GREMLIN Database
Q97ZN6 - Uncharacterized protein
UniProt: Q97ZN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (143)
Sequences: 920 (758)
Seq/√Len: 63.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_K138_I4.8291.00
113_L158_E4.2091.00
133_R136_V3.3551.00
99_D102_E3.0101.00
82_V158_E2.7231.00
88_R100_Y2.5431.00
104_S108_I2.4271.00
115_L119_M2.2861.00
134_K139_N2.2331.00
92_N147_S2.2211.00
82_V87_S2.2051.00
75_S78_K1.9981.00
113_L117_I1.9921.00
77_D160_K1.9351.00
48_L54_L1.8941.00
147_S175_E1.8841.00
99_D104_S1.8571.00
41_T48_L1.7941.00
41_T46_M1.7380.99
100_Y104_S1.6800.99
92_N145_A1.6770.99
133_R138_I1.6570.99
52_T58_L1.6460.99
32_Y39_P1.6070.99
54_L58_L1.6050.99
136_V152_I1.6040.99
41_T52_T1.5870.99
82_V104_S1.5320.99
32_Y41_T1.5280.99
41_T50_S1.5230.99
39_P50_S1.4750.98
28_K32_Y1.4620.98
146_N150_V1.4600.98
127_L130_S1.4590.98
96_G99_D1.4290.98
133_R137_R1.4020.98
145_A175_E1.3990.97
46_M50_S1.3950.97
104_S110_N1.3890.97
38_L41_T1.3720.97
93_L147_S1.3690.97
46_M52_T1.3140.96
57_D61_E1.2960.96
146_N175_E1.2860.96
40_L43_P1.2500.95
77_D106_E1.2460.95
32_Y36_S1.2240.95
55_K59_I1.2140.94
101_I104_S1.2100.94
121_G154_Y1.2060.94
102_E108_I1.1640.93
110_N113_L1.1420.92
34_I41_T1.1380.92
73_I78_K1.1370.92
92_N146_N1.1350.92
127_L152_I1.1340.92
32_Y40_L1.1290.92
59_I63_N1.1250.92
106_E160_K1.1240.92
115_L158_E1.1220.92
118_N157_N1.1120.91
134_K137_R1.1120.91
42_P46_M1.1030.91
82_V156_L1.0950.91
35_S51_V1.0810.90
117_I120_L1.0770.90
112_K115_L1.0760.90
80_D106_E1.0730.90
87_S158_E1.0650.89
144_M147_S1.0600.89
113_L119_M1.0420.88
30_L33_V1.0310.88
40_L44_G0.9970.86
163_D166_T0.9930.86
48_L52_T0.9840.85
169_I172_D0.9830.85
136_V154_Y0.9720.84
78_K154_Y0.9520.83
166_T175_E0.9500.83
161_D164_K0.9380.82
39_P46_M0.9360.82
46_M49_G0.9300.82
43_P46_M0.9300.82
28_K31_S0.9280.82
135_N138_I0.9250.81
48_L58_L0.9230.81
170_K173_I0.9110.80
152_I156_L0.8840.78
104_S115_L0.8810.78
44_G47_I0.8770.78
81_L107_M0.8740.78
42_P48_L0.8650.77
78_K106_E0.8640.77
69_I75_S0.8630.77
84_E87_S0.8610.76
40_L48_L0.8580.76
96_G100_Y0.8470.75
50_S54_L0.8360.74
78_K107_M0.8340.74
151_L173_I0.8330.74
77_D80_D0.8320.74
99_D108_I0.8310.74
29_D32_Y0.8300.74
130_S133_R0.8230.73
78_K160_K0.8160.73
71_F78_K0.8140.72
77_D162_L0.8120.72
44_G53_A0.8090.72
32_Y38_L0.8070.72
35_S93_L0.8050.72
40_L52_T0.8050.72
50_S71_F0.8040.71
40_L74_Q0.7930.70
50_S57_D0.7900.70
38_L46_M0.7890.70
75_S106_E0.7880.70
147_S152_I0.7880.70
75_S108_I0.7790.69
80_D160_K0.7750.69
66_T121_G0.7670.68
127_L136_V0.7660.68
112_K117_I0.7630.67
77_D110_N0.7570.67
55_K61_E0.7420.65
31_S35_S0.7380.65
50_S56_D0.7380.65
127_L154_Y0.7220.63
34_I37_N0.7210.63
41_T54_L0.7160.62
77_D108_I0.7050.61
58_L78_K0.7050.61
124_V139_N0.7010.61
126_G129_V0.7000.61
93_L138_I0.6920.60
150_V154_Y0.6920.60
167_E172_D0.6870.59
155_K167_E0.6780.58
31_S34_I0.6750.58
60_V63_N0.6730.58
32_Y43_P0.6600.56
131_S149_S0.6590.56
90_V138_I0.6570.56
35_S66_T0.6560.56
32_Y46_M0.6520.55
56_D60_V0.6500.55
118_N174_Q0.6500.55
144_M152_I0.6450.55
102_E156_L0.6430.54
39_P52_T0.6410.54
130_S135_N0.6400.54
82_V113_L0.6340.53
94_N130_S0.6300.53
75_S82_V0.6300.53
165_V168_E0.6250.52
77_D171_R0.6220.52
34_I38_L0.6170.51
46_M54_L0.6160.51
164_K167_E0.6140.51
127_L134_K0.6130.51
33_V171_R0.6120.51
100_Y144_M0.6120.51
76_L165_V0.6100.50
38_L43_P0.6080.50
146_N169_I0.6070.50
139_N144_M0.6050.50
56_D59_I0.6020.50
30_L39_P0.6020.50
39_P48_L0.5950.49
101_I156_L0.5930.49
147_S150_V0.5910.48
117_I168_E0.5910.48
99_D165_V0.5860.48
34_I40_L0.5830.47
92_N175_E0.5770.47
39_P44_G0.5680.46
121_G124_V0.5680.46
38_L50_S0.5630.45
109_L171_R0.5630.45
157_N164_K0.5630.45
128_E166_T0.5550.44
45_S52_T0.5550.44
115_L129_V0.5510.44
138_I144_M0.5500.44
30_L34_I0.5460.43
95_L131_S0.5420.43
49_G74_Q0.5420.43
116_N173_I0.5400.42
29_D34_I0.5390.42
64_N67_G0.5380.42
36_S42_P0.5370.42
114_N123_E0.5370.42
58_L63_N0.5350.42
129_V132_E0.5350.42
103_L133_R0.5350.42
76_L95_L0.5340.42
57_D66_T0.5320.42
88_R94_N0.5310.41
125_V174_Q0.5300.41
144_M150_V0.5250.41
48_L56_D0.5250.41
145_A151_L0.5240.41
70_S74_Q0.5200.40
101_I150_V0.5190.40
31_S39_P0.5190.40
58_L110_N0.5180.40
150_V155_K0.5130.39
96_G149_S0.5110.39
77_D164_K0.5110.39
28_K76_L0.5100.39
130_S137_R0.5080.39
105_L166_T0.5060.39
91_G174_Q0.5020.38
62_F84_E0.5020.38
28_K34_I0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q55A 2 0.956 99.7 0.455 Contact Map
1l3wA 1 0.956 99.7 0.471 Contact Map
3q2vA 2 0.956 99.7 0.472 Contact Map
3q2wA 2 0.9615 99.7 0.486 Contact Map
3ubfA 2 0.9341 99.6 0.5 Contact Map
3mvsA 1 0.9121 99.6 0.501 Contact Map
4ux8A 1 0.9121 99.6 0.52 Contact Map
3ubhA 1 0.967 99.6 0.523 Contact Map
2a4eA 2 0.9121 99.6 0.525 Contact Map
2a62A 2 0.9505 99.5 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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