GREMLIN Database
Q97ZQ9 - 7-carboxy-7-deazaguanine synthase
UniProt: Q97ZQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (190)
Sequences: 2503 (1682)
Seq/√Len: 122.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K64_K3.6061.00
63_D91_I3.4671.00
35_N100_N2.6561.00
156_V194_R2.5001.00
152_I194_R2.4931.00
71_I80_N2.3881.00
11_I61_K2.3731.00
56_D87_E2.2711.00
54_S57_E2.2391.00
191_V200_V2.2181.00
24_I94_K2.1661.00
139_T167_R2.1541.00
185_N189_Q2.0381.00
99_T118_V2.0331.00
29_I62_L1.9921.00
77_L105_P1.9481.00
57_E60_A1.9291.00
71_I88_L1.9281.00
26_S68_T1.9071.00
190_I194_R1.8511.00
40_W146_V1.8441.00
53_M61_K1.8291.00
20_E170_I1.8291.00
26_S70_T1.8261.00
189_Q193_D1.8111.00
89_K114_D1.7871.00
170_I199_R1.7821.00
27_N62_L1.7521.00
11_I58_I1.7311.00
146_V174_D1.7121.00
20_E140_Y1.6881.00
13_T66_I1.6611.00
188_V208_I1.6441.00
105_P135_D1.6271.00
21_V68_T1.5951.00
149_N153_D1.5921.00
189_Q192_L1.5831.00
153_D156_V1.5711.00
9_I49_I1.5711.00
24_I199_R1.5661.00
149_N190_I1.5611.00
53_M58_I1.5561.00
13_T25_P1.5541.00
31_L71_I1.5081.00
202_P207_I1.5061.00
105_P116_F1.5021.00
22_I204_L1.5011.00
11_I27_N1.4811.00
8_V53_M1.4801.00
51_T61_K1.4661.00
89_K95_I1.4411.00
35_N102_T1.4311.00
152_I156_V1.4261.00
60_A91_I1.4251.00
59_I87_E1.4241.00
43_T46_S1.4221.00
203_Q206_R1.4001.00
35_N78_L1.3731.00
44_K47_W1.3481.00
7_R79_Q1.3431.00
68_T94_K1.3141.00
68_T96_V1.2581.00
157_K161_S1.2450.99
40_W122_L1.2440.99
36_L100_N1.2360.99
124_N148_P1.2260.99
13_T192_L1.2140.99
117_S140_Y1.2110.99
86_K90_S1.2100.99
26_S96_V1.1920.99
69_T88_L1.1890.99
145_I171_L1.1850.99
152_I190_I1.1840.99
31_L81_I1.1720.99
67_K93_H1.1580.99
99_T116_F1.1520.99
6_Y52_E1.1490.99
59_I91_I1.1390.99
11_I53_M1.1350.99
35_N103_I1.1260.99
55_I83_P1.1080.99
157_K160_E1.1050.99
29_I69_T1.0930.99
60_A63_D1.0920.99
150_K155_V1.0850.99
135_D139_T1.0820.99
163_S166_P1.0810.98
14_S70_T1.0730.98
185_N188_V1.0710.98
20_E168_K1.0680.98
172_Q203_Q1.0630.98
86_K89_K1.0620.98
56_D60_A1.0550.98
6_Y31_L1.0500.98
71_I81_I1.0480.98
59_I63_D1.0400.98
152_I155_V1.0370.98
188_V192_L1.0270.98
158_F161_S1.0260.98
70_T96_V1.0150.98
96_V117_S1.0100.98
24_I68_T1.0040.98
184_I188_V1.0010.98
71_I95_I0.9980.97
21_V94_K0.9920.97
85_A95_I0.9920.97
124_N146_V0.9910.97
87_E91_I0.9810.97
82_L111_K0.9800.97
81_I85_A0.9710.97
65_K195_G0.9650.97
97_V113_I0.9650.97
96_V140_Y0.9630.97
62_L71_I0.9570.97
7_R51_T0.9530.97
15_I188_V0.9480.97
29_I71_I0.9350.96
53_M57_E0.9240.96
11_I29_I0.9200.96
62_L88_L0.9170.96
82_L86_K0.9160.96
122_L154_E0.9120.96
158_F162_Q0.9060.96
159_V169_V0.9040.95
86_K112_I0.8990.95
6_Y55_I0.8930.95
155_V171_L0.8920.95
115_I140_Y0.8890.95
9_I45_Y0.8790.95
143_F171_L0.8720.95
37_R47_W0.8640.94
126_G134_A0.8590.94
9_I32_A0.8570.94
22_I202_P0.8500.94
163_S167_R0.8480.94
6_Y84_L0.8460.94
16_Q120_P0.8400.93
151_D155_V0.8390.93
145_I190_I0.8380.93
63_D93_H0.8310.93
156_V159_V0.8310.93
150_K153_D0.8300.93
55_I87_E0.8250.93
8_V31_L0.8230.93
19_G70_T0.8160.92
154_E158_F0.8130.92
89_K113_I0.8120.92
56_D91_I0.8080.92
7_R52_E0.8080.92
77_L103_I0.8050.92
55_I84_L0.8020.92
87_E90_S0.7960.91
63_D67_K0.7910.91
77_L97_V0.7910.91
172_Q201_L0.7870.91
68_T97_V0.7790.90
176_N183_A0.7780.90
172_Q175_G0.7760.90
57_E61_K0.7730.90
151_D154_E0.7720.90
194_R197_Q0.7710.90
59_I84_L0.7650.90
78_L103_I0.7640.90
59_I62_L0.7620.89
149_N193_D0.7620.89
97_V116_F0.7540.89
6_Y81_I0.7540.89
16_Q96_V0.7500.89
194_R198_F0.7460.88
144_V174_D0.7440.88
70_T119_S0.7430.88
69_T93_H0.7410.88
11_I62_L0.7390.88
39_V123_S0.7380.88
86_K111_K0.7370.88
186_E189_Q0.7330.88
156_V160_E0.7280.87
55_I59_I0.7230.87
21_V96_V0.7210.87
83_P86_K0.7180.87
21_V117_S0.7110.86
151_D187_I0.7080.86
171_L191_V0.7050.86
153_D157_K0.7040.85
140_Y170_I0.7040.85
154_E157_K0.6930.85
171_L190_I0.6930.85
103_I135_D0.6920.84
20_E117_S0.6920.84
116_F136_D0.6890.84
88_L95_I0.6850.84
37_R124_N0.6840.84
156_V198_F0.6840.84
123_S154_E0.6830.84
116_F139_T0.6820.84
105_P118_V0.6810.83
191_V195_G0.6810.83
145_I187_I0.6800.83
45_Y187_I0.6800.83
120_P158_F0.6790.83
172_Q188_V0.6770.83
14_S72_T0.6770.83
85_A89_K0.6740.83
148_P151_D0.6710.83
172_Q200_V0.6670.82
26_S72_T0.6660.82
69_T95_I0.6640.82
90_S157_K0.6620.82
32_A79_Q0.6620.82
21_V24_I0.6600.82
60_A64_K0.6530.81
21_V140_Y0.6490.80
118_V135_D0.6410.80
149_N152_I0.6370.79
22_I201_L0.6280.78
63_D87_E0.6270.78
83_P87_E0.6250.78
165_N168_K0.6240.78
60_A90_S0.6230.78
36_L75_E0.6200.77
122_L174_D0.6180.77
51_T57_E0.6140.77
24_I93_H0.6090.76
138_A166_P0.6070.76
105_P139_T0.6020.75
47_W100_N0.5970.75
70_T201_L0.5950.74
80_N83_P0.5950.74
160_E197_Q0.5940.74
36_L102_T0.5910.74
6_Y83_P0.5890.74
7_R33_T0.5890.74
202_P206_R0.5880.74
8_V29_I0.5850.73
125_S209_G0.5790.72
148_P154_E0.5780.72
201_L204_L0.5760.72
178_S208_I0.5750.72
118_V134_A0.5750.72
105_P113_I0.5710.71
159_V163_S0.5700.71
60_A193_D0.5680.71
45_Y49_I0.5660.71
102_T127_H0.5610.70
29_I58_I0.5610.70
32_A47_W0.5600.70
145_I186_E0.5600.70
137_W161_S0.5590.70
62_L91_I0.5590.70
116_F135_D0.5580.70
59_I64_K0.5570.70
27_N93_H0.5560.69
75_E100_N0.5560.69
154_E159_V0.5540.69
198_F201_L0.5530.69
32_A170_I0.5520.69
175_G206_R0.5520.69
179_D184_I0.5430.68
39_V126_G0.5420.67
142_K172_Q0.5410.67
24_I67_K0.5400.67
112_I136_D0.5370.67
77_L104_K0.5350.67
122_L143_F0.5340.66
143_F169_V0.5330.66
149_N186_E0.5330.66
86_K150_K0.5320.66
12_F204_L0.5310.66
31_L55_I0.5300.66
82_L112_I0.5290.66
40_W120_P0.5280.65
151_D156_V0.5260.65
200_V203_Q0.5220.65
31_L79_Q0.5220.65
70_T117_S0.5170.64
31_L96_V0.5090.63
169_V197_Q0.5080.63
25_P192_L0.5070.62
19_G24_I0.5050.62
19_G140_Y0.5040.62
97_V105_P0.5040.62
162_Q169_V0.5030.62
118_V138_A0.5030.62
13_T65_K0.5000.61
70_T115_I0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4njhA 2 0.891 100 0.38 Contact Map
3c8fA 1 0.9147 99.9 0.698 Contact Map
3rfaA 1 0.9716 99.6 0.764 Contact Map
2yx0A 1 0.9716 99.6 0.768 Contact Map
2z2uA 1 0.8768 99.6 0.775 Contact Map
1tv8A 2 0.91 99.6 0.776 Contact Map
4k36A 1 0.8815 99.4 0.799 Contact Map
2a5hA 4 0.981 99.4 0.8 Contact Map
2qgqA 1 0.7773 99.3 0.803 Contact Map
3canA 2 0.6445 99.2 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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