GREMLIN Database
Q97ZM3 - Uncharacterized protein
UniProt: Q97ZM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (349)
Sequences: 338 (256)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S24_S4.1121.00
251_I262_V4.1101.00
276_I303_V3.8961.00
236_I311_V3.8741.00
51_Y63_F3.7430.99
139_A145_A3.5750.99
288_I327_T3.5470.99
278_L288_I3.5080.99
259_K262_V3.4530.99
87_I112_D3.3070.98
251_I270_L3.0970.98
60_E64_T3.0920.98
325_I354_T3.0460.97
288_I300_L3.0460.97
50_I71_E2.9080.97
63_F68_L2.8900.96
237_E244_T2.8540.96
41_F146_A2.8480.96
40_R143_E2.7400.95
12_Y24_S2.7390.95
310_V340_Y2.7280.95
54_P74_P2.6770.94
301_R332_L2.6000.93
8_L90_V2.5900.93
39_T65_K2.5760.93
226_I267_L2.5670.93
124_I185_V2.5390.93
163_E181_L2.5290.92
7_F38_V2.5180.92
104_V127_V2.4710.92
227_M233_V2.4560.91
268_I298_I2.4300.91
264_Y296_G2.4180.91
4_K50_I2.3660.90
264_Y299_F2.3420.89
98_V101_I2.3200.89
227_M237_E2.3100.88
288_I308_L2.2820.88
54_P89_S2.2240.86
114_A183_H2.1660.85
141_T324_R2.1160.83
332_L335_L2.1060.83
224_T251_I2.0470.81
165_L181_L2.0230.80
251_I267_L2.0170.80
328_G333_D1.9550.78
12_Y15_S1.9370.77
63_F70_Y1.9120.76
300_L336_F1.8860.75
222_N254_G1.8480.74
56_L100_I1.8380.74
133_M138_F1.8300.73
8_L113_V1.8060.72
100_I149_L1.8010.72
94_V116_G1.7740.71
60_E72_T1.7600.70
19_I24_S1.7500.70
263_N266_D1.7310.69
226_I262_V1.7300.69
301_R329_D1.7290.69
90_V119_G1.7190.68
90_V113_V1.7180.68
226_I251_I1.7170.68
39_T66_S1.7010.67
133_M146_A1.6980.67
314_F348_K1.6980.67
304_K307_D1.6560.65
251_I259_K1.6510.65
264_Y298_I1.6440.65
116_G185_V1.6230.64
66_S70_Y1.6050.63
54_P58_M1.6030.63
9_V68_L1.6030.63
165_L351_A1.5980.62
202_Q210_E1.5950.62
55_R76_G1.5580.60
226_I295_L1.5440.60
9_V62_H1.5420.59
21_K26_E1.5300.59
20_G263_N1.4900.57
214_Y343_I1.4820.56
165_L179_V1.4720.56
224_T262_V1.4690.56
15_S19_I1.4520.55
101_I122_I1.4490.55
84_Y88_D1.4210.53
190_S279_T1.4190.53
19_I32_P1.4120.53
305_K308_L1.4050.52
148_L187_T1.3990.52
271_T299_F1.3890.51
141_T215_I1.3880.51
214_Y347_N1.3570.50
7_F127_V1.3510.49
62_H66_S1.3430.49
95_K310_V1.3300.48
20_G295_L1.3210.48
297_P333_D1.3190.48
339_V353_K1.3070.47
297_P329_D1.2960.46
277_V311_V1.2930.46
288_I336_F1.2780.45
93_F101_I1.2680.45
103_F110_A1.2620.45
224_T253_R1.2620.45
179_V200_E1.2550.44
275_K307_D1.2440.44
15_S18_R1.2440.44
81_T94_V1.2400.43
81_T313_T1.2360.43
104_V280_P1.2300.43
177_Y200_E1.2200.42
55_R74_P1.2090.42
175_G326_D1.2050.42
254_G274_L1.2010.41
38_V127_V1.1840.41
102_V149_L1.1810.40
26_E296_G1.1790.40
51_Y300_L1.1640.39
267_L271_T1.1630.39
161_K317_L1.1460.39
298_I302_K1.1430.38
170_E174_K1.1270.38
305_K340_Y1.1270.38
301_R335_L1.1190.37
219_M252_I1.1160.37
90_V117_L1.1140.37
211_I216_I1.1130.37
261_N294_E1.1130.37
49_A68_L1.1090.37
111_R182_Y1.1050.36
201_M208_L1.1010.36
78_K82_T1.0870.36
104_V136_G1.0860.36
138_F286_F1.0840.35
113_V124_I1.0780.35
27_L30_E1.0770.35
30_E172_Y1.0750.35
181_L184_I1.0730.35
39_T62_H1.0680.35
172_Y286_F1.0680.35
18_R37_R1.0500.34
92_E95_K1.0470.34
35_P62_H1.0440.34
212_A240_L1.0400.33
45_A127_V1.0360.33
324_R352_I1.0190.32
9_V66_S1.0160.32
76_G81_T1.0160.32
92_E96_R1.0140.32
124_I164_I1.0080.32
88_D95_K0.9980.31
339_V351_A0.9960.31
223_I275_K0.9910.31
182_Y252_I0.9900.31
4_K189_S0.9870.31
243_D260_E0.9850.31
88_D92_E0.9810.31
341_N353_K0.9810.31
215_I277_V0.9810.31
197_S286_F0.9800.31
41_F133_M0.9750.30
101_I272_G0.9710.30
146_A190_S0.9700.30
61_I92_E0.9660.30
20_G104_V0.9590.30
46_P64_T0.9580.30
90_V93_F0.9570.29
9_V354_T0.9560.29
322_C352_I0.9550.29
299_F327_T0.9530.29
64_T70_Y0.9500.29
185_V324_R0.9470.29
83_R87_I0.9440.29
51_Y336_F0.9430.29
227_M277_V0.9410.29
141_T233_V0.9390.29
231_S243_D0.9370.29
182_Y194_L0.9370.29
220_D254_G0.9330.28
5_I51_Y0.9290.28
9_V35_P0.9260.28
344_V350_Y0.9260.28
287_L310_V0.9230.28
271_T287_L0.9230.28
172_Y229_P0.9170.28
87_I115_E0.9160.28
4_K302_K0.9140.28
276_I295_L0.9030.27
329_D333_D0.9000.27
300_L325_I0.9000.27
171_A178_F0.8970.27
300_L304_K0.8970.27
24_S152_F0.8930.27
127_V233_V0.8880.26
219_M225_Y0.8840.26
308_L351_A0.8810.26
163_E204_S0.8770.26
285_G323_L0.8770.26
229_P263_N0.8770.26
160_V189_S0.8740.26
217_D351_A0.8710.26
117_L183_H0.8690.26
20_G229_P0.8640.26
172_Y279_T0.8620.25
267_L333_D0.8620.25
90_V317_L0.8590.25
52_L73_I0.8580.25
13_A16_G0.8570.25
180_K334_K0.8510.25
211_I217_D0.8500.25
175_G345_G0.8490.25
327_T336_F0.8480.25
276_I279_T0.8380.24
131_V229_P0.8370.24
41_F102_V0.8360.24
297_P332_L0.8330.24
340_Y354_T0.8330.24
11_P16_G0.8310.24
11_P14_G0.8310.24
229_P295_L0.8290.24
149_L204_S0.8280.24
61_I65_K0.8270.24
216_I219_M0.8240.24
58_M89_S0.8180.24
231_S279_T0.8170.24
153_L310_V0.8120.23
113_V149_L0.8120.23
167_I172_Y0.8090.23
226_I276_I0.8060.23
42_L175_G0.8050.23
5_I50_I0.8020.23
196_P277_V0.8000.23
164_I313_T0.7940.23
189_S317_L0.7930.23
244_T280_P0.7880.23
271_T302_K0.7880.23
69_K180_K0.7830.22
33_E37_R0.7830.22
237_E242_I0.7820.22
111_R293_L0.7800.22
72_T309_I0.7800.22
134_H193_L0.7780.22
100_I192_N0.7780.22
134_H284_Q0.7750.22
7_F208_L0.7720.22
208_L280_P0.7710.22
115_E194_L0.7650.22
299_F305_K0.7650.22
147_I236_I0.7610.22
49_A153_L0.7600.21
91_R121_E0.7600.21
153_L339_V0.7590.21
148_L194_L0.7580.21
112_D287_L0.7550.21
15_S32_P0.7550.21
146_A344_V0.7520.21
81_T269_N0.7520.21
248_G261_N0.7500.21
51_Y76_G0.7480.21
24_S244_T0.7480.21
219_M313_T0.7450.21
10_N16_G0.7440.21
10_N14_G0.7440.21
301_R354_T0.7420.21
38_V104_V0.7420.21
249_I336_F0.7410.21
186_L328_G0.7380.21
86_T342_V0.7380.21
21_K296_G0.7360.21
58_M284_Q0.7330.21
83_R213_D0.7310.20
125_L310_V0.7270.20
148_L164_I0.7250.20
131_V325_I0.7230.20
92_E270_L0.7170.20
82_T330_E0.7140.20
60_E156_E0.7100.20
38_V45_A0.7070.20
233_V336_F0.7060.20
211_I219_M0.7030.20
188_I248_G0.7000.19
19_I26_E0.6990.19
272_G354_T0.6970.19
93_F119_G0.6960.19
74_P139_A0.6960.19
7_F93_F0.6960.19
302_K332_L0.6960.19
252_I313_T0.6950.19
113_V213_D0.6930.19
209_G264_Y0.6920.19
7_F63_F0.6920.19
10_N13_A0.6920.19
140_N202_Q0.6910.19
37_R112_D0.6870.19
227_M264_Y0.6850.19
267_L270_L0.6840.19
216_I225_Y0.6770.19
216_I236_I0.6760.19
152_F327_T0.6760.19
188_I261_N0.6750.19
245_P313_T0.6750.19
254_G295_L0.6740.19
6_G10_N0.6730.19
104_V179_V0.6730.19
57_K61_I0.6720.18
275_K343_I0.6710.18
221_D331_N0.6700.18
265_F269_N0.6700.18
119_G315_S0.6690.18
264_Y268_I0.6670.18
41_F129_A0.6660.18
182_Y219_M0.6650.18
15_S131_V0.6600.18
112_D115_E0.6590.18
172_Y348_K0.6590.18
251_I333_D0.6580.18
163_E184_I0.6580.18
101_I183_H0.6560.18
54_P310_V0.6560.18
30_E82_T0.6560.18
136_G208_L0.6560.18
48_D154_H0.6530.18
69_K218_N0.6500.18
262_V299_F0.6500.18
259_K266_D0.6490.18
15_S353_K0.6490.18
226_I306_D0.6480.18
104_V283_K0.6470.18
113_V266_D0.6470.18
139_A262_V0.6460.18
131_V191_N0.6440.18
134_H195_T0.6440.18
327_T333_D0.6440.18
287_L309_I0.6440.18
179_V267_L0.6420.18
281_I326_D0.6420.18
194_L272_G0.6410.17
104_V146_A0.6400.17
72_T351_A0.6390.17
91_R218_N0.6380.17
54_P73_I0.6370.17
151_K156_E0.6350.17
55_R113_V0.6340.17
341_N349_F0.6300.17
308_L336_F0.6300.17
141_T262_V0.6290.17
16_G23_G0.6290.17
14_G23_G0.6290.17
121_E331_N0.6260.17
146_A179_V0.6240.17
87_I171_A0.6230.17
242_I252_I0.6230.17
195_T245_P0.6220.17
156_E233_V0.6210.17
199_G206_D0.6200.17
169_E173_R0.6190.17
222_N256_K0.6180.17
64_T121_E0.6180.17
111_R198_K0.6180.17
338_G344_V0.6180.17
129_A133_M0.6170.17
146_A293_L0.6140.17
323_L345_G0.6130.17
47_E88_D0.6110.17
275_K309_I0.6110.17
112_D262_V0.6110.17
8_L93_F0.6100.17
144_A157_A0.6100.17
153_L301_R0.6090.17
15_S30_E0.6060.16
300_L332_L0.6050.16
265_F332_L0.6050.16
15_S80_K0.6030.16
69_K287_L0.6030.16
123_P241_K0.6030.16
32_P57_K0.6020.16
64_T302_K0.6020.16
287_L302_K0.5990.16
148_L184_I0.5970.16
295_L348_K0.5970.16
217_D346_Y0.5970.16
41_F149_L0.5960.16
229_P233_V0.5950.16
278_L327_T0.5940.16
101_I114_A0.5940.16
33_E36_M0.5920.16
8_L347_N0.5920.16
295_L332_L0.5910.16
138_F227_M0.5900.16
7_F283_K0.5890.16
112_D158_K0.5890.16
113_V117_L0.5890.16
51_Y264_Y0.5880.16
219_M227_M0.5880.16
219_M254_G0.5870.16
69_K72_T0.5870.16
112_D276_I0.5870.16
120_A185_V0.5870.16
190_S244_T0.5850.16
224_T259_K0.5850.16
86_T131_V0.5850.16
4_K35_P0.5850.16
101_I336_F0.5840.16
101_I123_P0.5830.16
229_P280_P0.5810.16
297_P301_R0.5810.16
262_V268_I0.5800.16
101_I254_G0.5800.16
13_A23_G0.5790.16
24_S189_S0.5790.16
101_I258_I0.5790.16
229_P244_T0.5790.16
159_T193_L0.5780.16
167_I295_L0.5780.16
46_P332_L0.5770.16
144_A264_Y0.5760.16
177_Y352_I0.5750.16
81_T260_E0.5730.15
281_I287_L0.5700.15
134_H332_L0.5680.15
147_I163_E0.5660.15
218_N225_Y0.5660.15
4_K52_L0.5650.15
251_I279_T0.5640.15
17_G20_G0.5640.15
53_T161_K0.5640.15
46_P277_V0.5630.15
117_L125_L0.5620.15
11_P23_G0.5620.15
97_G215_I0.5600.15
233_V277_V0.5600.15
93_F283_K0.5590.15
279_T320_I0.5590.15
220_D225_Y0.5590.15
12_Y210_E0.5590.15
37_R326_D0.5550.15
147_I201_M0.5530.15
259_K312_S0.5520.15
149_L180_K0.5520.15
91_R221_D0.5510.15
202_Q206_D0.5510.15
98_V324_R0.5510.15
176_T180_K0.5500.15
89_S147_I0.5500.15
248_G296_G0.5500.15
164_I283_K0.5490.15
214_Y245_P0.5490.15
12_Y353_K0.5480.15
6_G17_G0.5480.15
21_K32_P0.5470.15
217_D330_E0.5470.15
214_Y218_N0.5470.15
231_S244_T0.5470.15
148_L319_T0.5460.15
217_D347_N0.5450.15
209_G300_L0.5440.15
142_P312_S0.5440.15
136_G184_I0.5440.15
224_T252_I0.5440.15
133_M149_L0.5430.15
95_K331_N0.5430.15
188_I345_G0.5420.15
187_T266_D0.5410.15
175_G288_I0.5410.15
111_R165_L0.5400.15
186_L325_I0.5390.15
4_K235_Y0.5390.15
268_I299_F0.5380.15
55_R73_I0.5380.15
5_I319_T0.5370.15
327_T338_G0.5370.15
57_K79_K0.5360.14
71_E96_R0.5350.14
164_I185_V0.5350.14
263_N300_L0.5350.14
127_V340_Y0.5340.14
224_T271_T0.5310.14
120_A252_I0.5300.14
146_A177_Y0.5290.14
213_D239_K0.5280.14
286_F348_K0.5270.14
71_E215_I0.5270.14
165_L308_L0.5260.14
324_R344_V0.5260.14
89_S97_G0.5250.14
101_I343_I0.5240.14
111_R180_K0.5230.14
233_V324_R0.5230.14
191_N231_S0.5220.14
224_T274_L0.5220.14
19_I229_P0.5220.14
115_E252_I0.5210.14
9_V276_I0.5210.14
52_L57_K0.5210.14
17_G23_G0.5190.14
51_Y68_L0.5180.14
254_G342_V0.5170.14
74_P204_S0.5160.14
15_S264_Y0.5150.14
15_S21_K0.5150.14
99_D216_I0.5150.14
12_Y310_V0.5150.14
209_G239_K0.5140.14
174_K269_N0.5130.14
127_V194_L0.5120.14
339_V354_T0.5100.14
225_Y334_K0.5090.14
33_E196_P0.5090.14
219_M257_L0.5090.14
7_F54_P0.5080.14
31_N36_M0.5080.14
279_T286_F0.5070.14
138_F244_T0.5070.14
78_K84_Y0.5070.14
34_I113_V0.5070.14
8_L73_I0.5070.14
273_E348_K0.5060.14
287_L327_T0.5040.14
172_Y320_I0.5030.14
173_R247_L0.5020.14
133_M200_E0.5010.14
6_G11_P0.5010.14
12_Y30_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qv7A 2 0.6994 99.2 0.912 Contact Map
4werA 2 0.6798 99.1 0.916 Contact Map
2an1A 4 0.6798 98.9 0.923 Contact Map
3s40A 3 0.7107 98.8 0.926 Contact Map
1u0tA 4 0.7079 98.7 0.929 Contact Map
1yt5A 4 0.6376 98.6 0.93 Contact Map
1z0sA 4 0.6011 98.5 0.933 Contact Map
2i2cA 3 0.6208 98.3 0.936 Contact Map
2bonA 1 0.691 98.2 0.938 Contact Map
4v24A 1 0.7697 97.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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