Q97ZU1 - SULSO - GREMLIN Contacts

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Q97ZU1 - Iron (III) ABC transporter, permease protein (HEMU 1)

UniProt:	Q97ZU1	Sequences: MVRLSGIFLIIGFIISFLLGLLYGDVTIPISEIFHPSGVYAYILLNIRLPTLTVAILIGAILSTSGAVLQMLLRNPLVDPYISGTASGGAFGAVLTYLLLMLNLPFSWIIYFQPLVAFFTATLATLITIMIGKKSGYLGLVIGGVLVSFIFSSLVTVILSVMSAKYPQIPPLTFWLLGDISVVGWFNAIILSLFAILLLYFSLSNSRLIDLLSISDEISYSQGVNPNKQRVFWLLFISLVVAYCVSIAGIIGFLGIIVPHIIRRLIGGNTSQLVMYSSLLGSTILILSNILSHGIFGYFIPLTALLSIMGAPIMIFALVRKDVNVEEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (310)
Sequences:	13789 (9928)
Seq/√Len:	563.9

ECOLI - FEPG FEPD FECD FECC BTUC FHUB
BACSU - FHUB FHUG FEUC YVRB YCLN YFME FEUB YFMD YFIZ YFHA YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
210_D	269_N	4.008	1.00
60_A	278_S	3.647	1.00
96_T	116_V	3.523	1.00
16_S	287_L	3.412	1.00
68_V	202_S	3.340	1.00
17_F	52_L	3.198	1.00
225_N	228_K	3.183	1.00
61_I	195_A	2.993	1.00
68_V	233_W	2.989	1.00
56_I	282_S	2.853	1.00
262_I	280_L	2.773	1.00
55_A	180_I	2.766	1.00
32_E	40_Y	2.692	1.00
64_T	278_S	2.559	1.00
54_V	183_V	2.513	1.00
91_F	154_L	2.406	1.00
61_I	240_V	2.399	1.00
17_F	56_I	2.392	1.00
61_I	244_C	2.361	1.00
32_E	35_H	2.338	1.00
216_D	230_R	2.338	1.00
13_F	283_T	2.296	1.00
58_I	244_C	2.264	1.00
67_A	277_S	2.150	1.00
64_T	199_L	2.146	1.00
266_I	276_Y	2.130	1.00
12_G	283_T	2.123	1.00
194_F	243_Y	2.112	1.00
56_I	286_I	2.099	1.00
208_L	229_Q	2.096	1.00
22_L	30_I	2.048	1.00
58_I	248_A	2.046	1.00
29_P	32_E	2.006	1.00
13_F	56_I	1.986	1.00
57_L	192_S	1.973	1.00
31_S	35_H	1.969	1.00
37_S	40_Y	1.963	1.00
95_L	99_L	1.935	1.00
205_N	208_L	1.914	1.00
91_F	151_F	1.895	1.00
211_L	224_V	1.894	1.00
51_T	289_N	1.870	1.00
69_L	237_I	1.867	1.00
41_A	45_L	1.842	1.00
71_M	270_T	1.841	1.00
201_F	236_F	1.834	1.00
94_V	155_V	1.825	1.00
198_L	240_V	1.805	1.00
38_G	41_A	1.763	1.00
20_G	52_L	1.752	1.00
6_G	276_Y	1.751	1.00
16_S	283_T	1.726	1.00
205_N	232_F	1.711	1.00
210_D	270_T	1.704	1.00
67_A	273_L	1.655	1.00
228_K	232_F	1.619	1.00
183_V	187_N	1.616	1.00
184_G	187_N	1.607	1.00
189_I	193_L	1.580	1.00
53_T	188_A	1.565	1.00
205_N	229_Q	1.563	1.00
291_L	295_I	1.554	1.00
198_L	239_L	1.522	1.00
254_L	285_L	1.516	1.00
125_T	238_S	1.492	1.00
19_L	23_Y	1.491	1.00
9_L	279_L	1.488	1.00
19_L	22_L	1.463	1.00
121_A	242_A	1.461	1.00
92_G	116_V	1.458	1.00
13_F	279_L	1.429	1.00
93_A	117_A	1.427	1.00
20_G	290_I	1.422	1.00
180_I	285_L	1.392	1.00
292_S	302_L	1.385	1.00
262_I	276_Y	1.376	1.00
16_S	286_I	1.376	1.00
198_L	236_F	1.368	1.00
9_L	280_L	1.366	1.00
272_Q	275_M	1.339	1.00
291_L	305_L	1.336	1.00
201_F	205_N	1.316	1.00
193_L	197_L	1.301	1.00
124_A	151_F	1.301	1.00
65_S	240_V	1.288	1.00
13_F	282_S	1.286	1.00
220_Y	227_N	1.285	1.00
9_L	276_Y	1.280	1.00
39_V	42_Y	1.277	1.00
205_N	233_W	1.272	1.00
36_P	41_A	1.268	1.00
211_L	222_Q	1.264	1.00
42_Y	46_N	1.253	1.00
258_V	280_L	1.253	1.00
258_V	284_I	1.244	1.00
218_I	221_S	1.243	1.00
57_L	188_A	1.232	1.00
248_A	251_I	1.224	1.00
92_G	120_T	1.220	1.00
27_T	30_I	1.219	1.00
150_I	311_A	1.219	1.00
54_V	247_I	1.214	1.00
90_A	155_V	1.205	1.00
228_K	231_V	1.205	1.00
86_A	241_V	1.199	1.00
63_S	258_V	1.197	1.00
262_I	273_L	1.195	1.00
189_I	192_S	1.188	1.00
60_A	282_S	1.185	1.00
55_A	286_I	1.181	1.00
227_N	230_R	1.177	1.00
6_G	272_Q	1.174	1.00
191_L	247_I	1.169	1.00
88_G	124_A	1.166	1.00
9_L	283_T	1.148	1.00
72_L	233_W	1.143	1.00
200_Y	204_S	1.140	1.00
229_Q	232_F	1.139	1.00
227_N	231_V	1.130	1.00
94_V	172_L	1.129	1.00
201_F	232_F	1.125	1.00
270_T	273_L	1.113	1.00
67_A	274_V	1.112	1.00
55_A	285_L	1.111	1.00
90_A	176_L	1.111	1.00
202_S	236_F	1.106	1.00
148_S	152_S	1.106	1.00
275_M	278_S	1.093	1.00
57_L	191_L	1.088	1.00
87_S	151_F	1.073	1.00
98_L	158_I	1.072	1.00
60_A	63_S	1.069	1.00
133_K	227_N	1.068	1.00
130_M	133_K	1.068	1.00
54_V	188_A	1.064	1.00
115_L	119_F	1.057	1.00
118_F	239_L	1.056	1.00
91_F	95_L	1.054	1.00
33_I	44_L	1.052	1.00
116_V	120_T	1.044	1.00
134_K	137_Y	1.040	1.00
88_G	120_T	1.038	1.00
22_L	33_I	1.034	1.00
166_Y	170_P	1.015	1.00
292_S	305_L	1.015	1.00
209_I	233_W	1.013	1.00
215_S	219_S	1.012	1.00
86_A	250_I	1.010	1.00
36_P	40_Y	0.998	1.00
10_I	14_I	0.998	1.00
197_L	200_Y	0.997	1.00
272_Q	276_Y	0.995	1.00
191_L	195_A	0.995	1.00
293_H	299_F	0.992	1.00
266_I	272_Q	0.992	1.00
157_V	161_V	0.990	1.00
229_Q	233_W	0.990	1.00
53_T	185_W	0.989	1.00
126_L	130_M	0.989	1.00
312_P	316_F	0.989	1.00
128_T	147_V	0.980	1.00
18_L	22_L	0.974	1.00
26_V	43_I	0.973	1.00
67_A	270_T	0.969	1.00
11_I	15_I	0.968	1.00
198_L	243_Y	0.967	1.00
251_I	285_L	0.965	1.00
95_L	158_I	0.965	1.00
45_L	49_L	0.958	1.00
283_T	287_L	0.958	1.00
57_L	195_A	0.954	1.00
165_K	168_Q	0.954	1.00
291_L	294_G	0.951	1.00
190_I	193_L	0.945	1.00
289_N	293_H	0.944	1.00
17_F	286_I	0.943	1.00
23_Y	294_G	0.938	1.00
258_V	262_I	0.932	1.00
21_L	52_L	0.929	1.00
224_V	229_Q	0.920	1.00
41_A	46_N	0.919	1.00
216_D	220_Y	0.918	1.00
273_L	277_S	0.917	1.00
269_N	272_Q	0.913	1.00
85_T	121_A	0.913	1.00
52_L	290_I	0.910	1.00
193_L	196_I	0.906	1.00
244_C	248_A	0.899	1.00
91_F	155_V	0.897	1.00
186_F	189_I	0.897	1.00
231_V	235_L	0.896	1.00
265_L	280_L	0.895	1.00
10_I	279_L	0.888	1.00
294_G	297_G	0.887	1.00
89_G	121_A	0.881	1.00
185_W	188_A	0.871	1.00
65_S	237_I	0.864	1.00
60_A	199_L	0.863	1.00
172_L	176_L	0.862	1.00
307_S	312_P	0.859	1.00
167_P	171_P	0.858	1.00
287_L	291_L	0.854	1.00
124_A	128_T	0.851	1.00
313_I	316_F	0.851	1.00
16_S	290_I	0.849	1.00
201_F	204_S	0.849	1.00
119_F	123_L	0.846	1.00
210_D	271_S	0.845	1.00
18_L	30_I	0.843	1.00
22_L	27_T	0.841	1.00
217_E	220_Y	0.839	1.00
226_P	230_R	0.831	1.00
66_G	259_P	0.829	1.00
88_G	151_F	0.828	1.00
187_N	247_I	0.828	1.00
96_T	113_Q	0.826	1.00
14_I	18_L	0.826	1.00
38_G	42_Y	0.825	1.00
52_L	286_I	0.823	1.00
123_L	127_I	0.821	1.00
24_G	48_R	0.815	1.00
292_S	301_P	0.812	1.00
49_L	185_W	0.811	1.00
42_Y	45_L	0.809	1.00
234_L	238_S	0.806	1.00
263_R	273_L	0.805	1.00
93_A	113_Q	0.804	1.00
129_I	231_V	0.804	1.00
216_D	226_P	0.801	1.00
170_P	173_T	0.800	1.00
112_F	115_L	0.800	1.00
61_I	65_S	0.796	1.00
118_F	122_T	0.792	1.00
203_L	206_S	0.790	1.00
254_L	306_L	0.790	1.00
91_F	158_I	0.789	1.00
205_N	236_F	0.786	1.00
262_I	266_I	0.783	1.00
81_Y	86_A	0.778	1.00
20_G	293_H	0.778	1.00
97_Y	113_Q	0.775	1.00
296_F	300_I	0.773	1.00
26_V	30_I	0.772	1.00
206_S	271_S	0.772	1.00
69_L	83_S	0.771	1.00
316_F	320_R	0.770	1.00
95_L	154_L	0.770	1.00
202_S	233_W	0.766	1.00
204_S	208_L	0.764	1.00
28_I	44_L	0.760	1.00
195_A	244_C	0.760	1.00
63_S	67_A	0.759	1.00
196_I	200_Y	0.758	1.00
191_L	243_Y	0.757	1.00
23_Y	27_T	0.755	1.00
194_F	198_L	0.751	1.00
37_S	41_A	0.751	1.00
199_L	203_L	0.750	1.00
60_A	195_A	0.746	1.00
279_L	283_T	0.746	1.00
85_T	125_T	0.745	1.00
73_L	141_V	0.741	1.00
21_L	49_L	0.739	1.00
51_T	293_H	0.737	1.00
308_I	312_P	0.735	1.00
208_L	224_V	0.733	1.00
113_Q	116_V	0.733	1.00
282_S	286_I	0.732	1.00
122_T	242_A	0.730	1.00
219_S	226_P	0.730	1.00
15_I	18_L	0.730	1.00
79_D	82_I	0.729	1.00
64_T	202_S	0.728	1.00
191_L	194_F	0.726	1.00
51_T	299_F	0.725	1.00
133_K	137_Y	0.721	1.00
212_L	226_P	0.721	1.00
98_L	162_M	0.721	1.00
128_T	132_G	0.721	1.00
111_Y	115_L	0.720	1.00
285_L	306_L	0.717	1.00
94_V	159_L	0.716	1.00
270_T	275_M	0.709	1.00
65_S	241_V	0.701	1.00
261_I	264_R	0.700	1.00
251_I	302_L	0.700	1.00
192_S	196_I	0.700	1.00
13_F	17_F	0.700	1.00
95_L	100_L	0.699	1.00
54_V	191_L	0.698	1.00
87_S	90_A	0.697	1.00
262_I	265_L	0.695	1.00
28_I	40_Y	0.694	1.00
14_I	17_F	0.693	1.00
159_L	173_T	0.692	1.00
30_I	33_I	0.691	1.00
264_R	317_A	0.688	1.00
62_L	254_L	0.688	1.00
21_L	44_L	0.688	1.00
243_Y	246_S	0.687	1.00
166_Y	169_I	0.685	1.00
131_I	143_G	0.684	1.00
243_Y	247_I	0.683	1.00
53_T	57_L	0.682	1.00
285_L	302_L	0.680	1.00
129_I	227_N	0.680	1.00
152_S	176_L	0.679	1.00
185_W	189_I	0.679	1.00
104_L	112_F	0.678	1.00
292_S	299_F	0.677	1.00
9_L	13_F	0.677	1.00
64_T	274_V	0.675	1.00
156_T	160_S	0.672	1.00
97_Y	171_P	0.671	1.00
96_T	112_F	0.666	1.00
13_F	286_I	0.665	1.00
180_I	302_L	0.663	1.00
125_T	234_L	0.662	1.00
220_Y	226_P	0.661	1.00
254_L	284_I	0.661	1.00
26_V	29_P	0.660	1.00
194_F	239_L	0.656	1.00
233_W	237_I	0.654	1.00
20_G	286_I	0.652	1.00
122_T	238_S	0.651	1.00
288_S	305_L	0.650	1.00
138_L	141_V	0.650	1.00
90_A	250_I	0.650	1.00
87_S	148_S	0.648	1.00
284_I	288_S	0.646	1.00
284_I	309_M	0.646	1.00
63_S	278_S	0.645	1.00
143_G	146_L	0.645	1.00
127_I	130_M	0.642	1.00
58_I	180_I	0.640	1.00
261_I	280_L	0.640	1.00
121_A	238_S	0.640	1.00
156_T	175_W	0.637	1.00
129_I	133_K	0.634	1.00
257_I	261_I	0.634	1.00
71_M	213_S	0.632	1.00
8_F	11_I	0.632	1.00
257_I	314_M	0.632	1.00
162_M	168_Q	0.631	1.00
15_I	19_L	0.631	1.00
120_T	124_A	0.629	1.00
210_D	275_M	0.629	1.00
44_L	49_L	0.628	1.00
31_S	34_F	0.627	1.00
208_L	211_L	0.627	1.00
173_T	176_L	0.626	1.00
42_Y	47_I	0.626	1.00
60_A	64_T	0.625	1.00
278_S	282_S	0.624	1.00
97_Y	172_L	0.623	1.00
204_S	207_R	0.622	1.00
32_E	36_P	0.621	1.00
16_S	19_L	0.618	1.00
198_L	202_S	0.618	1.00
280_L	283_T	0.616	1.00
186_F	190_I	0.616	1.00
287_L	290_I	0.615	1.00
212_L	229_Q	0.615	1.00
92_G	96_T	0.613	1.00
18_L	34_F	0.612	1.00
259_P	277_S	0.612	1.00
195_A	199_L	0.611	1.00
124_A	147_V	0.611	1.00
152_S	156_T	0.609	1.00
261_I	284_I	0.608	1.00
119_F	122_T	0.608	1.00
86_A	89_G	0.603	1.00
96_T	100_L	0.602	1.00
180_I	248_A	0.602	1.00
162_M	166_Y	0.602	1.00
275_M	279_L	0.601	1.00
49_L	53_T	0.600	1.00
27_T	31_S	0.600	1.00
232_F	236_F	0.599	1.00
23_Y	290_I	0.598	1.00
162_M	169_I	0.597	1.00
6_G	279_L	0.597	1.00
168_Q	171_P	0.596	1.00
261_I	313_I	0.595	1.00
125_T	129_I	0.594	1.00
79_D	255_G	0.591	1.00
123_L	126_L	0.590	1.00
133_K	136_G	0.588	1.00
68_V	236_F	0.587	1.00
74_R	216_D	0.586	1.00
207_R	210_D	0.586	1.00
257_I	313_I	0.585	1.00
202_S	274_V	0.584	1.00
232_F	235_L	0.583	1.00
17_F	21_L	0.583	1.00
69_L	85_T	0.581	1.00
6_G	9_L	0.580	1.00
8_F	12_G	0.580	1.00
22_L	34_F	0.574	0.99
319_V	322_D	0.574	0.99
54_V	248_A	0.571	0.99
6_G	10_I	0.571	0.99
238_S	242_A	0.568	0.99
100_L	103_N	0.565	0.99
30_I	34_F	0.564	0.99
159_L	176_L	0.564	0.99
54_V	58_I	0.564	0.99
87_S	152_S	0.562	0.99
162_M	165_K	0.558	0.99
159_L	172_L	0.555	0.99
242_A	246_S	0.554	0.99
241_V	245_V	0.554	0.99
225_N	232_F	0.553	0.99
209_I	274_V	0.552	0.99
68_V	237_I	0.552	0.99
73_L	76_P	0.552	0.99
188_A	191_L	0.551	0.99
197_L	201_F	0.551	0.99
55_A	302_L	0.550	0.99
29_P	40_Y	0.549	0.99
271_S	275_M	0.549	0.99
190_I	194_F	0.548	0.99
69_L	78_V	0.548	0.99
210_D	213_S	0.548	0.99
26_V	40_Y	0.546	0.99
290_I	294_G	0.544	0.99
289_N	299_F	0.544	0.99
113_Q	117_A	0.540	0.99
85_T	128_T	0.539	0.99
89_G	117_A	0.537	0.99
102_L	112_F	0.535	0.99
143_G	147_V	0.535	0.99
39_V	43_I	0.531	0.99
256_I	317_A	0.530	0.99
99_L	102_L	0.529	0.99
88_G	147_V	0.529	0.99
110_I	114_P	0.526	0.99
171_P	174_F	0.525	0.99
188_A	192_S	0.524	0.99
194_F	197_L	0.524	0.99
292_S	295_I	0.523	0.99
68_V	209_I	0.520	0.99
132_G	143_G	0.520	0.99
258_V	288_S	0.518	0.99
286_I	290_I	0.517	0.99
157_V	304_A	0.516	0.99
174_F	179_D	0.514	0.99
78_V	85_T	0.513	0.99
260_H	263_R	0.512	0.99
67_A	262_I	0.512	0.99
267_G	275_M	0.510	0.99
159_L	169_I	0.509	0.99
63_S	281_G	0.509	0.99
316_F	319_V	0.509	0.99
29_P	33_I	0.508	0.99
150_I	154_L	0.507	0.99
69_L	238_S	0.507	0.99
64_T	277_S	0.506	0.99
7_I	11_I	0.504	0.99
28_I	43_I	0.503	0.99
6_G	275_M	0.503	0.99
225_N	231_V	0.502	0.99
261_I	265_L	0.502	0.99
170_P	174_F	0.502	0.99
94_V	158_I	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi9A	2	0.9512	100	0.21	Contact Map
4g1uA	2	0.8902	100	0.216	Contact Map
2nq2A	2	0.939	100	0.217	Contact Map
2m20A	2	0.0884	14.5	0.965	Contact Map
3dh4A	3	0.5884	13.1	0.966	Contact Map
2xq2A	2	0.5823	12.8	0.966	Contact Map
2l2tA	2	0.122	8.7	0.968	Contact Map
4f35D	2	0.6098	8.5	0.968	Contact Map
4wgvA	2	0.3659	8.1	0.969	Contact Map
2l9uA	2	0.0976	7.7	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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