GREMLIN Database
Q97ZT5 - Threonine synthase (ThrC-1)
UniProt: Q97ZT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (277)
Sequences: 21375 (10805)
Seq/√Len: 649.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_S133_A3.9211.00
76_N332_D3.3801.00
73_K76_N2.9551.00
299_E327_K2.6771.00
109_Q134_Y2.6301.00
208_Y242_V2.6171.00
197_I334_V2.5681.00
139_E160_R2.5061.00
143_G147_K2.4921.00
167_A171_E2.4731.00
101_Y185_Q2.4261.00
132_E155_H2.4121.00
247_E296_S2.3501.00
101_Y105_K2.3501.00
68_R199_K2.2791.00
134_Y155_H2.2491.00
188_D191_R2.2411.00
296_S299_E2.1941.00
103_A131_I2.1301.00
240_K291_E2.1251.00
78_W332_D2.1041.00
248_Q297_D2.0931.00
134_Y157_V2.0311.00
321_V335_L2.0241.00
68_R200_D2.0091.00
253_C257_K2.0071.00
100_S129_A1.9481.00
223_Y288_A1.9301.00
103_A106_G1.9051.00
71_L334_V1.8711.00
168_K172_N1.8641.00
223_Y241_I1.8631.00
190_I228_H1.8571.00
236_S239_P1.8501.00
195_Y225_G1.8361.00
307_L314_V1.8351.00
162_S165_D1.8261.00
87_S124_A1.8061.00
169_A172_N1.8051.00
244_V324_A1.7771.00
78_W201_L1.7761.00
306_E326_K1.7411.00
250_M254_A1.7371.00
109_Q132_E1.7371.00
303_A323_A1.7351.00
179_S182_L1.7341.00
207_N331_N1.7331.00
73_K78_W1.7261.00
206_P334_V1.7251.00
209_V226_F1.7161.00
242_V291_E1.7011.00
213_V243_A1.6881.00
190_I224_K1.6831.00
274_L320_T1.6571.00
307_L322_F1.6321.00
209_V222_V1.6101.00
146_L158_R1.6051.00
207_N332_D1.6031.00
283_D287_K1.5921.00
208_Y331_N1.5761.00
323_A327_K1.5711.00
303_A326_K1.5191.00
198_V229_L1.5181.00
227_K290_S1.4911.00
161_G165_D1.4911.00
114_S119_G1.4761.00
103_A129_A1.4721.00
79_F337_L1.4651.00
194_A222_V1.4581.00
96_V100_S1.4571.00
147_K150_E1.4571.00
293_I324_A1.4561.00
210_F244_V1.4181.00
208_Y240_K1.4111.00
166_V170_A1.4061.00
143_G146_L1.4021.00
98_L183_Q1.3991.00
165_D168_K1.3951.00
99_V110_I1.3861.00
263_P278_R1.3781.00
146_L150_E1.3761.00
136_F169_A1.3711.00
299_E323_A1.3651.00
254_A257_K1.3581.00
253_C294_V1.3581.00
194_A226_F1.3511.00
210_F328_Y1.3361.00
303_A322_F1.3111.00
314_V337_L1.2891.00
219_L289_S1.2831.00
250_M294_V1.2631.00
302_E306_E1.2531.00
225_G229_L1.2521.00
253_C292_C1.2451.00
247_E294_V1.2391.00
305_K309_K1.2331.00
194_A225_G1.2331.00
208_Y333_A1.2291.00
137_V149_I1.2271.00
201_L206_P1.2241.00
167_A170_A1.2221.00
137_V158_R1.2181.00
220_L281_L1.2161.00
271_A300_I1.2131.00
72_I81_L1.1961.00
61_F64_L1.1941.00
254_A258_K1.1901.00
60_H64_L1.1851.00
308_A313_L1.1801.00
74_K79_F1.1681.00
195_Y199_K1.1651.00
198_V225_G1.1581.00
295_V323_A1.1551.00
205_I332_D1.1521.00
149_I154_A1.1501.00
97_T191_R1.1471.00
258_K262_T1.1431.00
71_L201_L1.1381.00
293_I327_K1.1371.00
226_F239_P1.1361.00
100_S104_E1.1301.00
224_K283_D1.1251.00
270_I301_V1.1241.00
299_E302_E1.1201.00
219_L243_A1.1201.00
303_A306_E1.1191.00
119_G149_I1.1181.00
146_L156_V1.1051.00
70_P84_L1.0951.00
101_Y104_E1.0951.00
242_V293_I1.0861.00
318_S337_L1.0841.00
170_A177_Y1.0821.00
243_A292_C1.0751.00
327_K330_V1.0741.00
219_L241_I1.0661.00
222_V336_V1.0471.00
298_N302_E1.0451.00
112_E135_I1.0391.00
99_V129_A1.0391.00
201_L334_V1.0361.00
77_I325_Y1.0341.00
304_W319_A1.0311.00
122_I133_A1.0301.00
71_L197_I1.0271.00
124_A152_Y1.0151.00
110_I126_S1.0141.00
111_S175_Y1.0131.00
109_Q175_Y1.0061.00
97_T101_Y0.9911.00
95_A121_A0.9901.00
97_T100_S0.9871.00
61_F97_T0.9851.00
325_Y335_L0.9841.00
256_F292_C0.9811.00
127_A133_A0.9791.00
219_L285_M0.9791.00
269_S275_V0.9731.00
197_I206_P0.9721.00
168_K171_E0.9671.00
98_L178_A0.9621.00
250_M255_K0.9601.00
150_E155_H0.9551.00
191_R195_Y0.9551.00
198_V236_S0.9451.00
97_T188_D0.9401.00
195_Y229_L0.9381.00
314_V318_S0.9291.00
210_F325_Y0.9261.00
99_V125_Y0.9261.00
259_I286_V0.9191.00
208_Y328_Y0.9181.00
251_P277_T0.9171.00
318_S338_T0.9151.00
284_Y288_A0.9091.00
270_I297_D0.9011.00
240_K290_S0.9001.00
250_M253_C0.8971.00
147_K151_S0.8961.00
249_V256_F0.8911.00
251_P254_A0.8901.00
283_D286_V0.8851.00
313_L341_G0.8811.00
210_F242_V0.8801.00
105_K185_Q0.8781.00
211_I222_V0.8771.00
213_V219_L0.8731.00
108_K174_G0.8701.00
101_Y188_D0.8651.00
224_K228_H0.8651.00
225_G228_H0.8641.00
201_L332_D0.8611.00
103_A107_V0.8531.00
74_K310_M0.8481.00
300_I320_T0.8461.00
60_H63_S0.8411.00
121_A125_Y0.8401.00
81_L337_L0.8351.00
65_G96_V0.8341.00
189_G193_L0.8341.00
274_L317_S0.8231.00
127_A152_Y0.8191.00
282_L286_V0.8191.00
123_A154_A0.8151.00
124_A128_A0.8101.00
113_D163_R0.8061.00
187_R281_L0.8061.00
252_L285_M0.8061.00
326_K330_V0.8041.00
252_L292_C0.8021.00
322_F337_L0.8011.00
193_L218_L0.8011.00
190_I225_G0.8001.00
206_P239_P0.7981.00
110_I131_I0.7981.00
252_L279_P0.7931.00
69_T85_N0.7881.00
321_V338_T0.7851.00
240_K331_N0.7851.00
80_K196_E0.7821.00
102_L176_Y0.7811.00
69_T80_K0.7751.00
102_L106_G0.7731.00
193_L336_V0.7721.00
202_D205_I0.7711.00
322_F335_L0.7691.00
210_F324_A0.7681.00
150_E158_R0.7671.00
74_K322_F0.7671.00
107_V131_I0.7671.00
136_F159_V0.7651.00
284_Y289_S0.7621.00
98_L186_F0.7611.00
139_E161_G0.7601.00
285_M289_S0.7591.00
205_I236_S0.7591.00
79_F322_F0.7521.00
213_V292_C0.7521.00
134_Y175_Y0.7501.00
81_L84_L0.7501.00
314_V319_A0.7481.00
145_K272_D0.7471.00
198_V226_F0.7421.00
60_H73_K0.7421.00
97_T185_Q0.7421.00
193_L222_V0.7311.00
120_S149_I0.7281.00
69_T93_R0.7271.00
213_V252_L0.7251.00
187_R224_K0.7211.00
95_A125_Y0.7181.00
257_K291_E0.7171.00
179_S183_Q0.7161.00
88_G340_S0.7151.00
222_V226_F0.7151.00
113_D177_Y0.7131.00
193_L197_I0.7081.00
136_F157_V0.7081.00
107_V176_Y0.7071.00
98_L185_Q0.7041.00
135_I149_I0.7041.00
183_Q186_F0.7001.00
198_V201_L0.6961.00
139_E158_R0.6951.00
246_T274_L0.6941.00
66_E92_D0.6861.00
301_V316_Y0.6861.00
254_A262_T0.6861.00
166_V171_E0.6851.00
273_A317_S0.6841.00
271_A274_L0.6821.00
197_I222_V0.6821.00
209_V336_V0.6811.00
110_I133_A0.6801.00
166_V169_A0.6781.00
108_K132_E0.6741.00
212_P338_T0.6741.00
120_S148_Q0.6701.00
81_L312_L0.6681.00
67_G86_P0.6601.00
185_Q188_D0.6581.00
210_F333_A0.6581.00
59_K63_S0.6581.00
90_Y218_L0.6571.00
182_L220_L0.6551.00
324_A328_Y0.6551.00
188_D224_K0.6541.00
66_E85_N0.6501.00
304_W316_Y0.6481.00
79_F335_L0.6481.00
111_S136_F0.6481.00
252_L281_L0.6411.00
92_D124_A0.6401.00
132_E175_Y0.6401.00
59_K64_L0.6391.00
206_P332_D0.6381.00
322_F326_K0.6321.00
244_V293_I0.6301.00
101_Y107_V0.6271.00
177_Y180_H0.6271.00
307_L337_L0.6251.00
62_I65_G0.6231.00
148_Q151_S0.6231.00
244_V320_T0.6211.00
141_A272_D0.6191.00
212_P321_V0.6191.00
133_A154_A0.6191.00
71_L78_W0.6191.00
242_V328_Y0.6181.00
83_F340_S0.6181.00
227_K288_A0.6161.00
184_P187_R0.6161.00
282_L288_A0.6151.00
199_K229_L0.6151.00
209_V239_P0.6131.00
164_E167_A0.6131.00
283_D288_A0.6131.00
122_I135_I0.6121.00
61_F100_S0.6061.00
59_K199_K0.6031.00
87_S152_Y0.6011.00
211_I219_L0.5991.00
59_K195_Y0.5981.00
116_G119_G0.5981.00
137_V146_L0.5921.00
285_M288_A0.5921.00
83_F312_L0.5911.00
111_S170_A0.5891.00
307_L312_L0.5891.00
281_L284_Y0.5881.00
67_G85_N0.5881.00
143_G150_E0.5871.00
163_R167_A0.5861.00
201_L205_I0.5861.00
247_E250_M0.5851.00
165_D169_A0.5851.00
176_Y179_S0.5821.00
141_A146_L0.5821.00
86_P92_D0.5811.00
291_E328_Y0.5811.00
71_L200_D0.5781.00
155_H158_R0.5771.00
119_G135_I0.5751.00
220_L224_K0.5721.00
79_F307_L0.5721.00
76_N331_N0.5711.00
248_Q267_V0.5681.00
302_E305_K0.5681.00
95_A122_I0.5681.00
122_I178_A0.5671.00
106_G176_Y0.5631.00
251_P279_P0.5631.00
123_A133_A0.5621.00
79_F314_V0.5611.00
209_V241_I0.5611.00
197_I209_V0.5611.00
229_L236_S0.5601.00
325_Y329_S0.5591.00
109_Q155_H0.5551.00
243_A289_S0.5531.00
202_D332_D0.5531.00
295_V324_A0.5521.00
155_H173_S0.5521.00
307_L310_M0.5521.00
113_D178_A0.5521.00
69_T196_E0.5491.00
297_D301_V0.5481.00
164_E168_K0.5481.00
206_P236_S0.5481.00
62_I66_E0.5481.00
108_K131_I0.5461.00
112_E122_I0.5431.00
295_V300_I0.5431.00
94_G98_L0.5411.00
59_K65_G0.5411.00
324_A327_K0.5411.00
298_N301_V0.5401.00
282_L292_C0.5391.00
197_I336_V0.5371.00
86_P124_A0.5361.00
282_L289_S0.5340.99
87_S92_D0.5320.99
66_E96_V0.5320.99
245_Q253_C0.5310.99
276_S279_P0.5280.99
296_S327_K0.5270.99
160_R165_D0.5270.99
205_I238_M0.5260.99
222_V241_I0.5260.99
332_D335_L0.5260.99
222_V225_G0.5250.99
264_P267_V0.5250.99
254_A265_D0.5240.99
98_L176_Y0.5230.99
299_E303_A0.5220.99
189_G192_T0.5220.99
110_I178_A0.5170.99
255_K262_T0.5170.99
255_K261_Y0.5160.99
94_G118_A0.5150.99
137_V141_A0.5120.99
229_L237_E0.5110.99
195_Y228_H0.5110.99
169_A173_S0.5100.99
79_F312_L0.5100.99
191_R225_G0.5090.99
65_G84_L0.5080.99
140_T158_R0.5070.99
183_Q187_R0.5060.99
284_Y287_K0.5050.99
111_S169_A0.5040.99
79_F318_S0.5040.99
295_V320_T0.5040.99
72_I312_L0.5040.99
254_A294_V0.5000.99
115_S273_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5xA 2 0.9333 100 0.217 Contact Map
1tdjA 2 0.8551 100 0.296 Contact Map
3ss7X 1 0.9768 100 0.302 Contact Map
2zsjA 2 0.8551 100 0.307 Contact Map
2d1fA 2 0.858 100 0.311 Contact Map
3aeyA 2 0.8522 100 0.313 Contact Map
1v71A 2 0.8377 100 0.318 Contact Map
2gn0A 2 0.8638 100 0.319 Contact Map
4cooA 2 0.8435 100 0.323 Contact Map
1y7lA 2 0.8058 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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