GREMLIN Database
Q97ZT6 - Phosphate transport system permease protein (PstA)
UniProt: Q97ZT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (246)
Sequences: 69595 (44533)
Seq/√Len: 2839.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_Q180_K3.8751.00
65_E69_Y3.2781.00
169_Y178_V3.1581.00
154_S158_R3.0711.00
62_P65_E2.6321.00
63_A233_M2.6071.00
91_F165_E2.5691.00
174_T177_Q2.5601.00
34_G51_P2.5401.00
168_A178_V2.5351.00
156_A189_G2.5081.00
165_E182_V2.4951.00
73_L138_A2.4461.00
49_L52_N2.4221.00
228_T236_N2.4201.00
175_T178_V2.3651.00
61_G65_E2.3541.00
75_V194_L2.3471.00
49_L53_P2.2201.00
52_N56_G2.2181.00
153_I190_I2.2141.00
95_S98_A2.1471.00
77_I142_A2.1271.00
173_L177_Q2.0771.00
83_I179_I1.9911.00
90_S158_R1.9501.00
149_S193_G1.9481.00
69_Y134_G1.9391.00
157_L186_G1.9371.00
164_Y185_I1.9221.00
28_Y32_V1.8881.00
32_V36_K1.8811.00
168_A173_L1.8681.00
83_I186_G1.8111.00
102_R154_S1.7991.00
79_A194_L1.7841.00
62_P66_G1.7811.00
169_Y175_T1.7681.00
165_E178_V1.7591.00
245_L248_V1.7541.00
71_V198_F1.7171.00
82_S149_S1.6741.00
69_Y73_L1.6731.00
74_A201_I1.6671.00
53_P248_V1.6261.00
89_L150_T1.6261.00
83_I153_I1.6191.00
165_E169_Y1.6121.00
85_T150_T1.5771.00
13_T17_I1.5061.00
134_G227_V1.4941.00
233_M237_Y1.4921.00
162_K165_E1.4671.00
97_I100_L1.4371.00
205_T209_I1.4201.00
149_S197_G1.4161.00
86_G153_I1.3981.00
25_F29_T1.3971.00
183_M190_I1.3941.00
59_G62_P1.3921.00
31_V254_F1.3881.00
80_P84_F1.3861.00
22_P26_L1.3771.00
90_S154_S1.3741.00
92_F95_S1.3721.00
78_S197_G1.3581.00
192_N196_I1.3561.00
70_M229_G1.3531.00
157_L182_V1.3421.00
29_T33_N1.3291.00
215_T226_A1.3231.00
48_D52_N1.3191.00
53_P56_G1.3151.00
153_I193_G1.3141.00
214_S226_A1.2891.00
207_P211_L1.2821.00
162_K166_E1.2821.00
91_F162_K1.2771.00
94_R98_A1.2691.00
168_A181_L1.2661.00
83_I190_I1.2591.00
205_T235_Y1.2591.00
163_L166_E1.2591.00
130_L135_I1.2371.00
47_I50_P1.2161.00
100_L103_A1.2071.00
229_G232_V1.2001.00
73_L76_L1.1901.00
87_V157_L1.1891.00
17_I21_L1.1891.00
66_G69_Y1.1891.00
67_S230_I1.1881.00
124_L136_T1.1831.00
228_T233_M1.1641.00
40_S45_F1.1601.00
140_A211_L1.1571.00
174_T178_V1.1561.00
212_T227_V1.1561.00
160_P185_I1.1541.00
76_L80_P1.1491.00
237_Y245_L1.1491.00
237_Y241_G1.1491.00
29_T32_V1.1311.00
187_R191_I1.1281.00
130_L133_N1.1191.00
79_A190_I1.1141.00
132_L135_I1.1141.00
30_V254_F1.0901.00
133_N227_V1.0841.00
10_S14_L1.0801.00
165_E175_T1.0791.00
228_T232_V1.0731.00
100_L104_S1.0711.00
146_L150_T1.0661.00
153_I189_G1.0571.00
236_N240_S1.0561.00
90_S157_L1.0481.00
53_P57_L1.0431.00
77_I138_A1.0321.00
74_A78_S1.0311.00
152_Q193_G1.0191.00
137_A208_I1.0151.00
39_I42_G1.0121.00
10_S13_T1.0111.00
84_F88_F1.0051.00
135_I139_M1.0001.00
185_I188_R1.0001.00
68_L72_S0.9981.00
87_V179_I0.9901.00
173_L178_V0.9841.00
204_E207_P0.9811.00
87_V175_T0.9781.00
37_V40_S0.9621.00
73_L77_I0.9561.00
64_L230_I0.9561.00
51_P254_F0.9461.00
74_A141_L0.9431.00
204_E208_I0.9421.00
50_P247_E0.9391.00
55_E61_G0.9391.00
122_T126_V0.9331.00
134_G138_A0.9311.00
76_L194_L0.9281.00
141_L201_I0.9261.00
120_I211_L0.9171.00
98_A158_R0.9161.00
20_L24_T0.9131.00
233_M252_A0.9081.00
9_V13_T0.9051.00
233_M236_N0.9041.00
69_Y135_I0.9031.00
208_I229_G0.9021.00
69_Y72_S0.9001.00
86_G90_S0.8971.00
70_M134_G0.8871.00
131_G135_I0.8831.00
33_N250_W0.8791.00
235_Y239_F0.8751.00
82_S150_T0.8741.00
72_S76_L0.8731.00
214_S227_V0.8681.00
12_I16_V0.8671.00
238_A249_A0.8641.00
64_L68_L0.8621.00
99_S102_R0.8601.00
77_I80_P0.8581.00
186_G189_G0.8561.00
96_K99_S0.8541.00
153_I186_G0.8491.00
78_S82_S0.8471.00
187_R190_I0.8461.00
74_A138_A0.8461.00
156_A186_G0.8411.00
131_G134_G0.8411.00
106_E151_I0.8401.00
209_I232_V0.8401.00
36_K40_S0.8371.00
140_A207_P0.8351.00
173_L180_K0.8251.00
138_A142_A0.8241.00
53_P245_L0.8211.00
88_F95_S0.8201.00
89_L102_R0.8191.00
178_V182_V0.8191.00
78_S145_M0.8191.00
66_G134_G0.8161.00
117_G206_A0.8151.00
121_F125_V0.8131.00
86_G157_L0.8091.00
35_S46_F0.8081.00
65_E68_L0.8071.00
135_I138_A0.8051.00
197_G201_I0.8021.00
113_T144_V0.7991.00
86_G150_T0.7981.00
70_M141_L0.7971.00
179_I183_M0.7951.00
149_S153_I0.7931.00
175_T179_I0.7901.00
120_I140_A0.7891.00
71_V75_V0.7881.00
60_I252_A0.7871.00
132_L214_S0.7751.00
237_Y248_V0.7611.00
33_N36_K0.7551.00
30_V250_W0.7481.00
37_V44_R0.7471.00
164_Y181_L0.7451.00
125_V131_G0.7391.00
179_I182_V0.7331.00
14_L17_I0.7321.00
48_D51_P0.7311.00
133_N136_T0.7301.00
78_S149_S0.7291.00
215_T228_T0.7281.00
232_V236_N0.7281.00
237_Y252_A0.7281.00
262_I266_V0.7271.00
20_L23_I0.7191.00
79_A153_I0.7181.00
260_V264_F0.7181.00
46_F49_L0.7151.00
82_S153_I0.7131.00
167_V171_L0.7131.00
132_L136_T0.7121.00
63_A230_I0.7081.00
78_S201_I0.7081.00
106_E109_V0.7081.00
89_L101_I0.7061.00
256_L260_V0.7051.00
265_V268_R0.7041.00
89_L154_S0.7021.00
117_G210_F0.7001.00
37_V45_F0.6991.00
58_G62_P0.6991.00
75_V198_F0.6971.00
247_E250_W0.6931.00
248_V252_A0.6921.00
30_V253_S0.6921.00
242_Y245_L0.6891.00
250_W254_F0.6881.00
25_F28_Y0.6861.00
153_I157_L0.6861.00
63_A66_G0.6851.00
234_I252_A0.6851.00
75_V79_A0.6841.00
40_S44_R0.6821.00
162_K169_Y0.6811.00
125_V128_I0.6801.00
61_G64_L0.6771.00
54_G255_V0.6761.00
45_F48_D0.6731.00
190_I193_G0.6731.00
160_P186_G0.6691.00
204_E229_G0.6671.00
70_M137_A0.6661.00
95_S101_I0.6651.00
19_F23_I0.6651.00
190_I194_L0.6631.00
33_N37_V0.6621.00
231_P256_L0.6601.00
88_F92_F0.6601.00
167_V170_S0.6591.00
92_F98_A0.6591.00
85_T105_L0.6581.00
85_T146_L0.6561.00
35_S47_I0.6551.00
113_T206_A0.6551.00
11_L15_L0.6511.00
264_F268_R0.6411.00
136_T140_A0.6391.00
189_G193_G0.6381.00
11_L14_L0.6381.00
246_N250_W0.6381.00
54_G248_V0.6341.00
57_L61_G0.6321.00
102_R151_I0.6311.00
137_A141_L0.6301.00
58_G61_G0.6281.00
121_F131_G0.6241.00
182_V185_I0.6241.00
67_S231_P0.6211.00
137_A212_T0.6191.00
230_I256_L0.6181.00
70_M138_A0.6141.00
81_I142_A0.6141.00
67_S202_I0.6121.00
50_P53_P0.6121.00
122_T125_V0.6081.00
97_I101_I0.6021.00
120_I123_I0.5981.00
212_T228_T0.5931.00
78_S142_A0.5911.00
96_K100_L0.5911.00
34_G251_G0.5901.00
194_L197_G0.5881.00
9_V12_I0.5841.00
152_Q189_G0.5841.00
87_V182_V0.5841.00
116_I143_I0.5821.00
232_V235_Y0.5821.00
74_A142_A0.5811.00
38_I42_G0.5811.00
206_A209_I0.5801.00
52_N55_E0.5801.00
145_M197_G0.5781.00
16_V20_L0.5741.00
178_V181_L0.5731.00
105_L147_P0.5721.00
246_N249_A0.5701.00
199_A203_G0.5681.00
109_V147_P0.5681.00
36_K44_R0.5671.00
114_I210_F0.5661.00
136_T211_L0.5651.00
71_V201_I0.5641.00
51_P251_G0.5621.00
99_S103_A0.5601.00
145_M200_K0.5581.00
71_V202_I0.5531.00
191_I194_L0.5521.00
109_V148_Y0.5521.00
75_V201_I0.5511.00
259_L263_I0.5511.00
113_T117_G0.5501.00
13_T16_V0.5491.00
117_G121_F0.5481.00
241_G245_L0.5461.00
250_W253_S0.5461.00
24_T28_Y0.5451.00
259_L262_I0.5441.00
86_G154_S0.5441.00
81_I146_L0.5431.00
21_L25_F0.5431.00
36_K45_F0.5421.00
141_L208_I0.5421.00
34_G37_V0.5411.00
66_G227_V0.5391.00
206_A210_F0.5361.00
248_V251_G0.5311.00
34_G38_I0.5311.00
261_T265_V0.5301.00
70_M74_A0.5281.00
103_A107_L0.5261.00
130_L139_M0.5261.00
126_V129_G0.5241.00
200_K203_G0.5211.00
79_A83_I0.5211.00
83_I183_M0.5211.00
166_E169_Y0.5201.00
253_S256_L0.5201.00
59_G233_M0.5191.00
111_F115_V0.5181.00
15_L19_F0.5161.00
62_P69_Y0.5131.00
102_R158_R0.5131.00
73_L142_A0.5101.00
85_T88_F0.5091.00
160_P165_E0.5081.00
75_V80_P0.5071.00
32_V46_F0.5071.00
104_S108_M0.5071.00
47_I51_P0.5051.00
59_G228_T0.5051.00
101_I105_L0.5041.00
31_V35_S0.5031.00
201_I204_E0.5021.00
108_M147_P0.5011.00
14_L18_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.886 100 0.284 Contact Map
4tquM 1 0.9301 100 0.301 Contact Map
3d31C 2 0.8676 100 0.308 Contact Map
4tquN 1 0.9412 100 0.314 Contact Map
3rlfG 1 0.9265 100 0.317 Contact Map
3rlfF 1 0.9559 100 0.353 Contact Map
4ymuD 2 0.7684 99.9 0.472 Contact Map
3tuiA 2 0.7537 99.9 0.489 Contact Map
3mktA 1 0.5368 9 0.946 Contact Map
3w4tA 1 0.5 5.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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