GREMLIN Database
OTC - Ornithine carbamoyltransferase
UniProt: Q97ZM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (291)
Sequences: 7140 (3646)
Seq/√Len: 213.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_A279_E4.0651.00
153_K178_E3.9381.00
153_K180_H3.4301.00
39_N42_S3.3401.00
155_A221_V3.1851.00
264_F276_V3.1661.00
215_Y257_Y2.9431.00
143_I223_V2.8111.00
29_K145_E2.7881.00
24_V304_S2.7521.00
96_G120_G2.6251.00
146_R287_A2.5871.00
97_R290_D2.5831.00
213_D216_E2.5711.00
222_H259_V2.5591.00
263_I287_A2.5541.00
26_F144_R2.4731.00
9_C131_S2.3051.00
47_A99_V2.2931.00
89_E114_K2.2671.00
23_E144_R2.2571.00
65_V70_G2.2161.00
265_M287_A2.1671.00
19_E144_R2.1181.00
46_V65_V2.1151.00
26_F141_M2.0771.00
101_G303_F2.0701.00
136_A171_I2.0311.00
147_F261_D1.9921.00
191_D195_K1.9901.00
182_A217_A1.9541.00
185_K212_E1.9541.00
140_L171_I1.9411.00
188_K212_E1.9331.00
218_V224_V1.8831.00
67_L300_M1.8381.00
271_N274_E1.8321.00
172_V179_L1.7931.00
15_T19_E1.7871.00
97_R293_E1.7851.00
255_M262_A1.7821.00
146_R290_D1.7811.00
252_A256_K1.7781.00
66_S71_I1.7781.00
103_G126_L1.7401.00
178_E209_E1.7351.00
14_Q17_E1.6681.00
258_A262_A1.6411.00
59_V95_L1.6281.00
108_N111_T1.6251.00
147_F152_V1.6191.00
180_H211_H1.6101.00
211_H216_E1.5951.00
46_V101_G1.5721.00
134_L302_V1.5701.00
20_K305_L1.5641.00
262_A285_K1.5611.00
253_D256_K1.5471.00
28_M304_S1.5361.00
5_K17_E1.5151.00
21_M305_L1.5121.00
185_K188_K1.4891.00
187_L244_M1.4871.00
168_L225_Y1.4781.00
131_S170_A1.4781.00
76_N79_D1.4701.00
15_T174_K1.4601.00
15_T150_N1.4601.00
155_A182_A1.4541.00
178_E207_V1.4501.00
51_E111_T1.4351.00
215_Y254_L1.4251.00
155_A180_H1.4231.00
223_V263_I1.4211.00
7_L137_L1.4101.00
40_S304_S1.3851.00
225_Y291_Q1.3581.00
134_L299_T1.3521.00
25_S141_M1.3511.00
183_T188_K1.3481.00
93_R282_D1.3441.00
240_Q244_M1.3351.00
24_V305_L1.3351.00
220_G259_V1.3281.00
22_L141_M1.3241.00
157_V218_V1.3181.00
31_Y36_K1.3081.00
22_L144_R1.2871.00
214_P254_L1.2861.00
251_T277_D1.2831.00
273_G278_P1.2801.00
224_V250_V1.2691.00
92_G115_L1.2691.00
270_A281_I1.2371.00
27_L31_Y1.2371.00
249_R277_D1.2361.00
24_V27_L1.2341.00
219_R257_Y1.2321.00
58_R62_E1.2301.00
46_V103_G1.2281.00
11_L170_A1.2281.00
55_T91_T1.2241.00
255_M264_F1.2101.00
19_E175_L1.2101.00
141_M298_T1.2071.00
55_T85_G1.2071.00
10_L171_I1.2071.00
113_V117_E1.2071.00
297_Y300_M1.2061.00
93_R289_W1.2011.00
89_E118_S1.1971.00
7_L302_V1.1951.00
226_T250_V1.1891.00
149_N152_V1.1881.00
102_I121_V1.1681.00
272_R282_D1.1591.00
172_V177_L1.1581.00
6_S116_K1.1481.00
211_H217_A1.1391.00
180_H209_E1.1291.00
137_L302_V1.1281.00
147_F222_H1.1271.00
32_V67_L1.1261.00
55_T81_Q1.1171.00
66_S72_P1.1101.00
218_V254_L1.1091.00
238_A242_K1.0991.00
239_E243_R1.0931.00
255_M285_K1.0831.00
102_I115_L1.0811.00
53_P83_S1.0781.00
7_L13_F1.0771.00
65_V72_P1.0721.00
22_L26_F1.0691.00
152_V223_V1.0671.00
26_F145_E1.0571.00
64_A303_F1.0561.00
250_V264_F1.0551.00
147_F263_I1.0421.00
29_K294_N1.0411.00
293_E297_Y1.0401.00
9_C12_D1.0341.00
94_V292_A1.0301.00
19_E23_E1.0281.00
194_Y210_F1.0241.00
283_G286_S1.0181.00
169_M181_V1.0141.00
154_I168_L1.0121.00
136_A168_L1.0071.00
182_A211_H1.0051.00
110_L114_K1.0021.00
22_L298_T0.9881.00
160_G183_T0.9881.00
96_G121_V0.9861.00
18_I175_L0.9721.00
140_L175_L0.9701.00
136_A164_V0.9661.00
281_I288_V0.9651.00
154_I172_V0.9641.00
67_L296_L0.9611.00
62_E74_V0.9561.00
93_R118_S0.9531.00
101_G124_F0.9511.00
212_E248_Y0.9340.99
9_C170_A0.9330.99
46_V70_G0.9260.99
29_K141_M0.9240.99
81_Q84_R0.9210.99
59_V75_L0.9140.99
216_E219_R0.9110.99
145_E294_N0.9090.99
112_L128_S0.9090.99
124_F302_V0.9080.99
189_P210_F0.9080.99
6_S96_G0.9070.99
89_E282_D0.8990.99
240_Q243_R0.8990.99
166_L193_L0.8990.99
272_R281_I0.8950.99
147_F287_A0.8940.99
109_H113_V0.8940.99
143_I152_V0.8920.99
18_I174_K0.8880.99
106_V128_S0.8870.99
104_A115_L0.8810.99
89_E93_R0.8800.99
244_M247_N0.8790.99
45_R71_I0.8760.99
39_N69_G0.8760.99
62_E66_S0.8750.99
6_S119_S0.8740.99
81_Q91_T0.8730.99
65_V303_F0.8690.99
272_R278_P0.8690.99
182_A221_V0.8680.99
180_H221_V0.8680.99
10_L136_A0.8640.99
141_M145_E0.8630.99
253_D257_Y0.8630.99
153_K220_G0.8610.99
62_E72_P0.8600.99
131_S167_S0.8600.99
215_Y219_R0.8600.99
23_E27_L0.8550.99
157_V224_V0.8550.99
45_R67_L0.8500.99
239_E242_K0.8440.99
31_Y38_P0.8340.99
137_L298_T0.8340.99
252_A283_G0.8310.99
290_D293_E0.8270.99
61_T134_L0.8260.99
180_H220_G0.8220.99
27_L30_S0.8120.99
130_L190_R0.8100.98
182_A214_P0.8070.98
255_M280_V0.7970.98
81_Q85_G0.7960.98
169_M179_L0.7950.98
44_K100_N0.7920.98
92_G119_S0.7920.98
148_G151_L0.7910.98
278_P282_D0.7890.98
45_R63_L0.7880.98
60_S98_V0.7870.98
157_V254_L0.7860.98
209_E216_E0.7820.98
104_A111_T0.7800.98
113_V116_K0.7800.98
26_F30_S0.7780.98
160_G165_L0.7760.98
89_E278_P0.7720.98
217_A221_V0.7710.98
280_V283_G0.7690.98
10_L18_I0.7620.98
21_M298_T0.7610.98
242_K274_E0.7600.98
20_K24_V0.7580.98
143_I147_F0.7540.98
287_A290_D0.7520.98
51_E82_W0.7510.98
18_I171_I0.7460.97
215_Y253_D0.7450.97
8_L116_K0.7440.97
41_L101_G0.7420.97
142_T287_A0.7400.97
114_K117_E0.7360.97
147_F223_V0.7360.97
142_T294_N0.7350.97
93_R96_G0.7300.97
85_G91_T0.7290.97
301_A305_L0.7280.97
168_L172_V0.7280.97
13_F21_M0.7270.97
278_P281_I0.7260.97
25_S301_A0.7250.97
255_M258_A0.7220.97
153_K221_V0.7210.97
250_V276_V0.7170.97
114_K118_S0.7150.97
64_A299_T0.7120.97
230_V238_A0.7070.96
16_H19_E0.7060.96
251_T254_L0.7050.96
108_N129_D0.7030.96
106_V111_T0.7020.96
99_V121_V0.7000.96
47_A102_I0.7000.96
165_L181_V0.6990.96
15_T204_T0.6980.96
60_S299_T0.6950.96
169_M189_P0.6900.96
25_S298_T0.6890.96
188_K210_F0.6850.96
224_V262_A0.6850.96
5_K305_L0.6850.96
21_M301_A0.6840.96
24_V28_M0.6820.96
10_L13_F0.6790.96
41_L70_G0.6770.95
194_Y208_I0.6740.95
218_V257_Y0.6720.95
146_R263_I0.6720.95
31_Y37_V0.6720.95
140_L144_R0.6720.95
157_V214_P0.6680.95
214_P218_V0.6680.95
246_Q249_R0.6650.95
143_I263_I0.6650.95
55_T80_L0.6630.95
252_A277_D0.6630.95
143_I172_V0.6600.95
80_L85_G0.6590.95
55_T84_R0.6580.95
264_F280_V0.6580.95
110_L113_V0.6570.95
88_I111_T0.6550.95
48_L72_P0.6530.94
18_I137_L0.6510.94
46_V303_F0.6500.94
243_R246_Q0.6490.94
236_N240_Q0.6460.94
225_Y228_V0.6420.94
256_K285_K0.6420.94
45_R66_S0.6410.94
7_L306_F0.6390.94
154_I225_Y0.6390.94
48_L65_V0.6390.94
255_M276_V0.6390.94
80_L84_R0.6370.94
28_M40_S0.6370.94
96_G119_S0.6370.94
270_A276_V0.6360.94
228_V232_M0.6310.93
156_F162_D0.6310.93
254_L257_Y0.6300.93
283_G288_V0.6270.93
48_L74_V0.6270.93
155_A224_V0.6240.93
188_K191_D0.6230.93
53_P81_Q0.6210.93
39_N43_G0.6170.93
136_A291_Q0.6150.93
63_L73_I0.6140.92
61_T299_T0.6120.92
37_V42_S0.6100.92
60_S134_L0.6100.92
10_L131_S0.6070.92
87_L282_D0.6050.92
143_I154_I0.6050.92
53_P85_G0.6030.92
92_G102_I0.6020.92
228_V271_N0.6010.92
21_M302_V0.6000.92
238_A271_N0.6000.92
157_V226_T0.5990.92
127_L163_N0.5990.92
225_Y265_M0.5990.92
155_A217_A0.5940.91
52_K233_G0.5940.91
245_L277_D0.5930.91
8_L113_V0.5920.91
223_V265_M0.5900.91
224_V255_M0.5890.91
171_I175_L0.5890.91
50_F54_S0.5860.91
154_I177_L0.5860.91
189_P194_Y0.5860.91
124_F303_F0.5850.91
54_S57_T0.5840.91
155_A211_H0.5830.90
144_R148_G0.5810.90
37_V40_S0.5800.90
136_A140_L0.5750.90
144_R149_N0.5750.90
252_A285_K0.5730.90
67_L100_N0.5730.90
234_Q237_I0.5710.90
183_T189_P0.5690.89
28_M31_Y0.5670.89
61_T103_G0.5650.89
152_V222_H0.5630.89
237_I241_K0.5600.89
51_E106_V0.5590.89
53_P79_D0.5580.88
182_A218_V0.5560.88
94_V97_R0.5550.88
60_S94_V0.5550.88
258_A285_K0.5530.88
173_A206_S0.5530.88
173_A204_T0.5520.88
91_T95_L0.5520.88
110_L130_L0.5520.88
164_V225_Y0.5510.88
164_V168_L0.5510.88
192_D195_K0.5500.88
110_L128_S0.5470.87
183_T212_E0.5460.87
283_G287_A0.5460.87
281_I286_S0.5460.87
7_L18_I0.5460.87
79_D83_S0.5450.87
38_P42_S0.5440.87
127_L232_M0.5430.87
12_D174_K0.5430.87
63_L67_L0.5430.87
250_V255_M0.5420.87
181_V208_I0.5420.87
173_A179_L0.5390.87
186_E243_R0.5390.87
131_S193_L0.5390.87
170_A193_L0.5380.87
22_L25_S0.5380.87
61_T126_L0.5370.86
63_L296_L0.5360.86
281_I289_W0.5350.86
174_K204_T0.5340.86
145_E290_D0.5340.86
54_S58_R0.5330.86
6_S120_G0.5330.86
16_H20_K0.5320.86
211_H214_P0.5310.86
86_E90_D0.5300.86
24_V301_A0.5290.86
187_L245_L0.5280.86
20_K23_E0.5240.85
18_I22_L0.5240.85
212_E216_E0.5230.85
32_V37_V0.5220.85
29_K297_Y0.5220.85
218_V258_A0.5210.85
50_F57_T0.5210.85
237_I240_Q0.5180.85
160_G181_V0.5170.84
102_I119_S0.5160.84
23_E26_F0.5150.84
28_M37_V0.5140.84
11_L131_S0.5130.84
156_F225_Y0.5120.84
9_C113_V0.5120.84
92_G123_V0.5100.84
190_R195_K0.5090.83
231_S241_K0.5090.83
94_V98_V0.5090.83
52_K232_M0.5070.83
103_G124_F0.5070.83
17_E20_K0.5070.83
264_F286_S0.5070.83
88_I104_A0.5060.83
277_D280_V0.5050.83
157_V247_N0.5040.83
94_V289_W0.5040.83
250_V254_L0.5030.83
170_A174_K0.5030.83
58_R74_V0.5000.82
101_G306_F0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pvvA 6 0.9967 100 0.014 Contact Map
2i6uA 3 0.987 100 0.019 Contact Map
1vlvA 6 0.9674 100 0.023 Contact Map
3gd5A 4 0.9121 100 0.023 Contact Map
4nf2A 3 0.9805 100 0.023 Contact Map
1dxhA 6 1 100 0.029 Contact Map
3grfA 3 0.9316 100 0.029 Contact Map
2w37A 5 0.9967 100 0.032 Contact Map
4amuA 6 1 100 0.032 Contact Map
1duvG 3 1 100 0.033 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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