Q97ZN4 - SULSO - GREMLIN Contacts

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Q97ZN4 - Transposase ISC1190

UniProt:	Q97ZN4	Sequences: MEAPVAGIDVSKDKLIVYFQGKFYEFPNDKQGFEEVKKVLPRGCKVGIESTGVYHVNLAKCLMNEYEVRVINPLVIKKFKDFRGKKSDKNDAKKLAELVVNMGSEFTLSDARELTSQWDFIVKSIVRVKNRLRRDLILLGYSDSLSRKNLSEVLEGGDNIILSEVKFLLDELERLEARKREVEKRLEDVVPRDSLIFTIPGIGKTLGLIILARVGDVRRFDDKRKFVAYCGLDPVVESSGGSVVSRGISRRGDAVLRRAFYLAALTAIKVNPVIKRFYEEHKGRLKGKKLIVACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (304)
Sequences:	4483 (3407)
Seq/√Len:	195.4

SULSO - Q97ZN4 Q97WZ5 Q97X07 Q97Y59 Q97VS0 Q97XK2 Q97WC0 Q97X26 Q97X12 Q97UF7 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97VB2 Q97Y06 Q97Z62 Q97XR9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_G	99_V	4.492	1.00
18_Y	92_A	2.848	1.00
163_S	185_R	2.766	1.00
125_I	176_E	2.718	1.00
226_F	299_A	2.715	1.00
195_L	311_P	2.677	1.00
281_H	284_R	2.616	1.00
214_V	226_F	2.379	1.00
76_I	95_L	2.372	1.00
167_F	178_R	2.351	1.00
47_G	95_L	2.330	1.00
124_S	127_R	2.283	1.00
230_C	256_L	2.219	1.00
170_D	178_R	2.194	1.00
210_I	302_T	2.153	1.00
118_W	122_V	2.099	1.00
198_T	311_P	2.090	1.00
275_K	279_E	2.076	1.00
248_I	292_V	2.057	1.00
221_D	225_K	2.057	1.00
87_S	236_V	2.044	1.00
78_K	81_D	2.038	1.00
296_R	300_V	2.021	1.00
14_K	25_E	1.979	1.00
46_V	66_Y	1.965	1.00
195_L	305_V	1.927	1.00
126_V	130_N	1.910	1.00
124_S	131_R	1.898	1.00
286_K	289_K	1.892	1.00
174_R	178_R	1.884	1.00
8_I	15_L	1.845	1.00
222_D	225_K	1.835	1.00
125_I	179_K	1.825	1.00
238_S	243_V	1.806	1.00
199_I	302_T	1.804	1.00
6_A	19_F	1.798	1.00
17_V	36_V	1.793	1.00
202_I	207_G	1.793	1.00
29_D	32_G	1.783	1.00
230_C	299_A	1.763	1.00
220_F	229_Y	1.762	1.00
116_S	213_R	1.762	1.00
232_L	295_A	1.744	1.00
119_D	258_R	1.726	1.00
185_R	188_D	1.725	1.00
171_E	174_R	1.681	1.00
118_W	183_E	1.667	1.00
45_K	69_R	1.667	1.00
305_V	311_P	1.660	1.00
196_I	302_T	1.640	1.00
171_E	178_R	1.625	1.00
124_S	171_E	1.613	1.00
132_L	172_L	1.609	1.00
58_L	62_L	1.600	1.00
77_K	80_K	1.591	1.00
183_E	186_L	1.581	1.00
206_L	259_A	1.579	1.00
48_I	68_V	1.571	1.00
122_V	125_I	1.565	1.00
11_S	16_I	1.563	1.00
97_E	101_N	1.530	1.00
209_I	259_A	1.530	1.00
304_A	308_Y	1.529	1.00
195_L	198_T	1.529	1.00
262_L	265_L	1.523	1.00
125_I	172_L	1.503	1.00
149_N	153_V	1.501	1.00
121_I	179_K	1.501	1.00
280_E	284_R	1.492	1.00
274_I	294_C	1.487	1.00
13_D	241_G	1.484	1.00
274_I	301_I	1.462	1.00
268_I	278_Y	1.442	1.00
170_D	177_A	1.441	1.00
18_Y	93_K	1.430	1.00
151_S	155_E	1.422	1.00
85_K	236_V	1.413	1.00
122_V	179_K	1.406	1.00
197_F	204_K	1.404	1.00
199_I	305_V	1.396	1.00
279_E	283_G	1.383	1.00
61_C	64_N	1.381	1.00
278_Y	294_C	1.380	1.00
47_G	71_I	1.376	1.00
24_Y	39_V	1.373	1.00
118_W	205_T	1.357	1.00
16_I	25_E	1.348	1.00
277_F	297_K	1.348	1.00
148_K	152_E	1.347	1.00
264_A	295_A	1.346	1.00
8_I	58_L	1.344	1.00
190_V	197_F	1.337	1.00
180_R	183_E	1.327	1.00
132_L	165_V	1.320	1.00
60_K	109_S	1.312	1.00
258_R	262_L	1.312	1.00
6_A	40_L	1.310	1.00
170_D	174_R	1.300	1.00
272_P	276_R	1.298	1.00
169_L	173_E	1.296	1.00
125_I	129_K	1.294	1.00
285_L	289_K	1.293	1.00
227_V	233_D	1.286	1.00
149_N	152_E	1.283	1.00
167_F	181_E	1.278	1.00
152_E	155_E	1.264	1.00
147_R	153_V	1.264	1.00
183_E	187_E	1.257	1.00
120_F	131_R	1.254	1.00
264_A	298_L	1.252	1.00
227_V	296_R	1.237	1.00
261_Y	295_A	1.230	1.00
119_D	255_V	1.228	1.00
202_I	206_L	1.228	1.00
8_I	17_V	1.228	1.00
196_I	207_G	1.226	1.00
48_I	59_A	1.223	1.00
33_F	61_C	1.221	1.00
124_S	128_V	1.219	1.00
213_R	253_D	1.216	1.00
11_S	14_K	1.213	1.00
282_K	287_G	1.207	1.00
143_D	155_E	1.204	1.00
303_W	307_Y	1.202	1.00
45_K	67_E	1.187	1.00
147_R	151_S	1.182	1.00
128_V	131_R	1.179	1.00
199_I	298_L	1.175	1.00
7_G	96_A	1.174	1.00
264_A	294_C	1.173	1.00
278_Y	290_L	1.168	1.00
147_R	155_E	1.166	1.00
172_L	176_E	1.166	1.00
178_R	181_E	1.158	1.00
301_I	305_V	1.151	1.00
27_P	32_G	1.143	1.00
149_N	155_E	1.138	1.00
28_N	33_F	1.132	1.00
8_I	36_V	1.130	1.00
263_A	298_L	1.127	1.00
261_Y	292_V	1.121	1.00
32_G	35_E	1.121	1.00
123_K	127_R	1.121	1.00
127_R	130_N	1.118	1.00
206_L	263_A	1.113	1.00
40_L	46_V	1.108	1.00
6_A	46_V	1.104	1.00
6_A	17_V	1.099	1.00
277_F	281_H	1.096	1.00
117_Q	121_I	1.096	1.00
281_H	290_L	1.095	1.00
304_A	307_Y	1.093	1.00
80_K	94_K	1.088	1.00
74_L	78_K	1.075	1.00
93_K	97_E	1.073	1.00
23_F	93_K	1.070	1.00
188_D	192_R	1.067	1.00
115_T	255_V	1.060	1.00
143_D	153_V	1.049	1.00
305_V	310_K	1.048	1.00
151_S	156_G	1.045	1.00
71_I	76_I	1.035	1.00
202_I	302_T	1.035	1.00
10_V	15_L	1.034	1.00
26_F	39_V	1.024	1.00
148_K	151_S	1.020	1.00
277_F	293_A	1.017	1.00
261_Y	265_L	1.009	1.00
118_W	179_K	1.006	1.00
5_V	100_V	1.004	1.00
176_E	180_R	1.001	1.00
147_R	154_L	0.991	1.00
33_F	57_N	0.980	0.99
26_F	32_G	0.975	0.99
114_L	182_V	0.974	0.99
264_A	291_I	0.972	0.99
187_E	204_K	0.972	0.99
248_I	257_R	0.968	0.99
250_R	257_R	0.964	0.99
277_F	294_C	0.960	0.99
105_E	108_L	0.953	0.99
59_A	62_L	0.953	0.99
177_A	181_E	0.952	0.99
112_R	213_R	0.950	0.99
12_K	137_I	0.949	0.99
5_V	99_V	0.949	0.99
128_V	132_L	0.944	0.99
282_K	290_L	0.943	0.99
86_K	91_D	0.940	0.99
151_S	154_L	0.939	0.99
150_L	153_V	0.931	0.99
153_V	156_G	0.926	0.99
214_V	217_V	0.926	0.99
37_K	64_N	0.920	0.99
57_N	62_L	0.915	0.99
196_I	306_L	0.908	0.99
265_L	268_I	0.903	0.99
274_I	298_L	0.901	0.99
16_I	23_F	0.897	0.99
217_V	306_L	0.897	0.99
202_I	298_L	0.893	0.99
143_D	149_N	0.891	0.99
50_S	73_P	0.890	0.99
51_T	54_Y	0.889	0.99
239_S	243_V	0.888	0.99
55_H	70_V	0.887	0.99
152_E	156_G	0.883	0.99
260_F	299_A	0.879	0.99
110_D	158_D	0.879	0.99
159_N	185_R	0.879	0.99
31_Q	35_E	0.875	0.99
59_A	68_V	0.870	0.99
117_Q	164_E	0.867	0.99
148_K	155_E	0.867	0.99
174_R	177_A	0.860	0.99
147_R	152_E	0.853	0.99
84_G	228_A	0.846	0.98
149_N	154_L	0.844	0.98
115_T	208_L	0.841	0.98
185_R	189_V	0.840	0.98
28_N	36_V	0.839	0.98
265_L	288_K	0.839	0.98
150_L	155_E	0.839	0.98
162_L	166_K	0.836	0.98
288_K	291_I	0.836	0.98
17_V	26_F	0.831	0.98
261_Y	288_K	0.829	0.98
122_V	126_V	0.828	0.98
69_R	99_V	0.825	0.98
17_V	39_V	0.825	0.98
143_D	147_R	0.819	0.98
143_D	151_S	0.816	0.98
6_A	44_C	0.815	0.98
95_L	98_L	0.813	0.98
32_G	36_V	0.812	0.98
37_K	66_Y	0.811	0.98
115_T	209_I	0.810	0.98
59_A	70_V	0.807	0.98
273_V	312_F	0.806	0.98
281_H	286_K	0.805	0.98
148_K	153_V	0.803	0.98
281_H	285_L	0.802	0.98
107_T	192_R	0.800	0.98
10_V	48_I	0.797	0.98
115_T	186_L	0.797	0.98
229_Y	253_D	0.796	0.98
225_K	228_A	0.796	0.98
11_S	15_L	0.794	0.98
115_T	212_A	0.793	0.98
57_N	60_K	0.790	0.98
222_D	303_W	0.788	0.98
167_F	185_R	0.788	0.98
277_F	280_E	0.787	0.98
30_K	34_E	0.785	0.97
197_F	207_G	0.784	0.97
164_E	167_F	0.784	0.97
129_K	172_L	0.783	0.97
160_I	163_S	0.781	0.97
292_V	295_A	0.776	0.97
265_L	295_A	0.775	0.97
213_R	255_V	0.770	0.97
193_D	211_L	0.769	0.97
7_G	92_A	0.767	0.97
233_D	249_S	0.762	0.97
16_I	89_K	0.761	0.97
73_P	213_R	0.756	0.97
147_R	156_G	0.756	0.97
60_K	63_M	0.755	0.97
262_L	288_K	0.754	0.97
119_D	123_K	0.751	0.97
268_I	282_K	0.750	0.97
58_L	61_C	0.748	0.97
181_E	185_R	0.746	0.97
272_P	275_K	0.744	0.97
235_V	249_S	0.743	0.97
276_R	280_E	0.742	0.96
173_E	177_A	0.740	0.96
186_L	190_V	0.740	0.96
148_K	154_L	0.739	0.96
176_E	179_K	0.733	0.96
270_V	275_K	0.730	0.96
175_L	179_K	0.727	0.96
84_G	251_R	0.726	0.96
210_I	256_L	0.726	0.96
128_V	172_L	0.725	0.96
187_E	191_P	0.725	0.96
72_N	75_V	0.725	0.96
252_G	257_R	0.722	0.96
129_K	147_R	0.718	0.96
117_Q	167_F	0.718	0.96
43_G	67_E	0.716	0.96
38_K	41_P	0.715	0.96
236_V	243_V	0.713	0.96
280_E	283_G	0.710	0.95
183_E	190_V	0.710	0.95
35_E	38_K	0.706	0.95
45_K	99_V	0.705	0.95
15_L	28_N	0.704	0.95
50_S	70_V	0.703	0.95
167_F	171_E	0.702	0.95
233_D	236_V	0.702	0.95
233_D	250_R	0.702	0.95
163_S	174_R	0.694	0.95
302_T	305_V	0.693	0.95
238_S	244_V	0.692	0.95
116_S	255_V	0.690	0.95
37_K	41_P	0.687	0.95
53_V	137_I	0.687	0.95
88_D	239_S	0.687	0.95
202_I	210_I	0.687	0.95
199_I	202_I	0.686	0.95
38_K	64_N	0.681	0.94
281_H	293_A	0.681	0.94
43_G	66_Y	0.678	0.94
143_D	152_E	0.673	0.94
59_A	63_M	0.670	0.94
15_L	26_F	0.669	0.94
57_N	61_C	0.668	0.94
41_P	64_N	0.666	0.94
195_L	309_N	0.666	0.94
105_E	109_S	0.665	0.94
79_F	98_L	0.664	0.94
168_L	171_E	0.664	0.94
265_L	291_I	0.664	0.94
120_F	124_S	0.664	0.94
74_L	251_R	0.661	0.93
18_Y	96_A	0.660	0.93
161_I	164_E	0.658	0.93
267_A	274_I	0.656	0.93
286_K	290_L	0.649	0.93
160_I	185_R	0.647	0.93
128_V	171_E	0.645	0.93
289_K	293_A	0.643	0.92
149_N	156_G	0.641	0.92
129_K	151_S	0.639	0.92
117_Q	182_V	0.636	0.92
71_I	98_L	0.636	0.92
18_Y	23_F	0.635	0.92
143_D	150_L	0.633	0.92
262_L	266_T	0.631	0.92
48_I	70_V	0.631	0.92
209_I	213_R	0.630	0.92
85_K	90_N	0.629	0.92
77_K	81_D	0.629	0.92
190_V	208_L	0.629	0.92
32_G	39_V	0.626	0.91
11_S	240_G	0.621	0.91
233_D	257_R	0.621	0.91
216_D	219_R	0.618	0.91
26_F	33_F	0.617	0.91
114_L	185_R	0.617	0.91
260_F	295_A	0.616	0.91
121_I	182_V	0.615	0.91
307_Y	310_K	0.613	0.91
175_L	178_R	0.613	0.91
128_V	175_L	0.611	0.90
107_T	110_D	0.611	0.90
120_F	127_R	0.607	0.90
16_I	239_S	0.606	0.90
300_V	303_W	0.606	0.90
248_I	293_A	0.605	0.90
224_R	296_R	0.604	0.90
248_I	252_G	0.603	0.90
10_V	54_Y	0.603	0.90
63_M	103_G	0.602	0.90
121_I	178_R	0.600	0.90
128_V	168_L	0.600	0.90
278_Y	282_K	0.599	0.90
268_I	291_I	0.599	0.90
35_E	39_V	0.596	0.89
278_Y	291_I	0.592	0.89
116_S	253_D	0.591	0.89
109_S	113_E	0.591	0.89
163_S	166_K	0.591	0.89
41_P	66_Y	0.591	0.89
74_L	84_G	0.590	0.89
223_K	303_W	0.590	0.89
46_V	62_L	0.588	0.89
265_L	269_K	0.583	0.88
259_A	263_A	0.582	0.88
79_F	101_N	0.582	0.88
114_L	118_W	0.581	0.88
131_R	134_R	0.581	0.88
227_V	300_V	0.580	0.88
167_F	170_D	0.576	0.88
87_S	238_S	0.573	0.87
76_I	94_K	0.571	0.87
121_I	175_L	0.571	0.87
166_K	170_D	0.570	0.87
163_S	167_F	0.570	0.87
97_E	100_V	0.570	0.87
126_V	129_K	0.569	0.87
130_N	134_R	0.568	0.87
189_V	192_R	0.567	0.87
183_E	205_T	0.566	0.87
268_I	294_C	0.566	0.87
33_F	39_V	0.564	0.87
56_V	59_A	0.564	0.87
271_N	275_K	0.562	0.86
258_R	261_Y	0.562	0.86
119_D	209_I	0.561	0.86
76_I	98_L	0.561	0.86
150_L	156_G	0.560	0.86
33_F	37_K	0.559	0.86
122_V	183_E	0.556	0.86
237_E	246_R	0.555	0.86
232_L	296_R	0.554	0.86
111_A	193_D	0.554	0.86
37_K	61_C	0.553	0.86
143_D	154_L	0.552	0.85
217_V	303_W	0.551	0.85
121_I	125_I	0.550	0.85
228_A	233_D	0.549	0.85
15_L	58_L	0.549	0.85
223_K	300_V	0.548	0.85
48_I	95_L	0.544	0.85
301_I	304_A	0.542	0.84
23_F	89_K	0.542	0.84
48_I	55_H	0.540	0.84
36_V	39_V	0.540	0.84
202_I	263_A	0.539	0.84
184_K	188_D	0.536	0.84
266_T	270_V	0.536	0.84
263_A	267_A	0.535	0.84
257_R	292_V	0.534	0.84
81_D	84_G	0.534	0.84
113_E	135_D	0.531	0.83
48_I	58_L	0.530	0.83
249_S	252_G	0.529	0.83
276_R	279_E	0.529	0.83
271_N	276_R	0.529	0.83
131_R	168_L	0.525	0.83
31_Q	34_E	0.525	0.83
38_K	185_R	0.523	0.82
183_E	204_K	0.523	0.82
33_F	36_V	0.522	0.82
111_A	189_V	0.521	0.82
90_N	94_K	0.519	0.82
182_V	186_L	0.518	0.82
279_E	282_K	0.515	0.81
198_T	305_V	0.512	0.81
210_I	226_F	0.511	0.81
235_V	246_R	0.511	0.81
177_A	180_R	0.509	0.81
271_N	312_F	0.508	0.80
190_V	193_D	0.508	0.80
297_K	300_V	0.508	0.80
117_Q	120_F	0.507	0.80
249_S	257_R	0.505	0.80
125_I	175_L	0.504	0.80
34_E	38_K	0.504	0.80
34_E	61_C	0.503	0.80
51_T	55_H	0.502	0.80
151_S	198_T	0.502	0.80
110_D	139_L	0.502	0.80
215_G	219_R	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	93	0.933	Contact Map
4ep4A	2	0.3418	92.4	0.934	Contact Map
1nu0A	1	0.3133	85.1	0.943	Contact Map
1keaA	2	0.6108	81.6	0.945	Contact Map
2a1jB	2	0.2437	79.6	0.946	Contact Map
1pu6A	1	0.6108	78.7	0.947	Contact Map
1vhxA	2	0.3323	77.9	0.947	Contact Map
4ofaA	1	0.4304	76.9	0.948	Contact Map
1kftA	1	0.1709	76.3	0.948	Contact Map
3fhfA	1	0.6234	75.2	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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