GREMLIN Database
Q97ZS8 - Uncharacterized protein
UniProt: Q97ZS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (207)
Sequences: 3361 (2013)
Seq/√Len: 139.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_L168_A4.7521.00
79_S115_A3.6341.00
112_V124_M3.4591.00
136_M140_D3.3511.00
134_E137_A3.3011.00
123_G145_F3.2801.00
197_F201_N2.9831.00
76_R114_L2.8611.00
161_G170_P2.7841.00
105_Y114_L2.7751.00
91_F115_A2.6801.00
126_I146_F2.6501.00
155_D159_Y2.6221.00
48_S52_Y2.5741.00
124_M146_F2.4171.00
112_V122_S2.4071.00
109_D137_A2.2871.00
132_E164_L2.2431.00
116_K144_D2.1691.00
133_N164_L2.1431.00
135_I146_F2.1361.00
51_R61_I2.1291.00
124_M143_A1.9691.00
80_I118_Y1.9291.00
62_I145_F1.8861.00
133_N137_A1.8441.00
150_R187_D1.8031.00
161_G166_E1.7921.00
79_S120_V1.7701.00
49_L53_S1.7621.00
51_R60_T1.7491.00
184_K200_I1.7361.00
154_V158_K1.7181.00
110_E113_N1.7001.00
130_K133_N1.6761.00
71_N103_V1.6721.00
80_I84_M1.6201.00
21_K53_S1.6091.00
121_K145_F1.5671.00
153_D194_N1.5381.00
180_R184_K1.4601.00
48_S85_L1.4541.00
109_D113_N1.4471.00
51_R88_Q1.4431.00
209_K212_L1.4391.00
83_K88_Q1.4291.00
109_D134_E1.4271.00
24_S55_S1.4121.00
121_K144_D1.3781.00
146_F168_A1.3741.00
109_D141_S1.3601.00
182_L186_L1.3471.00
17_L49_L1.3231.00
44_T82_A1.3111.00
185_S189_P1.3071.00
201_N204_D1.2971.00
130_K134_E1.2961.00
136_M166_E1.2951.00
4_L28_G1.2941.00
162_P165_I1.2841.00
62_I90_A1.2661.00
34_S37_G1.2661.00
72_E104_G1.2541.00
210_T213_I1.2471.00
106_L110_E1.2391.00
139_L146_F1.2321.00
113_N117_E1.2301.00
113_N137_A1.2291.00
24_S59_K1.2271.00
40_S74_F1.2231.00
137_A141_S1.2201.00
136_M164_L1.2061.00
10_K42_I1.1921.00
206_I213_I1.1841.00
126_I148_V1.1831.00
184_K204_D1.1771.00
65_Q78_L1.1640.99
31_I47_A1.1590.99
47_A63_I1.1520.99
187_D195_E1.1270.99
63_I82_A1.1240.99
116_K122_S1.1200.99
139_L167_R1.1120.99
5_V26_F1.1120.99
96_K104_G1.1120.99
70_V74_F1.0970.99
207_G213_I1.0720.99
156_Q194_N1.0610.99
202_S205_S1.0580.99
14_E18_N1.0470.99
20_I50_I1.0400.99
107_S110_E1.0330.99
156_Q159_Y1.0290.99
81_T84_M1.0250.99
21_K24_S1.0170.99
18_N22_I1.0080.98
97_P100_G1.0050.98
33_D70_V1.0030.98
190_S193_E0.9940.98
15_K19_E0.9940.98
150_R186_L0.9890.98
13_P17_L0.9880.98
181_E184_K0.9830.98
122_S144_D0.9760.98
73_L76_R0.9590.98
72_E117_E0.9560.98
180_R203_L0.9490.98
136_M161_G0.9390.98
148_V157_I0.9370.98
180_R204_D0.9370.98
79_S89_I0.9290.97
183_V195_E0.9260.97
112_V143_A0.9260.97
177_D199_I0.9230.97
40_S70_V0.9210.97
127_S131_N0.9140.97
7_L50_I0.9030.97
69_D103_V0.9020.97
207_G210_T0.9020.97
62_I123_G0.9010.97
129_R194_N0.8910.97
92_T125_M0.8890.97
208_V211_V0.8890.97
76_R118_Y0.8860.97
71_N104_G0.8790.96
91_F122_S0.8750.96
29_F59_K0.8740.96
7_L29_F0.8740.96
197_F200_I0.8700.96
83_K119_G0.8640.96
32_P92_T0.8630.96
50_I61_I0.8620.96
47_A87_A0.8600.96
76_R80_I0.8550.96
126_I160_Y0.8540.96
137_A140_D0.8520.96
65_Q89_I0.8520.96
70_V78_L0.8520.96
75_I78_L0.8500.96
157_I172_L0.8490.96
186_L190_S0.8380.95
206_I212_L0.8280.95
162_P167_R0.8260.95
67_L111_A0.8240.95
136_M165_I0.8240.95
7_L20_I0.8000.94
148_V170_P0.7970.94
11_K14_E0.7960.94
175_M185_S0.7950.94
7_L16_L0.7900.94
12_K16_L0.7890.94
77_S81_T0.7860.93
15_K18_N0.7850.93
7_L47_A0.7770.93
91_F112_V0.7760.93
18_N21_K0.7730.93
21_K54_L0.7720.93
184_K188_Q0.7720.93
12_K15_K0.7680.93
115_A122_S0.7660.93
34_S77_S0.7620.92
200_I204_D0.7620.92
68_L96_K0.7610.92
68_L104_G0.7570.92
161_G165_I0.7550.92
132_E136_M0.7550.92
73_L77_S0.7530.92
31_I50_I0.7510.92
180_R200_I0.7500.92
30_D147_L0.7440.91
113_N141_S0.7410.91
206_I210_T0.7380.91
70_V75_I0.7350.91
76_R117_E0.7350.91
80_I119_G0.7300.91
71_N74_F0.7210.90
63_I87_A0.7210.90
22_I25_S0.7200.90
74_F78_L0.7190.90
166_E170_P0.7160.90
10_K13_P0.7130.90
8_H32_P0.7110.90
23_L173_I0.7090.89
51_R85_L0.7090.89
55_S60_T0.7060.89
140_D161_G0.7060.89
44_T81_T0.7050.89
89_I120_V0.7040.89
187_D190_S0.6980.89
126_I135_I0.6940.88
17_L21_K0.6940.88
77_S80_I0.6910.88
89_I115_A0.6880.88
155_D158_K0.6870.88
72_E105_Y0.6860.88
177_D203_L0.6800.87
150_R175_M0.6740.87
43_P63_I0.6730.87
138_R149_L0.6720.87
13_P45_F0.6700.87
35_P38_M0.6700.87
179_N182_L0.6670.86
165_I170_P0.6660.86
33_D66_R0.6650.86
199_I202_S0.6650.86
13_P20_I0.6650.86
153_D198_S0.6600.86
28_G62_I0.6590.86
29_F60_T0.6560.85
73_L103_V0.6550.85
28_G145_F0.6540.85
83_K120_V0.6540.85
16_L19_E0.6520.85
179_N186_L0.6510.85
107_S134_E0.6440.84
180_R207_G0.6440.84
153_D156_Q0.6430.84
145_F171_Y0.6420.84
32_P131_N0.6400.84
90_A125_M0.6390.84
182_L189_P0.6380.84
198_S202_S0.6380.84
98_K101_K0.6360.84
148_V171_Y0.6360.84
139_L166_E0.6350.84
44_T87_A0.6330.83
41_P45_F0.6310.83
13_P46_V0.6280.83
82_A89_I0.6260.83
33_D68_L0.6240.82
8_H193_E0.6240.82
112_V116_K0.6220.82
186_L189_P0.6180.82
112_V141_S0.6170.82
135_I166_E0.6160.82
49_L54_L0.6160.82
166_E169_I0.6120.81
135_I139_L0.6120.81
41_P84_M0.6060.81
127_S190_S0.5980.80
45_F81_T0.5980.80
157_I170_P0.5970.80
48_S87_A0.5970.80
37_G192_V0.5960.80
44_T63_I0.5950.79
124_M135_I0.5930.79
155_D198_S0.5880.79
203_L213_I0.5860.78
12_K69_D0.5850.78
79_S119_G0.5840.78
88_Q115_A0.5820.78
114_L117_E0.5820.78
77_S103_V0.5820.78
27_D171_Y0.5820.78
123_G153_D0.5790.78
4_L8_H0.5750.77
19_E22_I0.5730.77
93_K127_S0.5720.77
15_K22_I0.5710.77
136_M160_Y0.5700.76
67_L70_V0.5700.76
173_I176_T0.5700.76
60_T121_K0.5630.76
201_N205_S0.5620.75
95_D149_L0.5600.75
45_F85_L0.5590.75
180_R205_S0.5590.75
75_I114_L0.5580.75
195_E200_I0.5580.75
152_K172_L0.5560.75
75_I105_Y0.5530.74
38_M193_E0.5520.74
52_Y85_L0.5500.74
71_N106_L0.5440.73
187_D200_I0.5390.72
24_S54_L0.5380.72
91_F111_A0.5370.72
165_I169_I0.5360.72
48_S51_R0.5350.72
149_L173_I0.5340.72
10_K14_E0.5340.72
178_K203_L0.5320.71
140_D164_L0.5310.71
41_P81_T0.5310.71
13_P49_L0.5300.71
128_L196_I0.5290.71
29_F50_I0.5270.71
74_F77_S0.5260.71
18_N24_S0.5250.70
4_L147_L0.5200.70
44_T78_L0.5180.69
30_D192_V0.5170.69
108_S125_M0.5160.69
200_I207_G0.5160.69
5_V23_L0.5160.69
25_S52_Y0.5160.69
17_L53_S0.5140.69
31_I43_P0.5100.68
76_R105_Y0.5090.68
29_F49_L0.5090.68
132_E166_E0.5080.68
30_D62_I0.5070.68
39_P96_K0.5060.68
162_P166_E0.5040.67
96_K99_Y0.5020.67
19_E23_L0.5020.67
35_P97_P0.5020.67
50_I59_K0.5010.67
107_S125_M0.5000.67
74_F104_G0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aptA 2 0.9738 100 0.218 Contact Map
3fstA 4 0.9476 100 0.227 Contact Map
3ijdA 2 0.9083 100 0.345 Contact Map
2p10A 5 0.8734 96.3 0.897 Contact Map
1tqjA 4 0.8734 96.1 0.899 Contact Map
1h1yA 2 0.8472 95.7 0.902 Contact Map
1rpxA 4 0.8603 95.2 0.906 Contact Map
4ht3A 1 0.9127 95.1 0.906 Contact Map
2ekcA 1 0.8821 95.1 0.906 Contact Map
3navA 2 0.9127 95 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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