Q97ZT5 - SULSO - GREMLIN Contacts

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Q97ZT5 - Threonine synthase (ThrC-1)

UniProt:	Q97ZT5	Sequences: MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKHFISLGEGRTPLIKKGNIWFKLDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGSAIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVRGSREDVAKAAENSGYYYASHVLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPKIVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEIVEAWKELAKMGLLVEYSSATVFAAYKKYSVNDAVLVLTGSGLKVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (277)
Sequences:	21375 (10805)
Seq/√Len:	649.2

ECOLI - SDHD ILVA TRPB CYSK DPAL CYSM TDCB DCYD THRC
BACSU - ILVA SDHD TRPB CYSM CYSK MCCA THRC
HALSA - Q9HMQ7 Q9HRU4 Q9HNH0 Q9HNH6 Q9HQ70 TRPB Q9HRP3
SULSO - Q97ZT5 Q97ZL6 Q980P1 TRPB1 TRPB2 Q980F2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
126_S	133_A	3.921	1.00
76_N	332_D	3.380	1.00
73_K	76_N	2.955	1.00
299_E	327_K	2.677	1.00
109_Q	134_Y	2.630	1.00
208_Y	242_V	2.617	1.00
197_I	334_V	2.568	1.00
139_E	160_R	2.506	1.00
143_G	147_K	2.492	1.00
167_A	171_E	2.473	1.00
101_Y	185_Q	2.426	1.00
132_E	155_H	2.412	1.00
247_E	296_S	2.350	1.00
101_Y	105_K	2.350	1.00
68_R	199_K	2.279	1.00
134_Y	155_H	2.249	1.00
188_D	191_R	2.241	1.00
296_S	299_E	2.194	1.00
103_A	131_I	2.130	1.00
240_K	291_E	2.125	1.00
78_W	332_D	2.104	1.00
248_Q	297_D	2.093	1.00
134_Y	157_V	2.031	1.00
321_V	335_L	2.024	1.00
68_R	200_D	2.009	1.00
253_C	257_K	2.007	1.00
100_S	129_A	1.948	1.00
223_Y	288_A	1.930	1.00
103_A	106_G	1.905	1.00
71_L	334_V	1.871	1.00
168_K	172_N	1.864	1.00
223_Y	241_I	1.863	1.00
190_I	228_H	1.857	1.00
236_S	239_P	1.850	1.00
195_Y	225_G	1.836	1.00
307_L	314_V	1.835	1.00
162_S	165_D	1.826	1.00
87_S	124_A	1.806	1.00
169_A	172_N	1.805	1.00
244_V	324_A	1.777	1.00
78_W	201_L	1.776	1.00
306_E	326_K	1.741	1.00
250_M	254_A	1.737	1.00
109_Q	132_E	1.737	1.00
303_A	323_A	1.735	1.00
179_S	182_L	1.734	1.00
207_N	331_N	1.733	1.00
73_K	78_W	1.726	1.00
206_P	334_V	1.725	1.00
209_V	226_F	1.716	1.00
242_V	291_E	1.701	1.00
213_V	243_A	1.688	1.00
190_I	224_K	1.683	1.00
274_L	320_T	1.657	1.00
307_L	322_F	1.632	1.00
209_V	222_V	1.610	1.00
146_L	158_R	1.605	1.00
207_N	332_D	1.603	1.00
283_D	287_K	1.592	1.00
208_Y	331_N	1.576	1.00
323_A	327_K	1.571	1.00
303_A	326_K	1.519	1.00
198_V	229_L	1.518	1.00
227_K	290_S	1.491	1.00
161_G	165_D	1.491	1.00
114_S	119_G	1.476	1.00
103_A	129_A	1.472	1.00
79_F	337_L	1.465	1.00
194_A	222_V	1.458	1.00
96_V	100_S	1.457	1.00
147_K	150_E	1.457	1.00
293_I	324_A	1.456	1.00
210_F	244_V	1.418	1.00
208_Y	240_K	1.411	1.00
166_V	170_A	1.406	1.00
143_G	146_L	1.402	1.00
98_L	183_Q	1.399	1.00
165_D	168_K	1.395	1.00
99_V	110_I	1.386	1.00
263_P	278_R	1.378	1.00
146_L	150_E	1.376	1.00
136_F	169_A	1.371	1.00
299_E	323_A	1.365	1.00
254_A	257_K	1.358	1.00
253_C	294_V	1.358	1.00
194_A	226_F	1.351	1.00
210_F	328_Y	1.336	1.00
303_A	322_F	1.311	1.00
314_V	337_L	1.289	1.00
219_L	289_S	1.283	1.00
250_M	294_V	1.263	1.00
302_E	306_E	1.253	1.00
225_G	229_L	1.252	1.00
253_C	292_C	1.245	1.00
247_E	294_V	1.239	1.00
305_K	309_K	1.233	1.00
194_A	225_G	1.233	1.00
208_Y	333_A	1.229	1.00
137_V	149_I	1.227	1.00
201_L	206_P	1.224	1.00
167_A	170_A	1.222	1.00
137_V	158_R	1.218	1.00
220_L	281_L	1.216	1.00
271_A	300_I	1.213	1.00
72_I	81_L	1.196	1.00
61_F	64_L	1.194	1.00
254_A	258_K	1.190	1.00
60_H	64_L	1.185	1.00
308_A	313_L	1.180	1.00
74_K	79_F	1.168	1.00
195_Y	199_K	1.165	1.00
198_V	225_G	1.158	1.00
295_V	323_A	1.155	1.00
205_I	332_D	1.152	1.00
149_I	154_A	1.150	1.00
97_T	191_R	1.147	1.00
258_K	262_T	1.143	1.00
71_L	201_L	1.138	1.00
293_I	327_K	1.137	1.00
226_F	239_P	1.136	1.00
100_S	104_E	1.130	1.00
224_K	283_D	1.125	1.00
270_I	301_V	1.124	1.00
299_E	302_E	1.120	1.00
219_L	243_A	1.120	1.00
303_A	306_E	1.119	1.00
119_G	149_I	1.118	1.00
146_L	156_V	1.105	1.00
70_P	84_L	1.095	1.00
101_Y	104_E	1.095	1.00
242_V	293_I	1.086	1.00
318_S	337_L	1.084	1.00
170_A	177_Y	1.082	1.00
243_A	292_C	1.075	1.00
327_K	330_V	1.074	1.00
219_L	241_I	1.066	1.00
222_V	336_V	1.047	1.00
298_N	302_E	1.045	1.00
112_E	135_I	1.039	1.00
99_V	129_A	1.039	1.00
201_L	334_V	1.036	1.00
77_I	325_Y	1.034	1.00
304_W	319_A	1.031	1.00
122_I	133_A	1.030	1.00
71_L	197_I	1.027	1.00
124_A	152_Y	1.015	1.00
110_I	126_S	1.014	1.00
111_S	175_Y	1.013	1.00
109_Q	175_Y	1.006	1.00
97_T	101_Y	0.991	1.00
95_A	121_A	0.990	1.00
97_T	100_S	0.987	1.00
61_F	97_T	0.985	1.00
325_Y	335_L	0.984	1.00
256_F	292_C	0.981	1.00
127_A	133_A	0.979	1.00
219_L	285_M	0.979	1.00
269_S	275_V	0.973	1.00
197_I	206_P	0.972	1.00
168_K	171_E	0.967	1.00
98_L	178_A	0.962	1.00
250_M	255_K	0.960	1.00
150_E	155_H	0.955	1.00
191_R	195_Y	0.955	1.00
198_V	236_S	0.945	1.00
97_T	188_D	0.940	1.00
195_Y	229_L	0.938	1.00
314_V	318_S	0.929	1.00
210_F	325_Y	0.926	1.00
99_V	125_Y	0.926	1.00
259_I	286_V	0.919	1.00
208_Y	328_Y	0.918	1.00
251_P	277_T	0.917	1.00
318_S	338_T	0.915	1.00
284_Y	288_A	0.909	1.00
270_I	297_D	0.901	1.00
240_K	290_S	0.900	1.00
250_M	253_C	0.897	1.00
147_K	151_S	0.896	1.00
249_V	256_F	0.891	1.00
251_P	254_A	0.890	1.00
283_D	286_V	0.885	1.00
313_L	341_G	0.881	1.00
210_F	242_V	0.880	1.00
105_K	185_Q	0.878	1.00
211_I	222_V	0.877	1.00
213_V	219_L	0.873	1.00
108_K	174_G	0.870	1.00
101_Y	188_D	0.865	1.00
224_K	228_H	0.865	1.00
225_G	228_H	0.864	1.00
201_L	332_D	0.861	1.00
103_A	107_V	0.853	1.00
74_K	310_M	0.848	1.00
300_I	320_T	0.846	1.00
60_H	63_S	0.841	1.00
121_A	125_Y	0.840	1.00
81_L	337_L	0.835	1.00
65_G	96_V	0.834	1.00
189_G	193_L	0.834	1.00
274_L	317_S	0.823	1.00
127_A	152_Y	0.819	1.00
282_L	286_V	0.819	1.00
123_A	154_A	0.815	1.00
124_A	128_A	0.810	1.00
113_D	163_R	0.806	1.00
187_R	281_L	0.806	1.00
252_L	285_M	0.806	1.00
326_K	330_V	0.804	1.00
252_L	292_C	0.802	1.00
322_F	337_L	0.801	1.00
193_L	218_L	0.801	1.00
190_I	225_G	0.800	1.00
206_P	239_P	0.798	1.00
110_I	131_I	0.798	1.00
252_L	279_P	0.793	1.00
69_T	85_N	0.788	1.00
321_V	338_T	0.785	1.00
240_K	331_N	0.785	1.00
80_K	196_E	0.782	1.00
102_L	176_Y	0.781	1.00
69_T	80_K	0.775	1.00
102_L	106_G	0.773	1.00
193_L	336_V	0.772	1.00
202_D	205_I	0.771	1.00
322_F	335_L	0.769	1.00
210_F	324_A	0.768	1.00
150_E	158_R	0.767	1.00
74_K	322_F	0.767	1.00
107_V	131_I	0.767	1.00
136_F	159_V	0.765	1.00
284_Y	289_S	0.762	1.00
98_L	186_F	0.761	1.00
139_E	161_G	0.760	1.00
285_M	289_S	0.759	1.00
205_I	236_S	0.759	1.00
79_F	322_F	0.752	1.00
213_V	292_C	0.752	1.00
134_Y	175_Y	0.750	1.00
81_L	84_L	0.750	1.00
314_V	319_A	0.748	1.00
145_K	272_D	0.747	1.00
198_V	226_F	0.742	1.00
60_H	73_K	0.742	1.00
97_T	185_Q	0.742	1.00
193_L	222_V	0.731	1.00
120_S	149_I	0.728	1.00
69_T	93_R	0.727	1.00
213_V	252_L	0.725	1.00
187_R	224_K	0.721	1.00
95_A	125_Y	0.718	1.00
257_K	291_E	0.717	1.00
179_S	183_Q	0.716	1.00
88_G	340_S	0.715	1.00
222_V	226_F	0.715	1.00
113_D	177_Y	0.713	1.00
193_L	197_I	0.708	1.00
136_F	157_V	0.708	1.00
107_V	176_Y	0.707	1.00
98_L	185_Q	0.704	1.00
135_I	149_I	0.704	1.00
183_Q	186_F	0.700	1.00
198_V	201_L	0.696	1.00
139_E	158_R	0.695	1.00
246_T	274_L	0.694	1.00
66_E	92_D	0.686	1.00
301_V	316_Y	0.686	1.00
254_A	262_T	0.686	1.00
166_V	171_E	0.685	1.00
273_A	317_S	0.684	1.00
271_A	274_L	0.682	1.00
197_I	222_V	0.682	1.00
209_V	336_V	0.681	1.00
110_I	133_A	0.680	1.00
166_V	169_A	0.678	1.00
108_K	132_E	0.674	1.00
212_P	338_T	0.674	1.00
120_S	148_Q	0.670	1.00
81_L	312_L	0.668	1.00
67_G	86_P	0.660	1.00
185_Q	188_D	0.658	1.00
210_F	333_A	0.658	1.00
59_K	63_S	0.658	1.00
90_Y	218_L	0.657	1.00
182_L	220_L	0.655	1.00
324_A	328_Y	0.655	1.00
188_D	224_K	0.654	1.00
66_E	85_N	0.650	1.00
304_W	316_Y	0.648	1.00
79_F	335_L	0.648	1.00
111_S	136_F	0.648	1.00
252_L	281_L	0.641	1.00
92_D	124_A	0.640	1.00
132_E	175_Y	0.640	1.00
59_K	64_L	0.639	1.00
206_P	332_D	0.638	1.00
322_F	326_K	0.632	1.00
244_V	293_I	0.630	1.00
101_Y	107_V	0.627	1.00
177_Y	180_H	0.627	1.00
307_L	337_L	0.625	1.00
62_I	65_G	0.623	1.00
148_Q	151_S	0.623	1.00
244_V	320_T	0.621	1.00
141_A	272_D	0.619	1.00
212_P	321_V	0.619	1.00
133_A	154_A	0.619	1.00
71_L	78_W	0.619	1.00
242_V	328_Y	0.618	1.00
83_F	340_S	0.618	1.00
227_K	288_A	0.616	1.00
184_P	187_R	0.616	1.00
282_L	288_A	0.615	1.00
199_K	229_L	0.615	1.00
209_V	239_P	0.613	1.00
164_E	167_A	0.613	1.00
283_D	288_A	0.613	1.00
122_I	135_I	0.612	1.00
61_F	100_S	0.606	1.00
59_K	199_K	0.603	1.00
87_S	152_Y	0.601	1.00
211_I	219_L	0.599	1.00
59_K	195_Y	0.598	1.00
116_G	119_G	0.598	1.00
137_V	146_L	0.592	1.00
285_M	288_A	0.592	1.00
83_F	312_L	0.591	1.00
111_S	170_A	0.589	1.00
307_L	312_L	0.589	1.00
281_L	284_Y	0.588	1.00
67_G	85_N	0.588	1.00
143_G	150_E	0.587	1.00
163_R	167_A	0.586	1.00
201_L	205_I	0.586	1.00
247_E	250_M	0.585	1.00
165_D	169_A	0.585	1.00
176_Y	179_S	0.582	1.00
141_A	146_L	0.582	1.00
86_P	92_D	0.581	1.00
291_E	328_Y	0.581	1.00
71_L	200_D	0.578	1.00
155_H	158_R	0.577	1.00
119_G	135_I	0.575	1.00
220_L	224_K	0.572	1.00
79_F	307_L	0.572	1.00
76_N	331_N	0.571	1.00
248_Q	267_V	0.568	1.00
302_E	305_K	0.568	1.00
95_A	122_I	0.568	1.00
122_I	178_A	0.567	1.00
106_G	176_Y	0.563	1.00
251_P	279_P	0.563	1.00
123_A	133_A	0.562	1.00
79_F	314_V	0.561	1.00
209_V	241_I	0.561	1.00
197_I	209_V	0.561	1.00
229_L	236_S	0.560	1.00
325_Y	329_S	0.559	1.00
109_Q	155_H	0.555	1.00
243_A	289_S	0.553	1.00
202_D	332_D	0.553	1.00
295_V	324_A	0.552	1.00
155_H	173_S	0.552	1.00
307_L	310_M	0.552	1.00
113_D	178_A	0.552	1.00
69_T	196_E	0.549	1.00
297_D	301_V	0.548	1.00
164_E	168_K	0.548	1.00
206_P	236_S	0.548	1.00
62_I	66_E	0.548	1.00
108_K	131_I	0.546	1.00
112_E	122_I	0.543	1.00
295_V	300_I	0.543	1.00
94_G	98_L	0.541	1.00
59_K	65_G	0.541	1.00
324_A	327_K	0.541	1.00
298_N	301_V	0.540	1.00
282_L	292_C	0.539	1.00
197_I	336_V	0.537	1.00
86_P	124_A	0.536	1.00
282_L	289_S	0.534	0.99
87_S	92_D	0.532	0.99
66_E	96_V	0.532	0.99
245_Q	253_C	0.531	0.99
276_S	279_P	0.528	0.99
296_S	327_K	0.527	0.99
160_R	165_D	0.527	0.99
205_I	238_M	0.526	0.99
222_V	241_I	0.526	0.99
332_D	335_L	0.526	0.99
222_V	225_G	0.525	0.99
264_P	267_V	0.525	0.99
254_A	265_D	0.524	0.99
98_L	176_Y	0.523	0.99
299_E	303_A	0.522	0.99
189_G	192_T	0.522	0.99
110_I	178_A	0.517	0.99
255_K	262_T	0.517	0.99
255_K	261_Y	0.516	0.99
94_G	118_A	0.515	0.99
137_V	141_A	0.512	0.99
229_L	237_E	0.511	0.99
195_Y	228_H	0.511	0.99
169_A	173_S	0.510	0.99
79_F	312_L	0.510	0.99
191_R	225_G	0.509	0.99
65_G	84_L	0.508	0.99
140_T	158_R	0.507	0.99
183_Q	187_R	0.506	0.99
284_Y	287_K	0.505	0.99
111_S	169_A	0.504	0.99
79_F	318_S	0.504	0.99
295_V	320_T	0.504	0.99
72_I	312_L	0.504	0.99
254_A	294_V	0.500	0.99
115_S	273_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e5xA	2	0.9333	100	0.217	Contact Map
1tdjA	2	0.8551	100	0.296	Contact Map
3ss7X	1	0.9768	100	0.302	Contact Map
2zsjA	2	0.8551	100	0.307	Contact Map
2d1fA	2	0.858	100	0.311	Contact Map
3aeyA	2	0.8522	100	0.313	Contact Map
1v71A	2	0.8377	100	0.318	Contact Map
2gn0A	2	0.8638	100	0.319	Contact Map
4cooA	2	0.8435	100	0.323	Contact Map
1y7lA	2	0.8058	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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