GREMLIN Database
Q97ZT3 - Pyrroline-5-carboxylate reductase (P5CR) (P5C reductase) (ProC)
UniProt: Q97ZT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (258)
Sequences: 5177 (3843)
Seq/√Len: 239.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_E140_S3.2411.00
77_F98_M2.7661.00
128_K210_I2.7441.00
218_D226_Q2.4661.00
179_I250_L2.4591.00
176_I205_I2.4421.00
118_A131_T2.4331.00
210_I214_E2.3981.00
180_I212_L2.3631.00
240_V244_K2.2381.00
10_G61_A2.2211.00
37_T58_N2.1921.00
153_N199_N2.1341.00
107_S136_N2.1081.00
177_S208_T2.0921.00
193_Q196_I2.0711.00
89_W92_K2.0711.00
145_E156_W2.0581.00
130_T153_N1.9921.00
184_S198_Y1.9831.00
141_R156_W1.9751.00
155_Y199_N1.9281.00
244_K249_A1.9271.00
145_E149_K1.9111.00
206_S210_I1.8861.00
172_G204_M1.8771.00
14_A36_A1.8231.00
175_F237_G1.7981.00
210_I213_K1.7891.00
218_D222_L1.7561.00
123_N129_S1.7501.00
242_E247_K1.7471.00
41_D45_R1.7411.00
183_L254_I1.7321.00
222_L226_Q1.7321.00
135_E141_R1.7291.00
179_I246_V1.6981.00
132_T165_W1.6821.00
188_V194_R1.6771.00
149_K154_V1.6701.00
21_I151_L1.6381.00
244_K252_E1.6241.00
38_A43_T1.6161.00
10_G65_S1.5911.00
235_I239_M1.5701.00
95_I144_V1.5561.00
202_L213_K1.5511.00
163_D261_A1.5501.00
260_R263_E1.5331.00
17_I97_I1.5291.00
67_V93_V1.5261.00
133_I156_W1.5211.00
36_A52_V1.5141.00
222_L225_D1.4961.00
94_V110_L1.4951.00
35_I53_E1.4851.00
243_A252_E1.4751.00
228_T235_I1.4741.00
128_K206_S1.4671.00
19_S43_T1.4581.00
81_L110_L1.4561.00
45_R48_K1.4531.00
8_T33_H1.4451.00
39_R76_H1.4451.00
246_V249_A1.4231.00
96_S106_L1.4121.00
203_D206_S1.4051.00
43_T46_N1.4041.00
78_P109_L1.3971.00
78_P105_T1.3881.00
157_L162_L1.3861.00
35_I55_T1.3811.00
190_C255_E1.3751.00
185_L194_R1.3711.00
180_I205_I1.3501.00
240_V243_A1.3441.00
189_A255_E1.3431.00
171_S233_T1.3341.00
57_D60_Y1.3281.00
181_D224_R1.3241.00
176_I179_I1.3151.00
116_Y144_V1.3101.00
102_K105_T1.3081.00
246_V250_L1.3011.00
130_T203_D1.2931.00
255_E259_K1.2751.00
189_A251_I1.2671.00
219_H222_L1.2621.00
11_I18_G1.2621.00
258_Y262_V1.2481.00
71_S97_I1.2451.00
185_L247_K1.2441.00
77_F101_V1.2291.00
107_S138_G1.2271.00
46_N49_D1.2261.00
98_M101_V1.2211.00
248_S252_E1.2161.00
11_I22_V1.2111.00
181_D221_M1.1911.00
167_A254_I1.1841.00
133_I154_V1.1841.00
215_G218_D1.1821.00
105_T109_L1.1761.00
124_A129_S1.1721.00
237_G253_T1.1711.00
40_K43_T1.1391.00
145_E154_V1.1391.00
21_I25_I1.1361.00
128_K203_D1.1321.00
158_P161_Y1.1271.00
228_T238_L1.1241.00
241_M253_T1.1221.00
142_E146_N1.1221.00
18_G22_V1.1161.00
67_V143_L1.1131.00
61_A65_S1.1081.00
187_A192_M1.1041.00
107_S137_N1.1021.00
104_S108_T1.1011.00
157_L165_W1.0991.00
30_P33_H1.0971.00
11_I69_I1.0911.00
239_M243_A1.0881.00
103_L115_V1.0801.00
93_V140_S1.0801.00
130_T155_Y1.0741.00
133_I148_F1.0731.00
236_R239_M1.0711.00
180_I201_V1.0691.00
103_L134_A1.0671.00
19_S50_L1.0601.00
35_I64_K1.0551.00
241_M250_L1.0491.00
224_R228_T1.0451.00
190_C258_Y1.0411.00
168_L254_I1.0411.00
163_D262_V1.0381.00
67_V95_I1.0341.00
23_R49_D1.0321.00
72_V98_M1.0311.00
133_I145_E1.0261.00
25_I147_I1.0251.00
23_R50_L1.0251.00
38_A44_L1.0101.00
21_I97_I0.9981.00
103_L106_L0.9971.00
7_L33_H0.9951.00
27_L127_Y0.9941.00
118_A148_F0.9921.00
135_E156_W0.9921.00
206_S213_K0.9921.00
165_W200_A0.9851.00
24_A151_L0.9821.00
8_T35_I0.9801.00
169_V200_A0.9791.00
42_E45_R0.9791.00
70_L77_F0.9781.00
22_V36_A0.9761.00
177_S211_M0.9741.00
44_L54_T0.9741.00
16_K226_Q0.9741.00
212_L220_P0.9701.00
60_Y64_K0.9701.00
178_E238_L0.9671.00
59_N83_Q0.9611.00
155_Y196_I0.9541.00
153_N203_D0.9491.00
76_H80_V0.9481.00
165_W169_V0.9451.00
14_A47_V0.9451.00
134_A162_L0.9411.00
68_I92_K0.9381.00
44_L56_K0.9281.00
78_P82_R0.9191.00
76_H79_T0.9171.00
69_I95_I0.9121.00
240_V256_A0.9071.00
245_S248_S0.8991.00
101_V105_T0.8991.00
26_R31_S0.8951.00
195_E199_N0.8921.00
178_E242_E0.8901.00
202_L209_I0.8870.99
236_R260_R0.8860.99
116_Y135_E0.8840.99
164_I192_M0.8830.99
105_T108_T0.8830.99
240_V252_E0.8790.99
219_H225_D0.8780.99
184_S188_V0.8720.99
259_K263_E0.8720.99
256_A259_K0.8710.99
106_L115_V0.8700.99
23_R125_I0.8630.99
9_I25_I0.8600.99
196_I199_N0.8490.99
185_L188_V0.8470.99
10_G37_T0.8450.99
37_T55_T0.8350.99
59_N63_N0.8300.99
245_S249_A0.8300.99
19_S46_N0.8290.99
225_D235_I0.8280.99
16_K229_T0.8230.99
168_L187_A0.8210.99
66_D92_K0.8200.99
62_V68_I0.8180.99
12_L80_V0.8170.99
77_F81_L0.8080.99
124_A151_L0.8070.99
8_T66_D0.8060.99
182_A247_K0.8050.99
43_T47_V0.8040.99
130_T200_A0.8040.99
77_F96_S0.8030.99
190_C254_I0.8000.99
88_S92_K0.7960.99
82_R85_G0.7960.99
233_T261_A0.7940.99
167_A258_Y0.7870.99
41_D44_L0.7810.99
82_R109_L0.7780.99
107_S112_N0.7770.99
178_E247_K0.7760.99
187_A201_V0.7740.99
93_V144_V0.7730.99
88_S94_V0.7710.99
221_M225_D0.7680.99
198_Y202_L0.7660.99
206_S209_I0.7650.98
35_I65_S0.7630.98
117_R159_E0.7600.98
237_G240_V0.7520.98
38_A41_D0.7510.98
236_R240_V0.7510.98
22_V47_V0.7430.98
8_T64_K0.7420.98
97_I118_A0.7410.98
237_G257_S0.7400.98
53_E64_K0.7380.98
139_K142_E0.7370.98
171_S257_S0.7370.98
62_V84_V0.7350.98
189_A239_M0.7300.98
238_L242_E0.7290.98
22_V34_V0.7280.98
202_L212_L0.7270.98
166_T172_G0.7240.98
110_L113_A0.7230.98
18_G71_S0.7220.98
103_L136_N0.7220.98
78_P101_V0.7190.98
99_A233_T0.7170.98
60_Y63_N0.7160.98
119_M170_G0.7160.98
146_N149_K0.7150.98
68_I94_V0.7120.98
29_Y33_H0.7120.98
192_M200_A0.7110.98
181_D185_L0.7110.98
244_K248_S0.7080.98
69_I148_F0.7060.97
163_D265_G0.7030.97
162_L261_A0.7020.97
126_V210_I0.7010.97
142_E145_E0.6920.97
19_S49_D0.6890.97
221_M224_R0.6880.97
161_Y164_I0.6880.97
259_K262_V0.6820.97
194_R198_Y0.6790.97
58_N83_Q0.6770.97
128_K153_N0.6770.97
19_S23_R0.6750.97
10_G68_I0.6730.97
169_V204_M0.6710.97
185_L189_A0.6700.97
130_T199_N0.6690.96
166_T261_A0.6660.96
81_L98_M0.6660.96
239_M252_E0.6650.96
114_E136_N0.6630.96
79_T82_R0.6630.96
168_L183_L0.6600.96
132_T162_L0.6590.96
99_A264_I0.6570.96
254_I257_S0.6550.96
22_V52_V0.6550.96
140_S143_L0.6520.96
79_T83_Q0.6520.96
103_L107_S0.6500.96
102_K265_G0.6450.96
184_S220_P0.6420.96
187_A197_A0.6410.96
7_L143_L0.6410.96
37_T57_D0.6410.96
184_S201_V0.6380.95
186_G254_I0.6310.95
93_V116_Y0.6260.95
56_K60_Y0.6220.95
177_S223_L0.6180.95
239_M242_E0.6180.95
107_S115_V0.6180.95
58_N62_V0.6170.95
131_T151_L0.6170.95
164_I190_C0.6160.94
73_K229_T0.6130.94
35_I61_A0.6130.94
123_N173_P0.6110.94
143_L146_N0.6110.94
58_N61_A0.6090.94
38_A97_I0.6080.94
41_D56_K0.6060.94
20_A24_A0.6040.94
180_I220_P0.6040.94
172_G257_S0.6040.94
115_V136_N0.6020.94
9_I29_Y0.6020.94
7_L66_D0.5990.94
174_A234_T0.5990.94
177_S212_L0.5980.94
10_G35_I0.5970.94
229_T233_T0.5950.93
67_V147_I0.5940.93
255_E258_Y0.5900.93
36_A47_V0.5870.93
134_A159_E0.5850.93
55_T61_A0.5850.93
37_T61_A0.5850.93
174_A237_G0.5840.93
126_V211_M0.5830.93
116_Y141_R0.5820.93
132_T155_Y0.5790.92
70_L98_M0.5760.92
31_S51_E0.5760.92
248_S251_I0.5740.92
39_R44_L0.5720.92
235_I238_L0.5710.92
161_Y196_I0.5710.92
205_I246_V0.5690.92
80_V83_Q0.5650.92
16_K73_K0.5630.91
162_L165_W0.5620.91
250_L254_I0.5620.91
172_G254_I0.5610.91
132_T169_V0.5600.91
166_T171_S0.5590.91
131_T152_G0.5540.91
62_V92_K0.5510.91
21_I148_F0.5500.90
94_V113_A0.5460.90
93_V114_E0.5460.90
85_G111_N0.5450.90
170_G233_T0.5440.90
65_S92_K0.5430.90
127_Y151_L0.5430.90
148_F151_L0.5420.90
87_E92_K0.5410.90
161_Y193_Q0.5400.90
112_N138_G0.5380.89
186_G251_I0.5380.89
153_N213_K0.5380.89
70_L84_V0.5370.89
62_V65_S0.5320.89
121_N170_G0.5320.89
241_M246_V0.5300.89
17_I120_P0.5300.89
119_M162_L0.5290.89
175_F257_S0.5290.89
122_I226_Q0.5280.89
28_K127_Y0.5250.88
12_L37_T0.5240.88
239_M251_I0.5230.88
70_L106_L0.5220.88
175_F204_M0.5190.88
110_L115_V0.5180.88
124_A131_T0.5150.87
142_E149_K0.5130.87
181_D247_K0.5120.87
14_A22_V0.5100.87
164_I187_A0.5090.87
47_V52_V0.5070.87
93_V143_L0.5070.87
149_K153_N0.5070.87
157_L161_Y0.5050.86
32_I53_E0.5010.86
19_S47_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.9711 100 0.393 Contact Map
2rcyA 5 0.9206 100 0.415 Contact Map
2ahrA 5 0.917 100 0.417 Contact Map
1yqgA 2 0.9278 100 0.423 Contact Map
3triA 2 0.9531 100 0.439 Contact Map
3gt0A 3 0.7581 100 0.48 Contact Map
4kqwA 2 0.9675 100 0.488 Contact Map
4wjiA 2 0.9495 100 0.533 Contact Map
3fr7A 2 0.9531 100 0.555 Contact Map
2i76A 2 0.8375 100 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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