GREMLIN Database
Q97ZT4 - Uncharacterized protein
UniProt: Q97ZT4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (214)
Sequences: 2658 (1934)
Seq/√Len: 132.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_A198_F4.6121.00
177_E211_Y4.5391.00
181_K215_I4.2461.00
20_L23_Y3.1971.00
17_D20_L3.1661.00
62_V95_F2.6791.00
49_R53_F2.6291.00
28_G210_R2.5981.00
67_T95_F2.5431.00
44_R48_E2.4151.00
51_S89_N2.2571.00
109_K113_Q2.1921.00
103_R130_Q2.1651.00
4_F30_N2.1451.00
109_K138_V2.1101.00
123_A143_V2.0521.00
180_L215_I2.0231.00
17_D22_W1.9771.00
37_S47_V1.9721.00
30_N213_L1.9351.00
59_I198_F1.9111.00
159_Y196_Y1.9071.00
211_Y214_K1.9021.00
164_L197_V1.8891.00
3_I191_N1.8641.00
42_P47_V1.8131.00
184_A188_I1.8121.00
112_F140_C1.7901.00
158_D193_K1.7801.00
201_N205_M1.7691.00
115_A122_M1.7191.00
70_K74_D1.7171.00
18_D21_E1.7101.00
21_E24_V1.6971.00
4_F57_R1.6721.00
162_L183_L1.6471.00
43_T46_Q1.6451.00
97_L108_E1.6421.00
95_F122_M1.6381.00
176_S179_E1.6191.00
101_F107_N1.5821.00
187_I197_V1.5751.00
187_I212_M1.5741.00
7_T25_K1.5521.00
17_D23_Y1.5521.00
113_Q138_V1.5491.00
57_R196_Y1.5441.00
160_I195_V1.5201.00
62_V93_Y1.5041.00
141_V159_Y1.4971.00
47_V88_L1.4931.00
174_D204_W1.4851.00
77_S80_E1.4811.00
51_S91_D1.4401.00
174_D208_N1.4351.00
8_S198_F1.4311.00
48_E87_S1.4231.00
109_K137_N1.4191.00
48_E52_K1.4171.00
49_R52_K1.3781.00
45_K48_E1.3461.00
79_K83_Q1.3401.00
76_Q114_F1.3311.00
170_W173_Y1.3251.00
5_V213_L1.3191.00
25_K32_V1.3021.00
126_F136_L1.2921.00
60_V88_L1.2881.00
44_R83_Q1.2611.00
42_P84_I1.2471.00
141_V157_N1.2161.00
208_N211_Y1.2061.00
102_K128_D1.2051.00
174_D207_D1.1680.99
47_V85_V1.1650.99
18_D22_W1.1620.99
4_F196_Y1.1600.99
34_V46_Q1.1520.99
165_H201_N1.1500.99
71_R100_T1.1460.99
18_D23_Y1.1400.99
123_A141_V1.1360.99
38_F68_H1.1330.99
10_W34_V1.1310.99
65_R70_K1.1150.99
4_F194_Y1.1110.99
66_I78_W1.0920.99
9_G12_Y1.0920.99
34_V58_W1.0870.99
112_F138_V1.0860.99
73_K107_N1.0700.99
5_V212_M1.0690.99
45_K49_R1.0640.99
182_E186_K1.0490.99
167_R179_E1.0480.99
10_W50_W1.0460.99
51_S88_L1.0430.99
82_Q93_Y1.0390.99
12_Y202_N1.0350.98
108_E124_V1.0290.98
80_E83_Q1.0220.98
199_F208_N1.0160.98
110_R113_Q1.0050.98
51_S90_P0.9980.98
110_R114_F0.9970.98
142_I145_I0.9920.98
165_H208_N0.9860.98
55_E90_P0.9850.98
199_F212_M0.9830.98
172_T203_H0.9750.98
5_V216_L0.9720.98
62_V78_W0.9720.98
103_R136_L0.9700.98
177_E181_K0.9690.98
111_V115_A0.9640.98
121_K158_D0.9550.97
175_Y180_L0.9510.97
166_G171_Y0.9380.97
148_P166_G0.9370.97
5_V209_G0.9330.97
184_A212_M0.9280.97
104_N107_N0.9230.97
78_W82_Q0.9170.97
37_S81_F0.9160.97
44_R84_I0.9160.97
24_V27_S0.9130.97
25_K29_L0.9120.97
165_H171_Y0.8990.96
183_L186_K0.8980.96
150_G156_N0.8970.96
177_E215_I0.8950.96
132_Y142_I0.8940.96
155_K160_I0.8910.96
68_H72_L0.8860.96
65_R69_M0.8800.96
59_I161_Y0.8780.96
175_Y199_F0.8780.96
167_R173_Y0.8720.96
171_Y200_N0.8680.95
34_V60_V0.8680.95
106_E110_R0.8670.95
44_R87_S0.8630.95
165_H200_N0.8620.95
101_F104_N0.8590.95
139_T158_D0.8570.95
60_V81_F0.8570.95
71_R101_F0.8570.95
19_T22_W0.8540.95
146_D167_R0.8530.95
183_L190_L0.8520.95
41_Y84_I0.8500.95
47_V84_I0.8480.95
68_H98_P0.8450.95
71_R74_D0.8380.95
9_G161_Y0.8360.94
199_F209_G0.8360.94
201_N208_N0.8330.94
164_L200_N0.8300.94
8_S35_N0.8290.94
108_E112_F0.8290.94
38_F98_P0.8290.94
56_I91_D0.8270.94
97_L114_F0.8250.94
187_I195_V0.8240.94
19_T23_Y0.8200.94
164_L183_L0.8170.94
121_K194_Y0.8160.94
133_L136_L0.8120.94
62_V67_T0.8080.93
41_Y63_N0.8050.93
23_Y53_F0.8010.93
76_Q79_K0.7970.93
111_V122_M0.7910.93
15_N21_E0.7870.93
142_I147_S0.7860.92
40_R43_T0.7810.92
54_K91_D0.7790.92
129_I132_Y0.7740.92
64_R69_M0.7720.92
121_K159_Y0.7720.92
63_N81_F0.7710.92
44_R86_D0.7650.91
17_D24_V0.7630.91
17_D21_E0.7610.91
95_F124_V0.7590.91
166_G201_N0.7510.91
34_V37_S0.7500.91
60_V85_V0.7490.91
113_Q137_N0.7480.90
165_H202_N0.7440.90
86_D119_K0.7420.90
24_V28_G0.7400.90
186_K189_S0.7380.90
3_I216_L0.7370.90
181_K184_A0.7360.90
168_D179_E0.7350.90
160_I193_K0.7290.89
166_G173_Y0.7180.89
126_F131_W0.7160.88
15_N18_D0.7150.88
8_S200_N0.7130.88
8_S12_Y0.7100.88
23_Y27_S0.7090.88
160_I190_L0.7050.88
107_N111_V0.7000.87
94_L201_N0.6980.87
103_R133_L0.6980.87
72_L111_V0.6950.87
159_Y194_Y0.6950.87
197_V212_M0.6900.87
124_V140_C0.6900.87
148_P179_E0.6900.87
67_T98_P0.6880.86
19_T53_F0.6880.86
148_P200_N0.6840.86
165_H175_Y0.6820.86
204_W207_D0.6810.86
162_L187_I0.6810.86
85_V93_Y0.6750.85
61_K127_R0.6720.85
174_D211_Y0.6710.85
8_S14_W0.6690.85
144_S162_L0.6680.85
12_Y16_D0.6680.85
202_N208_N0.6640.84
78_W114_F0.6580.84
30_N55_E0.6580.84
150_G183_L0.6400.82
184_A216_L0.6370.82
46_Q49_R0.6340.82
80_E84_I0.6330.82
148_P165_H0.6300.81
31_A196_Y0.6280.81
83_Q86_D0.6270.81
144_S190_L0.6220.80
61_K96_Q0.6200.80
62_V122_M0.6140.80
22_W58_W0.6130.79
37_S85_V0.6120.79
96_Q127_R0.6090.79
63_N66_I0.6090.79
7_T32_V0.6060.79
47_V60_V0.6030.78
106_E109_K0.6010.78
43_T84_I0.5990.78
76_Q117_V0.5980.78
102_K129_I0.5960.78
188_I191_N0.5960.78
104_N130_Q0.5950.77
197_V200_N0.5940.77
54_K90_P0.5870.76
167_R201_N0.5860.76
58_W91_D0.5850.76
181_K189_S0.5850.76
153_V186_K0.5820.76
134_K154_I0.5760.75
107_N110_R0.5750.75
34_V47_V0.5730.75
101_F126_F0.5720.75
150_G155_K0.5720.75
210_R213_L0.5720.75
71_R107_N0.5660.74
20_L24_V0.5620.73
126_F132_Y0.5610.73
214_K217_T0.5610.73
33_E50_W0.5610.73
111_V114_F0.5580.73
19_T24_V0.5560.73
167_R176_S0.5550.72
121_K141_V0.5540.72
99_P130_Q0.5520.72
178_K182_E0.5500.72
165_H199_F0.5490.72
181_K211_Y0.5490.72
142_I146_D0.5480.71
41_Y69_M0.5480.71
144_S151_T0.5470.71
11_T40_R0.5470.71
90_P214_K0.5450.71
94_L143_V0.5440.71
184_A215_I0.5430.71
181_K194_Y0.5430.71
69_M74_D0.5420.71
29_L209_G0.5400.70
117_V139_T0.5400.70
190_L195_V0.5390.70
177_E180_L0.5380.70
70_K73_K0.5380.70
48_E51_S0.5380.70
85_V92_F0.5330.69
4_F55_E0.5320.69
116_E119_K0.5310.69
25_K56_I0.5300.69
97_L101_F0.5290.69
68_H71_R0.5260.68
142_I148_P0.5260.68
32_V56_I0.5250.68
78_W111_V0.5210.68
55_E91_D0.5200.68
35_N198_F0.5190.67
38_F97_L0.5180.67
173_Y179_E0.5170.67
155_K193_K0.5160.67
167_R205_M0.5160.67
98_P101_F0.5150.67
112_F116_E0.5150.67
200_N208_N0.5140.67
185_D188_I0.5140.67
11_T36_M0.5140.67
116_E122_M0.5140.67
94_L205_M0.5110.66
179_E208_N0.5090.66
176_S208_N0.5090.66
23_Y28_G0.5080.66
180_L184_A0.5080.66
8_S36_M0.5070.66
94_L165_H0.5040.65
122_M140_C0.5030.65
80_E85_V0.5030.65
136_L142_I0.5020.65
144_S148_P0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpqA 2 0.9864 100 0.225 Contact Map
1vpyA 1 0.9591 100 0.246 Contact Map
1yx1A 3 0.9591 95.2 0.916 Contact Map
3cnyA 1 0.9409 93.8 0.922 Contact Map
3l23A 2 0.9818 92.2 0.926 Contact Map
3kwsA 2 0.9818 91.3 0.928 Contact Map
3obeA 1 0.9864 89.9 0.93 Contact Map
4ovxA 1 0.9864 89.9 0.93 Contact Map
3lmzA 2 0.9227 88.2 0.932 Contact Map
3vniA 4 0.9273 87.1 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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