GREMLIN Database
Q97ZS5 - Purine nucleosidase, putative (IunH-1)
UniProt: Q97ZS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (301)
Sequences: 3958 (2835)
Seq/√Len: 163.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_K107_D3.9771.00
103_L133_L3.7171.00
173_K177_N3.2671.00
132_L174_I2.9121.00
3_H27_D2.7851.00
165_I272_T2.7621.00
252_T294_E2.7071.00
30_A104_A2.6491.00
64_A129_L2.5041.00
110_N134_D2.4521.00
192_N294_E2.4471.00
173_K260_V2.4261.00
33_I44_V2.3561.00
256_K290_E2.3371.00
247_D299_S2.3031.00
131_Y138_V2.2761.00
110_N140_K2.2231.00
32_T101_A2.1981.00
10_T47_A2.1491.00
119_L242_T2.1191.00
18_L31_V2.1101.00
107_D111_E2.0861.00
21_L242_T2.0711.00
3_H29_V2.0591.00
110_N136_S2.0531.00
6_I121_I2.0351.00
190_I237_P2.0321.00
165_I172_A1.9881.00
48_L60_V1.9251.00
61_Y104_A1.8891.00
106_I134_D1.8861.00
115_E142_K1.8851.00
253_R292_V1.8811.00
120_A127_L1.8791.00
160_V271_M1.8431.00
296_N299_S1.8371.00
109_A116_L1.8131.00
19_Y54_V1.8081.00
120_A146_V1.7901.00
130_A134_D1.7841.00
7_D126_N1.7771.00
236_H239_A1.7521.00
29_V116_L1.7321.00
5_I32_T1.7221.00
8_C121_I1.7031.00
143_K183_T1.7021.00
61_Y97_Q1.6741.00
48_L95_K1.6541.00
22_L56_R1.6491.00
45_K49_W1.6411.00
70_K269_R1.6321.00
22_L28_V1.6121.00
120_A124_L1.6011.00
106_I130_A1.5931.00
262_D268_T1.5691.00
104_A108_L1.5641.00
117_E145_W1.5621.00
40_Y62_P1.5591.00
23_K307_L1.5501.00
212_E216_S1.5481.00
150_A153_G1.5341.00
185_I292_V1.5311.00
100_H103_L1.5311.00
124_L175_V1.5191.00
130_A137_I1.4981.00
146_V165_I1.4871.00
146_V184_M1.4871.00
302_E306_D1.4841.00
244_I251_A1.4811.00
4_F119_L1.4771.00
146_V176_F1.4691.00
106_I137_I1.4651.00
250_I299_S1.4631.00
109_A130_A1.4461.00
170_D269_R1.4371.00
105_I130_A1.4131.00
109_A140_K1.4041.00
41_E62_P1.3881.00
134_D137_I1.3791.00
100_H133_L1.3781.00
108_L111_E1.3781.00
298_K302_E1.3751.00
204_K215_V1.3691.00
40_Y44_V1.3621.00
82_G88_T1.3511.00
202_V302_E1.3431.00
183_T290_E1.3391.00
165_I176_F1.3121.00
52_E94_L1.3071.00
117_E143_K1.2891.00
8_C47_A1.2821.00
124_L146_V1.2801.00
243_A300_F1.2791.00
127_L144_V1.2771.00
22_L58_I1.2741.00
243_A303_K1.2731.00
70_K170_D1.2701.00
108_L116_L1.2621.00
45_K91_P1.2621.00
51_L58_I1.2571.00
3_H112_Y1.2531.00
20_L303_K1.2281.00
240_I251_A1.2261.00
44_V62_P1.2261.00
103_L107_D1.2251.00
119_L245_A1.2171.00
265_D268_T1.2141.00
118_F141_I1.2141.00
68_L128_A1.2131.00
262_D266_N1.2131.00
112_Y115_E1.2001.00
176_F184_M1.1931.00
173_K263_N1.1921.00
38_I42_Q1.1801.00
5_I30_A1.1781.00
53_Q213_L1.1681.00
25_N307_L1.1591.00
102_A130_A1.1541.00
262_D265_D1.1531.00
6_I21_L1.1511.00
52_E92_K1.1511.00
143_K181_D1.1461.00
105_I137_I1.1421.00
113_A140_K1.1351.00
262_D267_I1.1261.00
148_G165_I1.1241.00
109_A141_I1.1231.00
183_T244_I1.1211.00
80_G83_G1.1191.00
240_I295_I1.1191.00
109_A137_I1.1111.00
199_E301_M1.1101.00
257_R291_I1.1021.00
268_T271_M1.1011.00
23_K246_I1.1001.00
33_I47_A1.0981.00
6_I28_V1.0931.00
145_W245_A1.0881.00
158_T161_A1.0871.00
139_K142_K1.0811.00
202_V305_Y1.0780.99
105_I109_A1.0720.99
66_K132_L1.0690.99
268_T273_L1.0690.99
207_K212_E1.0680.99
145_W244_I1.0620.99
259_V289_A1.0620.99
105_I127_L1.0610.99
82_G85_G1.0600.99
194_P233_G1.0570.99
257_R274_V1.0560.99
141_I180_F1.0560.99
151_V186_P1.0550.99
94_L97_Q1.0500.99
29_V108_L1.0490.99
6_I18_L1.0470.99
39_S42_Q1.0340.99
119_L241_T1.0210.99
69_L170_D1.0130.99
102_A133_L1.0080.99
78_V224_Y1.0080.99
51_L60_V1.0070.99
241_T245_A1.0060.99
144_V180_F1.0040.99
28_V121_I1.0030.99
81_K86_D0.9990.99
183_T253_R0.9980.99
31_V51_L0.9970.99
52_E93_R0.9970.99
44_V96_A0.9960.99
51_L56_R0.9940.99
201_N205_N0.9940.99
123_P167_V0.9920.99
3_H115_E0.9910.99
260_V267_I0.9860.99
16_L304_I0.9740.99
204_K219_L0.9710.99
120_A144_V0.9640.99
109_A112_Y0.9640.99
5_I104_A0.9610.99
144_V182_I0.9560.99
106_I110_N0.9450.99
249_S299_S0.9410.99
193_Y295_I0.9410.99
197_D201_N0.9350.99
15_V50_A0.9310.98
185_I244_I0.9280.98
22_L51_L0.9270.98
5_I105_I0.9250.98
20_L307_L0.9230.98
196_T199_E0.9230.98
118_F127_L0.9210.98
12_E221_Y0.9150.98
199_E305_Y0.9150.98
136_S139_K0.9120.98
129_L132_L0.9090.98
258_F285_D0.9060.98
30_A108_L0.9050.98
147_M190_I0.9030.98
10_T43_E0.9000.98
247_D303_K0.8990.98
169_P269_R0.8990.98
4_F26_I0.8960.98
79_H83_G0.8920.98
131_Y178_A0.8910.98
35_E167_V0.8890.98
243_A250_I0.8880.98
38_I43_E0.8830.98
184_M291_I0.8750.98
124_L172_A0.8740.98
32_T126_N0.8680.98
176_F182_I0.8660.98
177_N260_V0.8650.98
61_Y99_K0.8640.98
41_E65_N0.8630.98
40_Y43_E0.8610.98
181_D290_E0.8560.97
32_T105_I0.8550.97
5_I116_L0.8550.97
106_I133_L0.8500.97
117_E142_K0.8420.97
223_Q227_T0.8420.97
161_A166_W0.8360.97
187_W237_P0.8350.97
68_L129_L0.8300.97
109_A138_V0.8290.97
253_R290_E0.8280.97
146_V182_I0.8260.97
162_E187_W0.8260.97
77_K157_I0.8250.97
258_F288_N0.8220.97
302_E305_Y0.8200.97
163_F167_V0.8190.97
251_A292_V0.8160.97
33_I43_E0.8130.96
242_T245_A0.8060.96
151_V184_M0.8030.96
115_E140_K0.8020.96
261_I272_T0.8020.96
48_L94_L0.7970.96
155_G161_A0.7960.96
21_L26_I0.7950.96
208_T211_S0.7920.96
64_A125_T0.7900.96
299_S303_K0.7870.96
186_P189_V0.7860.96
19_Y214_Y0.7800.96
50_A213_L0.7800.96
54_V210_M0.7780.95
102_A129_L0.7780.95
112_Y116_L0.7750.95
158_T166_W0.7730.95
16_L214_Y0.7720.95
147_M238_D0.7710.95
193_Y300_F0.7650.95
244_I253_R0.7650.95
69_L174_I0.7620.95
68_L171_A0.7610.95
113_A116_L0.7610.95
241_T244_I0.7550.95
62_P96_A0.7540.95
22_L54_V0.7530.95
170_D263_N0.7500.94
12_E85_G0.7490.94
150_A154_I0.7490.94
44_V48_L0.7480.94
29_V112_Y0.7480.94
256_K288_N0.7470.94
37_N46_N0.7450.94
82_G87_V0.7430.94
207_K211_S0.7420.94
213_L217_M0.7390.94
64_A100_H0.7380.94
20_L243_A0.7360.94
42_Q45_K0.7350.94
124_L165_I0.7350.94
252_T296_N0.7320.94
68_L174_I0.7280.94
5_I108_L0.7280.94
145_W241_T0.7260.93
68_L132_L0.7250.93
26_I246_I0.7230.93
176_F272_T0.7230.93
112_Y140_K0.7220.93
7_D32_T0.7200.93
82_G86_D0.7180.93
31_V47_A0.7150.93
19_Y50_A0.7150.93
73_I166_W0.7140.93
153_G188_D0.7130.93
247_D250_I0.7120.93
297_K301_M0.7110.93
21_L119_L0.7090.93
33_I126_N0.7040.92
48_L96_A0.7030.92
258_F287_P0.7030.92
109_A134_D0.7010.92
143_K244_I0.6890.92
151_V293_Y0.6890.92
118_F144_V0.6820.91
131_Y141_I0.6770.91
32_T104_A0.6760.91
18_L21_L0.6730.91
143_K290_E0.6710.91
74_T167_V0.6700.90
13_D238_D0.6690.90
184_M272_T0.6680.90
303_K307_L0.6670.90
185_I241_T0.6650.90
37_N79_H0.6600.90
14_D238_D0.6600.90
121_I241_T0.6550.89
254_R293_Y0.6550.89
131_Y180_F0.6530.89
99_K103_L0.6520.89
185_I253_R0.6520.89
244_I292_V0.6520.89
30_A61_Y0.6500.89
17_S242_T0.6470.89
18_L22_L0.6460.89
39_S74_T0.6460.89
253_R293_Y0.6450.89
114_G140_K0.6430.89
150_A188_D0.6390.88
240_I300_F0.6370.88
137_I140_K0.6360.88
138_V141_I0.6360.88
109_A113_A0.6350.88
259_V272_T0.6350.88
250_I303_K0.6340.88
4_F21_L0.6320.88
267_I273_L0.6320.88
11_A15_V0.6290.87
143_K248_G0.6290.87
156_N187_W0.6280.87
45_K92_K0.6250.87
103_L106_I0.6240.87
114_G142_K0.6240.87
148_G172_A0.6210.87
111_E114_G0.6210.87
189_V295_I0.6190.87
79_H85_G0.6180.87
102_A106_I0.6170.86
200_W204_K0.6160.86
3_H114_G0.6150.86
145_W185_I0.6130.86
134_D140_K0.6120.86
209_R212_E0.6110.86
170_D264_T0.6100.86
80_G85_G0.6100.86
206_M211_S0.6090.86
224_Y228_V0.6090.86
259_V291_I0.6080.86
147_M237_P0.6070.86
87_V216_S0.6070.86
204_K212_E0.6060.86
34_V122_S0.6050.85
117_E245_A0.6040.85
16_L218_Y0.6020.85
174_I177_N0.6000.85
226_S232_N0.6000.85
49_W53_Q0.5980.85
121_I146_V0.5980.85
137_I141_I0.5970.85
138_V180_F0.5960.85
35_E163_F0.5950.84
131_Y174_I0.5920.84
79_H84_I0.5910.84
66_K71_N0.5900.84
184_M289_A0.5900.84
40_Y65_N0.5890.84
33_I62_P0.5850.83
303_K306_D0.5850.83
215_V219_L0.5850.83
172_A175_V0.5830.83
194_P235_P0.5810.83
129_L133_L0.5810.83
34_V126_N0.5810.83
101_A126_N0.5800.83
26_I119_L0.5770.83
151_V274_V0.5770.83
189_V192_N0.5760.83
203_I211_S0.5760.83
278_D283_W0.5720.82
257_R293_Y0.5720.82
124_L127_L0.5720.82
157_I166_W0.5700.82
11_A237_P0.5690.82
153_G191_I0.5680.82
159_P283_W0.5640.81
138_V179_G0.5640.81
156_N162_E0.5640.81
68_L125_T0.5620.81
26_I245_A0.5610.81
15_V46_N0.5610.81
104_A107_D0.5600.81
75_V78_V0.5590.81
110_N137_I0.5570.80
36_G123_P0.5540.80
100_H129_L0.5530.80
195_V234_H0.5520.80
108_L112_Y0.5520.80
131_Y137_I0.5510.80
28_V31_V0.5500.80
62_P65_N0.5490.79
69_L132_L0.5490.79
200_W219_L0.5460.79
47_A51_L0.5460.79
263_N269_R0.5450.79
253_R294_E0.5440.79
183_T292_V0.5440.79
151_V188_D0.5430.79
171_A175_V0.5430.79
156_N161_A0.5420.79
139_K143_K0.5410.78
54_V214_Y0.5410.78
199_E297_K0.5410.78
284_S287_P0.5390.78
145_W183_T0.5390.78
204_K216_S0.5340.78
20_L242_T0.5340.78
72_Y167_V0.5330.77
191_I237_P0.5330.77
69_L173_K0.5330.77
198_E201_N0.5320.77
97_Q107_D0.5310.77
219_L223_Q0.5300.77
155_G187_W0.5280.77
102_A109_A0.5280.77
36_G46_N0.5280.77
214_Y308_L0.5250.76
254_R257_R0.5250.76
199_E202_V0.5240.76
130_A133_L0.5240.76
106_I109_A0.5230.76
275_D278_D0.5220.76
49_W92_K0.5160.75
195_V218_Y0.5130.75
214_Y217_M0.5130.75
49_W90_E0.5090.74
85_G88_T0.5080.74
199_E203_I0.5080.74
67_P70_K0.5070.74
222_R234_H0.5050.74
34_V123_P0.5030.73
106_I136_S0.5030.73
221_Y237_P0.5020.73
191_I274_V0.5020.73
197_D222_R0.5010.73
125_T168_D0.5010.73
172_A261_I0.5000.73
45_K48_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t8jA 3 1 100 0.052 Contact Map
2masA 3 0.9839 100 0.069 Contact Map
4wr2A 4 0.9518 100 0.07 Contact Map
1q8fA 4 0.9839 100 0.074 Contact Map
3t8iA 3 0.9775 100 0.081 Contact Map
4kpoA 2 0.9936 100 0.081 Contact Map
4kpnA 2 0.9936 100 0.083 Contact Map
3fz0A 3 0.9807 100 0.106 Contact Map
2c40A 2 0.9164 100 0.144 Contact Map
4i71A 2 0.9486 100 0.151 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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