GREMLIN Database
Q97ZS3 - Uncharacterized protein
UniProt: Q97ZS3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (275)
Sequences: 4737 (4344)
Seq/√Len: 261.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_R77_I6.4101.00
112_E115_N6.3741.00
36_K39_K5.7361.00
148_E154_E5.1441.00
311_N314_K4.5601.00
214_D217_K4.3761.00
278_F281_E4.2401.00
185_L188_K3.9921.00
245_L248_Q3.2941.00
104_S120_L3.1581.00
66_G82_F3.0591.00
28_I44_L2.7981.00
140_V159_L2.5541.00
100_L119_T2.5481.00
31_Y39_K2.4531.00
45_D65_L2.4331.00
147_G152_I2.2261.00
69_Y77_I2.1621.00
83_K103_L2.1581.00
107_Y119_T2.1261.00
101_Y138_L2.0861.00
139_L143_C2.0581.00
156_R160_E2.0271.00
44_L64_I2.0221.00
103_L119_T1.9931.00
82_F102_N1.9811.00
143_C154_E1.9631.00
267_Y298_A1.9451.00
104_S119_T1.9421.00
28_I47_A1.9251.00
117_Y121_K1.9061.00
107_Y115_N1.8901.00
27_L31_Y1.8881.00
117_Y143_C1.8011.00
136_K158_L1.7921.00
120_L138_L1.7681.00
41_T45_D1.7181.00
66_G85_L1.7161.00
65_L81_T1.7021.00
180_Y185_L1.6811.00
47_A50_I1.6741.00
197_G200_K1.6631.00
79_I110_K1.6581.00
65_L69_Y1.6431.00
101_Y135_S1.6121.00
107_Y112_E1.5811.00
62_L81_T1.5701.00
104_S123_L1.5651.00
63_N102_N1.5621.00
188_K191_D1.5551.00
69_Y74_R1.5511.00
31_Y36_K1.5511.00
269_I273_T1.5441.00
103_L107_Y1.5411.00
69_Y81_T1.5161.00
79_I83_K1.5141.00
143_C158_L1.5011.00
62_L85_L1.4961.00
143_C148_E1.4911.00
28_I43_F1.4511.00
31_Y43_F1.4421.00
161_E165_P1.3971.00
67_L102_N1.3891.00
249_I253_I1.3731.00
306_E311_N1.3631.00
140_V162_F1.3571.00
283_I287_E1.3541.00
176_L180_Y1.3301.00
235_L239_S1.3281.00
117_Y146_L1.3211.00
117_Y139_L1.3071.00
83_K115_N1.3041.00
41_T65_L1.3001.00
273_T281_E1.2921.00
299_Y303_A1.2891.00
302_L306_E1.2811.00
77_I80_L1.2791.00
32_H68_I1.2771.00
122_G126_N1.2751.00
217_K220_Q1.2701.00
39_K42_E1.2681.00
263_L270_Y1.2541.00
101_Y105_L1.2371.00
41_T72_K1.2361.00
219_I223_E1.2341.00
121_K139_L1.2231.00
41_T69_Y1.2221.00
190_K194_I1.2191.00
203_A206_L1.2071.00
41_T68_I1.1931.00
306_E314_K1.1831.00
169_L173_Y1.1801.00
70_L106_A1.1781.00
27_L30_E1.1731.00
79_I106_A1.1721.00
169_L177_A1.1541.00
63_N99_I1.1401.00
79_I107_Y1.1381.00
248_Q251_E1.1301.00
66_G78_A1.1301.00
29_Q44_L1.1291.00
115_N118_N1.1271.00
108_F120_L1.1201.00
178_K182_D1.0911.00
231_E234_P1.0891.00
121_K126_N1.0861.00
59_P85_L1.0741.00
97_N123_L1.0621.00
300_S304_N1.0591.00
37_K68_I1.0481.00
139_L158_L1.0441.00
270_Y286_A1.0401.00
205_I209_S1.0321.00
180_Y188_K1.0281.00
45_D49_S1.0201.00
43_F46_R1.0141.00
30_E34_L1.0101.00
47_A52_N0.9941.00
64_I67_L0.9891.00
159_L163_N0.9811.00
266_L270_Y0.9731.00
138_L141_K0.9681.00
154_E158_L0.9641.00
62_L100_L0.9551.00
296_A303_A0.9521.00
140_V158_L0.9521.00
270_Y282_A0.9481.00
144_L159_L0.9451.00
283_I306_E0.9441.00
231_E235_L0.9421.00
44_L48_L0.9411.00
174_A177_A0.9391.00
141_K145_A0.9361.00
67_L82_F0.9341.00
63_N66_G0.9301.00
46_R50_I0.9241.00
86_L100_L0.9231.00
124_V136_K0.9191.00
108_F145_A0.9171.00
68_I72_K0.9161.00
51_A58_N0.9131.00
62_L136_K0.9121.00
281_E284_K0.9081.00
113_L142_V0.9081.00
105_L108_F0.9071.00
263_L267_Y0.9061.00
27_L43_F0.9041.00
52_N58_N0.9011.00
136_K161_E0.9011.00
154_E157_E0.9011.00
46_R49_S0.8941.00
294_F298_A0.8911.00
45_D77_I0.8911.00
159_L175_A0.8891.00
38_Y72_K0.8871.00
156_R180_Y0.8871.00
161_E164_I0.8831.00
47_A61_V0.8801.00
100_L122_G0.8781.00
190_K209_S0.8771.00
37_K41_T0.8741.00
170_A177_A0.8741.00
105_L109_Q0.8701.00
300_S303_A0.8661.00
262_K266_L0.8661.00
250_L254_G0.8621.00
296_A300_S0.8621.00
48_L61_V0.8541.00
297_R304_N0.8490.99
59_P63_N0.8480.99
133_V162_F0.8460.99
162_F172_A0.8440.99
177_A180_Y0.8420.99
100_L123_L0.8370.99
186_L189_A0.8330.99
101_Y132_N0.8320.99
230_S235_L0.8300.99
84_E87_S0.8210.99
304_N308_E0.8180.99
283_I286_A0.8140.99
141_K159_L0.8120.99
244_S249_I0.8090.99
284_K287_E0.8080.99
77_I81_T0.8050.99
102_N105_L0.8050.99
76_D110_K0.8050.99
252_K255_N0.8030.99
299_Y307_E0.7990.99
61_V64_I0.7960.99
193_A197_G0.7950.99
66_G70_L0.7920.99
142_V146_L0.7920.99
39_K77_I0.7910.99
106_A110_K0.7860.99
108_F113_L0.7850.99
192_I195_V0.7850.99
204_D207_S0.7810.99
292_Y295_L0.7810.99
159_L172_A0.7800.99
117_Y142_V0.7800.99
244_S257_E0.7790.99
253_I269_I0.7760.99
287_E295_L0.7740.99
120_L135_S0.7700.99
63_N82_F0.7690.99
86_L103_L0.7680.99
295_L299_Y0.7650.99
255_N259_S0.7640.99
301_E305_Y0.7640.99
70_L78_A0.7620.99
232_L236_Y0.7610.99
205_I208_I0.7600.99
118_N122_G0.7550.99
38_Y42_E0.7510.99
273_T278_F0.7510.99
82_F103_L0.7490.99
70_L75_P0.7490.99
97_N101_Y0.7490.99
274_K305_Y0.7480.99
42_E53_K0.7480.99
32_H44_L0.7450.99
137_K140_V0.7420.99
28_I42_E0.7410.99
141_K144_L0.7400.99
266_L269_I0.7370.99
104_S116_A0.7360.99
178_K181_N0.7320.99
80_L83_K0.7310.98
85_L99_I0.7280.98
267_Y301_E0.7250.98
203_A208_I0.7240.98
158_L161_E0.7220.98
267_Y270_Y0.7200.98
230_S239_S0.7110.98
231_E239_S0.7100.98
180_Y192_I0.7100.98
119_T122_G0.7020.98
247_A250_L0.7010.98
124_V135_S0.6990.98
75_P79_I0.6980.98
215_L219_I0.6920.98
234_P237_K0.6920.98
206_L210_D0.6910.98
307_E312_L0.6910.98
158_L221_I0.6880.98
78_A85_L0.6880.98
104_S108_F0.6880.98
289_L294_F0.6870.98
303_A307_E0.6850.98
279_L309_V0.6830.98
230_S234_P0.6830.98
173_Y195_V0.6820.98
269_I286_A0.6800.98
58_N96_K0.6770.98
29_Q64_I0.6750.97
129_G132_N0.6750.97
60_T64_I0.6730.97
75_P106_A0.6730.97
288_K291_D0.6710.97
43_F47_A0.6660.97
99_I102_N0.6640.97
254_G258_D0.6600.97
221_I224_K0.6590.97
266_L289_L0.6590.97
294_F307_E0.6590.97
268_D271_R0.6590.97
96_K99_I0.6580.97
42_E46_R0.6580.97
101_Y123_L0.6540.97
209_S214_D0.6530.97
48_L62_L0.6520.97
47_A51_A0.6510.97
181_N193_A0.6500.97
49_S52_N0.6500.97
62_L69_Y0.6420.97
262_K272_R0.6420.97
101_Y104_S0.6400.97
67_L71_E0.6380.96
32_H37_K0.6360.96
79_I103_L0.6340.96
203_A234_P0.6310.96
105_L138_L0.6290.96
160_E164_I0.6280.96
36_K74_R0.6280.96
297_R301_E0.6270.96
233_K236_Y0.6270.96
230_S236_Y0.6240.96
60_T63_N0.6230.96
137_K172_A0.6220.96
298_A306_E0.6190.96
62_L84_E0.6190.96
123_L127_S0.6160.96
115_N119_T0.6140.96
173_Y177_A0.6140.96
28_I40_N0.6140.96
120_L142_V0.6120.96
234_P241_K0.6110.96
205_I210_D0.6080.95
292_Y296_A0.6070.95
204_D208_I0.6060.95
58_N62_L0.6050.95
31_Y69_Y0.6040.95
218_A225_L0.6020.95
304_N307_E0.6010.95
299_Y305_Y0.5980.95
221_I225_L0.5980.95
123_L135_S0.5970.95
108_F138_L0.5960.95
144_L175_A0.5960.95
43_F119_T0.5960.95
288_K292_Y0.5950.95
286_A290_Q0.5950.95
80_L84_E0.5920.95
236_Y265_I0.5900.95
246_F250_L0.5890.95
31_Y34_L0.5880.94
162_F167_E0.5880.94
66_G102_N0.5880.94
169_L174_A0.5850.94
116_A142_V0.5840.94
105_L120_L0.5820.94
296_A301_E0.5790.94
298_A308_E0.5790.94
180_Y184_K0.5780.94
177_A189_A0.5780.94
234_P239_S0.5770.94
30_E48_L0.5760.94
119_T123_L0.5750.94
37_K71_E0.5740.94
39_K115_N0.5730.94
279_L305_Y0.5690.93
228_H231_E0.5680.93
294_F300_S0.5670.93
79_I112_E0.5640.93
305_Y311_N0.5630.93
70_L73_R0.5620.93
95_D99_I0.5620.93
153_E157_E0.5610.93
245_L249_I0.5610.93
231_E241_K0.5590.93
37_K72_K0.5590.93
209_S217_K0.5580.93
63_N67_L0.5580.93
298_A301_E0.5580.93
160_E176_L0.5550.93
249_I252_K0.5540.93
39_K43_F0.5520.92
132_N135_S0.5520.92
97_N132_N0.5510.92
82_F86_L0.5510.92
177_A184_K0.5500.92
34_L43_F0.5490.92
123_L129_G0.5490.92
40_N44_L0.5480.92
249_I257_E0.5480.92
34_L37_K0.5450.92
122_G127_S0.5450.92
273_T276_L0.5440.92
134_L137_K0.5440.92
270_Y273_T0.5410.92
84_E88_N0.5390.92
184_K189_A0.5380.91
222_Y226_G0.5360.91
231_E237_K0.5360.91
137_K175_A0.5350.91
144_L152_I0.5350.91
120_L124_V0.5350.91
301_E308_E0.5340.91
235_L238_L0.5330.91
270_Y289_L0.5330.91
29_Q33_N0.5330.91
83_K87_S0.5310.91
191_D195_V0.5310.91
282_A285_T0.5310.91
62_L66_G0.5310.91
309_V313_R0.5300.91
28_I32_H0.5300.91
290_Q293_L0.5290.91
48_L52_N0.5280.91
250_L253_I0.5280.91
290_Q295_L0.5270.91
291_D294_F0.5260.91
298_A302_L0.5260.91
202_L210_D0.5260.91
297_R312_L0.5260.91
166_S169_L0.5250.90
229_N237_K0.5240.90
262_K267_Y0.5230.90
78_A82_F0.5220.90
171_I175_A0.5180.90
66_G81_T0.5180.90
269_I272_R0.5180.90
299_Y306_E0.5180.90
308_E312_L0.5170.90
143_C146_L0.5160.90
97_N133_V0.5150.90
136_K143_C0.5140.90
58_N61_V0.5140.90
290_Q294_F0.5140.90
177_A182_D0.5130.89
286_A294_F0.5120.89
136_K162_F0.5120.89
286_A296_A0.5100.89
305_Y309_V0.5090.89
233_K237_K0.5090.89
64_I68_I0.5080.89
235_L240_N0.5060.89
301_E306_E0.5050.89
37_K42_E0.5030.89
299_Y309_V0.5010.88
163_N176_L0.5010.88
176_L179_Y0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w3bA 2 0.9604 100 0.278 Contact Map
5aioA 1 0.8902 100 0.293 Contact Map
4kvmA 3 0.9512 100 0.296 Contact Map
4ui9X 2 0.9726 100 0.297 Contact Map
4bujB 1 0.9634 100 0.301 Contact Map
4ui9F 2 0.8872 100 0.302 Contact Map
2y4tA 1 0.9055 100 0.314 Contact Map
2xpiA 2 0.9573 100 0.317 Contact Map
4ui9C 2 0.9634 100 0.322 Contact Map
4rg9A 2 0.8232 100 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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