GREMLIN Database
Q97ZU1 - Iron (III) ABC transporter, permease protein (HEMU 1)
UniProt: Q97ZU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (310)
Sequences: 13789 (9928)
Seq/√Len: 563.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_D269_N4.0081.00
60_A278_S3.6471.00
96_T116_V3.5231.00
16_S287_L3.4121.00
68_V202_S3.3401.00
17_F52_L3.1981.00
225_N228_K3.1831.00
61_I195_A2.9931.00
68_V233_W2.9891.00
56_I282_S2.8531.00
262_I280_L2.7731.00
55_A180_I2.7661.00
32_E40_Y2.6921.00
64_T278_S2.5591.00
54_V183_V2.5131.00
91_F154_L2.4061.00
61_I240_V2.3991.00
17_F56_I2.3921.00
61_I244_C2.3611.00
32_E35_H2.3381.00
216_D230_R2.3381.00
13_F283_T2.2961.00
58_I244_C2.2641.00
67_A277_S2.1501.00
64_T199_L2.1461.00
266_I276_Y2.1301.00
12_G283_T2.1231.00
194_F243_Y2.1121.00
56_I286_I2.0991.00
208_L229_Q2.0961.00
22_L30_I2.0481.00
58_I248_A2.0461.00
29_P32_E2.0061.00
13_F56_I1.9861.00
57_L192_S1.9731.00
31_S35_H1.9691.00
37_S40_Y1.9631.00
95_L99_L1.9351.00
205_N208_L1.9141.00
91_F151_F1.8951.00
211_L224_V1.8941.00
51_T289_N1.8701.00
69_L237_I1.8671.00
41_A45_L1.8421.00
71_M270_T1.8411.00
201_F236_F1.8341.00
94_V155_V1.8251.00
198_L240_V1.8051.00
38_G41_A1.7631.00
20_G52_L1.7521.00
6_G276_Y1.7511.00
16_S283_T1.7261.00
205_N232_F1.7111.00
210_D270_T1.7041.00
67_A273_L1.6551.00
228_K232_F1.6191.00
183_V187_N1.6161.00
184_G187_N1.6071.00
189_I193_L1.5801.00
53_T188_A1.5651.00
205_N229_Q1.5631.00
291_L295_I1.5541.00
198_L239_L1.5221.00
254_L285_L1.5161.00
125_T238_S1.4921.00
19_L23_Y1.4911.00
9_L279_L1.4881.00
19_L22_L1.4631.00
121_A242_A1.4611.00
92_G116_V1.4581.00
13_F279_L1.4291.00
93_A117_A1.4271.00
20_G290_I1.4221.00
180_I285_L1.3921.00
292_S302_L1.3851.00
262_I276_Y1.3761.00
16_S286_I1.3761.00
198_L236_F1.3681.00
9_L280_L1.3661.00
272_Q275_M1.3391.00
291_L305_L1.3361.00
201_F205_N1.3161.00
193_L197_L1.3011.00
124_A151_F1.3011.00
65_S240_V1.2881.00
13_F282_S1.2861.00
220_Y227_N1.2851.00
9_L276_Y1.2801.00
39_V42_Y1.2771.00
205_N233_W1.2721.00
36_P41_A1.2681.00
211_L222_Q1.2641.00
42_Y46_N1.2531.00
258_V280_L1.2531.00
258_V284_I1.2441.00
218_I221_S1.2431.00
57_L188_A1.2321.00
248_A251_I1.2241.00
92_G120_T1.2201.00
27_T30_I1.2191.00
150_I311_A1.2191.00
54_V247_I1.2141.00
90_A155_V1.2051.00
228_K231_V1.2051.00
86_A241_V1.1991.00
63_S258_V1.1971.00
262_I273_L1.1951.00
189_I192_S1.1881.00
60_A282_S1.1851.00
55_A286_I1.1811.00
227_N230_R1.1771.00
6_G272_Q1.1741.00
191_L247_I1.1691.00
88_G124_A1.1661.00
9_L283_T1.1481.00
72_L233_W1.1431.00
200_Y204_S1.1401.00
229_Q232_F1.1391.00
227_N231_V1.1301.00
94_V172_L1.1291.00
201_F232_F1.1251.00
270_T273_L1.1131.00
67_A274_V1.1121.00
55_A285_L1.1111.00
90_A176_L1.1111.00
202_S236_F1.1061.00
148_S152_S1.1061.00
275_M278_S1.0931.00
57_L191_L1.0881.00
87_S151_F1.0731.00
98_L158_I1.0721.00
60_A63_S1.0691.00
133_K227_N1.0681.00
130_M133_K1.0681.00
54_V188_A1.0641.00
115_L119_F1.0571.00
118_F239_L1.0561.00
91_F95_L1.0541.00
33_I44_L1.0521.00
116_V120_T1.0441.00
134_K137_Y1.0401.00
88_G120_T1.0381.00
22_L33_I1.0341.00
166_Y170_P1.0151.00
292_S305_L1.0151.00
209_I233_W1.0131.00
215_S219_S1.0121.00
86_A250_I1.0101.00
36_P40_Y0.9981.00
10_I14_I0.9981.00
197_L200_Y0.9971.00
272_Q276_Y0.9951.00
191_L195_A0.9951.00
293_H299_F0.9921.00
266_I272_Q0.9921.00
157_V161_V0.9901.00
229_Q233_W0.9901.00
53_T185_W0.9891.00
126_L130_M0.9891.00
312_P316_F0.9891.00
128_T147_V0.9801.00
18_L22_L0.9741.00
26_V43_I0.9731.00
67_A270_T0.9691.00
11_I15_I0.9681.00
198_L243_Y0.9671.00
251_I285_L0.9651.00
95_L158_I0.9651.00
45_L49_L0.9581.00
283_T287_L0.9581.00
57_L195_A0.9541.00
165_K168_Q0.9541.00
291_L294_G0.9511.00
190_I193_L0.9451.00
289_N293_H0.9441.00
17_F286_I0.9431.00
23_Y294_G0.9381.00
258_V262_I0.9321.00
21_L52_L0.9291.00
224_V229_Q0.9201.00
41_A46_N0.9191.00
216_D220_Y0.9181.00
273_L277_S0.9171.00
269_N272_Q0.9131.00
85_T121_A0.9131.00
52_L290_I0.9101.00
193_L196_I0.9061.00
244_C248_A0.8991.00
91_F155_V0.8971.00
186_F189_I0.8971.00
231_V235_L0.8961.00
265_L280_L0.8951.00
10_I279_L0.8881.00
294_G297_G0.8871.00
89_G121_A0.8811.00
185_W188_A0.8711.00
65_S237_I0.8641.00
60_A199_L0.8631.00
172_L176_L0.8621.00
307_S312_P0.8591.00
167_P171_P0.8581.00
287_L291_L0.8541.00
124_A128_T0.8511.00
313_I316_F0.8511.00
16_S290_I0.8491.00
201_F204_S0.8491.00
119_F123_L0.8461.00
210_D271_S0.8451.00
18_L30_I0.8431.00
22_L27_T0.8411.00
217_E220_Y0.8391.00
226_P230_R0.8311.00
66_G259_P0.8291.00
88_G151_F0.8281.00
187_N247_I0.8281.00
96_T113_Q0.8261.00
14_I18_L0.8261.00
38_G42_Y0.8251.00
52_L286_I0.8231.00
123_L127_I0.8211.00
24_G48_R0.8151.00
292_S301_P0.8121.00
49_L185_W0.8111.00
42_Y45_L0.8091.00
234_L238_S0.8061.00
263_R273_L0.8051.00
93_A113_Q0.8041.00
129_I231_V0.8041.00
216_D226_P0.8011.00
170_P173_T0.8001.00
112_F115_L0.8001.00
61_I65_S0.7961.00
118_F122_T0.7921.00
203_L206_S0.7901.00
254_L306_L0.7901.00
91_F158_I0.7891.00
205_N236_F0.7861.00
262_I266_I0.7831.00
81_Y86_A0.7781.00
20_G293_H0.7781.00
97_Y113_Q0.7751.00
296_F300_I0.7731.00
26_V30_I0.7721.00
206_S271_S0.7721.00
69_L83_S0.7711.00
316_F320_R0.7701.00
95_L154_L0.7701.00
202_S233_W0.7661.00
204_S208_L0.7641.00
28_I44_L0.7601.00
195_A244_C0.7601.00
63_S67_A0.7591.00
196_I200_Y0.7581.00
191_L243_Y0.7571.00
23_Y27_T0.7551.00
194_F198_L0.7511.00
37_S41_A0.7511.00
199_L203_L0.7501.00
60_A195_A0.7461.00
279_L283_T0.7461.00
85_T125_T0.7451.00
73_L141_V0.7411.00
21_L49_L0.7391.00
51_T293_H0.7371.00
308_I312_P0.7351.00
208_L224_V0.7331.00
113_Q116_V0.7331.00
282_S286_I0.7321.00
122_T242_A0.7301.00
219_S226_P0.7301.00
15_I18_L0.7301.00
79_D82_I0.7291.00
64_T202_S0.7281.00
191_L194_F0.7261.00
51_T299_F0.7251.00
133_K137_Y0.7211.00
212_L226_P0.7211.00
98_L162_M0.7211.00
128_T132_G0.7211.00
111_Y115_L0.7201.00
285_L306_L0.7171.00
94_V159_L0.7161.00
270_T275_M0.7091.00
65_S241_V0.7011.00
261_I264_R0.7001.00
251_I302_L0.7001.00
192_S196_I0.7001.00
13_F17_F0.7001.00
95_L100_L0.6991.00
54_V191_L0.6981.00
87_S90_A0.6971.00
262_I265_L0.6951.00
28_I40_Y0.6941.00
14_I17_F0.6931.00
159_L173_T0.6921.00
30_I33_I0.6911.00
264_R317_A0.6881.00
62_L254_L0.6881.00
21_L44_L0.6881.00
243_Y246_S0.6871.00
166_Y169_I0.6851.00
131_I143_G0.6841.00
243_Y247_I0.6831.00
53_T57_L0.6821.00
285_L302_L0.6801.00
129_I227_N0.6801.00
152_S176_L0.6791.00
185_W189_I0.6791.00
104_L112_F0.6781.00
292_S299_F0.6771.00
9_L13_F0.6771.00
64_T274_V0.6751.00
156_T160_S0.6721.00
97_Y171_P0.6711.00
96_T112_F0.6661.00
13_F286_I0.6651.00
180_I302_L0.6631.00
125_T234_L0.6621.00
220_Y226_P0.6611.00
254_L284_I0.6611.00
26_V29_P0.6601.00
194_F239_L0.6561.00
233_W237_I0.6541.00
20_G286_I0.6521.00
122_T238_S0.6511.00
288_S305_L0.6501.00
138_L141_V0.6501.00
90_A250_I0.6501.00
87_S148_S0.6481.00
284_I288_S0.6461.00
284_I309_M0.6461.00
63_S278_S0.6451.00
143_G146_L0.6451.00
127_I130_M0.6421.00
58_I180_I0.6401.00
261_I280_L0.6401.00
121_A238_S0.6401.00
156_T175_W0.6371.00
129_I133_K0.6341.00
257_I261_I0.6341.00
71_M213_S0.6321.00
8_F11_I0.6321.00
257_I314_M0.6321.00
162_M168_Q0.6311.00
15_I19_L0.6311.00
120_T124_A0.6291.00
210_D275_M0.6291.00
44_L49_L0.6281.00
31_S34_F0.6271.00
208_L211_L0.6271.00
173_T176_L0.6261.00
42_Y47_I0.6261.00
60_A64_T0.6251.00
278_S282_S0.6241.00
97_Y172_L0.6231.00
204_S207_R0.6221.00
32_E36_P0.6211.00
16_S19_L0.6181.00
198_L202_S0.6181.00
280_L283_T0.6161.00
186_F190_I0.6161.00
287_L290_I0.6151.00
212_L229_Q0.6151.00
92_G96_T0.6131.00
18_L34_F0.6121.00
259_P277_S0.6121.00
195_A199_L0.6111.00
124_A147_V0.6111.00
152_S156_T0.6091.00
261_I284_I0.6081.00
119_F122_T0.6081.00
86_A89_G0.6031.00
96_T100_L0.6021.00
180_I248_A0.6021.00
162_M166_Y0.6021.00
275_M279_L0.6011.00
49_L53_T0.6001.00
27_T31_S0.6001.00
232_F236_F0.5991.00
23_Y290_I0.5981.00
162_M169_I0.5971.00
6_G279_L0.5971.00
168_Q171_P0.5961.00
261_I313_I0.5951.00
125_T129_I0.5941.00
79_D255_G0.5911.00
123_L126_L0.5901.00
133_K136_G0.5881.00
68_V236_F0.5871.00
74_R216_D0.5861.00
207_R210_D0.5861.00
257_I313_I0.5851.00
202_S274_V0.5841.00
232_F235_L0.5831.00
17_F21_L0.5831.00
69_L85_T0.5811.00
6_G9_L0.5801.00
8_F12_G0.5801.00
22_L34_F0.5740.99
319_V322_D0.5740.99
54_V248_A0.5710.99
6_G10_I0.5710.99
238_S242_A0.5680.99
100_L103_N0.5650.99
30_I34_F0.5640.99
159_L176_L0.5640.99
54_V58_I0.5640.99
87_S152_S0.5620.99
162_M165_K0.5580.99
159_L172_L0.5550.99
242_A246_S0.5540.99
241_V245_V0.5540.99
225_N232_F0.5530.99
209_I274_V0.5520.99
68_V237_I0.5520.99
73_L76_P0.5520.99
188_A191_L0.5510.99
197_L201_F0.5510.99
55_A302_L0.5500.99
29_P40_Y0.5490.99
271_S275_M0.5490.99
190_I194_F0.5480.99
69_L78_V0.5480.99
210_D213_S0.5480.99
26_V40_Y0.5460.99
290_I294_G0.5440.99
289_N299_F0.5440.99
113_Q117_A0.5400.99
85_T128_T0.5390.99
89_G117_A0.5370.99
102_L112_F0.5350.99
143_G147_V0.5350.99
39_V43_I0.5310.99
256_I317_A0.5300.99
99_L102_L0.5290.99
88_G147_V0.5290.99
110_I114_P0.5260.99
171_P174_F0.5250.99
188_A192_S0.5240.99
194_F197_L0.5240.99
292_S295_I0.5230.99
68_V209_I0.5200.99
132_G143_G0.5200.99
258_V288_S0.5180.99
286_I290_I0.5170.99
157_V304_A0.5160.99
174_F179_D0.5140.99
78_V85_T0.5130.99
260_H263_R0.5120.99
67_A262_I0.5120.99
267_G275_M0.5100.99
159_L169_I0.5090.99
63_S281_G0.5090.99
316_F319_V0.5090.99
29_P33_I0.5080.99
150_I154_L0.5070.99
69_L238_S0.5070.99
64_T277_S0.5060.99
7_I11_I0.5040.99
28_I43_I0.5030.99
6_G275_M0.5030.99
225_N231_V0.5020.99
261_I265_L0.5020.99
170_P174_F0.5020.99
94_V158_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.9512 100 0.21 Contact Map
4g1uA 2 0.8902 100 0.216 Contact Map
2nq2A 2 0.939 100 0.217 Contact Map
2m20A 2 0.0884 14.5 0.965 Contact Map
3dh4A 3 0.5884 13.1 0.966 Contact Map
2xq2A 2 0.5823 12.8 0.966 Contact Map
2l2tA 2 0.122 8.7 0.968 Contact Map
4f35D 2 0.6098 8.5 0.968 Contact Map
4wgvA 2 0.3659 8.1 0.969 Contact Map
2l9uA 2 0.0976 7.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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