GREMLIN Database
Q97ZN4 - Transposase ISC1190
UniProt: Q97ZN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (304)
Sequences: 4483 (3407)
Seq/√Len: 195.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G99_V4.4921.00
18_Y92_A2.8481.00
163_S185_R2.7661.00
125_I176_E2.7181.00
226_F299_A2.7151.00
195_L311_P2.6771.00
281_H284_R2.6161.00
214_V226_F2.3791.00
76_I95_L2.3721.00
167_F178_R2.3511.00
47_G95_L2.3301.00
124_S127_R2.2831.00
230_C256_L2.2191.00
170_D178_R2.1941.00
210_I302_T2.1531.00
118_W122_V2.0991.00
198_T311_P2.0901.00
275_K279_E2.0761.00
248_I292_V2.0571.00
221_D225_K2.0571.00
87_S236_V2.0441.00
78_K81_D2.0381.00
296_R300_V2.0211.00
14_K25_E1.9791.00
46_V66_Y1.9651.00
195_L305_V1.9271.00
126_V130_N1.9101.00
124_S131_R1.8981.00
286_K289_K1.8921.00
174_R178_R1.8841.00
8_I15_L1.8451.00
222_D225_K1.8351.00
125_I179_K1.8251.00
238_S243_V1.8061.00
199_I302_T1.8041.00
6_A19_F1.7981.00
17_V36_V1.7931.00
202_I207_G1.7931.00
29_D32_G1.7831.00
230_C299_A1.7631.00
220_F229_Y1.7621.00
116_S213_R1.7621.00
232_L295_A1.7441.00
119_D258_R1.7261.00
185_R188_D1.7251.00
171_E174_R1.6811.00
118_W183_E1.6671.00
45_K69_R1.6671.00
305_V311_P1.6601.00
196_I302_T1.6401.00
171_E178_R1.6251.00
124_S171_E1.6131.00
132_L172_L1.6091.00
58_L62_L1.6001.00
77_K80_K1.5911.00
183_E186_L1.5811.00
206_L259_A1.5791.00
48_I68_V1.5711.00
122_V125_I1.5651.00
11_S16_I1.5631.00
97_E101_N1.5301.00
209_I259_A1.5301.00
304_A308_Y1.5291.00
195_L198_T1.5291.00
262_L265_L1.5231.00
125_I172_L1.5031.00
149_N153_V1.5011.00
121_I179_K1.5011.00
280_E284_R1.4921.00
274_I294_C1.4871.00
13_D241_G1.4841.00
274_I301_I1.4621.00
268_I278_Y1.4421.00
170_D177_A1.4411.00
18_Y93_K1.4301.00
151_S155_E1.4221.00
85_K236_V1.4131.00
122_V179_K1.4061.00
197_F204_K1.4041.00
199_I305_V1.3961.00
279_E283_G1.3831.00
61_C64_N1.3811.00
278_Y294_C1.3801.00
47_G71_I1.3761.00
24_Y39_V1.3731.00
118_W205_T1.3571.00
16_I25_E1.3481.00
277_F297_K1.3481.00
148_K152_E1.3471.00
264_A295_A1.3461.00
8_I58_L1.3441.00
190_V197_F1.3371.00
180_R183_E1.3271.00
132_L165_V1.3201.00
60_K109_S1.3121.00
258_R262_L1.3121.00
6_A40_L1.3101.00
170_D174_R1.3001.00
272_P276_R1.2981.00
169_L173_E1.2961.00
125_I129_K1.2941.00
285_L289_K1.2931.00
227_V233_D1.2861.00
149_N152_E1.2831.00
167_F181_E1.2781.00
152_E155_E1.2641.00
147_R153_V1.2641.00
183_E187_E1.2571.00
120_F131_R1.2541.00
264_A298_L1.2521.00
227_V296_R1.2371.00
261_Y295_A1.2301.00
119_D255_V1.2281.00
202_I206_L1.2281.00
8_I17_V1.2281.00
196_I207_G1.2261.00
48_I59_A1.2231.00
33_F61_C1.2211.00
124_S128_V1.2191.00
213_R253_D1.2161.00
11_S14_K1.2131.00
282_K287_G1.2071.00
143_D155_E1.2041.00
303_W307_Y1.2021.00
45_K67_E1.1871.00
147_R151_S1.1821.00
128_V131_R1.1791.00
199_I298_L1.1751.00
7_G96_A1.1741.00
264_A294_C1.1731.00
278_Y290_L1.1681.00
147_R155_E1.1661.00
172_L176_E1.1661.00
178_R181_E1.1581.00
301_I305_V1.1511.00
27_P32_G1.1431.00
149_N155_E1.1381.00
28_N33_F1.1321.00
8_I36_V1.1301.00
263_A298_L1.1271.00
261_Y292_V1.1211.00
32_G35_E1.1211.00
123_K127_R1.1211.00
127_R130_N1.1181.00
206_L263_A1.1131.00
40_L46_V1.1081.00
6_A46_V1.1041.00
6_A17_V1.0991.00
277_F281_H1.0961.00
117_Q121_I1.0961.00
281_H290_L1.0951.00
304_A307_Y1.0931.00
80_K94_K1.0881.00
74_L78_K1.0751.00
93_K97_E1.0731.00
23_F93_K1.0701.00
188_D192_R1.0671.00
115_T255_V1.0601.00
143_D153_V1.0491.00
305_V310_K1.0481.00
151_S156_G1.0451.00
71_I76_I1.0351.00
202_I302_T1.0351.00
10_V15_L1.0341.00
26_F39_V1.0241.00
148_K151_S1.0201.00
277_F293_A1.0171.00
261_Y265_L1.0091.00
118_W179_K1.0061.00
5_V100_V1.0041.00
176_E180_R1.0011.00
147_R154_L0.9911.00
33_F57_N0.9800.99
26_F32_G0.9750.99
114_L182_V0.9740.99
264_A291_I0.9720.99
187_E204_K0.9720.99
248_I257_R0.9680.99
250_R257_R0.9640.99
277_F294_C0.9600.99
105_E108_L0.9530.99
59_A62_L0.9530.99
177_A181_E0.9520.99
112_R213_R0.9500.99
12_K137_I0.9490.99
5_V99_V0.9490.99
128_V132_L0.9440.99
282_K290_L0.9430.99
86_K91_D0.9400.99
151_S154_L0.9390.99
150_L153_V0.9310.99
153_V156_G0.9260.99
214_V217_V0.9260.99
37_K64_N0.9200.99
57_N62_L0.9150.99
196_I306_L0.9080.99
265_L268_I0.9030.99
274_I298_L0.9010.99
16_I23_F0.8970.99
217_V306_L0.8970.99
202_I298_L0.8930.99
143_D149_N0.8910.99
50_S73_P0.8900.99
51_T54_Y0.8890.99
239_S243_V0.8880.99
55_H70_V0.8870.99
152_E156_G0.8830.99
260_F299_A0.8790.99
110_D158_D0.8790.99
159_N185_R0.8790.99
31_Q35_E0.8750.99
59_A68_V0.8700.99
117_Q164_E0.8670.99
148_K155_E0.8670.99
174_R177_A0.8600.99
147_R152_E0.8530.99
84_G228_A0.8460.98
149_N154_L0.8440.98
115_T208_L0.8410.98
185_R189_V0.8400.98
28_N36_V0.8390.98
265_L288_K0.8390.98
150_L155_E0.8390.98
162_L166_K0.8360.98
288_K291_I0.8360.98
17_V26_F0.8310.98
261_Y288_K0.8290.98
122_V126_V0.8280.98
69_R99_V0.8250.98
17_V39_V0.8250.98
143_D147_R0.8190.98
143_D151_S0.8160.98
6_A44_C0.8150.98
95_L98_L0.8130.98
32_G36_V0.8120.98
37_K66_Y0.8110.98
115_T209_I0.8100.98
59_A70_V0.8070.98
273_V312_F0.8060.98
281_H286_K0.8050.98
148_K153_V0.8030.98
281_H285_L0.8020.98
107_T192_R0.8000.98
10_V48_I0.7970.98
115_T186_L0.7970.98
229_Y253_D0.7960.98
225_K228_A0.7960.98
11_S15_L0.7940.98
115_T212_A0.7930.98
57_N60_K0.7900.98
222_D303_W0.7880.98
167_F185_R0.7880.98
277_F280_E0.7870.98
30_K34_E0.7850.97
197_F207_G0.7840.97
164_E167_F0.7840.97
129_K172_L0.7830.97
160_I163_S0.7810.97
292_V295_A0.7760.97
265_L295_A0.7750.97
213_R255_V0.7700.97
193_D211_L0.7690.97
7_G92_A0.7670.97
233_D249_S0.7620.97
16_I89_K0.7610.97
73_P213_R0.7560.97
147_R156_G0.7560.97
60_K63_M0.7550.97
262_L288_K0.7540.97
119_D123_K0.7510.97
268_I282_K0.7500.97
58_L61_C0.7480.97
181_E185_R0.7460.97
272_P275_K0.7440.97
235_V249_S0.7430.97
276_R280_E0.7420.96
173_E177_A0.7400.96
186_L190_V0.7400.96
148_K154_L0.7390.96
176_E179_K0.7330.96
270_V275_K0.7300.96
175_L179_K0.7270.96
84_G251_R0.7260.96
210_I256_L0.7260.96
128_V172_L0.7250.96
187_E191_P0.7250.96
72_N75_V0.7250.96
252_G257_R0.7220.96
129_K147_R0.7180.96
117_Q167_F0.7180.96
43_G67_E0.7160.96
38_K41_P0.7150.96
236_V243_V0.7130.96
280_E283_G0.7100.95
183_E190_V0.7100.95
35_E38_K0.7060.95
45_K99_V0.7050.95
15_L28_N0.7040.95
50_S70_V0.7030.95
167_F171_E0.7020.95
233_D236_V0.7020.95
233_D250_R0.7020.95
163_S174_R0.6940.95
302_T305_V0.6930.95
238_S244_V0.6920.95
116_S255_V0.6900.95
37_K41_P0.6870.95
53_V137_I0.6870.95
88_D239_S0.6870.95
202_I210_I0.6870.95
199_I202_I0.6860.95
38_K64_N0.6810.94
281_H293_A0.6810.94
43_G66_Y0.6780.94
143_D152_E0.6730.94
59_A63_M0.6700.94
15_L26_F0.6690.94
57_N61_C0.6680.94
41_P64_N0.6660.94
195_L309_N0.6660.94
105_E109_S0.6650.94
79_F98_L0.6640.94
168_L171_E0.6640.94
265_L291_I0.6640.94
120_F124_S0.6640.94
74_L251_R0.6610.93
18_Y96_A0.6600.93
161_I164_E0.6580.93
267_A274_I0.6560.93
286_K290_L0.6490.93
160_I185_R0.6470.93
128_V171_E0.6450.93
289_K293_A0.6430.92
149_N156_G0.6410.92
129_K151_S0.6390.92
117_Q182_V0.6360.92
71_I98_L0.6360.92
18_Y23_F0.6350.92
143_D150_L0.6330.92
262_L266_T0.6310.92
48_I70_V0.6310.92
209_I213_R0.6300.92
85_K90_N0.6290.92
77_K81_D0.6290.92
190_V208_L0.6290.92
32_G39_V0.6260.91
11_S240_G0.6210.91
233_D257_R0.6210.91
216_D219_R0.6180.91
26_F33_F0.6170.91
114_L185_R0.6170.91
260_F295_A0.6160.91
121_I182_V0.6150.91
307_Y310_K0.6130.91
175_L178_R0.6130.91
128_V175_L0.6110.90
107_T110_D0.6110.90
120_F127_R0.6070.90
16_I239_S0.6060.90
300_V303_W0.6060.90
248_I293_A0.6050.90
224_R296_R0.6040.90
248_I252_G0.6030.90
10_V54_Y0.6030.90
63_M103_G0.6020.90
121_I178_R0.6000.90
128_V168_L0.6000.90
278_Y282_K0.5990.90
268_I291_I0.5990.90
35_E39_V0.5960.89
278_Y291_I0.5920.89
116_S253_D0.5910.89
109_S113_E0.5910.89
163_S166_K0.5910.89
41_P66_Y0.5910.89
74_L84_G0.5900.89
223_K303_W0.5900.89
46_V62_L0.5880.89
265_L269_K0.5830.88
259_A263_A0.5820.88
79_F101_N0.5820.88
114_L118_W0.5810.88
131_R134_R0.5810.88
227_V300_V0.5800.88
167_F170_D0.5760.88
87_S238_S0.5730.87
76_I94_K0.5710.87
121_I175_L0.5710.87
166_K170_D0.5700.87
163_S167_F0.5700.87
97_E100_V0.5700.87
126_V129_K0.5690.87
130_N134_R0.5680.87
189_V192_R0.5670.87
183_E205_T0.5660.87
268_I294_C0.5660.87
33_F39_V0.5640.87
56_V59_A0.5640.87
271_N275_K0.5620.86
258_R261_Y0.5620.86
119_D209_I0.5610.86
76_I98_L0.5610.86
150_L156_G0.5600.86
33_F37_K0.5590.86
122_V183_E0.5560.86
237_E246_R0.5550.86
232_L296_R0.5540.86
111_A193_D0.5540.86
37_K61_C0.5530.86
143_D154_L0.5520.85
217_V303_W0.5510.85
121_I125_I0.5500.85
228_A233_D0.5490.85
15_L58_L0.5490.85
223_K300_V0.5480.85
48_I95_L0.5440.85
301_I304_A0.5420.84
23_F89_K0.5420.84
48_I55_H0.5400.84
36_V39_V0.5400.84
202_I263_A0.5390.84
184_K188_D0.5360.84
266_T270_V0.5360.84
263_A267_A0.5350.84
257_R292_V0.5340.84
81_D84_G0.5340.84
113_E135_D0.5310.83
48_I58_L0.5300.83
249_S252_G0.5290.83
276_R279_E0.5290.83
271_N276_R0.5290.83
131_R168_L0.5250.83
31_Q34_E0.5250.83
38_K185_R0.5230.82
183_E204_K0.5230.82
33_F36_V0.5220.82
111_A189_V0.5210.82
90_N94_K0.5190.82
182_V186_L0.5180.82
279_E282_K0.5150.81
198_T305_V0.5120.81
210_I226_F0.5110.81
235_V246_R0.5110.81
177_A180_R0.5090.81
271_N312_F0.5080.80
190_V193_D0.5080.80
297_K300_V0.5080.80
117_Q120_F0.5070.80
249_S257_R0.5050.80
125_I175_L0.5040.80
34_E38_K0.5040.80
34_E61_C0.5030.80
51_T55_H0.5020.80
151_S198_T0.5020.80
110_D139_L0.5020.80
215_G219_R0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 93 0.933 Contact Map
4ep4A 2 0.3418 92.4 0.934 Contact Map
1nu0A 1 0.3133 85.1 0.943 Contact Map
1keaA 2 0.6108 81.6 0.945 Contact Map
2a1jB 2 0.2437 79.6 0.946 Contact Map
1pu6A 1 0.6108 78.7 0.947 Contact Map
1vhxA 2 0.3323 77.9 0.947 Contact Map
4ofaA 1 0.4304 76.9 0.948 Contact Map
1kftA 1 0.1709 76.3 0.948 Contact Map
3fhfA 1 0.6234 75.2 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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