Q97ZQ9 - SULSO - GREMLIN Contacts

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Q97ZQ9 - 7-carboxy-7-deazaguanine synthase

UniProt:	Q97ZQ9	Sequences: MVQMKYRVIEIFTSIQGEGEVIGIPSNFIRLATCNLRCVWCDTKYSWEIGTEMSIDEIIAKLDKKIKTTTITGGEPLLQNILPLAKELKSIGHKIVVETNGTIKPSEELRKIIDIFSVSPKLSNSGHKLKYDFADDWATYYKFVIVYPNKDIDEVVKFVESQSINPRKVILQPDGNRSDYINAINEIVQIVLDRGLQFRVLPQLHRIIGAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	211 (190)
Sequences:	2503 (1682)
Seq/√Len:	122.0

ECOLI - QUEE
BACSU - QUEE
HALSA - Q9HHN7
SULSO - Q97ZQ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_K	64_K	3.606	1.00
63_D	91_I	3.467	1.00
35_N	100_N	2.656	1.00
156_V	194_R	2.500	1.00
152_I	194_R	2.493	1.00
71_I	80_N	2.388	1.00
11_I	61_K	2.373	1.00
56_D	87_E	2.271	1.00
54_S	57_E	2.239	1.00
191_V	200_V	2.218	1.00
24_I	94_K	2.166	1.00
139_T	167_R	2.154	1.00
185_N	189_Q	2.038	1.00
99_T	118_V	2.033	1.00
29_I	62_L	1.992	1.00
77_L	105_P	1.948	1.00
57_E	60_A	1.929	1.00
71_I	88_L	1.928	1.00
26_S	68_T	1.907	1.00
190_I	194_R	1.851	1.00
40_W	146_V	1.844	1.00
53_M	61_K	1.829	1.00
20_E	170_I	1.829	1.00
26_S	70_T	1.826	1.00
189_Q	193_D	1.811	1.00
89_K	114_D	1.787	1.00
170_I	199_R	1.782	1.00
27_N	62_L	1.752	1.00
11_I	58_I	1.731	1.00
146_V	174_D	1.712	1.00
20_E	140_Y	1.688	1.00
13_T	66_I	1.661	1.00
188_V	208_I	1.644	1.00
105_P	135_D	1.627	1.00
21_V	68_T	1.595	1.00
149_N	153_D	1.592	1.00
189_Q	192_L	1.583	1.00
153_D	156_V	1.571	1.00
9_I	49_I	1.571	1.00
24_I	199_R	1.566	1.00
149_N	190_I	1.561	1.00
53_M	58_I	1.556	1.00
13_T	25_P	1.554	1.00
31_L	71_I	1.508	1.00
202_P	207_I	1.506	1.00
105_P	116_F	1.502	1.00
22_I	204_L	1.501	1.00
11_I	27_N	1.481	1.00
8_V	53_M	1.480	1.00
51_T	61_K	1.466	1.00
89_K	95_I	1.441	1.00
35_N	102_T	1.431	1.00
152_I	156_V	1.426	1.00
60_A	91_I	1.425	1.00
59_I	87_E	1.424	1.00
43_T	46_S	1.422	1.00
203_Q	206_R	1.400	1.00
35_N	78_L	1.373	1.00
44_K	47_W	1.348	1.00
7_R	79_Q	1.343	1.00
68_T	94_K	1.314	1.00
68_T	96_V	1.258	1.00
157_K	161_S	1.245	0.99
40_W	122_L	1.244	0.99
36_L	100_N	1.236	0.99
124_N	148_P	1.226	0.99
13_T	192_L	1.214	0.99
117_S	140_Y	1.211	0.99
86_K	90_S	1.210	0.99
26_S	96_V	1.192	0.99
69_T	88_L	1.189	0.99
145_I	171_L	1.185	0.99
152_I	190_I	1.184	0.99
31_L	81_I	1.172	0.99
67_K	93_H	1.158	0.99
99_T	116_F	1.152	0.99
6_Y	52_E	1.149	0.99
59_I	91_I	1.139	0.99
11_I	53_M	1.135	0.99
35_N	103_I	1.126	0.99
55_I	83_P	1.108	0.99
157_K	160_E	1.105	0.99
29_I	69_T	1.093	0.99
60_A	63_D	1.092	0.99
150_K	155_V	1.085	0.99
135_D	139_T	1.082	0.99
163_S	166_P	1.081	0.98
14_S	70_T	1.073	0.98
185_N	188_V	1.071	0.98
20_E	168_K	1.068	0.98
172_Q	203_Q	1.063	0.98
86_K	89_K	1.062	0.98
56_D	60_A	1.055	0.98
6_Y	31_L	1.050	0.98
71_I	81_I	1.048	0.98
59_I	63_D	1.040	0.98
152_I	155_V	1.037	0.98
188_V	192_L	1.027	0.98
158_F	161_S	1.026	0.98
70_T	96_V	1.015	0.98
96_V	117_S	1.010	0.98
24_I	68_T	1.004	0.98
184_I	188_V	1.001	0.98
71_I	95_I	0.998	0.97
21_V	94_K	0.992	0.97
85_A	95_I	0.992	0.97
124_N	146_V	0.991	0.97
87_E	91_I	0.981	0.97
82_L	111_K	0.980	0.97
81_I	85_A	0.971	0.97
65_K	195_G	0.965	0.97
97_V	113_I	0.965	0.97
96_V	140_Y	0.963	0.97
62_L	71_I	0.957	0.97
7_R	51_T	0.953	0.97
15_I	188_V	0.948	0.97
29_I	71_I	0.935	0.96
53_M	57_E	0.924	0.96
11_I	29_I	0.920	0.96
62_L	88_L	0.917	0.96
82_L	86_K	0.916	0.96
122_L	154_E	0.912	0.96
158_F	162_Q	0.906	0.96
159_V	169_V	0.904	0.95
86_K	112_I	0.899	0.95
6_Y	55_I	0.893	0.95
155_V	171_L	0.892	0.95
115_I	140_Y	0.889	0.95
9_I	45_Y	0.879	0.95
143_F	171_L	0.872	0.95
37_R	47_W	0.864	0.94
126_G	134_A	0.859	0.94
9_I	32_A	0.857	0.94
22_I	202_P	0.850	0.94
163_S	167_R	0.848	0.94
6_Y	84_L	0.846	0.94
16_Q	120_P	0.840	0.93
151_D	155_V	0.839	0.93
145_I	190_I	0.838	0.93
63_D	93_H	0.831	0.93
156_V	159_V	0.831	0.93
150_K	153_D	0.830	0.93
55_I	87_E	0.825	0.93
8_V	31_L	0.823	0.93
19_G	70_T	0.816	0.92
154_E	158_F	0.813	0.92
89_K	113_I	0.812	0.92
56_D	91_I	0.808	0.92
7_R	52_E	0.808	0.92
77_L	103_I	0.805	0.92
55_I	84_L	0.802	0.92
87_E	90_S	0.796	0.91
63_D	67_K	0.791	0.91
77_L	97_V	0.791	0.91
172_Q	201_L	0.787	0.91
68_T	97_V	0.779	0.90
176_N	183_A	0.778	0.90
172_Q	175_G	0.776	0.90
57_E	61_K	0.773	0.90
151_D	154_E	0.772	0.90
194_R	197_Q	0.771	0.90
59_I	84_L	0.765	0.90
78_L	103_I	0.764	0.90
59_I	62_L	0.762	0.89
149_N	193_D	0.762	0.89
97_V	116_F	0.754	0.89
6_Y	81_I	0.754	0.89
16_Q	96_V	0.750	0.89
194_R	198_F	0.746	0.88
144_V	174_D	0.744	0.88
70_T	119_S	0.743	0.88
69_T	93_H	0.741	0.88
11_I	62_L	0.739	0.88
39_V	123_S	0.738	0.88
86_K	111_K	0.737	0.88
186_E	189_Q	0.733	0.88
156_V	160_E	0.728	0.87
55_I	59_I	0.723	0.87
21_V	96_V	0.721	0.87
83_P	86_K	0.718	0.87
21_V	117_S	0.711	0.86
151_D	187_I	0.708	0.86
171_L	191_V	0.705	0.86
153_D	157_K	0.704	0.85
140_Y	170_I	0.704	0.85
154_E	157_K	0.693	0.85
171_L	190_I	0.693	0.85
103_I	135_D	0.692	0.84
20_E	117_S	0.692	0.84
116_F	136_D	0.689	0.84
88_L	95_I	0.685	0.84
37_R	124_N	0.684	0.84
156_V	198_F	0.684	0.84
123_S	154_E	0.683	0.84
116_F	139_T	0.682	0.84
105_P	118_V	0.681	0.83
191_V	195_G	0.681	0.83
145_I	187_I	0.680	0.83
45_Y	187_I	0.680	0.83
120_P	158_F	0.679	0.83
172_Q	188_V	0.677	0.83
14_S	72_T	0.677	0.83
85_A	89_K	0.674	0.83
148_P	151_D	0.671	0.83
172_Q	200_V	0.667	0.82
26_S	72_T	0.666	0.82
69_T	95_I	0.664	0.82
90_S	157_K	0.662	0.82
32_A	79_Q	0.662	0.82
21_V	24_I	0.660	0.82
60_A	64_K	0.653	0.81
21_V	140_Y	0.649	0.80
118_V	135_D	0.641	0.80
149_N	152_I	0.637	0.79
22_I	201_L	0.628	0.78
63_D	87_E	0.627	0.78
83_P	87_E	0.625	0.78
165_N	168_K	0.624	0.78
60_A	90_S	0.623	0.78
36_L	75_E	0.620	0.77
122_L	174_D	0.618	0.77
51_T	57_E	0.614	0.77
24_I	93_H	0.609	0.76
138_A	166_P	0.607	0.76
105_P	139_T	0.602	0.75
47_W	100_N	0.597	0.75
70_T	201_L	0.595	0.74
80_N	83_P	0.595	0.74
160_E	197_Q	0.594	0.74
36_L	102_T	0.591	0.74
6_Y	83_P	0.589	0.74
7_R	33_T	0.589	0.74
202_P	206_R	0.588	0.74
8_V	29_I	0.585	0.73
125_S	209_G	0.579	0.72
148_P	154_E	0.578	0.72
201_L	204_L	0.576	0.72
178_S	208_I	0.575	0.72
118_V	134_A	0.575	0.72
105_P	113_I	0.571	0.71
159_V	163_S	0.570	0.71
60_A	193_D	0.568	0.71
45_Y	49_I	0.566	0.71
102_T	127_H	0.561	0.70
29_I	58_I	0.561	0.70
32_A	47_W	0.560	0.70
145_I	186_E	0.560	0.70
137_W	161_S	0.559	0.70
62_L	91_I	0.559	0.70
116_F	135_D	0.558	0.70
59_I	64_K	0.557	0.70
27_N	93_H	0.556	0.69
75_E	100_N	0.556	0.69
154_E	159_V	0.554	0.69
198_F	201_L	0.553	0.69
32_A	170_I	0.552	0.69
175_G	206_R	0.552	0.69
179_D	184_I	0.543	0.68
39_V	126_G	0.542	0.67
142_K	172_Q	0.541	0.67
24_I	67_K	0.540	0.67
112_I	136_D	0.537	0.67
77_L	104_K	0.535	0.67
122_L	143_F	0.534	0.66
143_F	169_V	0.533	0.66
149_N	186_E	0.533	0.66
86_K	150_K	0.532	0.66
12_F	204_L	0.531	0.66
31_L	55_I	0.530	0.66
82_L	112_I	0.529	0.66
40_W	120_P	0.528	0.65
151_D	156_V	0.526	0.65
200_V	203_Q	0.522	0.65
31_L	79_Q	0.522	0.65
70_T	117_S	0.517	0.64
31_L	96_V	0.509	0.63
169_V	197_Q	0.508	0.63
25_P	192_L	0.507	0.62
19_G	24_I	0.505	0.62
19_G	140_Y	0.504	0.62
97_V	105_P	0.504	0.62
162_Q	169_V	0.503	0.62
118_V	138_A	0.503	0.62
13_T	65_K	0.500	0.61
70_T	115_I	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4njhA	2	0.891	100	0.38	Contact Map
3c8fA	1	0.9147	99.9	0.698	Contact Map
3rfaA	1	0.9716	99.6	0.764	Contact Map
2yx0A	1	0.9716	99.6	0.768	Contact Map
2z2uA	1	0.8768	99.6	0.775	Contact Map
1tv8A	2	0.91	99.6	0.776	Contact Map
4k36A	1	0.8815	99.4	0.799	Contact Map
2a5hA	4	0.981	99.4	0.8	Contact Map
2qgqA	1	0.7773	99.3	0.803	Contact Map
3canA	2	0.6445	99.2	0.814	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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