Q97ZU3 - SULSO - GREMLIN Contacts

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Q97ZU3 - Sec-independent protein translocase protein TatC

UniProt:	Q97ZU3	Sequences: MTERTREVEKLEERPLIEHLRELAYRLRRILIALAITFMIYFMLGLELVRVYLPYPFFGLKYVLAEVPVLYPSLFDSISVQLTQLFIYNELPKGVKLIIINLFDPLFASFYISLYLAIFTTIPIIVREIWAFVAPGLYEHEKKLFKSIIFPAFLLFALGSAFAYFLLIPLMLRIILLYATALGSAVEPTLGLRSFVSTVMTLLIATGLSFELPLIMGGLTGVGVVKSITWLKNWRWGVLVSFIIAWIISPGTTGGIIETVIGITLSTLYFIGALISKFMEKGRKKESQKTLERI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	294 (241)
Sequences:	3400 (2144)
Seq/√Len:	138.1

ECOLI - TATC
BACSU - TATCY TATCD
HALSA - Q9HN36
SULSO - Q97ZU3 Q97UB0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_T	276_S	4.315	1.00
234_W	270_F	4.069	1.00
33_A	124_I	3.994	1.00
25_Y	29_R	3.859	1.00
231_L	277_K	3.709	1.00
29_R	124_I	3.390	1.00
127_R	131_A	3.065	1.00
242_F	262_G	2.937	1.00
227_S	280_E	2.701	1.00
22_E	26_R	2.628	1.00
38_F	117_A	2.528	1.00
30_I	125_I	2.233	1.00
237_G	269_Y	2.152	1.00
41_Y	116_L	2.055	1.00
39_M	43_M	2.052	1.00
96_K	187_E	2.019	1.00
219_L	224_V	2.015	1.00
227_S	276_S	1.980	1.00
28_R	32_I	1.970	1.00
226_K	229_T	1.960	1.00
251_G	257_I	1.940	1.00
216_M	230_W	1.938	1.00
55_Y	59_G	1.930	1.00
161_A	165_F	1.891	1.00
37_T	117_A	1.888	1.00
44_L	47_E	1.886	1.00
269_Y	273_A	1.876	1.00
117_A	121_T	1.859	1.00
48_L	116_L	1.841	1.00
238_V	266_S	1.836	1.00
98_I	189_T	1.820	1.00
137_L	141_E	1.817	1.00
27_L	31_L	1.805	1.00
100_I	191_G	1.798	1.00
179_A	188_P	1.790	1.00
29_R	128_E	1.783	1.00
236_W	240_V	1.734	1.00
15_P	18_E	1.730	1.00
149_I	153_F	1.718	1.00
104_D	191_G	1.708	1.00
26_R	128_E	1.706	1.00
34_L	114_L	1.703	1.00
242_F	258_E	1.701	1.00
241_S	265_L	1.697	1.00
225_V	230_W	1.673	1.00
156_F	207_G	1.663	1.00
26_R	131_A	1.663	1.00
101_N	104_D	1.661	1.00
121_T	125_I	1.629	1.00
37_T	120_T	1.626	1.00
231_L	234_W	1.600	1.00
157_A	161_A	1.596	1.00
228_I	232_K	1.593	1.00
152_A	211_E	1.591	1.00
233_N	236_W	1.568	1.00
253_T	258_E	1.542	1.00
229_T	233_N	1.525	1.00
227_S	277_K	1.502	1.00
244_I	248_I	1.502	1.00
134_A	142_K	1.493	1.00
29_R	32_I	1.478	1.00
30_I	121_T	1.462	1.00
220_T	227_S	1.461	1.00
227_S	231_L	1.455	1.00
102_L	172_L	1.441	1.00
99_I	105_P	1.438	1.00
231_L	270_F	1.429	1.00
33_A	121_T	1.428	1.00
279_M	283_R	1.425	1.00
37_T	121_T	1.425	1.00
14_R	18_E	1.424	1.00
40_I	43_M	1.366	1.00
102_L	105_P	1.335	1.00
168_I	199_V	1.298	1.00
34_L	125_I	1.280	1.00
191_G	194_S	1.278	1.00
274_L	278_F	1.268	1.00
109_S	178_Y	1.267	1.00
246_W	258_E	1.260	1.00
239_L	243_I	1.249	1.00
102_L	198_T	1.234	1.00
221_G	279_M	1.233	1.00
34_L	121_T	1.232	1.00
248_I	261_I	1.223	1.00
217_G	279_M	1.211	1.00
56_P	195_F	1.211	1.00
154_L	158_L	1.209	1.00
228_I	231_L	1.198	1.00
101_N	194_S	1.194	1.00
251_G	258_E	1.190	1.00
122_I	126_V	1.187	1.00
176_L	188_P	1.182	1.00
51_V	165_F	1.176	0.99
30_I	33_A	1.164	0.99
103_F	175_I	1.157	0.99
40_I	44_L	1.155	0.99
270_F	274_L	1.140	0.99
216_M	276_S	1.137	0.99
216_M	272_G	1.135	0.99
282_G	285_K	1.133	0.99
160_S	203_L	1.126	0.99
100_I	189_T	1.119	0.99
230_W	269_Y	1.116	0.99
259_T	263_I	1.112	0.99
21_R	25_Y	1.099	0.99
29_R	127_R	1.086	0.99
160_S	207_G	1.086	0.99
32_I	35_A	1.085	0.99
118_I	125_I	1.074	0.99
31_L	35_A	1.067	0.99
45_G	109_S	1.061	0.99
99_I	186_V	1.060	0.99
233_N	237_G	1.056	0.99
132_F	135_P	1.038	0.99
139_E	143_K	1.036	0.99
42_F	110_F	1.033	0.99
136_G	141_E	1.032	0.99
32_I	36_I	1.024	0.99
241_S	266_S	1.018	0.99
212_L	241_S	1.010	0.98
42_F	109_S	1.005	0.98
128_E	131_A	0.988	0.98
227_S	273_A	0.982	0.98
41_Y	120_T	0.973	0.98
22_E	128_E	0.964	0.98
19_H	141_E	0.952	0.98
99_I	192_L	0.950	0.98
19_H	132_F	0.948	0.98
212_L	272_G	0.943	0.98
36_I	40_I	0.942	0.98
249_S	261_I	0.939	0.98
186_V	192_L	0.935	0.97
235_R	258_E	0.933	0.97
99_I	104_D	0.932	0.97
231_L	273_A	0.927	0.97
168_I	172_L	0.926	0.97
27_L	30_I	0.917	0.97
171_M	257_I	0.916	0.97
19_H	23_L	0.913	0.97
132_F	136_G	0.906	0.97
234_W	274_L	0.900	0.97
132_F	141_E	0.896	0.97
249_S	258_E	0.896	0.97
245_A	249_S	0.895	0.97
281_K	284_K	0.893	0.97
258_E	262_G	0.892	0.97
245_A	248_I	0.888	0.97
234_W	238_V	0.888	0.97
246_W	249_S	0.883	0.96
118_I	122_I	0.881	0.96
172_L	198_T	0.877	0.96
35_A	39_M	0.876	0.96
102_L	190_L	0.872	0.96
276_S	280_E	0.867	0.96
171_M	175_I	0.863	0.96
175_I	212_L	0.862	0.96
230_W	273_A	0.860	0.96
238_V	262_G	0.852	0.96
19_H	22_E	0.851	0.96
225_V	229_T	0.846	0.95
122_I	125_I	0.839	0.95
46_L	50_R	0.838	0.95
99_I	188_P	0.833	0.95
130_W	145_F	0.830	0.95
170_L	173_R	0.829	0.95
226_K	284_K	0.824	0.95
26_R	136_G	0.815	0.94
274_L	277_K	0.815	0.94
159_G	207_G	0.813	0.94
205_A	248_I	0.811	0.94
146_K	150_F	0.810	0.94
222_V	225_V	0.809	0.94
238_V	270_F	0.807	0.94
216_M	225_V	0.800	0.94
41_Y	44_L	0.799	0.94
152_A	214_L	0.793	0.94
209_S	265_L	0.793	0.94
16_L	25_Y	0.792	0.94
101_N	193_R	0.792	0.94
241_S	245_A	0.792	0.94
49_V	53_L	0.792	0.94
252_T	258_E	0.786	0.93
240_V	243_I	0.785	0.93
24_A	28_R	0.784	0.93
111_Y	197_S	0.784	0.93
19_H	135_P	0.774	0.93
138_Y	141_E	0.773	0.93
119_F	160_S	0.770	0.93
34_L	118_I	0.770	0.93
170_L	260_V	0.769	0.92
99_I	179_A	0.764	0.92
144_L	147_S	0.763	0.92
22_E	132_F	0.763	0.92
252_T	257_I	0.762	0.92
228_I	277_K	0.761	0.92
50_R	53_L	0.758	0.92
43_M	113_S	0.758	0.92
145_F	149_I	0.755	0.92
105_P	178_Y	0.753	0.92
37_T	41_Y	0.753	0.92
49_V	58_F	0.747	0.91
212_L	265_L	0.741	0.91
38_F	114_L	0.735	0.91
167_L	206_T	0.735	0.91
179_A	186_V	0.732	0.91
53_L	58_F	0.730	0.90
47_E	51_V	0.730	0.90
55_Y	165_F	0.728	0.90
242_F	266_S	0.725	0.90
176_L	190_L	0.722	0.90
245_A	262_G	0.721	0.90
106_L	178_Y	0.718	0.90
59_G	90_E	0.712	0.89
247_I	253_T	0.712	0.89
158_L	161_A	0.711	0.89
122_I	153_F	0.710	0.89
134_A	138_Y	0.708	0.89
145_F	153_F	0.704	0.89
124_I	128_E	0.704	0.89
162_F	272_G	0.699	0.88
56_P	102_L	0.698	0.88
281_K	285_K	0.697	0.88
10_K	13_E	0.694	0.88
235_R	238_V	0.694	0.88
43_M	47_E	0.693	0.88
197_S	201_T	0.692	0.88
173_R	177_L	0.692	0.88
47_E	50_R	0.689	0.88
144_L	218_G	0.689	0.88
11_L	14_R	0.688	0.88
118_I	152_A	0.686	0.87
19_H	136_G	0.683	0.87
33_A	125_I	0.678	0.87
42_F	113_S	0.675	0.87
113_S	116_L	0.667	0.86
201_T	204_I	0.667	0.86
179_A	185_A	0.666	0.86
263_I	267_T	0.666	0.86
202_L	206_T	0.663	0.86
107_F	111_Y	0.661	0.85
210_F	268_L	0.659	0.85
100_I	104_D	0.656	0.85
114_L	118_I	0.654	0.85
192_L	214_L	0.654	0.85
40_I	120_T	0.653	0.85
37_T	40_I	0.651	0.85
217_G	275_I	0.649	0.84
132_F	137_L	0.643	0.84
105_P	188_P	0.640	0.84
153_F	157_A	0.637	0.83
155_L	268_L	0.636	0.83
49_V	112_I	0.634	0.83
133_V	145_F	0.631	0.83
209_S	261_I	0.630	0.83
42_F	46_L	0.628	0.82
104_D	108_A	0.627	0.82
163_A	206_T	0.624	0.82
171_M	235_R	0.624	0.82
130_W	167_L	0.624	0.82
108_A	112_I	0.619	0.82
168_I	264_T	0.618	0.81
251_G	259_T	0.617	0.81
282_G	286_E	0.616	0.81
220_T	230_W	0.615	0.81
105_P	186_V	0.611	0.81
52_Y	216_M	0.610	0.81
118_I	204_I	0.609	0.81
126_V	152_A	0.608	0.80
117_A	144_L	0.606	0.80
156_F	211_E	0.605	0.80
44_L	50_R	0.605	0.80
42_F	105_P	0.604	0.80
96_K	189_T	0.603	0.80
30_I	117_A	0.599	0.79
46_L	109_S	0.599	0.79
22_E	136_G	0.596	0.79
260_V	265_L	0.594	0.79
172_L	178_Y	0.592	0.79
51_V	157_A	0.588	0.78
44_L	48_L	0.587	0.78
238_V	242_F	0.586	0.78
115_Y	119_F	0.585	0.78
115_Y	200_M	0.585	0.78
266_S	270_F	0.583	0.78
103_F	107_F	0.582	0.77
16_L	21_R	0.580	0.77
17_I	20_L	0.576	0.77
57_F	162_F	0.573	0.76
26_R	135_P	0.572	0.76
201_T	257_I	0.570	0.76
234_W	273_A	0.570	0.76
109_S	186_V	0.569	0.76
220_T	280_E	0.569	0.76
163_A	202_L	0.567	0.76
104_D	190_L	0.566	0.76
105_P	130_W	0.563	0.75
50_R	55_Y	0.563	0.75
41_Y	117_A	0.558	0.74
176_L	179_A	0.556	0.74
149_I	196_V	0.555	0.74
22_E	135_P	0.554	0.74
167_L	231_L	0.552	0.74
126_V	130_W	0.552	0.74
16_L	115_Y	0.552	0.74
188_P	191_G	0.550	0.73
135_P	195_F	0.549	0.73
14_R	17_I	0.549	0.73
196_V	274_L	0.547	0.73
147_S	150_F	0.547	0.73
29_R	33_A	0.547	0.73
17_I	21_R	0.547	0.73
159_G	210_F	0.545	0.73
215_I	219_L	0.544	0.73
55_Y	58_F	0.543	0.73
104_D	193_R	0.543	0.73
19_H	137_L	0.541	0.72
16_L	132_F	0.541	0.72
245_A	265_L	0.540	0.72
170_L	258_E	0.538	0.72
245_A	256_I	0.537	0.72
151_P	214_L	0.535	0.71
233_N	240_V	0.534	0.71
117_A	122_I	0.533	0.71
92_P	95_V	0.532	0.71
11_L	143_K	0.531	0.71
156_F	159_G	0.528	0.70
249_S	257_I	0.528	0.70
221_G	275_I	0.525	0.70
36_I	39_M	0.525	0.70
216_M	268_L	0.525	0.70
19_H	26_R	0.524	0.70
206_T	261_I	0.523	0.70
108_A	192_L	0.523	0.70
135_P	141_E	0.522	0.70
242_F	259_T	0.522	0.70
41_Y	113_S	0.522	0.70
239_L	246_W	0.522	0.70
227_S	234_W	0.522	0.70
172_L	189_T	0.520	0.69
52_Y	199_V	0.520	0.69
101_N	114_L	0.519	0.69
101_N	172_L	0.519	0.69
280_E	284_K	0.518	0.69
160_S	208_L	0.517	0.69
46_L	99_I	0.517	0.69
270_F	273_A	0.515	0.69
278_F	281_K	0.514	0.68
237_G	240_V	0.514	0.68
246_W	259_T	0.513	0.68
259_T	262_G	0.512	0.68
38_F	113_S	0.511	0.68
162_F	268_L	0.510	0.68
170_L	272_G	0.510	0.68
257_I	261_I	0.510	0.68
248_I	258_E	0.509	0.68
18_E	21_R	0.508	0.68
166_L	260_V	0.505	0.67
152_A	203_L	0.503	0.67
273_A	276_S	0.503	0.67
22_E	131_A	0.502	0.67
245_A	251_G	0.500	0.66
128_E	141_E	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4httA	1	0.7585	100	0.161	Contact Map
4b4aA	1	0.7585	100	0.172	Contact Map
1pw4A	1	0.6973	18.5	0.961	Contact Map
2kluA	1	0.1497	14.2	0.963	Contact Map
2kncA	1	0.1531	13.6	0.963	Contact Map
2rddB	1	0.1259	13.3	0.964	Contact Map
4m64A	1	0.7211	10.8	0.965	Contact Map
2zy9A	2	0.6293	10.5	0.965	Contact Map
2l0eA	1	0.1054	9.8	0.966	Contact Map
2m7xA	1	0.102	9.5	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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