OTC - SULSO - GREMLIN Contacts

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OTC - Ornithine carbamoyltransferase

UniProt:	Q97ZM1	Sequences: MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVSTELAVSLLGGIPIVLNKQDLQWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSGVPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDGSDNVLLSLMAIVAKLGLELHVATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQKKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTMAVFSLFI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (291)
Sequences:	7140 (3646)
Seq/√Len:	213.7

ECOLI - OTC1 YGEW OTC2 PYRB
BACSU - OTC PYRB
HALSA - PYRB OTCC
SULSO - OTC PYRB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_A	279_E	4.065	1.00
153_K	178_E	3.938	1.00
153_K	180_H	3.430	1.00
39_N	42_S	3.340	1.00
155_A	221_V	3.185	1.00
264_F	276_V	3.166	1.00
215_Y	257_Y	2.943	1.00
143_I	223_V	2.811	1.00
29_K	145_E	2.788	1.00
24_V	304_S	2.752	1.00
96_G	120_G	2.625	1.00
146_R	287_A	2.587	1.00
97_R	290_D	2.583	1.00
213_D	216_E	2.571	1.00
222_H	259_V	2.559	1.00
263_I	287_A	2.554	1.00
26_F	144_R	2.473	1.00
9_C	131_S	2.305	1.00
47_A	99_V	2.293	1.00
89_E	114_K	2.267	1.00
23_E	144_R	2.257	1.00
65_V	70_G	2.216	1.00
265_M	287_A	2.167	1.00
19_E	144_R	2.118	1.00
46_V	65_V	2.115	1.00
26_F	141_M	2.077	1.00
101_G	303_F	2.070	1.00
136_A	171_I	2.031	1.00
147_F	261_D	1.992	1.00
191_D	195_K	1.990	1.00
182_A	217_A	1.954	1.00
185_K	212_E	1.954	1.00
140_L	171_I	1.941	1.00
188_K	212_E	1.933	1.00
218_V	224_V	1.883	1.00
67_L	300_M	1.838	1.00
271_N	274_E	1.832	1.00
172_V	179_L	1.793	1.00
15_T	19_E	1.787	1.00
97_R	293_E	1.785	1.00
255_M	262_A	1.782	1.00
146_R	290_D	1.781	1.00
252_A	256_K	1.778	1.00
66_S	71_I	1.778	1.00
103_G	126_L	1.740	1.00
178_E	209_E	1.735	1.00
14_Q	17_E	1.668	1.00
258_A	262_A	1.641	1.00
59_V	95_L	1.628	1.00
108_N	111_T	1.625	1.00
147_F	152_V	1.619	1.00
180_H	211_H	1.610	1.00
211_H	216_E	1.595	1.00
46_V	101_G	1.572	1.00
134_L	302_V	1.570	1.00
20_K	305_L	1.564	1.00
262_A	285_K	1.561	1.00
253_D	256_K	1.547	1.00
28_M	304_S	1.536	1.00
5_K	17_E	1.515	1.00
21_M	305_L	1.512	1.00
185_K	188_K	1.489	1.00
187_L	244_M	1.487	1.00
168_L	225_Y	1.478	1.00
131_S	170_A	1.478	1.00
76_N	79_D	1.470	1.00
15_T	174_K	1.460	1.00
15_T	150_N	1.460	1.00
155_A	182_A	1.454	1.00
178_E	207_V	1.450	1.00
51_E	111_T	1.435	1.00
215_Y	254_L	1.425	1.00
155_A	180_H	1.423	1.00
223_V	263_I	1.421	1.00
7_L	137_L	1.410	1.00
40_S	304_S	1.385	1.00
225_Y	291_Q	1.358	1.00
134_L	299_T	1.352	1.00
25_S	141_M	1.351	1.00
183_T	188_K	1.348	1.00
93_R	282_D	1.344	1.00
240_Q	244_M	1.335	1.00
24_V	305_L	1.335	1.00
220_G	259_V	1.328	1.00
22_L	141_M	1.324	1.00
157_V	218_V	1.318	1.00
31_Y	36_K	1.308	1.00
22_L	144_R	1.287	1.00
214_P	254_L	1.286	1.00
251_T	277_D	1.283	1.00
273_G	278_P	1.280	1.00
224_V	250_V	1.269	1.00
92_G	115_L	1.269	1.00
270_A	281_I	1.237	1.00
27_L	31_Y	1.237	1.00
249_R	277_D	1.236	1.00
24_V	27_L	1.234	1.00
219_R	257_Y	1.232	1.00
58_R	62_E	1.230	1.00
46_V	103_G	1.228	1.00
11_L	170_A	1.228	1.00
55_T	91_T	1.224	1.00
255_M	264_F	1.210	1.00
19_E	175_L	1.210	1.00
141_M	298_T	1.207	1.00
55_T	85_G	1.207	1.00
10_L	171_I	1.207	1.00
113_V	117_E	1.207	1.00
297_Y	300_M	1.206	1.00
93_R	289_W	1.201	1.00
89_E	118_S	1.197	1.00
7_L	302_V	1.195	1.00
226_T	250_V	1.189	1.00
149_N	152_V	1.188	1.00
102_I	121_V	1.168	1.00
272_R	282_D	1.159	1.00
172_V	177_L	1.158	1.00
6_S	116_K	1.148	1.00
211_H	217_A	1.139	1.00
180_H	209_E	1.129	1.00
137_L	302_V	1.128	1.00
147_F	222_H	1.127	1.00
32_V	67_L	1.126	1.00
55_T	81_Q	1.117	1.00
66_S	72_P	1.110	1.00
218_V	254_L	1.109	1.00
238_A	242_K	1.099	1.00
239_E	243_R	1.093	1.00
255_M	285_K	1.083	1.00
102_I	115_L	1.081	1.00
53_P	83_S	1.078	1.00
7_L	13_F	1.077	1.00
65_V	72_P	1.072	1.00
22_L	26_F	1.069	1.00
152_V	223_V	1.067	1.00
26_F	145_E	1.057	1.00
64_A	303_F	1.056	1.00
250_V	264_F	1.055	1.00
147_F	263_I	1.042	1.00
29_K	294_N	1.041	1.00
293_E	297_Y	1.040	1.00
9_C	12_D	1.034	1.00
94_V	292_A	1.030	1.00
19_E	23_E	1.028	1.00
194_Y	210_F	1.024	1.00
283_G	286_S	1.018	1.00
169_M	181_V	1.014	1.00
154_I	168_L	1.012	1.00
136_A	168_L	1.007	1.00
182_A	211_H	1.005	1.00
110_L	114_K	1.002	1.00
22_L	298_T	0.988	1.00
160_G	183_T	0.988	1.00
96_G	121_V	0.986	1.00
18_I	175_L	0.972	1.00
140_L	175_L	0.970	1.00
136_A	164_V	0.966	1.00
281_I	288_V	0.965	1.00
154_I	172_V	0.964	1.00
67_L	296_L	0.961	1.00
62_E	74_V	0.956	1.00
93_R	118_S	0.953	1.00
101_G	124_F	0.951	1.00
212_E	248_Y	0.934	0.99
9_C	170_A	0.933	0.99
46_V	70_G	0.926	0.99
29_K	141_M	0.924	0.99
81_Q	84_R	0.921	0.99
59_V	75_L	0.914	0.99
216_E	219_R	0.911	0.99
145_E	294_N	0.909	0.99
112_L	128_S	0.909	0.99
124_F	302_V	0.908	0.99
189_P	210_F	0.908	0.99
6_S	96_G	0.907	0.99
89_E	282_D	0.899	0.99
240_Q	243_R	0.899	0.99
166_L	193_L	0.899	0.99
272_R	281_I	0.895	0.99
147_F	287_A	0.894	0.99
109_H	113_V	0.894	0.99
143_I	152_V	0.892	0.99
18_I	174_K	0.888	0.99
106_V	128_S	0.887	0.99
104_A	115_L	0.881	0.99
89_E	93_R	0.880	0.99
244_M	247_N	0.879	0.99
45_R	71_I	0.876	0.99
39_N	69_G	0.876	0.99
62_E	66_S	0.875	0.99
6_S	119_S	0.874	0.99
81_Q	91_T	0.873	0.99
65_V	303_F	0.869	0.99
272_R	278_P	0.869	0.99
182_A	221_V	0.868	0.99
180_H	221_V	0.868	0.99
10_L	136_A	0.864	0.99
141_M	145_E	0.863	0.99
253_D	257_Y	0.863	0.99
153_K	220_G	0.861	0.99
62_E	72_P	0.860	0.99
131_S	167_S	0.860	0.99
215_Y	219_R	0.860	0.99
23_E	27_L	0.855	0.99
157_V	224_V	0.855	0.99
45_R	67_L	0.850	0.99
239_E	242_K	0.844	0.99
31_Y	38_P	0.834	0.99
137_L	298_T	0.834	0.99
252_A	283_G	0.831	0.99
290_D	293_E	0.827	0.99
61_T	134_L	0.826	0.99
180_H	220_G	0.822	0.99
27_L	30_S	0.812	0.99
130_L	190_R	0.810	0.98
182_A	214_P	0.807	0.98
255_M	280_V	0.797	0.98
81_Q	85_G	0.796	0.98
169_M	179_L	0.795	0.98
44_K	100_N	0.792	0.98
92_G	119_S	0.792	0.98
148_G	151_L	0.791	0.98
278_P	282_D	0.789	0.98
45_R	63_L	0.788	0.98
60_S	98_V	0.787	0.98
157_V	254_L	0.786	0.98
209_E	216_E	0.782	0.98
104_A	111_T	0.780	0.98
113_V	116_K	0.780	0.98
26_F	30_S	0.778	0.98
160_G	165_L	0.776	0.98
89_E	278_P	0.772	0.98
217_A	221_V	0.771	0.98
280_V	283_G	0.769	0.98
10_L	18_I	0.762	0.98
21_M	298_T	0.761	0.98
242_K	274_E	0.760	0.98
20_K	24_V	0.758	0.98
143_I	147_F	0.754	0.98
287_A	290_D	0.752	0.98
51_E	82_W	0.751	0.98
18_I	171_I	0.746	0.97
215_Y	253_D	0.745	0.97
8_L	116_K	0.744	0.97
41_L	101_G	0.742	0.97
142_T	287_A	0.740	0.97
114_K	117_E	0.736	0.97
147_F	223_V	0.736	0.97
142_T	294_N	0.735	0.97
93_R	96_G	0.730	0.97
85_G	91_T	0.729	0.97
301_A	305_L	0.728	0.97
168_L	172_V	0.728	0.97
13_F	21_M	0.727	0.97
278_P	281_I	0.726	0.97
25_S	301_A	0.725	0.97
255_M	258_A	0.722	0.97
153_K	221_V	0.721	0.97
250_V	276_V	0.717	0.97
114_K	118_S	0.715	0.97
64_A	299_T	0.712	0.97
230_V	238_A	0.707	0.96
16_H	19_E	0.706	0.96
251_T	254_L	0.705	0.96
108_N	129_D	0.703	0.96
106_V	111_T	0.702	0.96
99_V	121_V	0.700	0.96
47_A	102_I	0.700	0.96
165_L	181_V	0.699	0.96
15_T	204_T	0.698	0.96
60_S	299_T	0.695	0.96
169_M	189_P	0.690	0.96
25_S	298_T	0.689	0.96
188_K	210_F	0.685	0.96
224_V	262_A	0.685	0.96
5_K	305_L	0.685	0.96
21_M	301_A	0.684	0.96
24_V	28_M	0.682	0.96
10_L	13_F	0.679	0.96
41_L	70_G	0.677	0.95
194_Y	208_I	0.674	0.95
218_V	257_Y	0.672	0.95
146_R	263_I	0.672	0.95
31_Y	37_V	0.672	0.95
140_L	144_R	0.672	0.95
157_V	214_P	0.668	0.95
214_P	218_V	0.668	0.95
246_Q	249_R	0.665	0.95
143_I	263_I	0.665	0.95
55_T	80_L	0.663	0.95
252_A	277_D	0.663	0.95
143_I	172_V	0.660	0.95
80_L	85_G	0.659	0.95
55_T	84_R	0.658	0.95
264_F	280_V	0.658	0.95
110_L	113_V	0.657	0.95
88_I	111_T	0.655	0.95
48_L	72_P	0.653	0.94
18_I	137_L	0.651	0.94
46_V	303_F	0.650	0.94
243_R	246_Q	0.649	0.94
236_N	240_Q	0.646	0.94
225_Y	228_V	0.642	0.94
256_K	285_K	0.642	0.94
45_R	66_S	0.641	0.94
7_L	306_F	0.639	0.94
154_I	225_Y	0.639	0.94
48_L	65_V	0.639	0.94
255_M	276_V	0.639	0.94
80_L	84_R	0.637	0.94
28_M	40_S	0.637	0.94
96_G	119_S	0.637	0.94
270_A	276_V	0.636	0.94
228_V	232_M	0.631	0.93
156_F	162_D	0.631	0.93
254_L	257_Y	0.630	0.93
283_G	288_V	0.627	0.93
48_L	74_V	0.627	0.93
155_A	224_V	0.624	0.93
188_K	191_D	0.623	0.93
53_P	81_Q	0.621	0.93
39_N	43_G	0.617	0.93
136_A	291_Q	0.615	0.93
63_L	73_I	0.614	0.92
61_T	299_T	0.612	0.92
37_V	42_S	0.610	0.92
60_S	134_L	0.610	0.92
10_L	131_S	0.607	0.92
87_L	282_D	0.605	0.92
143_I	154_I	0.605	0.92
53_P	85_G	0.603	0.92
92_G	102_I	0.602	0.92
228_V	271_N	0.601	0.92
21_M	302_V	0.600	0.92
238_A	271_N	0.600	0.92
157_V	226_T	0.599	0.92
127_L	163_N	0.599	0.92
225_Y	265_M	0.599	0.92
155_A	217_A	0.594	0.91
52_K	233_G	0.594	0.91
245_L	277_D	0.593	0.91
8_L	113_V	0.592	0.91
223_V	265_M	0.590	0.91
224_V	255_M	0.589	0.91
171_I	175_L	0.589	0.91
50_F	54_S	0.586	0.91
154_I	177_L	0.586	0.91
189_P	194_Y	0.586	0.91
124_F	303_F	0.585	0.91
54_S	57_T	0.584	0.91
155_A	211_H	0.583	0.90
144_R	148_G	0.581	0.90
37_V	40_S	0.580	0.90
136_A	140_L	0.575	0.90
144_R	149_N	0.575	0.90
252_A	285_K	0.573	0.90
67_L	100_N	0.573	0.90
234_Q	237_I	0.571	0.90
183_T	189_P	0.569	0.89
28_M	31_Y	0.567	0.89
61_T	103_G	0.565	0.89
152_V	222_H	0.563	0.89
237_I	241_K	0.560	0.89
51_E	106_V	0.559	0.89
53_P	79_D	0.558	0.88
182_A	218_V	0.556	0.88
94_V	97_R	0.555	0.88
60_S	94_V	0.555	0.88
258_A	285_K	0.553	0.88
173_A	206_S	0.553	0.88
173_A	204_T	0.552	0.88
91_T	95_L	0.552	0.88
110_L	130_L	0.552	0.88
164_V	225_Y	0.551	0.88
164_V	168_L	0.551	0.88
192_D	195_K	0.550	0.88
110_L	128_S	0.547	0.87
183_T	212_E	0.546	0.87
283_G	287_A	0.546	0.87
281_I	286_S	0.546	0.87
7_L	18_I	0.546	0.87
79_D	83_S	0.545	0.87
38_P	42_S	0.544	0.87
127_L	232_M	0.543	0.87
12_D	174_K	0.543	0.87
63_L	67_L	0.543	0.87
250_V	255_M	0.542	0.87
181_V	208_I	0.542	0.87
173_A	179_L	0.539	0.87
186_E	243_R	0.539	0.87
131_S	193_L	0.539	0.87
170_A	193_L	0.538	0.87
22_L	25_S	0.538	0.87
61_T	126_L	0.537	0.86
63_L	296_L	0.536	0.86
281_I	289_W	0.535	0.86
174_K	204_T	0.534	0.86
145_E	290_D	0.534	0.86
54_S	58_R	0.533	0.86
6_S	120_G	0.533	0.86
16_H	20_K	0.532	0.86
211_H	214_P	0.531	0.86
86_E	90_D	0.530	0.86
24_V	301_A	0.529	0.86
187_L	245_L	0.528	0.86
20_K	23_E	0.524	0.85
18_I	22_L	0.524	0.85
212_E	216_E	0.523	0.85
32_V	37_V	0.522	0.85
29_K	297_Y	0.522	0.85
218_V	258_A	0.521	0.85
50_F	57_T	0.521	0.85
237_I	240_Q	0.518	0.85
160_G	181_V	0.517	0.84
102_I	119_S	0.516	0.84
23_E	26_F	0.515	0.84
28_M	37_V	0.514	0.84
11_L	131_S	0.513	0.84
156_F	225_Y	0.512	0.84
9_C	113_V	0.512	0.84
92_G	123_V	0.510	0.84
190_R	195_K	0.509	0.83
231_S	241_K	0.509	0.83
94_V	98_V	0.509	0.83
52_K	232_M	0.507	0.83
103_G	124_F	0.507	0.83
17_E	20_K	0.507	0.83
264_F	286_S	0.507	0.83
88_I	104_A	0.506	0.83
277_D	280_V	0.505	0.83
157_V	247_N	0.504	0.83
94_V	289_W	0.504	0.83
250_V	254_L	0.503	0.83
170_A	174_K	0.503	0.83
58_R	74_V	0.500	0.82
101_G	306_F	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pvvA	6	0.9967	100	0.014	Contact Map
2i6uA	3	0.987	100	0.019	Contact Map
1vlvA	6	0.9674	100	0.023	Contact Map
3gd5A	4	0.9121	100	0.023	Contact Map
4nf2A	3	0.9805	100	0.023	Contact Map
1dxhA	6	1	100	0.029	Contact Map
3grfA	3	0.9316	100	0.029	Contact Map
2w37A	5	0.9967	100	0.032	Contact Map
4amuA	6	1	100	0.032	Contact Map
1duvG	3	1	100	0.033	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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