GREMLIN Database
Q97ZR7 - Second ORF in transposon ISC1173
UniProt: Q97ZR7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (226)
Sequences: 195 (189)
Seq/√Len: 12.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E75_N6.6751.00
12_K16_G3.7820.99
72_E88_R3.7570.99
72_E85_V3.3690.98
75_N88_R3.2400.98
14_F18_L2.7430.94
75_N79_L2.6030.92
24_S27_C2.5010.90
72_E79_L2.5000.90
17_P21_P2.4330.89
36_G40_G2.4090.88
88_R93_V2.2610.85
24_S34_K2.2070.83
22_G33_I2.1660.82
24_S46_C2.1150.80
27_C34_K2.1090.80
75_N85_V2.1000.80
34_K38_S2.0940.80
34_K61_M2.0730.79
46_C49_C2.0100.77
27_C46_C2.0010.76
24_S61_M1.9910.76
40_G53_F1.9740.75
16_G24_S1.9570.75
24_S38_S1.9560.75
12_K34_K1.9420.74
49_C61_M1.9310.74
70_L75_N1.9150.73
42_S55_R1.9010.73
38_S61_M1.8890.72
16_G38_S1.8860.72
9_L12_K1.8190.69
113_A118_F1.8080.69
16_G61_M1.7930.68
16_G34_K1.7680.67
46_C61_M1.7630.67
36_G39_R1.6920.63
40_G43_K1.6600.62
12_K24_S1.6580.62
34_K49_C1.5990.59
212_S215_V1.5960.59
12_K61_M1.5810.58
18_L21_P1.5660.57
12_K38_S1.5500.56
110_I117_A1.5480.56
24_S49_C1.5220.55
17_P40_G1.5160.55
54_Y58_S1.5130.54
38_S49_C1.4290.50
27_C49_C1.4280.50
224_V228_R1.4270.50
4_P39_R1.4220.50
34_K46_C1.4180.50
17_P39_R1.4000.49
3_I53_F1.3930.48
74_T82_I1.3520.46
51_R65_Q1.3510.46
16_G49_C1.3420.46
24_S31_R1.3380.45
23_F57_A1.3350.45
14_F21_P1.3300.45
3_I12_K1.3090.44
223_A226_R1.2960.43
113_A120_S1.2930.43
193_H197_K1.2850.43
41_K50_G1.2730.42
12_K27_C1.2680.42
18_L39_R1.2570.41
18_L41_K1.2550.41
5_K20_L1.2430.41
38_S46_C1.2370.40
135_R140_R1.2310.40
199_Y202_T1.2270.40
21_P41_K1.2250.40
6_L9_L1.2230.40
27_C43_K1.2210.40
9_L16_G1.2180.39
7_K14_F1.2160.39
88_R92_T1.2150.39
158_T161_R1.2090.39
159_G168_L1.1930.38
27_C31_R1.1870.38
15_Y29_S1.1870.38
44_Y56_T1.1710.37
26_K42_S1.1620.37
27_C61_M1.1600.37
192_H197_K1.1570.36
3_I16_G1.1560.36
36_G53_F1.1500.36
16_G46_C1.1430.36
37_S55_R1.1420.36
17_P41_K1.1390.36
4_P7_K1.1380.36
5_K11_L1.1350.35
12_K49_C1.1350.35
27_C38_S1.1160.35
16_G27_C1.1080.34
39_R43_K1.0990.34
19_E41_K1.0910.33
4_P8_A1.0900.33
38_S43_K1.0840.33
15_Y63_R1.0820.33
109_S116_K1.0790.33
33_I54_Y1.0680.32
29_S50_G1.0650.32
89_P93_V1.0540.32
159_G165_T1.0470.31
28_Y50_G1.0440.31
18_L42_S1.0400.31
129_W132_V1.0380.31
216_R220_D1.0370.31
130_T140_R1.0350.31
6_L11_L1.0340.31
50_G66_R1.0320.31
9_L43_K1.0310.31
179_H185_P1.0080.30
19_E39_R1.0020.29
176_C181_T0.9920.29
26_K32_V0.9780.28
219_R225_N0.9740.28
75_N89_P0.9680.28
32_V39_R0.9640.28
23_F58_S0.9580.28
36_G44_Y0.9560.28
94_Y98_K0.9540.27
18_L26_K0.9510.27
111_L117_A0.9390.27
110_I116_K0.9360.27
52_T57_A0.9350.27
24_S43_K0.9330.27
122_F126_D0.9300.26
12_K46_C0.9230.26
193_H198_K0.9230.26
12_K22_G0.9090.26
63_R76_R0.9010.25
195_V207_N0.8980.25
16_G31_R0.8970.25
37_S80_R0.8950.25
35_N58_S0.8900.25
34_K43_K0.8870.25
218_A221_T0.8870.25
22_G53_F0.8840.25
12_K31_R0.8780.24
113_A116_K0.8700.24
22_G30_D0.8600.24
115_L120_S0.8470.23
33_I37_S0.8460.23
40_G52_T0.8440.23
14_F17_P0.8380.23
6_L20_L0.8340.23
4_P10_I0.8290.23
73_Y86_E0.8270.23
6_L15_Y0.8260.23
40_G54_Y0.8240.22
126_D216_R0.8210.22
39_R53_F0.8210.22
181_T185_P0.8200.22
159_G170_W0.8180.22
221_T226_R0.8170.22
6_L22_G0.8110.22
66_R69_I0.8090.22
114_Q118_F0.8080.22
7_K20_L0.8060.22
136_R139_R0.8050.22
14_F19_E0.8050.22
62_S66_R0.7990.22
192_H195_V0.7960.21
147_N151_D0.7930.21
5_K10_I0.7920.21
13_S62_S0.7920.21
10_I19_E0.7910.21
7_K13_S0.7870.21
96_S103_K0.7810.21
31_R46_C0.7770.21
122_F127_E0.7760.21
37_S43_K0.7740.21
99_R102_L0.7740.21
143_L161_R0.7720.21
90_L94_Y0.7690.21
75_N81_G0.7690.21
72_E89_P0.7660.20
44_Y173_L0.7640.20
182_D202_T0.7610.20
7_K65_Q0.7600.20
6_L59_H0.7590.20
223_A227_S0.7560.20
21_P40_G0.7520.20
30_D63_R0.7500.20
14_F54_Y0.7470.20
9_L58_S0.7460.20
14_F41_K0.7450.20
76_R80_R0.7400.20
18_L40_G0.7390.20
207_N210_C0.7330.19
14_F58_S0.7320.19
176_C179_H0.7260.19
39_R59_H0.7250.19
223_A228_R0.7220.19
10_I37_S0.7220.19
209_F219_R0.7200.19
4_P20_L0.7160.19
39_R48_V0.7150.19
18_L65_Q0.7140.19
47_K52_T0.7090.19
79_L82_I0.7070.19
215_V218_A0.7030.18
221_T224_V0.7020.18
115_L119_R0.7010.18
71_R76_R0.6990.18
28_Y57_A0.6970.18
73_Y76_R0.6970.18
103_K107_D0.6950.18
98_K101_A0.6940.18
41_K53_F0.6940.18
115_L118_F0.6930.18
22_G54_Y0.6920.18
116_K119_R0.6910.18
205_S211_R0.6880.18
30_D55_R0.6870.18
22_G65_Q0.6860.18
50_G62_S0.6850.18
33_I60_R0.6850.18
33_I36_G0.6830.18
150_I212_S0.6810.18
4_P13_S0.6770.18
85_V88_R0.6770.18
39_R70_L0.6720.17
217_L221_T0.6720.17
160_D172_S0.6700.17
39_R65_Q0.6700.17
222_K227_S0.6650.17
5_K57_A0.6630.17
128_S132_V0.6630.17
220_D223_A0.6560.17
14_F55_R0.6560.17
124_V129_W0.6550.17
6_L13_S0.6540.17
134_V203_V0.6540.17
175_K190_L0.6510.17
44_Y57_A0.6480.17
125_L145_I0.6480.17
14_F40_G0.6460.17
73_Y81_G0.6420.17
26_K40_G0.6420.17
213_H222_K0.6410.17
21_P39_R0.6400.17
153_V174_P0.6390.17
41_K57_A0.6360.16
137_G141_Q0.6340.16
48_V51_R0.6330.16
33_I39_R0.6320.16
117_A124_V0.6310.16
54_Y60_R0.6260.16
202_T210_C0.6250.16
45_K64_E0.6210.16
13_S52_T0.6200.16
52_T58_S0.6180.16
175_K186_I0.6180.16
44_Y53_F0.6170.16
113_A117_A0.6010.15
177_E181_T0.6010.15
29_S69_I0.6000.15
75_N92_T0.6000.15
16_G20_L0.5990.15
200_T206_Y0.5980.15
35_N50_G0.5970.15
221_T228_R0.5970.15
97_V100_A0.5960.15
218_A223_A0.5950.15
177_E188_Q0.5930.15
206_Y223_A0.5910.15
8_A37_S0.5860.15
218_A224_V0.5820.15
39_R57_A0.5810.15
43_K46_C0.5800.15
28_Y54_Y0.5790.15
213_H227_S0.5770.15
7_K42_S0.5770.15
15_Y30_D0.5770.15
3_I14_F0.5740.15
215_V220_D0.5740.15
111_L116_K0.5740.15
16_G22_G0.5740.15
4_P11_L0.5690.15
82_I86_E0.5680.15
191_Y215_V0.5650.15
6_L10_I0.5610.14
6_L28_Y0.5600.14
5_K64_E0.5560.14
79_L88_R0.5560.14
164_N178_V0.5560.14
73_Y84_K0.5550.14
208_S216_R0.5550.14
26_K59_H0.5540.14
9_L28_Y0.5540.14
8_A57_A0.5540.14
217_L226_R0.5510.14
9_L27_C0.5510.14
191_Y210_C0.5500.14
222_K226_R0.5490.14
216_R223_A0.5480.14
29_S60_R0.5460.14
47_K50_G0.5460.14
194_V197_K0.5440.14
131_Y140_R0.5430.14
89_P92_T0.5420.14
17_P33_I0.5410.14
224_V227_S0.5390.14
131_Y135_R0.5380.14
50_G64_E0.5380.14
136_R208_S0.5360.14
108_L116_K0.5360.14
32_V59_H0.5350.14
96_S107_D0.5340.14
43_K55_R0.5330.14
109_S112_Q0.5320.14
192_H196_G0.5280.14
10_I17_P0.5280.14
36_G51_R0.5270.14
121_K132_V0.5250.14
112_Q120_S0.5240.13
142_N156_F0.5240.13
219_R222_K0.5200.13
207_N212_S0.5160.13
35_N45_K0.5150.13
33_I64_E0.5140.13
11_L17_P0.5110.13
31_R61_M0.5100.13
5_K50_G0.5100.13
124_V127_E0.5070.13
25_D30_D0.5070.13
55_R58_S0.5050.13
52_T66_R0.5040.13
30_D45_K0.5040.13
149_L175_K0.5040.13
127_E136_R0.5030.13
110_I118_F0.5030.13
152_G174_P0.5000.13
222_K228_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.342 99.8 0.625 Contact Map
2n25A 1 0.0855 99.8 0.634 Contact Map
3w5kB 1 0.3494 99.8 0.638 Contact Map
2lt7A 1 0.4572 99.8 0.644 Contact Map
2jp9A 1 0.342 99.7 0.646 Contact Map
2dlqA 1 0.368 99.7 0.648 Contact Map
2gliA 1 0.3494 99.7 0.651 Contact Map
1ubdC 1 0.342 99.7 0.653 Contact Map
2wbtA 2 0.3606 99.7 0.657 Contact Map
3zmsC 1 0 99.7 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.