Q97ZS5 - SULSO - GREMLIN Contacts

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Q97ZS5 - Purine nucleosidase, putative (IunH-1)

UniProt:	Q97ZS5	Sequences: MRHFIIDCDTAEDDVLSLYLLLKNNIDVVAVTIVEGNISYEQEVKNALWALEQVNREIPVYPGANKPLLKNYITVEKVHGKGGIGDVTVEPKRLKAQEKHAALAIIDLANEYAGELEFLAISPLTNLALAYLLDNSIVKKIKKVWVMGGAVFGIGNITPVAEFNIWVDPDAAKIVFNAGFDITMIPWDVIINYPVTDEEWNVIKNMKTRMSELYVSMYLHYRQYSSTVQKINGHPHPDAITTAIAIDGSIATRREKRFVVIDNTDNITRGMTLVDRFDADTSWSDKPNAEIVYEINKKSFMEKIYDLLNWF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (301)
Sequences:	3958 (2835)
Seq/√Len:	163.4

ECOLI - RIHB RIHA RIHC
SULSO - Q97ZS5 Q97WH6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_K	107_D	3.977	1.00
103_L	133_L	3.717	1.00
173_K	177_N	3.267	1.00
132_L	174_I	2.912	1.00
3_H	27_D	2.785	1.00
165_I	272_T	2.762	1.00
252_T	294_E	2.707	1.00
30_A	104_A	2.649	1.00
64_A	129_L	2.504	1.00
110_N	134_D	2.452	1.00
192_N	294_E	2.447	1.00
173_K	260_V	2.426	1.00
33_I	44_V	2.356	1.00
256_K	290_E	2.337	1.00
247_D	299_S	2.303	1.00
131_Y	138_V	2.276	1.00
110_N	140_K	2.223	1.00
32_T	101_A	2.198	1.00
10_T	47_A	2.149	1.00
119_L	242_T	2.119	1.00
18_L	31_V	2.110	1.00
107_D	111_E	2.086	1.00
21_L	242_T	2.071	1.00
3_H	29_V	2.059	1.00
110_N	136_S	2.053	1.00
6_I	121_I	2.035	1.00
190_I	237_P	2.032	1.00
165_I	172_A	1.988	1.00
48_L	60_V	1.925	1.00
61_Y	104_A	1.889	1.00
106_I	134_D	1.886	1.00
115_E	142_K	1.885	1.00
253_R	292_V	1.881	1.00
120_A	127_L	1.879	1.00
160_V	271_M	1.843	1.00
296_N	299_S	1.837	1.00
109_A	116_L	1.813	1.00
19_Y	54_V	1.808	1.00
120_A	146_V	1.790	1.00
130_A	134_D	1.784	1.00
7_D	126_N	1.777	1.00
236_H	239_A	1.752	1.00
29_V	116_L	1.732	1.00
5_I	32_T	1.722	1.00
8_C	121_I	1.703	1.00
143_K	183_T	1.702	1.00
61_Y	97_Q	1.674	1.00
48_L	95_K	1.654	1.00
22_L	56_R	1.649	1.00
45_K	49_W	1.641	1.00
70_K	269_R	1.632	1.00
22_L	28_V	1.612	1.00
120_A	124_L	1.601	1.00
106_I	130_A	1.593	1.00
262_D	268_T	1.569	1.00
104_A	108_L	1.564	1.00
117_E	145_W	1.562	1.00
40_Y	62_P	1.559	1.00
23_K	307_L	1.550	1.00
212_E	216_S	1.548	1.00
150_A	153_G	1.534	1.00
185_I	292_V	1.531	1.00
100_H	103_L	1.531	1.00
124_L	175_V	1.519	1.00
130_A	137_I	1.498	1.00
146_V	165_I	1.487	1.00
146_V	184_M	1.487	1.00
302_E	306_D	1.484	1.00
244_I	251_A	1.481	1.00
4_F	119_L	1.477	1.00
146_V	176_F	1.469	1.00
106_I	137_I	1.465	1.00
250_I	299_S	1.463	1.00
109_A	130_A	1.446	1.00
170_D	269_R	1.437	1.00
105_I	130_A	1.413	1.00
109_A	140_K	1.404	1.00
41_E	62_P	1.388	1.00
134_D	137_I	1.379	1.00
100_H	133_L	1.378	1.00
108_L	111_E	1.378	1.00
298_K	302_E	1.375	1.00
204_K	215_V	1.369	1.00
40_Y	44_V	1.362	1.00
82_G	88_T	1.351	1.00
202_V	302_E	1.343	1.00
183_T	290_E	1.339	1.00
165_I	176_F	1.312	1.00
52_E	94_L	1.307	1.00
117_E	143_K	1.289	1.00
8_C	47_A	1.282	1.00
124_L	146_V	1.280	1.00
243_A	300_F	1.279	1.00
127_L	144_V	1.277	1.00
22_L	58_I	1.274	1.00
243_A	303_K	1.273	1.00
70_K	170_D	1.270	1.00
108_L	116_L	1.262	1.00
45_K	91_P	1.262	1.00
51_L	58_I	1.257	1.00
3_H	112_Y	1.253	1.00
20_L	303_K	1.228	1.00
240_I	251_A	1.226	1.00
44_V	62_P	1.226	1.00
103_L	107_D	1.225	1.00
119_L	245_A	1.217	1.00
265_D	268_T	1.214	1.00
118_F	141_I	1.214	1.00
68_L	128_A	1.213	1.00
262_D	266_N	1.213	1.00
112_Y	115_E	1.200	1.00
176_F	184_M	1.193	1.00
173_K	263_N	1.192	1.00
38_I	42_Q	1.180	1.00
5_I	30_A	1.178	1.00
53_Q	213_L	1.168	1.00
25_N	307_L	1.159	1.00
102_A	130_A	1.154	1.00
262_D	265_D	1.153	1.00
6_I	21_L	1.151	1.00
52_E	92_K	1.151	1.00
143_K	181_D	1.146	1.00
105_I	137_I	1.142	1.00
113_A	140_K	1.135	1.00
262_D	267_I	1.126	1.00
148_G	165_I	1.124	1.00
109_A	141_I	1.123	1.00
183_T	244_I	1.121	1.00
80_G	83_G	1.119	1.00
240_I	295_I	1.119	1.00
109_A	137_I	1.111	1.00
199_E	301_M	1.110	1.00
257_R	291_I	1.102	1.00
268_T	271_M	1.101	1.00
23_K	246_I	1.100	1.00
33_I	47_A	1.098	1.00
6_I	28_V	1.093	1.00
145_W	245_A	1.088	1.00
158_T	161_A	1.087	1.00
139_K	142_K	1.081	1.00
202_V	305_Y	1.078	0.99
105_I	109_A	1.072	0.99
66_K	132_L	1.069	0.99
268_T	273_L	1.069	0.99
207_K	212_E	1.068	0.99
145_W	244_I	1.062	0.99
259_V	289_A	1.062	0.99
105_I	127_L	1.061	0.99
82_G	85_G	1.060	0.99
194_P	233_G	1.057	0.99
257_R	274_V	1.056	0.99
141_I	180_F	1.056	0.99
151_V	186_P	1.055	0.99
94_L	97_Q	1.050	0.99
29_V	108_L	1.049	0.99
6_I	18_L	1.047	0.99
39_S	42_Q	1.034	0.99
119_L	241_T	1.021	0.99
69_L	170_D	1.013	0.99
102_A	133_L	1.008	0.99
78_V	224_Y	1.008	0.99
51_L	60_V	1.007	0.99
241_T	245_A	1.006	0.99
144_V	180_F	1.004	0.99
28_V	121_I	1.003	0.99
81_K	86_D	0.999	0.99
183_T	253_R	0.998	0.99
31_V	51_L	0.997	0.99
52_E	93_R	0.997	0.99
44_V	96_A	0.996	0.99
51_L	56_R	0.994	0.99
201_N	205_N	0.994	0.99
123_P	167_V	0.992	0.99
3_H	115_E	0.991	0.99
260_V	267_I	0.986	0.99
16_L	304_I	0.974	0.99
204_K	219_L	0.971	0.99
120_A	144_V	0.964	0.99
109_A	112_Y	0.964	0.99
5_I	104_A	0.961	0.99
144_V	182_I	0.956	0.99
106_I	110_N	0.945	0.99
249_S	299_S	0.941	0.99
193_Y	295_I	0.941	0.99
197_D	201_N	0.935	0.99
15_V	50_A	0.931	0.98
185_I	244_I	0.928	0.98
22_L	51_L	0.927	0.98
5_I	105_I	0.925	0.98
20_L	307_L	0.923	0.98
196_T	199_E	0.923	0.98
118_F	127_L	0.921	0.98
12_E	221_Y	0.915	0.98
199_E	305_Y	0.915	0.98
136_S	139_K	0.912	0.98
129_L	132_L	0.909	0.98
258_F	285_D	0.906	0.98
30_A	108_L	0.905	0.98
147_M	190_I	0.903	0.98
10_T	43_E	0.900	0.98
247_D	303_K	0.899	0.98
169_P	269_R	0.899	0.98
4_F	26_I	0.896	0.98
79_H	83_G	0.892	0.98
131_Y	178_A	0.891	0.98
35_E	167_V	0.889	0.98
243_A	250_I	0.888	0.98
38_I	43_E	0.883	0.98
184_M	291_I	0.875	0.98
124_L	172_A	0.874	0.98
32_T	126_N	0.868	0.98
176_F	182_I	0.866	0.98
177_N	260_V	0.865	0.98
61_Y	99_K	0.864	0.98
41_E	65_N	0.863	0.98
40_Y	43_E	0.861	0.98
181_D	290_E	0.856	0.97
32_T	105_I	0.855	0.97
5_I	116_L	0.855	0.97
106_I	133_L	0.850	0.97
117_E	142_K	0.842	0.97
223_Q	227_T	0.842	0.97
161_A	166_W	0.836	0.97
187_W	237_P	0.835	0.97
68_L	129_L	0.830	0.97
109_A	138_V	0.829	0.97
253_R	290_E	0.828	0.97
146_V	182_I	0.826	0.97
162_E	187_W	0.826	0.97
77_K	157_I	0.825	0.97
258_F	288_N	0.822	0.97
302_E	305_Y	0.820	0.97
163_F	167_V	0.819	0.97
251_A	292_V	0.816	0.97
33_I	43_E	0.813	0.96
242_T	245_A	0.806	0.96
151_V	184_M	0.803	0.96
115_E	140_K	0.802	0.96
261_I	272_T	0.802	0.96
48_L	94_L	0.797	0.96
155_G	161_A	0.796	0.96
21_L	26_I	0.795	0.96
208_T	211_S	0.792	0.96
64_A	125_T	0.790	0.96
299_S	303_K	0.787	0.96
186_P	189_V	0.786	0.96
19_Y	214_Y	0.780	0.96
50_A	213_L	0.780	0.96
54_V	210_M	0.778	0.95
102_A	129_L	0.778	0.95
112_Y	116_L	0.775	0.95
158_T	166_W	0.773	0.95
16_L	214_Y	0.772	0.95
147_M	238_D	0.771	0.95
193_Y	300_F	0.765	0.95
244_I	253_R	0.765	0.95
69_L	174_I	0.762	0.95
68_L	171_A	0.761	0.95
113_A	116_L	0.761	0.95
241_T	244_I	0.755	0.95
62_P	96_A	0.754	0.95
22_L	54_V	0.753	0.95
170_D	263_N	0.750	0.94
12_E	85_G	0.749	0.94
150_A	154_I	0.749	0.94
44_V	48_L	0.748	0.94
29_V	112_Y	0.748	0.94
256_K	288_N	0.747	0.94
37_N	46_N	0.745	0.94
82_G	87_V	0.743	0.94
207_K	211_S	0.742	0.94
213_L	217_M	0.739	0.94
64_A	100_H	0.738	0.94
20_L	243_A	0.736	0.94
42_Q	45_K	0.735	0.94
124_L	165_I	0.735	0.94
252_T	296_N	0.732	0.94
68_L	174_I	0.728	0.94
5_I	108_L	0.728	0.94
145_W	241_T	0.726	0.93
68_L	132_L	0.725	0.93
26_I	246_I	0.723	0.93
176_F	272_T	0.723	0.93
112_Y	140_K	0.722	0.93
7_D	32_T	0.720	0.93
82_G	86_D	0.718	0.93
31_V	47_A	0.715	0.93
19_Y	50_A	0.715	0.93
73_I	166_W	0.714	0.93
153_G	188_D	0.713	0.93
247_D	250_I	0.712	0.93
297_K	301_M	0.711	0.93
21_L	119_L	0.709	0.93
33_I	126_N	0.704	0.92
48_L	96_A	0.703	0.92
258_F	287_P	0.703	0.92
109_A	134_D	0.701	0.92
143_K	244_I	0.689	0.92
151_V	293_Y	0.689	0.92
118_F	144_V	0.682	0.91
131_Y	141_I	0.677	0.91
32_T	104_A	0.676	0.91
18_L	21_L	0.673	0.91
143_K	290_E	0.671	0.91
74_T	167_V	0.670	0.90
13_D	238_D	0.669	0.90
184_M	272_T	0.668	0.90
303_K	307_L	0.667	0.90
185_I	241_T	0.665	0.90
37_N	79_H	0.660	0.90
14_D	238_D	0.660	0.90
121_I	241_T	0.655	0.89
254_R	293_Y	0.655	0.89
131_Y	180_F	0.653	0.89
99_K	103_L	0.652	0.89
185_I	253_R	0.652	0.89
244_I	292_V	0.652	0.89
30_A	61_Y	0.650	0.89
17_S	242_T	0.647	0.89
18_L	22_L	0.646	0.89
39_S	74_T	0.646	0.89
253_R	293_Y	0.645	0.89
114_G	140_K	0.643	0.89
150_A	188_D	0.639	0.88
240_I	300_F	0.637	0.88
137_I	140_K	0.636	0.88
138_V	141_I	0.636	0.88
109_A	113_A	0.635	0.88
259_V	272_T	0.635	0.88
250_I	303_K	0.634	0.88
4_F	21_L	0.632	0.88
267_I	273_L	0.632	0.88
11_A	15_V	0.629	0.87
143_K	248_G	0.629	0.87
156_N	187_W	0.628	0.87
45_K	92_K	0.625	0.87
103_L	106_I	0.624	0.87
114_G	142_K	0.624	0.87
148_G	172_A	0.621	0.87
111_E	114_G	0.621	0.87
189_V	295_I	0.619	0.87
79_H	85_G	0.618	0.87
102_A	106_I	0.617	0.86
200_W	204_K	0.616	0.86
3_H	114_G	0.615	0.86
145_W	185_I	0.613	0.86
134_D	140_K	0.612	0.86
209_R	212_E	0.611	0.86
170_D	264_T	0.610	0.86
80_G	85_G	0.610	0.86
206_M	211_S	0.609	0.86
224_Y	228_V	0.609	0.86
259_V	291_I	0.608	0.86
147_M	237_P	0.607	0.86
87_V	216_S	0.607	0.86
204_K	212_E	0.606	0.86
34_V	122_S	0.605	0.85
117_E	245_A	0.604	0.85
16_L	218_Y	0.602	0.85
174_I	177_N	0.600	0.85
226_S	232_N	0.600	0.85
49_W	53_Q	0.598	0.85
121_I	146_V	0.598	0.85
137_I	141_I	0.597	0.85
138_V	180_F	0.596	0.85
35_E	163_F	0.595	0.84
131_Y	174_I	0.592	0.84
79_H	84_I	0.591	0.84
66_K	71_N	0.590	0.84
184_M	289_A	0.590	0.84
40_Y	65_N	0.589	0.84
33_I	62_P	0.585	0.83
303_K	306_D	0.585	0.83
215_V	219_L	0.585	0.83
172_A	175_V	0.583	0.83
194_P	235_P	0.581	0.83
129_L	133_L	0.581	0.83
34_V	126_N	0.581	0.83
101_A	126_N	0.580	0.83
26_I	119_L	0.577	0.83
151_V	274_V	0.577	0.83
189_V	192_N	0.576	0.83
203_I	211_S	0.576	0.83
278_D	283_W	0.572	0.82
257_R	293_Y	0.572	0.82
124_L	127_L	0.572	0.82
157_I	166_W	0.570	0.82
11_A	237_P	0.569	0.82
153_G	191_I	0.568	0.82
159_P	283_W	0.564	0.81
138_V	179_G	0.564	0.81
156_N	162_E	0.564	0.81
68_L	125_T	0.562	0.81
26_I	245_A	0.561	0.81
15_V	46_N	0.561	0.81
104_A	107_D	0.560	0.81
75_V	78_V	0.559	0.81
110_N	137_I	0.557	0.80
36_G	123_P	0.554	0.80
100_H	129_L	0.553	0.80
195_V	234_H	0.552	0.80
108_L	112_Y	0.552	0.80
131_Y	137_I	0.551	0.80
28_V	31_V	0.550	0.80
62_P	65_N	0.549	0.79
69_L	132_L	0.549	0.79
200_W	219_L	0.546	0.79
47_A	51_L	0.546	0.79
263_N	269_R	0.545	0.79
253_R	294_E	0.544	0.79
183_T	292_V	0.544	0.79
151_V	188_D	0.543	0.79
171_A	175_V	0.543	0.79
156_N	161_A	0.542	0.79
139_K	143_K	0.541	0.78
54_V	214_Y	0.541	0.78
199_E	297_K	0.541	0.78
284_S	287_P	0.539	0.78
145_W	183_T	0.539	0.78
204_K	216_S	0.534	0.78
20_L	242_T	0.534	0.78
72_Y	167_V	0.533	0.77
191_I	237_P	0.533	0.77
69_L	173_K	0.533	0.77
198_E	201_N	0.532	0.77
97_Q	107_D	0.531	0.77
219_L	223_Q	0.530	0.77
155_G	187_W	0.528	0.77
102_A	109_A	0.528	0.77
36_G	46_N	0.528	0.77
214_Y	308_L	0.525	0.76
254_R	257_R	0.525	0.76
199_E	202_V	0.524	0.76
130_A	133_L	0.524	0.76
106_I	109_A	0.523	0.76
275_D	278_D	0.522	0.76
49_W	92_K	0.516	0.75
195_V	218_Y	0.513	0.75
214_Y	217_M	0.513	0.75
49_W	90_E	0.509	0.74
85_G	88_T	0.508	0.74
199_E	203_I	0.508	0.74
67_P	70_K	0.507	0.74
222_R	234_H	0.505	0.74
34_V	123_P	0.503	0.73
106_I	136_S	0.503	0.73
221_Y	237_P	0.502	0.73
191_I	274_V	0.502	0.73
197_D	222_R	0.501	0.73
125_T	168_D	0.501	0.73
172_A	261_I	0.500	0.73
45_K	48_L	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3t8jA	3	1	100	0.052	Contact Map
2masA	3	0.9839	100	0.069	Contact Map
4wr2A	4	0.9518	100	0.07	Contact Map
1q8fA	4	0.9839	100	0.074	Contact Map
3t8iA	3	0.9775	100	0.081	Contact Map
4kpoA	2	0.9936	100	0.081	Contact Map
4kpnA	2	0.9936	100	0.083	Contact Map
3fz0A	3	0.9807	100	0.106	Contact Map
2c40A	2	0.9164	100	0.144	Contact Map
4i71A	2	0.9486	100	0.151	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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