Q97ZT3 - SULSO - GREMLIN Contacts

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Q97ZT3 - Pyrroline-5-carboxylate reductase (P5CR) (P5C reductase) (ProC)

UniProt:	Q97ZT3	Sequences: MKIMEDLTIGILGAGKIGSAIVRAIRLKYPSIHVIATARKDETLRNVKDLEVETTKDNNYAVNKSDVIILSVKPQHFPTVLRQVGIESWRDKVVISIMAGVKLSTLSTLLNNAEVYRAMPNINAIVYKSTTTIAENNGKSRELVENIFKTLGNVYWLPEEYLDIWTALVGSGPAFISEIIDALSLGAVACGMQREIAYNAVLDMISGTIIMLKEGKIDHPMLLRDQVTTPVGTTIRGLMVMEAKSVKSALIETIEASYKRAVEIGNEIDKSIRNNSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	277 (258)
Sequences:	5177 (3843)
Seq/√Len:	239.3

ECOLI - P5CR
BACSU - P5CR1 COMER P5CR2 P5CR3
SULSO - Q97ZT3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_E	140_S	3.241	1.00
77_F	98_M	2.766	1.00
128_K	210_I	2.744	1.00
218_D	226_Q	2.466	1.00
179_I	250_L	2.459	1.00
176_I	205_I	2.442	1.00
118_A	131_T	2.433	1.00
210_I	214_E	2.398	1.00
180_I	212_L	2.363	1.00
240_V	244_K	2.238	1.00
10_G	61_A	2.221	1.00
37_T	58_N	2.192	1.00
153_N	199_N	2.134	1.00
107_S	136_N	2.108	1.00
177_S	208_T	2.092	1.00
193_Q	196_I	2.071	1.00
89_W	92_K	2.071	1.00
145_E	156_W	2.058	1.00
130_T	153_N	1.992	1.00
184_S	198_Y	1.983	1.00
141_R	156_W	1.975	1.00
155_Y	199_N	1.928	1.00
244_K	249_A	1.927	1.00
145_E	149_K	1.911	1.00
206_S	210_I	1.886	1.00
172_G	204_M	1.877	1.00
14_A	36_A	1.823	1.00
175_F	237_G	1.798	1.00
210_I	213_K	1.789	1.00
218_D	222_L	1.756	1.00
123_N	129_S	1.750	1.00
242_E	247_K	1.747	1.00
41_D	45_R	1.741	1.00
183_L	254_I	1.732	1.00
222_L	226_Q	1.732	1.00
135_E	141_R	1.729	1.00
179_I	246_V	1.698	1.00
132_T	165_W	1.682	1.00
188_V	194_R	1.677	1.00
149_K	154_V	1.670	1.00
21_I	151_L	1.638	1.00
244_K	252_E	1.624	1.00
38_A	43_T	1.616	1.00
10_G	65_S	1.591	1.00
235_I	239_M	1.570	1.00
95_I	144_V	1.556	1.00
202_L	213_K	1.551	1.00
163_D	261_A	1.550	1.00
260_R	263_E	1.533	1.00
17_I	97_I	1.529	1.00
67_V	93_V	1.526	1.00
133_I	156_W	1.521	1.00
36_A	52_V	1.514	1.00
222_L	225_D	1.496	1.00
94_V	110_L	1.495	1.00
35_I	53_E	1.485	1.00
243_A	252_E	1.475	1.00
228_T	235_I	1.474	1.00
128_K	206_S	1.467	1.00
19_S	43_T	1.458	1.00
81_L	110_L	1.456	1.00
45_R	48_K	1.453	1.00
8_T	33_H	1.445	1.00
39_R	76_H	1.445	1.00
246_V	249_A	1.423	1.00
96_S	106_L	1.412	1.00
203_D	206_S	1.405	1.00
43_T	46_N	1.404	1.00
78_P	109_L	1.397	1.00
78_P	105_T	1.388	1.00
157_L	162_L	1.386	1.00
35_I	55_T	1.381	1.00
190_C	255_E	1.375	1.00
185_L	194_R	1.371	1.00
180_I	205_I	1.350	1.00
240_V	243_A	1.344	1.00
189_A	255_E	1.343	1.00
171_S	233_T	1.334	1.00
57_D	60_Y	1.328	1.00
181_D	224_R	1.324	1.00
176_I	179_I	1.315	1.00
116_Y	144_V	1.310	1.00
102_K	105_T	1.308	1.00
246_V	250_L	1.301	1.00
130_T	203_D	1.293	1.00
255_E	259_K	1.275	1.00
189_A	251_I	1.267	1.00
219_H	222_L	1.262	1.00
11_I	18_G	1.262	1.00
258_Y	262_V	1.248	1.00
71_S	97_I	1.245	1.00
185_L	247_K	1.244	1.00
77_F	101_V	1.229	1.00
107_S	138_G	1.227	1.00
46_N	49_D	1.226	1.00
98_M	101_V	1.221	1.00
248_S	252_E	1.216	1.00
11_I	22_V	1.211	1.00
181_D	221_M	1.191	1.00
167_A	254_I	1.184	1.00
133_I	154_V	1.184	1.00
215_G	218_D	1.182	1.00
105_T	109_L	1.176	1.00
124_A	129_S	1.172	1.00
237_G	253_T	1.171	1.00
40_K	43_T	1.139	1.00
145_E	154_V	1.139	1.00
21_I	25_I	1.136	1.00
128_K	203_D	1.132	1.00
158_P	161_Y	1.127	1.00
228_T	238_L	1.124	1.00
241_M	253_T	1.122	1.00
142_E	146_N	1.122	1.00
18_G	22_V	1.116	1.00
67_V	143_L	1.113	1.00
61_A	65_S	1.108	1.00
187_A	192_M	1.104	1.00
107_S	137_N	1.102	1.00
104_S	108_T	1.101	1.00
157_L	165_W	1.099	1.00
30_P	33_H	1.097	1.00
11_I	69_I	1.091	1.00
239_M	243_A	1.088	1.00
103_L	115_V	1.080	1.00
93_V	140_S	1.080	1.00
130_T	155_Y	1.074	1.00
133_I	148_F	1.073	1.00
236_R	239_M	1.071	1.00
180_I	201_V	1.069	1.00
103_L	134_A	1.067	1.00
19_S	50_L	1.060	1.00
35_I	64_K	1.055	1.00
241_M	250_L	1.049	1.00
224_R	228_T	1.045	1.00
190_C	258_Y	1.041	1.00
168_L	254_I	1.041	1.00
163_D	262_V	1.038	1.00
67_V	95_I	1.034	1.00
23_R	49_D	1.032	1.00
72_V	98_M	1.031	1.00
133_I	145_E	1.026	1.00
25_I	147_I	1.025	1.00
23_R	50_L	1.025	1.00
38_A	44_L	1.010	1.00
21_I	97_I	0.998	1.00
103_L	106_L	0.997	1.00
7_L	33_H	0.995	1.00
27_L	127_Y	0.994	1.00
118_A	148_F	0.992	1.00
135_E	156_W	0.992	1.00
206_S	213_K	0.992	1.00
165_W	200_A	0.985	1.00
24_A	151_L	0.982	1.00
8_T	35_I	0.980	1.00
169_V	200_A	0.979	1.00
42_E	45_R	0.979	1.00
70_L	77_F	0.978	1.00
22_V	36_A	0.976	1.00
177_S	211_M	0.974	1.00
44_L	54_T	0.974	1.00
16_K	226_Q	0.974	1.00
212_L	220_P	0.970	1.00
60_Y	64_K	0.970	1.00
178_E	238_L	0.967	1.00
59_N	83_Q	0.961	1.00
155_Y	196_I	0.954	1.00
153_N	203_D	0.949	1.00
76_H	80_V	0.948	1.00
165_W	169_V	0.945	1.00
14_A	47_V	0.945	1.00
134_A	162_L	0.941	1.00
68_I	92_K	0.938	1.00
44_L	56_K	0.928	1.00
78_P	82_R	0.919	1.00
76_H	79_T	0.917	1.00
69_I	95_I	0.912	1.00
240_V	256_A	0.907	1.00
245_S	248_S	0.899	1.00
101_V	105_T	0.899	1.00
26_R	31_S	0.895	1.00
195_E	199_N	0.892	1.00
178_E	242_E	0.890	1.00
202_L	209_I	0.887	0.99
236_R	260_R	0.886	0.99
116_Y	135_E	0.884	0.99
164_I	192_M	0.883	0.99
105_T	108_T	0.883	0.99
240_V	252_E	0.879	0.99
219_H	225_D	0.878	0.99
184_S	188_V	0.872	0.99
259_K	263_E	0.872	0.99
256_A	259_K	0.871	0.99
106_L	115_V	0.870	0.99
23_R	125_I	0.863	0.99
9_I	25_I	0.860	0.99
196_I	199_N	0.849	0.99
185_L	188_V	0.847	0.99
10_G	37_T	0.845	0.99
37_T	55_T	0.835	0.99
59_N	63_N	0.830	0.99
245_S	249_A	0.830	0.99
19_S	46_N	0.829	0.99
225_D	235_I	0.828	0.99
16_K	229_T	0.823	0.99
168_L	187_A	0.821	0.99
66_D	92_K	0.820	0.99
62_V	68_I	0.818	0.99
12_L	80_V	0.817	0.99
77_F	81_L	0.808	0.99
124_A	151_L	0.807	0.99
8_T	66_D	0.806	0.99
182_A	247_K	0.805	0.99
43_T	47_V	0.804	0.99
130_T	200_A	0.804	0.99
77_F	96_S	0.803	0.99
190_C	254_I	0.800	0.99
88_S	92_K	0.796	0.99
82_R	85_G	0.796	0.99
233_T	261_A	0.794	0.99
167_A	258_Y	0.787	0.99
41_D	44_L	0.781	0.99
82_R	109_L	0.778	0.99
107_S	112_N	0.777	0.99
178_E	247_K	0.776	0.99
187_A	201_V	0.774	0.99
93_V	144_V	0.773	0.99
88_S	94_V	0.771	0.99
221_M	225_D	0.768	0.99
198_Y	202_L	0.766	0.99
206_S	209_I	0.765	0.98
35_I	65_S	0.763	0.98
117_R	159_E	0.760	0.98
237_G	240_V	0.752	0.98
38_A	41_D	0.751	0.98
236_R	240_V	0.751	0.98
22_V	47_V	0.743	0.98
8_T	64_K	0.742	0.98
97_I	118_A	0.741	0.98
237_G	257_S	0.740	0.98
53_E	64_K	0.738	0.98
139_K	142_E	0.737	0.98
171_S	257_S	0.737	0.98
62_V	84_V	0.735	0.98
189_A	239_M	0.730	0.98
238_L	242_E	0.729	0.98
22_V	34_V	0.728	0.98
202_L	212_L	0.727	0.98
166_T	172_G	0.724	0.98
110_L	113_A	0.723	0.98
18_G	71_S	0.722	0.98
103_L	136_N	0.722	0.98
78_P	101_V	0.719	0.98
99_A	233_T	0.717	0.98
60_Y	63_N	0.716	0.98
119_M	170_G	0.716	0.98
146_N	149_K	0.715	0.98
68_I	94_V	0.712	0.98
29_Y	33_H	0.712	0.98
192_M	200_A	0.711	0.98
181_D	185_L	0.711	0.98
244_K	248_S	0.708	0.98
69_I	148_F	0.706	0.97
163_D	265_G	0.703	0.97
162_L	261_A	0.702	0.97
126_V	210_I	0.701	0.97
142_E	145_E	0.692	0.97
19_S	49_D	0.689	0.97
221_M	224_R	0.688	0.97
161_Y	164_I	0.688	0.97
259_K	262_V	0.682	0.97
194_R	198_Y	0.679	0.97
58_N	83_Q	0.677	0.97
128_K	153_N	0.677	0.97
19_S	23_R	0.675	0.97
10_G	68_I	0.673	0.97
169_V	204_M	0.671	0.97
185_L	189_A	0.670	0.97
130_T	199_N	0.669	0.96
166_T	261_A	0.666	0.96
81_L	98_M	0.666	0.96
239_M	252_E	0.665	0.96
114_E	136_N	0.663	0.96
79_T	82_R	0.663	0.96
168_L	183_L	0.660	0.96
132_T	162_L	0.659	0.96
99_A	264_I	0.657	0.96
254_I	257_S	0.655	0.96
22_V	52_V	0.655	0.96
140_S	143_L	0.652	0.96
79_T	83_Q	0.652	0.96
103_L	107_S	0.650	0.96
102_K	265_G	0.645	0.96
184_S	220_P	0.642	0.96
187_A	197_A	0.641	0.96
7_L	143_L	0.641	0.96
37_T	57_D	0.641	0.96
184_S	201_V	0.638	0.95
186_G	254_I	0.631	0.95
93_V	116_Y	0.626	0.95
56_K	60_Y	0.622	0.95
177_S	223_L	0.618	0.95
239_M	242_E	0.618	0.95
107_S	115_V	0.618	0.95
58_N	62_V	0.617	0.95
131_T	151_L	0.617	0.95
164_I	190_C	0.616	0.94
73_K	229_T	0.613	0.94
35_I	61_A	0.613	0.94
123_N	173_P	0.611	0.94
143_L	146_N	0.611	0.94
58_N	61_A	0.609	0.94
38_A	97_I	0.608	0.94
41_D	56_K	0.606	0.94
20_A	24_A	0.604	0.94
180_I	220_P	0.604	0.94
172_G	257_S	0.604	0.94
115_V	136_N	0.602	0.94
9_I	29_Y	0.602	0.94
7_L	66_D	0.599	0.94
174_A	234_T	0.599	0.94
177_S	212_L	0.598	0.94
10_G	35_I	0.597	0.94
229_T	233_T	0.595	0.93
67_V	147_I	0.594	0.93
255_E	258_Y	0.590	0.93
36_A	47_V	0.587	0.93
134_A	159_E	0.585	0.93
55_T	61_A	0.585	0.93
37_T	61_A	0.585	0.93
174_A	237_G	0.584	0.93
126_V	211_M	0.583	0.93
116_Y	141_R	0.582	0.93
132_T	155_Y	0.579	0.92
70_L	98_M	0.576	0.92
31_S	51_E	0.576	0.92
248_S	251_I	0.574	0.92
39_R	44_L	0.572	0.92
235_I	238_L	0.571	0.92
161_Y	196_I	0.571	0.92
205_I	246_V	0.569	0.92
80_V	83_Q	0.565	0.92
16_K	73_K	0.563	0.91
162_L	165_W	0.562	0.91
250_L	254_I	0.562	0.91
172_G	254_I	0.561	0.91
132_T	169_V	0.560	0.91
166_T	171_S	0.559	0.91
131_T	152_G	0.554	0.91
62_V	92_K	0.551	0.91
21_I	148_F	0.550	0.90
94_V	113_A	0.546	0.90
93_V	114_E	0.546	0.90
85_G	111_N	0.545	0.90
170_G	233_T	0.544	0.90
65_S	92_K	0.543	0.90
127_Y	151_L	0.543	0.90
148_F	151_L	0.542	0.90
87_E	92_K	0.541	0.90
161_Y	193_Q	0.540	0.90
112_N	138_G	0.538	0.89
186_G	251_I	0.538	0.89
153_N	213_K	0.538	0.89
70_L	84_V	0.537	0.89
62_V	65_S	0.532	0.89
121_N	170_G	0.532	0.89
241_M	246_V	0.530	0.89
17_I	120_P	0.530	0.89
119_M	162_L	0.529	0.89
175_F	257_S	0.529	0.89
122_I	226_Q	0.528	0.89
28_K	127_Y	0.525	0.88
12_L	37_T	0.524	0.88
239_M	251_I	0.523	0.88
70_L	106_L	0.522	0.88
175_F	204_M	0.519	0.88
110_L	115_V	0.518	0.88
124_A	131_T	0.515	0.87
142_E	149_K	0.513	0.87
181_D	247_K	0.512	0.87
14_A	22_V	0.510	0.87
164_I	187_A	0.509	0.87
47_V	52_V	0.507	0.87
93_V	143_L	0.507	0.87
149_K	153_N	0.507	0.87
157_L	161_Y	0.505	0.86
32_I	53_E	0.501	0.86
19_S	47_V	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2izzA	5	0.9711	100	0.393	Contact Map
2rcyA	5	0.9206	100	0.415	Contact Map
2ahrA	5	0.917	100	0.417	Contact Map
1yqgA	2	0.9278	100	0.423	Contact Map
3triA	2	0.9531	100	0.439	Contact Map
3gt0A	3	0.7581	100	0.48	Contact Map
4kqwA	2	0.9675	100	0.488	Contact Map
4wjiA	2	0.9495	100	0.533	Contact Map
3fr7A	2	0.9531	100	0.555	Contact Map
2i76A	2	0.8375	100	0.578	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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