GREMLIN Database
Q97ZU3 - Sec-independent protein translocase protein TatC
UniProt: Q97ZU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (241)
Sequences: 3400 (2144)
Seq/√Len: 138.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_T276_S4.3151.00
234_W270_F4.0691.00
33_A124_I3.9941.00
25_Y29_R3.8591.00
231_L277_K3.7091.00
29_R124_I3.3901.00
127_R131_A3.0651.00
242_F262_G2.9371.00
227_S280_E2.7011.00
22_E26_R2.6281.00
38_F117_A2.5281.00
30_I125_I2.2331.00
237_G269_Y2.1521.00
41_Y116_L2.0551.00
39_M43_M2.0521.00
96_K187_E2.0191.00
219_L224_V2.0151.00
227_S276_S1.9801.00
28_R32_I1.9701.00
226_K229_T1.9601.00
251_G257_I1.9401.00
216_M230_W1.9381.00
55_Y59_G1.9301.00
161_A165_F1.8911.00
37_T117_A1.8881.00
44_L47_E1.8861.00
269_Y273_A1.8761.00
117_A121_T1.8591.00
48_L116_L1.8411.00
238_V266_S1.8361.00
98_I189_T1.8201.00
137_L141_E1.8171.00
27_L31_L1.8051.00
100_I191_G1.7981.00
179_A188_P1.7901.00
29_R128_E1.7831.00
236_W240_V1.7341.00
15_P18_E1.7301.00
149_I153_F1.7181.00
104_D191_G1.7081.00
26_R128_E1.7061.00
34_L114_L1.7031.00
242_F258_E1.7011.00
241_S265_L1.6971.00
225_V230_W1.6731.00
156_F207_G1.6631.00
26_R131_A1.6631.00
101_N104_D1.6611.00
121_T125_I1.6291.00
37_T120_T1.6261.00
231_L234_W1.6001.00
157_A161_A1.5961.00
228_I232_K1.5931.00
152_A211_E1.5911.00
233_N236_W1.5681.00
253_T258_E1.5421.00
229_T233_N1.5251.00
227_S277_K1.5021.00
244_I248_I1.5021.00
134_A142_K1.4931.00
29_R32_I1.4781.00
30_I121_T1.4621.00
220_T227_S1.4611.00
227_S231_L1.4551.00
102_L172_L1.4411.00
99_I105_P1.4381.00
231_L270_F1.4291.00
33_A121_T1.4281.00
279_M283_R1.4251.00
37_T121_T1.4251.00
14_R18_E1.4241.00
40_I43_M1.3661.00
102_L105_P1.3351.00
168_I199_V1.2981.00
34_L125_I1.2801.00
191_G194_S1.2781.00
274_L278_F1.2681.00
109_S178_Y1.2671.00
246_W258_E1.2601.00
239_L243_I1.2491.00
102_L198_T1.2341.00
221_G279_M1.2331.00
34_L121_T1.2321.00
248_I261_I1.2231.00
217_G279_M1.2111.00
56_P195_F1.2111.00
154_L158_L1.2091.00
228_I231_L1.1981.00
101_N194_S1.1941.00
251_G258_E1.1901.00
122_I126_V1.1871.00
176_L188_P1.1821.00
51_V165_F1.1760.99
30_I33_A1.1640.99
103_F175_I1.1570.99
40_I44_L1.1550.99
270_F274_L1.1400.99
216_M276_S1.1370.99
216_M272_G1.1350.99
282_G285_K1.1330.99
160_S203_L1.1260.99
100_I189_T1.1190.99
230_W269_Y1.1160.99
259_T263_I1.1120.99
21_R25_Y1.0990.99
29_R127_R1.0860.99
160_S207_G1.0860.99
32_I35_A1.0850.99
118_I125_I1.0740.99
31_L35_A1.0670.99
45_G109_S1.0610.99
99_I186_V1.0600.99
233_N237_G1.0560.99
132_F135_P1.0380.99
139_E143_K1.0360.99
42_F110_F1.0330.99
136_G141_E1.0320.99
32_I36_I1.0240.99
241_S266_S1.0180.99
212_L241_S1.0100.98
42_F109_S1.0050.98
128_E131_A0.9880.98
227_S273_A0.9820.98
41_Y120_T0.9730.98
22_E128_E0.9640.98
19_H141_E0.9520.98
99_I192_L0.9500.98
19_H132_F0.9480.98
212_L272_G0.9430.98
36_I40_I0.9420.98
249_S261_I0.9390.98
186_V192_L0.9350.97
235_R258_E0.9330.97
99_I104_D0.9320.97
231_L273_A0.9270.97
168_I172_L0.9260.97
27_L30_I0.9170.97
171_M257_I0.9160.97
19_H23_L0.9130.97
132_F136_G0.9060.97
234_W274_L0.9000.97
132_F141_E0.8960.97
249_S258_E0.8960.97
245_A249_S0.8950.97
281_K284_K0.8930.97
258_E262_G0.8920.97
245_A248_I0.8880.97
234_W238_V0.8880.97
246_W249_S0.8830.96
118_I122_I0.8810.96
172_L198_T0.8770.96
35_A39_M0.8760.96
102_L190_L0.8720.96
276_S280_E0.8670.96
171_M175_I0.8630.96
175_I212_L0.8620.96
230_W273_A0.8600.96
238_V262_G0.8520.96
19_H22_E0.8510.96
225_V229_T0.8460.95
122_I125_I0.8390.95
46_L50_R0.8380.95
99_I188_P0.8330.95
130_W145_F0.8300.95
170_L173_R0.8290.95
226_K284_K0.8240.95
26_R136_G0.8150.94
274_L277_K0.8150.94
159_G207_G0.8130.94
205_A248_I0.8110.94
146_K150_F0.8100.94
222_V225_V0.8090.94
238_V270_F0.8070.94
216_M225_V0.8000.94
41_Y44_L0.7990.94
152_A214_L0.7930.94
209_S265_L0.7930.94
16_L25_Y0.7920.94
101_N193_R0.7920.94
241_S245_A0.7920.94
49_V53_L0.7920.94
252_T258_E0.7860.93
240_V243_I0.7850.93
24_A28_R0.7840.93
111_Y197_S0.7840.93
19_H135_P0.7740.93
138_Y141_E0.7730.93
119_F160_S0.7700.93
34_L118_I0.7700.93
170_L260_V0.7690.92
99_I179_A0.7640.92
144_L147_S0.7630.92
22_E132_F0.7630.92
252_T257_I0.7620.92
228_I277_K0.7610.92
50_R53_L0.7580.92
43_M113_S0.7580.92
145_F149_I0.7550.92
105_P178_Y0.7530.92
37_T41_Y0.7530.92
49_V58_F0.7470.91
212_L265_L0.7410.91
38_F114_L0.7350.91
167_L206_T0.7350.91
179_A186_V0.7320.91
53_L58_F0.7300.90
47_E51_V0.7300.90
55_Y165_F0.7280.90
242_F266_S0.7250.90
176_L190_L0.7220.90
245_A262_G0.7210.90
106_L178_Y0.7180.90
59_G90_E0.7120.89
247_I253_T0.7120.89
158_L161_A0.7110.89
122_I153_F0.7100.89
134_A138_Y0.7080.89
145_F153_F0.7040.89
124_I128_E0.7040.89
162_F272_G0.6990.88
56_P102_L0.6980.88
281_K285_K0.6970.88
10_K13_E0.6940.88
235_R238_V0.6940.88
43_M47_E0.6930.88
197_S201_T0.6920.88
173_R177_L0.6920.88
47_E50_R0.6890.88
144_L218_G0.6890.88
11_L14_R0.6880.88
118_I152_A0.6860.87
19_H136_G0.6830.87
33_A125_I0.6780.87
42_F113_S0.6750.87
113_S116_L0.6670.86
201_T204_I0.6670.86
179_A185_A0.6660.86
263_I267_T0.6660.86
202_L206_T0.6630.86
107_F111_Y0.6610.85
210_F268_L0.6590.85
100_I104_D0.6560.85
114_L118_I0.6540.85
192_L214_L0.6540.85
40_I120_T0.6530.85
37_T40_I0.6510.85
217_G275_I0.6490.84
132_F137_L0.6430.84
105_P188_P0.6400.84
153_F157_A0.6370.83
155_L268_L0.6360.83
49_V112_I0.6340.83
133_V145_F0.6310.83
209_S261_I0.6300.83
42_F46_L0.6280.82
104_D108_A0.6270.82
163_A206_T0.6240.82
171_M235_R0.6240.82
130_W167_L0.6240.82
108_A112_I0.6190.82
168_I264_T0.6180.81
251_G259_T0.6170.81
282_G286_E0.6160.81
220_T230_W0.6150.81
105_P186_V0.6110.81
52_Y216_M0.6100.81
118_I204_I0.6090.81
126_V152_A0.6080.80
117_A144_L0.6060.80
156_F211_E0.6050.80
44_L50_R0.6050.80
42_F105_P0.6040.80
96_K189_T0.6030.80
30_I117_A0.5990.79
46_L109_S0.5990.79
22_E136_G0.5960.79
260_V265_L0.5940.79
172_L178_Y0.5920.79
51_V157_A0.5880.78
44_L48_L0.5870.78
238_V242_F0.5860.78
115_Y119_F0.5850.78
115_Y200_M0.5850.78
266_S270_F0.5830.78
103_F107_F0.5820.77
16_L21_R0.5800.77
17_I20_L0.5760.77
57_F162_F0.5730.76
26_R135_P0.5720.76
201_T257_I0.5700.76
234_W273_A0.5700.76
109_S186_V0.5690.76
220_T280_E0.5690.76
163_A202_L0.5670.76
104_D190_L0.5660.76
105_P130_W0.5630.75
50_R55_Y0.5630.75
41_Y117_A0.5580.74
176_L179_A0.5560.74
149_I196_V0.5550.74
22_E135_P0.5540.74
167_L231_L0.5520.74
126_V130_W0.5520.74
16_L115_Y0.5520.74
188_P191_G0.5500.73
135_P195_F0.5490.73
14_R17_I0.5490.73
196_V274_L0.5470.73
147_S150_F0.5470.73
29_R33_A0.5470.73
17_I21_R0.5470.73
159_G210_F0.5450.73
215_I219_L0.5440.73
55_Y58_F0.5430.73
104_D193_R0.5430.73
19_H137_L0.5410.72
16_L132_F0.5410.72
245_A265_L0.5400.72
170_L258_E0.5380.72
245_A256_I0.5370.72
151_P214_L0.5350.71
233_N240_V0.5340.71
117_A122_I0.5330.71
92_P95_V0.5320.71
11_L143_K0.5310.71
156_F159_G0.5280.70
249_S257_I0.5280.70
221_G275_I0.5250.70
36_I39_M0.5250.70
216_M268_L0.5250.70
19_H26_R0.5240.70
206_T261_I0.5230.70
108_A192_L0.5230.70
135_P141_E0.5220.70
242_F259_T0.5220.70
41_Y113_S0.5220.70
239_L246_W0.5220.70
227_S234_W0.5220.70
172_L189_T0.5200.69
52_Y199_V0.5200.69
101_N114_L0.5190.69
101_N172_L0.5190.69
280_E284_K0.5180.69
160_S208_L0.5170.69
46_L99_I0.5170.69
270_F273_A0.5150.69
278_F281_K0.5140.68
237_G240_V0.5140.68
246_W259_T0.5130.68
259_T262_G0.5120.68
38_F113_S0.5110.68
162_F268_L0.5100.68
170_L272_G0.5100.68
257_I261_I0.5100.68
248_I258_E0.5090.68
18_E21_R0.5080.68
166_L260_V0.5050.67
152_A203_L0.5030.67
273_A276_S0.5030.67
22_E131_A0.5020.67
245_A251_G0.5000.66
128_E141_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.7585 100 0.161 Contact Map
4b4aA 1 0.7585 100 0.172 Contact Map
1pw4A 1 0.6973 18.5 0.961 Contact Map
2kluA 1 0.1497 14.2 0.963 Contact Map
2kncA 1 0.1531 13.6 0.963 Contact Map
2rddB 1 0.1259 13.3 0.964 Contact Map
4m64A 1 0.7211 10.8 0.965 Contact Map
2zy9A 2 0.6293 10.5 0.965 Contact Map
2l0eA 1 0.1054 9.8 0.966 Contact Map
2m7xA 1 0.102 9.5 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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