GREMLIN Database
Q97ZU2 - ABC transporter
UniProt: Q97ZU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (275)
Sequences: 14285 (11747)
Seq/√Len: 708.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_G161_A4.3201.00
149_L162_Q4.3001.00
145_E169_N4.1711.00
235_K258_K4.0851.00
157_V160_K3.5371.00
171_K288_Q3.4811.00
153_E158_T3.2531.00
258_K262_S3.1661.00
45_S51_T3.0401.00
149_L165_I2.9011.00
173_S177_T2.7901.00
160_K163_Q2.6771.00
166_D170_Q2.6421.00
162_Q166_D2.6151.00
208_I213_G2.5821.00
100_G103_L2.5311.00
230_P233_I2.3481.00
44_V101_L2.2641.00
43_I155_F2.1791.00
169_N173_S2.1441.00
54_L155_F2.1381.00
205_N209_V2.1061.00
174_D178_A2.0801.00
59_L155_F2.0301.00
32_L124_K2.0161.00
185_Y214_I2.0111.00
170_Q174_D1.9961.00
122_Q125_E1.9921.00
42_R64_V1.9511.00
237_S258_K1.9471.00
257_Y260_I1.9391.00
53_I148_I1.9381.00
59_L157_V1.9011.00
163_Q167_W1.8691.00
120_I124_K1.8541.00
110_V151_V1.8431.00
238_V266_Y1.8321.00
143_Q146_N1.7771.00
171_K285_Y1.7491.00
238_V264_N1.7481.00
173_S176_S1.7281.00
167_W171_K1.6601.00
159_S163_Q1.6501.00
258_K261_N1.6291.00
117_G121_E1.6121.00
254_I260_I1.5871.00
96_P101_L1.5761.00
160_K164_L1.5361.00
248_T251_N1.5331.00
146_N149_L1.5291.00
19_V22_V1.5161.00
256_Q261_N1.4991.00
44_V104_L1.4921.00
121_E125_E1.4801.00
102_L126_A1.4661.00
26_Y31_T1.4601.00
97_N100_G1.4581.00
266_Y293_I1.4571.00
88_T100_G1.4571.00
184_A188_W1.4431.00
65_G104_L1.4371.00
41_L62_Y1.4231.00
64_V104_L1.4231.00
146_N150_K1.4171.00
145_E165_I1.4081.00
45_S54_L1.4081.00
159_S162_Q1.3891.00
166_D169_N1.3891.00
99_S229_S1.3841.00
36_T39_N1.3761.00
249_Y252_Y1.3591.00
158_T162_Q1.3441.00
230_P234_I1.3391.00
183_V214_I1.3351.00
172_I287_I1.3331.00
121_E124_K1.3291.00
175_F287_I1.3191.00
174_D177_T1.3111.00
249_Y253_L1.3051.00
213_G294_I1.2951.00
171_K174_D1.2891.00
20_I24_Y1.2871.00
57_L157_V1.2841.00
239_V259_G1.2701.00
42_R105_H1.2631.00
170_Q173_S1.2591.00
187_L197_T1.2521.00
149_L169_N1.2511.00
67_D70_S1.2491.00
98_I122_Q1.2481.00
40_N107_T1.2471.00
164_L167_W1.2441.00
44_V65_G1.2371.00
219_N234_I1.2241.00
54_L59_L1.2211.00
74_L77_L1.2201.00
150_K153_E1.2201.00
41_L107_T1.2171.00
217_F234_I1.2161.00
216_V234_I1.2091.00
238_V294_I1.2091.00
148_I161_A1.2031.00
165_I169_N1.2001.00
194_S225_L1.1751.00
62_Y157_V1.1621.00
28_S31_T1.1401.00
43_I108_V1.1301.00
176_S210_Q1.1181.00
246_N249_Y1.1061.00
13_I16_V1.1021.00
200_G209_V1.0981.00
175_F291_K1.0981.00
54_L63_I1.0921.00
186_L208_I1.0761.00
167_W170_Q1.0751.00
289_V292_L1.0731.00
20_I23_Y1.0711.00
185_Y189_I1.0711.00
54_L110_V1.0671.00
150_K154_Y1.0671.00
55_I76_S1.0651.00
55_I60_G1.0611.00
184_A264_N1.0551.00
12_A15_I1.0401.00
185_Y237_S1.0361.00
131_L154_Y1.0331.00
25_Y28_S1.0291.00
288_Q292_L1.0261.00
181_V184_A1.0251.00
52_Q282_L1.0231.00
76_S79_L1.0201.00
172_I176_S1.0191.00
254_I257_Y1.0181.00
68_Y89_V1.0091.00
250_T253_L1.0091.00
36_T40_N1.0071.00
216_V219_N0.9971.00
152_G165_I0.9971.00
56_S164_L0.9951.00
248_T252_Y0.9821.00
214_I218_A0.9781.00
109_I127_G0.9721.00
185_Y190_C0.9711.00
179_G183_V0.9601.00
149_L153_E0.9581.00
27_K30_S0.9521.00
131_L150_K0.9491.00
240_I290_I0.9461.00
39_N157_V0.9451.00
247_L251_N0.9441.00
202_V205_N0.9391.00
119_Y122_Q0.9301.00
241_A267_I0.9291.00
274_N277_N0.9271.00
171_K175_F0.9271.00
140_T143_Q0.9271.00
151_V155_F0.9231.00
168_M172_I0.9221.00
139_S142_S0.9201.00
206_S210_Q0.9181.00
247_L250_T0.9061.00
36_T129_N0.9031.00
57_L164_L0.9031.00
147_C150_K0.9031.00
258_K264_N0.8991.00
206_S209_V0.8971.00
184_A191_P0.8921.00
52_Q280_G0.8921.00
55_I63_I0.8891.00
174_D288_Q0.8811.00
11_V15_I0.8781.00
75_Q78_N0.8741.00
27_K31_T0.8741.00
109_I128_L0.8731.00
178_A291_K0.8721.00
168_M210_Q0.8721.00
255_S260_I0.8691.00
269_G289_V0.8621.00
47_A112_E0.8571.00
40_N108_V0.8571.00
26_Y29_S0.8541.00
161_A165_I0.8511.00
60_G86_N0.8511.00
32_L120_I0.8511.00
106_P109_I0.8501.00
72_Q76_S0.8501.00
39_N156_N0.8431.00
53_I151_V0.8421.00
59_L62_Y0.8401.00
142_S146_N0.8381.00
45_S63_I0.8331.00
17_V20_I0.8281.00
260_I265_L0.8251.00
43_I54_L0.8131.00
185_Y188_W0.8121.00
162_Q165_I0.8111.00
282_L285_Y0.8021.00
66_T87_I0.8021.00
197_T217_F0.7981.00
286_S289_V0.7971.00
187_L190_C0.7941.00
108_V131_L0.7941.00
289_V293_I0.7931.00
50_D110_V0.7931.00
66_T89_V0.7911.00
207_I287_I0.7891.00
186_L213_G0.7871.00
16_V19_V0.7861.00
46_L109_I0.7831.00
145_E149_L0.7811.00
186_L190_C0.7791.00
246_N250_T0.7751.00
280_G285_Y0.7741.00
18_S21_S0.7731.00
172_I210_Q0.7721.00
163_Q166_D0.7691.00
145_E172_I0.7671.00
77_L80_T0.7661.00
102_L128_L0.7651.00
75_Q79_L0.7591.00
110_V154_Y0.7581.00
108_V154_Y0.7581.00
184_A189_I0.7541.00
226_L234_I0.7541.00
201_N205_N0.7521.00
183_V186_L0.7501.00
244_V270_N0.7501.00
60_G63_I0.7501.00
198_A223_Y0.7461.00
164_L168_M0.7451.00
240_I266_Y0.7451.00
38_N41_L0.7421.00
149_L152_G0.7421.00
232_L236_P0.7411.00
9_T12_A0.7401.00
25_Y29_S0.7401.00
217_F220_Y0.7371.00
25_Y33_Q0.7351.00
279_P284_V0.7351.00
186_L189_I0.7291.00
227_T230_P0.7291.00
57_L155_F0.7281.00
57_L148_I0.7271.00
109_I126_A0.7251.00
148_I164_L0.7241.00
217_F230_P0.7241.00
151_V154_Y0.7171.00
8_G11_V0.7151.00
129_N133_T0.7131.00
19_V23_Y0.7131.00
57_L160_K0.7091.00
232_L256_Q0.7081.00
27_K33_Q0.7081.00
232_L257_Y0.7011.00
133_T150_K0.7001.00
241_A265_L0.6991.00
215_N219_N0.6951.00
187_L191_P0.6941.00
280_G284_V0.6941.00
276_L279_P0.6901.00
188_W191_P0.6891.00
231_L257_Y0.6891.00
290_I294_I0.6891.00
184_A213_G0.6881.00
43_I62_Y0.6881.00
58_G160_K0.6861.00
14_I18_S0.6851.00
200_G218_A0.6831.00
142_S145_E0.6801.00
56_S148_I0.6751.00
98_I119_Y0.6721.00
179_G182_S0.6711.00
144_I168_M0.6711.00
14_I17_V0.6691.00
185_Y191_P0.6681.00
58_G157_V0.6671.00
211_A294_I0.6671.00
26_Y30_S0.6651.00
246_N251_N0.6631.00
228_P254_I0.6621.00
211_A287_I0.6611.00
118_S121_E0.6601.00
25_Y31_T0.6601.00
10_I13_I0.6551.00
42_R107_T0.6551.00
176_S211_A0.6451.00
101_L123_M0.6431.00
9_T13_I0.6431.00
188_W208_I0.6411.00
11_V14_I0.6401.00
145_E168_M0.6391.00
113_K134_N0.6381.00
181_V185_Y0.6351.00
15_I18_S0.6301.00
116_I119_Y0.6281.00
62_Y155_F0.6281.00
184_A238_V0.6251.00
57_L161_A0.6231.00
21_S24_Y0.6211.00
18_S22_V0.6181.00
44_V90_F0.6171.00
198_A202_V0.6161.00
109_I130_V0.6141.00
12_A16_V0.6141.00
20_I26_Y0.6131.00
180_N184_A0.6121.00
243_E267_I0.6121.00
111_V132_I0.6111.00
73_L76_S0.6111.00
171_K284_V0.6081.00
165_I168_M0.6081.00
65_G91_S0.6071.00
269_G274_N0.6061.00
213_G238_V0.6051.00
280_G283_S0.6051.00
186_L191_P0.6001.00
54_L151_V0.5991.00
58_G61_K0.5981.00
76_S80_T0.5951.00
36_T154_Y0.5951.00
8_G12_A0.5951.00
44_V64_V0.5941.00
13_I17_V0.5931.00
200_G220_Y0.5901.00
155_F158_T0.5901.00
57_L152_G0.5891.00
180_N183_V0.5861.00
39_N107_T0.5851.00
92_Q95_P0.5851.00
148_I165_I0.5841.00
26_Y32_L0.5831.00
279_P282_L0.5821.00
40_N155_F0.5821.00
63_I87_I0.5781.00
74_L78_N0.5771.00
10_I14_I0.5761.00
45_S50_D0.5751.00
44_V106_P0.5751.00
235_K259_G0.5741.00
183_V188_W0.5731.00
124_K130_V0.5721.00
50_D53_I0.5721.00
53_I56_S0.5701.00
144_I148_I0.5701.00
200_G219_N0.5691.00
44_V109_I0.5671.00
46_L90_F0.5651.00
203_F206_S0.5651.00
96_P119_Y0.5641.00
36_T108_V0.5641.00
50_D151_V0.5631.00
17_V22_V0.5621.00
12_A18_S0.5611.00
197_T226_L0.5611.00
199_G205_N0.5601.00
100_G104_L0.5591.00
198_A204_I0.5581.00
98_I101_L0.5571.00
30_S124_K0.5571.00
144_I283_S0.5571.00
99_S102_L0.5541.00
191_P194_S0.5531.00
133_T147_C0.5481.00
240_I294_I0.5461.00
127_G130_V0.5451.00
279_P286_S0.5441.00
111_V116_I0.5431.00
145_E210_Q0.5431.00
149_L158_T0.5411.00
91_S96_P0.5411.00
69_Y73_L0.5401.00
236_P239_V0.5391.00
188_W242_Q0.5381.00
175_F284_V0.5361.00
90_F104_L0.5361.00
215_N218_A0.5331.00
40_N43_I0.5321.00
168_M171_K0.5321.00
168_M284_V0.5311.00
10_I16_V0.5301.00
239_V254_I0.5261.00
185_Y216_V0.5251.00
198_A205_N0.5251.00
175_F211_A0.5251.00
124_K129_N0.5251.00
70_S73_L0.5241.00
175_F178_A0.5241.00
16_V20_I0.5231.00
279_P283_S0.5221.00
183_V187_L0.5211.00
196_Y225_L0.5211.00
120_I130_V0.5201.00
102_L229_S0.5181.00
254_I265_L0.5181.00
277_N280_G0.5181.00
285_Y289_V0.5171.00
34_P129_N0.5161.00
98_I126_A0.5151.00
42_R106_P0.5151.00
242_Q268_I0.5131.00
111_V131_L0.5131.00
238_V293_I0.5131.00
111_V115_L0.5110.99
196_Y223_Y0.5100.99
184_A190_C0.5090.99
9_T16_V0.5070.99
37_V129_N0.5070.99
25_Y30_S0.5050.99
207_I283_S0.5040.99
110_V133_T0.5030.99
185_Y213_G0.5010.99
75_Q80_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hn9A 1 0.9654 100 0.241 Contact Map
4pagA 2 0.9057 100 0.254 Contact Map
4n01A 1 0.8333 100 0.256 Contact Map
3pshA 1 0.9182 100 0.258 Contact Map
4ovkA 1 0.9151 100 0.262 Contact Map
4mo9A 1 0.9057 100 0.264 Contact Map
4mlzA 1 0.8428 100 0.289 Contact Map
2etvA 2 0.8553 100 0.295 Contact Map
4inoA 1 0.8836 100 0.296 Contact Map
4m7oA 1 0.7736 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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