5641.00
141_I144_I0.5631.00
48_I60_A0.5621.00
144_I170_A0.5591.00
73_E76_K0.5591.00
18_E22_L0.5581.00
37_V40_R0.5571.00
72_N112_Q0.5571.00
104_S162_Y0.5571.00
140_V167_Y0.5561.00
76_K116_V0.5541.00
85_V88_L0.5491.00
104_S135_P0.5491.00
85_V89_I0.5491.00
105_S158_G0.5491.00
110_A124_L0.5481.00
88_L91_R0.5481.00
46_K50_I0.5471.00
24_W28_L0.5461.00
6_I140_V0.5451.00
83_P199_S0.5431.00
176_I188_E0.5421.00
105_S109_S0.5411.00
20_H71_Y0.5401.00
185_N188_E0.5401.00
41_Y53_I0.5341.00
89_I99_I0.5341.00
72_N76_K0.5331.00
31_L63_L0.5331.00
50_I53_I0.5301.00
84_C179_R0.5281.00
13_L101_V0.5271.00
123_V126_T0.5261.00
88_L92_L0.5241.00
162_Y166_A0.5221.00
46_K51_A0.5191.00
127_G139_P0.5171.00
166_A169_S0.5161.00
114_L119_V0.5151.00
27_A66_V0.5121.00
17_D40_R0.5111.00
60_A64_A0.5071.00
27_A30_K0.5031.00
5_V99_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iruA 4 1 100 0.273 Contact Map
4uw9A 1 0.9238 100 0.275 Contact Map
1swvA 2 1 100 0.277 Contact Map
4eekA 2 0.9952 100 0.288 Contact Map
3qxgA 3 0.9905 100 0.289 Contact Map
1te2A 2 0.9857 100 0.292 Contact Map
2hdoA 1 0.9619 100 0.293 Contact Map
3s6jA 2 0.9905 100 0.293 Contact Map
3mc1A 2 0.9952 100 0.295 Contact Map
4uavA 1 0.9857 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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