GREMLIN Database
Q97ZT7 - Phosphate transport system permease protein (PstC)
UniProt: Q97ZT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (249)
Sequences: 69660 (45445)
Seq/√Len: 2880.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E200_T3.9111.00
68_Y72_V3.2091.00
29_I32_V3.0281.00
189_Y198_L3.0141.00
174_R178_F2.9811.00
65_A68_Y2.5901.00
94_D185_E2.5751.00
185_E202_K2.5681.00
188_V198_L2.5361.00
194_G197_E2.5131.00
66_A252_L2.4861.00
76_L158_S2.4411.00
176_V209_A2.4051.00
37_S54_W2.3971.00
52_N55_N2.3691.00
78_V214_Y2.3181.00
64_L68_Y2.3161.00
247_Y255_S2.2791.00
195_K198_L2.2751.00
173_I210_F2.2531.00
52_N56_P2.2491.00
264_Q267_A2.1041.00
193_L197_E2.0951.00
86_T199_I2.0421.00
13_Y18_P2.0311.00
55_N59_D2.0271.00
80_I162_A2.0251.00
98_K101_K1.9751.00
31_S35_Y1.9561.00
169_A213_A1.9311.00
184_F205_Y1.9271.00
93_N178_F1.9061.00
177_Y206_I1.8921.00
188_V193_L1.8371.00
35_Y39_P1.7971.00
86_T206_I1.7901.00
72_V154_I1.7891.00
189_Y195_K1.7481.00
82_I214_Y1.7471.00
284_I288_L1.7421.00
65_A69_G1.7301.00
15_L18_P1.7191.00
105_V174_R1.6941.00
185_E198_L1.6871.00
74_S218_F1.6841.00
14_F18_P1.6721.00
85_A169_A1.6671.00
77_S221_A1.6221.00
14_F17_I1.6141.00
72_V76_L1.6021.00
92_V170_S1.5891.00
28_L32_V1.5861.00
86_T173_I1.5841.00
17_I20_S1.5631.00
185_E189_Y1.5521.00
88_F170_S1.5511.00
56_P267_A1.5481.00
32_V37_S1.5441.00
252_L256_Q1.5411.00
32_V36_N1.4781.00
169_A217_A1.4021.00
203_L210_F1.3971.00
182_R185_E1.3931.00
100_V103_F1.3911.00
212_G216_L1.3731.00
225_T229_S1.3721.00
93_N174_R1.3621.00
177_Y202_K1.3531.00
12_F16_L1.3521.00
89_S173_I1.3471.00
81_S217_A1.3361.00
62_G65_A1.3301.00
29_I41_L1.3221.00
227_A231_T1.3201.00
173_I213_A1.3141.00
97_P101_K1.2881.00
95_I98_K1.2851.00
83_P87_A1.2811.00
51_K55_N1.2691.00
94_D182_R1.2441.00
153_S246_G1.2411.00
188_V201_L1.2361.00
248_T251_S1.2361.00
73_T248_T1.2321.00
256_Q264_Q1.2241.00
182_R186_E1.2181.00
90_I177_Y1.2071.00
225_T254_I1.2021.00
50_T53_I1.1891.00
86_T210_F1.1851.00
56_P59_D1.1811.00
70_T249_I1.1761.00
34_V273_L1.1751.00
54_W273_L1.1721.00
183_S186_E1.1721.00
247_Y252_L1.1671.00
40_I43_K1.1601.00
76_L79_M1.1541.00
160_I231_T1.1501.00
180_V205_Y1.1321.00
127_L156_L1.1291.00
194_G198_L1.1191.00
103_F106_N1.1021.00
79_M83_P1.0961.00
207_K211_L1.0941.00
69_G72_V1.0881.00
152_P155_L1.0721.00
39_P43_K1.0701.00
82_I210_F1.0651.00
103_F107_L1.0641.00
157_A228_V1.0621.00
166_T170_S1.0561.00
36_N39_P1.0541.00
29_I37_S1.0461.00
173_I209_A1.0461.00
185_E195_K1.0321.00
154_I246_G1.0261.00
77_S81_S1.0181.00
43_K48_I1.0181.00
90_I199_I1.0141.00
13_Y17_I1.0061.00
58_Y64_L1.0001.00
205_Y208_K0.9931.00
155_L159_I0.9921.00
247_Y251_S0.9901.00
80_I158_S0.9901.00
71_I75_V0.9881.00
77_S161_L0.9851.00
53_I266_N0.9821.00
255_S259_T0.9821.00
224_E227_A0.9781.00
76_L80_I0.9761.00
87_A91_F0.9741.00
252_L271_L0.9721.00
93_N177_Y0.9701.00
172_L213_A0.9671.00
12_F18_P0.9631.00
161_L221_A0.9621.00
13_Y16_L0.9611.00
224_E228_V0.9581.00
101_K178_F0.9541.00
90_I195_K0.9491.00
193_L198_L0.9491.00
33_L273_L0.9391.00
125_L129_P0.9351.00
252_L255_S0.9161.00
32_V35_Y0.9151.00
67_I249_I0.9111.00
36_N269_F0.9091.00
228_V248_T0.9001.00
75_V79_M0.8991.00
23_V27_I0.8911.00
56_P60_Q0.8861.00
72_V75_V0.8861.00
151_G155_L0.8831.00
257_F268_M0.8821.00
123_G231_T0.8811.00
60_Q64_L0.8751.00
63_G271_L0.8741.00
89_S93_N0.8701.00
123_G160_I0.8681.00
176_V206_I0.8671.00
99_K102_S0.8661.00
77_S158_S0.8651.00
285_I288_L0.8641.00
207_K210_F0.8641.00
73_T154_I0.8601.00
154_I158_S0.8581.00
25_T29_I0.8561.00
79_M214_Y0.8521.00
67_I71_I0.8471.00
285_I289_I0.8451.00
206_I209_A0.8421.00
102_S105_V0.8411.00
80_I83_P0.8411.00
169_A173_I0.8411.00
69_G154_I0.8401.00
109_D171_S0.8371.00
72_V155_L0.8281.00
81_S85_A0.8241.00
158_S162_A0.8241.00
57_I274_F0.8241.00
199_I203_L0.8231.00
81_S165_I0.8201.00
254_I258_G0.8201.00
217_A221_A0.8171.00
173_I206_I0.8151.00
91_F98_K0.8111.00
73_T161_L0.8111.00
193_L200_T0.8091.00
32_V40_I0.8081.00
229_S251_S0.8071.00
151_G154_I0.8051.00
85_A170_S0.8051.00
116_T164_M0.8001.00
152_P234_N0.7961.00
120_G226_V0.7961.00
128_G132_S0.7931.00
150_N153_S0.7921.00
15_L19_S0.7851.00
256_Q267_A0.7841.00
256_Q262_G0.7821.00
198_L202_K0.7821.00
195_K199_I0.7801.00
89_S177_Y0.7791.00
37_S40_I0.7771.00
32_V41_L0.7761.00
153_S156_L0.7711.00
281_I285_I0.7701.00
92_V105_V0.7661.00
68_Y71_I0.7591.00
232_I246_G0.7531.00
180_V206_I0.7501.00
279_G283_V0.7451.00
89_S170_S0.7391.00
14_F20_S0.7371.00
109_D112_A0.7311.00
129_P132_S0.7291.00
199_I202_K0.7271.00
74_S78_V0.7271.00
66_A69_G0.7261.00
160_I227_A0.7261.00
267_A271_L0.7251.00
12_F15_L0.7251.00
56_P264_Q0.7241.00
184_F201_L0.7231.00
124_L128_G0.7231.00
28_L31_S0.7201.00
256_Q271_L0.7171.00
27_I30_L0.7111.00
82_I173_I0.7111.00
269_F273_L0.7071.00
38_I49_Y0.7001.00
92_V104_L0.6981.00
33_L269_F0.6971.00
33_L272_A0.6951.00
120_G230_L0.6951.00
23_V26_F0.6911.00
78_V218_F0.6881.00
85_A173_I0.6871.00
132_S155_L0.6851.00
182_R189_Y0.6841.00
235_V247_Y0.6841.00
173_I177_Y0.6841.00
250_S275_L0.6841.00
232_I236_L0.6831.00
81_S169_A0.6811.00
48_I51_K0.6801.00
33_L36_N0.6801.00
43_K47_S0.6791.00
16_L20_S0.6761.00
128_G151_G0.6741.00
152_P156_L0.6671.00
40_I47_S0.6631.00
21_V25_T0.6631.00
187_A191_L0.6631.00
78_V82_I0.6631.00
128_G131_L0.6601.00
210_F213_A0.6601.00
156_L160_I0.6591.00
112_A167_P0.6581.00
265_Y268_M0.6571.00
54_W270_A0.6561.00
155_L158_S0.6551.00
70_T250_S0.6541.00
224_E248_T0.6481.00
92_V174_R0.6471.00
157_A161_L0.6381.00
21_V24_F0.6371.00
57_I267_A0.6371.00
64_L67_I0.6371.00
116_T226_V0.6361.00
253_I271_L0.6351.00
73_T157_A0.6291.00
232_I247_Y0.6291.00
202_K205_Y0.6281.00
66_A249_I0.6271.00
55_N58_Y0.6241.00
81_S221_A0.6231.00
88_F166_T0.6231.00
251_S255_S0.6221.00
172_L209_A0.6201.00
30_L33_L0.6191.00
36_N41_L0.6171.00
49_Y52_N0.6161.00
40_I48_I0.6141.00
209_A213_A0.6141.00
70_T222_V0.6131.00
210_F214_Y0.6131.00
98_K104_L0.6081.00
61_Y65_A0.6071.00
84_F162_A0.6071.00
29_I40_I0.6041.00
259_T262_G0.6041.00
61_Y64_L0.6031.00
105_V171_S0.6021.00
88_F108_S0.6021.00
156_L231_T0.6011.00
77_S162_A0.6001.00
165_I217_A0.5961.00
37_S273_L0.5951.00
266_N269_F0.5951.00
22_V26_F0.5901.00
187_A190_S0.5881.00
43_K46_L0.5871.00
81_S162_A0.5871.00
95_I101_K0.5851.00
36_N40_I0.5851.00
278_I281_I0.5841.00
157_A232_I0.5841.00
269_F272_A0.5821.00
91_F95_I0.5811.00
249_I275_L0.5811.00
198_L201_L0.5801.00
228_V251_S0.5721.00
251_S254_I0.5721.00
39_P42_E0.5711.00
73_T158_S0.5701.00
275_L279_G0.5701.00
76_L162_A0.5701.00
123_G126_S0.5701.00
100_V104_L0.5691.00
37_S41_L0.5691.00
112_A168_F0.5691.00
38_I50_T0.5681.00
265_Y269_F0.5681.00
57_I271_L0.5641.00
12_F17_I0.5601.00
42_E45_G0.5601.00
280_F284_I0.5591.00
74_S221_A0.5581.00
16_L19_S0.5501.00
165_I220_R0.5501.00
263_I267_A0.5491.00
236_L246_G0.5491.00
226_V230_L0.5481.00
120_G124_L0.5431.00
283_V287_K0.5391.00
125_L128_G0.5381.00
119_Y163_I0.5361.00
219_G223_G0.5341.00
267_A270_A0.5341.00
226_V229_S0.5331.00
272_A275_L0.5311.00
35_Y38_I0.5301.00
117_V230_L0.5281.00
161_L228_V0.5241.00
78_V221_A0.5231.00
89_S174_R0.5221.00
74_S222_V0.5211.00
24_F28_L0.5191.00
15_L20_S0.5191.00
211_L214_Y0.5171.00
102_S106_N0.5171.00
220_R223_G0.5161.00
73_T77_S0.5121.00
124_L151_G0.5111.00
90_I202_K0.5111.00
53_I56_P0.5101.00
108_S167_P0.5101.00
29_I38_I0.5101.00
99_K103_F0.5091.00
82_I86_T0.5091.00
180_V185_E0.5091.00
62_G247_Y0.5081.00
114_F118_L0.5071.00
84_F166_T0.5071.00
107_L111_L0.5041.00
131_L150_N0.5021.00
88_F91_F0.5021.00
32_V39_P0.5021.00
171_S175_E0.5021.00
104_L108_S0.5001.00
132_S150_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9354 100 0.332 Contact Map
2onkC 2 0.8333 100 0.335 Contact Map
3d31C 2 0.8401 100 0.339 Contact Map
3rlfG 1 0.8844 100 0.377 Contact Map
3rlfF 1 0.9456 100 0.38 Contact Map
4tquN 1 0.8844 100 0.39 Contact Map
4ymuD 2 0.7245 99.9 0.512 Contact Map
3tuiA 2 0.7075 99.9 0.538 Contact Map
2m8rA 1 0.1259 4.8 0.955 Contact Map
2k9pA 1 0.1633 4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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