GREMLIN Database
Q97ZT8 - Phosphate-binding protein
UniProt: Q97ZT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (319)
Sequences: 2403 (1693)
Seq/√Len: 94.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_T165_V4.7421.00
162_T185_L4.5611.00
194_Q261_Y4.1741.00
168_K173_Q3.8001.00
178_D193_H3.7991.00
176_Y193_H3.6971.00
153_P260_P3.6341.00
70_S73_V3.5981.00
71_T97_A3.5641.00
98_V102_A3.3521.00
176_Y195_K3.2601.00
210_I337_T3.0521.00
160_N289_Y3.0181.00
161_L279_A2.8751.00
280_A291_L2.8301.00
165_V185_L2.8221.00
113_D352_K2.6431.00
97_A250_D2.6401.00
178_D183_K2.6071.00
169_I196_I2.5721.00
68_G112_Y2.4201.00
84_F358_L2.3361.00
117_T342_V2.3281.00
165_V168_K2.3041.00
148_I166_L2.2931.00
68_G106_N2.2731.00
168_K181_A2.2731.00
149_I256_V2.2291.00
380_S384_Q2.2261.00
361_K387_L2.2011.00
162_T282_L2.1131.00
160_N280_A2.1021.00
73_V77_M2.0891.00
384_Q388_Q2.0881.00
282_L289_Y2.0141.00
167_A219_S1.9961.00
288_D330_H1.9911.00
66_I94_T1.9311.00
288_D331_N1.9281.00
285_S326_N1.8791.00
329_A332_A1.8721.00
293_T296_S1.8681.00
176_Y194_Q1.8501.00
194_Q260_P1.7781.00
77_M359_F1.7571.00
164_D168_K1.7471.00
166_L281_V1.7401.00
217_T325_L1.6991.00
170_Y198_A1.6981.00
143_V301_I1.6921.00
212_T233_V1.6901.00
74_N78_Q1.6441.00
150_Y279_A1.6201.00
256_V264_G1.6101.00
347_Y353_A1.6081.00
83_D370_E1.6051.00
354_E358_L1.5961.00
101_G204_G1.5841.00
349_D352_K1.5601.00
271_A278_P1.5561.00
67_A114_I1.5451.00
183_K190_N1.5351.00
180_P183_K1.5131.00
142_V339_S1.5061.00
165_V186_N1.4921.00
85_Q92_Q1.4871.00
183_K188_H1.4721.00
84_F91_I1.4701.00
146_V337_T1.4681.00
253_T266_V1.4651.00
123_S127_Q1.4341.00
106_N112_Y1.4291.00
365_T387_L1.4150.99
185_L289_Y1.4130.99
173_Q221_S1.4030.99
296_S331_N1.3970.99
74_N97_A1.3930.99
384_Q387_L1.3910.99
73_V341_L1.3900.99
368_Q383_Q1.3740.99
76_L142_V1.3740.99
281_V335_I1.3730.99
171_L221_S1.3670.99
72_F144_G1.3570.99
141_D339_S1.3560.99
283_N287_G1.3540.99
383_Q387_L1.3410.99
104_V125_L1.3350.99
128_Q134_G1.3250.99
246_G255_Y1.3130.99
83_D362_Y1.3130.99
148_I211_F1.2990.99
77_M141_D1.2990.99
149_I266_V1.2970.99
70_S77_M1.2910.99
145_A297_I1.2760.99
150_Y158_T1.2720.99
198_A263_I1.2690.99
68_G98_V1.2650.99
213_Y217_T1.2570.99
281_V333_Y1.2540.99
255_Y259_N1.2450.99
153_P261_Y1.2370.99
98_V106_N1.2340.99
129_L132_K1.2310.99
160_N282_L1.2280.98
108_L128_Q1.2090.98
350_K354_E1.2070.98
200_H243_G1.2030.98
83_D86_S1.2020.98
163_A214_W1.1990.98
84_F362_Y1.1830.98
64_S92_Q1.1770.98
163_A185_L1.1720.98
387_L391_K1.1690.98
200_H245_G1.1690.98
230_G233_V1.1650.98
364_A390_L1.1560.98
171_L224_S1.1520.98
298_E376_I1.1510.98
294_Q298_E1.1500.98
152_I261_Y1.1500.98
104_V233_V1.1450.98
122_P125_L1.1400.98
324_F327_V1.1350.97
388_Q391_K1.1290.97
283_N286_T1.1230.97
121_P136_V1.1230.97
295_A331_N1.1130.97
146_V210_I1.1120.97
104_V121_P1.1100.97
127_Q131_Q1.1080.97
180_P184_A1.1080.97
108_L129_L1.1060.97
121_P138_T1.0910.97
244_L255_Y1.0830.97
88_Y366_T1.0830.97
343_I360_L1.0820.97
165_V182_I1.0800.97
141_D341_L1.0790.97
359_F363_I1.0760.96
364_A386_I1.0730.96
345_V392_L1.0660.96
282_L285_S1.0650.96
81_I359_F1.0640.96
100_S117_T1.0610.96
366_T369_T1.0610.96
164_D221_S1.0570.96
361_K365_T1.0560.96
96_S106_N1.0460.96
208_T265_Y1.0390.96
221_S224_S1.0300.95
299_T331_N1.0290.95
70_S341_L1.0130.95
361_K391_K1.0040.95
149_I276_L0.9940.95
249_S270_Y0.9820.94
128_Q131_Q0.9800.94
385_L388_Q0.9790.94
358_L361_K0.9770.94
139_I386_I0.9770.94
197_I259_N0.9560.93
267_E270_Y0.9530.93
164_D181_A0.9480.93
360_L390_L0.9450.93
214_W218_S0.9410.93
143_V338_F0.9390.93
119_V209_F0.9350.93
144_G375_Y0.9350.93
71_T98_V0.9290.92
112_Y115_G0.9290.92
256_V266_V0.9280.92
299_T302_Q0.9230.92
220_Q224_S0.9210.92
165_V174_I0.9200.92
107_F136_V0.9180.92
364_A387_L0.9170.92
369_T372_P0.9060.91
80_W367_G0.8990.91
175_Q193_H0.8930.91
61_I91_I0.8930.91
80_W363_I0.8920.91
106_N111_A0.8880.90
161_L166_L0.8870.90
144_G267_E0.8840.90
183_K193_H0.8810.90
237_V243_G0.8810.90
79_V83_D0.8790.90
254_A258_Q0.8790.90
68_G102_A0.8760.90
94_T111_A0.8750.90
70_S141_D0.8750.90
161_L169_I0.8720.90
201_R207_T0.8650.89
355_A358_L0.8650.89
303_N332_A0.8650.89
158_T189_F0.8630.89
211_F335_I0.8610.89
110_G344_K0.8610.89
351_S354_E0.8590.89
152_I194_Q0.8540.89
139_I364_A0.8520.89
107_F115_G0.8490.88
321_L324_F0.8490.88
118_D339_S0.8470.88
99_G207_T0.8350.88
116_A339_S0.8340.88
77_M363_I0.8330.87
63_A355_A0.8280.87
201_R205_S0.8240.87
202_S247_K0.8200.87
213_Y325_L0.8190.87
77_M116_A0.8190.87
141_D364_A0.8180.86
364_A368_Q0.8150.86
327_V332_A0.8140.86
199_V255_Y0.8120.86
386_I389_N0.8100.86
184_A190_N0.8100.86
302_Q381_N0.8090.86
280_A289_Y0.8070.86
303_N327_V0.8030.85
77_M341_L0.8010.85
162_T289_Y0.8000.85
259_N262_S0.8000.85
389_N392_L0.8000.85
165_V282_L0.7920.85
183_K187_P0.7910.85
286_T330_H0.7910.85
76_L80_W0.7910.85
120_P138_T0.7880.84
68_G96_S0.7860.84
165_V181_A0.7820.84
204_G234_N0.7780.84
100_S201_R0.7770.84
278_P292_P0.7760.83
73_V141_D0.7740.83
170_Y263_I0.7740.83
149_I264_G0.7730.83
163_A218_S0.7730.83
119_V231_Y0.7720.83
341_L360_L0.7710.83
161_L182_I0.7690.83
110_G348_T0.7690.83
153_P194_Q0.7530.82
63_A91_I0.7510.81
164_D167_A0.7510.81
299_T329_A0.7500.81
168_K171_L0.7500.81
160_N185_L0.7450.81
212_T215_L0.7430.81
272_I374_G0.7430.81
380_S383_Q0.7390.80
381_N384_Q0.7350.80
73_V339_S0.7340.80
178_D191_F0.7300.80
72_F337_T0.7270.79
201_R206_G0.7260.79
186_N192_T0.7220.79
70_S206_G0.7210.79
99_G201_R0.7190.79
158_T291_L0.7190.79
256_V262_S0.7170.78
294_Q372_P0.7170.78
77_M339_S0.7160.78
255_Y258_Q0.7150.78
371_L377_E0.7050.77
297_I336_V0.7040.77
357_Y390_L0.7010.77
268_A292_P0.7010.77
181_A184_A0.6990.77
152_I262_S0.6940.76
201_R265_Y0.6890.76
148_I170_Y0.6890.76
100_S205_S0.6860.75
75_P270_Y0.6860.75
209_F213_Y0.6860.75
71_T99_G0.6840.75
162_T184_A0.6840.75
301_I364_A0.6750.74
102_A106_N0.6750.74
303_N324_F0.6740.74
150_Y160_N0.6740.74
165_V188_H0.6740.74
302_Q379_P0.6730.74
82_K86_S0.6720.74
220_Q223_R0.6680.73
99_G103_G0.6660.73
199_V244_L0.6620.73
269_Q375_Y0.6620.73
341_L363_I0.6610.73
123_S126_Y0.6600.72
174_I182_I0.6580.72
52_S56_T0.6570.72
188_H295_A0.6570.72
306_L385_L0.6550.72
204_G233_V0.6550.72
71_T201_R0.6540.72
207_T249_S0.6540.72
93_V376_I0.6530.72
249_S266_V0.6510.71
158_T280_A0.6500.71
305_N308_S0.6490.71
135_E345_V0.6470.71
155_F158_T0.6470.71
142_V371_L0.6460.71
78_Q81_I0.6460.71
388_Q392_L0.6450.71
203_D246_G0.6450.71
137_L389_N0.6440.71
148_I333_Y0.6420.70
159_L191_F0.6420.70
163_A326_N0.6410.70
57_A60_Q0.6410.70
173_Q176_Y0.6410.70
99_G206_G0.6400.70
290_V296_S0.6390.70
150_Y333_Y0.6370.70
99_G118_D0.6370.70
162_T168_K0.6360.70
282_L287_G0.6350.69
139_I360_L0.6340.69
94_T106_N0.6310.69
365_T383_Q0.6300.69
64_S94_T0.6290.69
171_L223_R0.6260.68
62_S91_I0.6240.68
344_K347_Y0.6240.68
55_T58_S0.6240.68
184_A305_N0.6240.68
246_G251_G0.6230.68
67_A356_I0.6230.68
199_V246_G0.6190.68
99_G102_A0.6190.68
168_K174_I0.6190.68
170_Y211_F0.6170.67
151_N260_P0.6150.67
281_V289_Y0.6140.67
171_L219_S0.6140.67
184_A369_T0.6130.67
150_Y159_L0.6110.67
203_D214_W0.6070.66
167_A214_W0.6050.66
137_L343_I0.6040.66
129_L136_V0.6030.66
163_A167_A0.6020.65
100_S207_T0.6010.65
81_I85_Q0.6000.65
304_A307_S0.6000.65
205_S208_T0.5990.65
198_A242_N0.5990.65
147_D292_P0.5970.65
71_T207_T0.5970.65
362_Y370_E0.5960.65
60_Q64_S0.5950.65
385_L389_N0.5930.64
382_I389_N0.5920.64
187_P190_N0.5920.64
186_N191_F0.5910.64
145_A338_F0.5900.64
183_K189_F0.5900.64
387_L390_L0.5900.64
107_F374_G0.5890.64
199_V252_V0.5880.64
128_Q369_T0.5880.64
294_Q376_I0.5880.64
104_V108_L0.5850.63
254_A257_S0.5840.63
304_A321_L0.5830.63
194_Q262_S0.5830.63
106_N115_G0.5830.63
270_Y375_Y0.5830.63
175_Q195_K0.5830.63
326_N335_I0.5800.63
100_S265_Y0.5790.62
353_A365_T0.5790.62
252_V264_G0.5780.62
72_F249_S0.5780.62
54_Q57_A0.5780.62
57_A61_I0.5770.62
267_E373_S0.5770.62
55_T60_Q0.5760.62
103_G207_T0.5740.62
71_T248_G0.5730.62
160_N187_P0.5730.62
184_A381_N0.5710.61
51_S59_S0.5700.61
105_N109_Q0.5670.61
168_K221_S0.5650.61
195_K198_A0.5650.61
161_L211_F0.5640.60
340_W344_K0.5640.60
190_N288_D0.5620.60
202_S245_G0.5620.60
119_V213_Y0.5610.60
101_G206_G0.5610.60
61_I355_A0.5600.60
352_K356_I0.5580.60
169_I263_I0.5560.59
52_S62_S0.5560.59
248_G251_G0.5560.59
85_Q88_Y0.5530.59
163_A282_L0.5520.59
152_I155_F0.5520.59
78_Q89_N0.5510.59
119_V125_L0.5500.58
216_Y231_Y0.5500.58
201_R252_V0.5490.58
328_K332_A0.5470.58
200_H235_W0.5460.58
266_V270_Y0.5450.58
160_N281_V0.5440.58
118_D206_G0.5440.58
94_T373_S0.5440.58
196_I261_Y0.5440.58
326_N329_A0.5430.58
197_I244_L0.5430.58
285_S289_Y0.5410.57
125_L231_Y0.5410.57
61_I64_S0.5410.57
54_Q62_S0.5380.57
101_G265_Y0.5380.57
53_S56_T0.5380.57
279_A333_Y0.5370.57
209_F323_V0.5360.57
222_W243_G0.5360.57
346_N350_K0.5360.57
175_Q369_T0.5340.56
286_T329_A0.5340.56
141_D386_I0.5340.56
323_V326_N0.5310.56
95_Y114_I0.5310.56
291_L296_S0.5300.56
137_L345_V0.5300.56
365_T368_Q0.5300.56
56_T59_S0.5290.56
52_S58_S0.5270.55
170_Y200_H0.5270.55
277_T283_N0.5240.55
159_L178_D0.5240.55
145_A376_I0.5240.55
254_A335_I0.5230.55
51_S54_Q0.5230.55
176_Y261_Y0.5220.55
121_P125_L0.5190.54
87_N366_T0.5180.54
332_A377_E0.5180.54
184_A289_Y0.5180.54
107_F139_I0.5140.53
101_G207_T0.5140.53
150_Y277_T0.5130.53
174_I179_D0.5120.53
166_L214_W0.5110.53
201_R251_G0.5110.53
118_D201_R0.5110.53
147_D278_P0.5110.53
58_S61_I0.5100.53
76_L371_L0.5100.53
147_D249_S0.5100.53
152_I192_T0.5100.53
103_G206_G0.5090.53
353_A356_I0.5090.53
253_T374_G0.5080.53
100_S206_G0.5070.53
216_Y223_R0.5060.52
179_D192_T0.5060.52
200_H234_N0.5050.52
200_H222_W0.5040.52
212_T231_Y0.5030.52
213_Y323_V0.5030.52
382_I385_L0.5020.52
160_N333_Y0.5020.52
160_N188_H0.5020.52
142_V337_T0.5020.52
198_A237_V0.5010.52
250_D253_T0.5000.52
73_V76_L0.5000.52
73_V142_V0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f1vA 1 0.7852 100 0.414 Contact Map
1ixhA 1 0.7827 100 0.55 Contact Map
1pc3A 1 0.8049 100 0.561 Contact Map
4n13A 1 0.6 100 0.618 Contact Map
4lvqA 1 0.7778 100 0.661 Contact Map
4jwoA 1 0.679 100 0.699 Contact Map
4ombA 1 0.7037 99.9 0.715 Contact Map
4ecfA 1 0.6346 99.9 0.732 Contact Map
4exlA 1 0.6444 99.9 0.733 Contact Map
4q8rA 1 0.5901 99.9 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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