GREMLIN Database
Q97ZM0 - Uncharacterized protein
UniProt: Q97ZM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (381)
Sequences: 209 (173)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_E328_I5.9481.00
258_Y324_H4.8891.00
57_G213_F4.8371.00
324_H328_I4.0730.98
236_S240_K3.5790.96
264_G343_E3.3760.95
19_C24_C3.3260.94
177_P206_K3.3110.94
320_A358_R3.2270.93
325_L332_S3.2210.93
267_F352_H3.2120.93
194_I237_I3.2000.93
183_L188_A3.1760.92
245_K326_E3.0780.91
180_L210_A2.9660.90
19_C25_P2.9620.89
368_Y374_A2.9200.89
194_I211_L2.8700.88
20_G24_C2.8390.87
250_N329_K2.7050.85
174_P177_P2.5490.81
20_G25_P2.5270.80
187_D222_R2.5130.80
348_V352_H2.4800.79
309_Y315_M2.4660.78
73_I141_A2.3740.76
274_S333_G2.3620.75
310_L313_G2.3320.74
258_Y328_I2.3180.74
276_F320_A2.2140.70
79_G82_A2.1320.67
344_Y352_H2.1160.66
255_I371_L2.0940.66
344_Y360_A2.0510.64
270_I378_V2.0250.63
52_S82_A1.9520.60
119_A124_D1.9400.59
202_V206_K1.9230.59
128_P299_L1.8720.56
239_G322_L1.8320.55
256_E365_L1.8260.55
238_V242_L1.7860.53
280_W310_L1.7860.53
309_Y350_N1.7630.52
250_N270_I1.7560.52
74_P161_P1.7480.51
74_P348_V1.7280.50
194_I375_I1.7180.50
173_N239_G1.6830.48
108_I394_I1.6500.47
286_P290_W1.6070.45
247_I303_F1.5980.45
58_I315_M1.5970.45
235_D355_E1.5930.45
309_Y314_Y1.5600.43
62_K223_R1.5480.43
401_K405_D1.5310.42
204_Y286_P1.5250.42
58_I350_N1.5230.42
58_I71_V1.4990.41
313_G352_H1.4780.40
75_P79_G1.4780.40
75_P82_A1.4770.40
72_N236_S1.4710.39
315_M350_N1.4670.39
70_I129_L1.4670.39
179_K200_Y1.4650.39
286_P291_S1.4630.39
249_Y335_I1.4410.38
222_R270_I1.4300.38
284_W340_I1.4220.37
83_R246_I1.4210.37
58_I61_E1.4190.37
87_N335_I1.4160.37
58_I309_Y1.4020.37
71_V82_A1.3960.36
313_G353_I1.3810.36
269_V344_Y1.3770.36
280_W313_G1.3660.35
140_E173_N1.3620.35
250_N364_R1.3620.35
71_V109_S1.3610.35
67_V249_Y1.3600.35
58_I70_I1.3560.35
107_L161_P1.3400.34
311_D353_I1.3350.34
188_A196_E1.3290.34
269_V360_A1.3270.34
311_D356_T1.3260.34
143_L163_G1.3250.34
283_I353_I1.3230.34
350_N353_I1.3230.34
235_D354_R1.3220.33
263_L336_I1.3030.33
211_L318_R1.3020.33
369_D376_S1.3020.33
360_A400_Q1.2980.33
59_V63_G1.2970.33
261_S266_Y1.2910.32
153_D324_H1.2900.32
247_I306_E1.2740.32
21_L29_R1.2670.31
311_D343_E1.2660.31
228_R330_R1.2610.31
264_G341_T1.2550.31
336_I344_Y1.2550.31
243_Y247_I1.2450.31
29_R399_N1.2450.31
280_W344_Y1.2440.31
70_I309_Y1.2410.30
58_I299_L1.2400.30
336_I360_A1.2370.30
69_L348_V1.2330.30
323_E358_R1.2320.30
317_A378_V1.2310.30
51_G161_P1.2290.30
258_Y267_F1.2250.30
211_L216_L1.2230.30
88_V283_I1.2190.30
234_V340_I1.2160.30
74_P136_P1.2160.30
258_Y300_K1.2120.29
89_K211_L1.2080.29
249_Y326_E1.2020.29
21_L310_L1.1980.29
277_N333_G1.1970.29
283_I313_G1.1970.29
135_N340_I1.1960.29
271_L361_M1.1920.29
299_L350_N1.1900.29
211_L237_I1.1880.29
278_S299_L1.1860.28
228_R338_R1.1720.28
344_Y400_Q1.1660.28
52_S75_P1.1600.28
143_L348_V1.1580.27
193_A371_L1.1520.27
291_S306_E1.1510.27
157_L299_L1.1370.27
210_A236_S1.1370.27
244_N364_R1.1330.27
71_V130_A1.1310.27
173_N176_V1.1270.26
174_P331_Q1.1240.26
249_Y329_K1.1200.26
181_D184_I1.1190.26
330_R370_N1.1140.26
74_P79_G1.1080.26
215_L292_Q1.1030.26
255_I367_K1.1010.26
74_P286_P1.1010.26
129_L236_S1.0980.25
370_N381_K1.0940.25
138_V223_R1.0920.25
313_G356_T1.0820.25
246_I281_I1.0800.25
50_E138_V1.0720.25
211_L382_L1.0650.24
311_D350_N1.0640.24
165_A168_I1.0580.24
89_K205_Y1.0570.24
154_G343_E1.0550.24
254_E367_K1.0530.24
249_Y404_Y1.0530.24
110_S141_A1.0500.24
279_T354_R1.0490.24
178_T223_R1.0430.24
286_P306_E1.0420.24
66_K223_R1.0330.23
74_P305_G1.0320.23
239_G310_L1.0300.23
59_V374_A1.0280.23
137_I174_P1.0270.23
99_D193_A1.0250.23
145_T340_I1.0190.23
209_H317_A1.0190.23
276_F313_G1.0180.23
267_F389_F1.0160.23
287_L336_I1.0160.23
237_I316_A1.0140.23
42_I224_F1.0120.23
133_S384_A1.0100.23
321_V334_I1.0100.23
222_R235_D1.0100.23
161_P224_F1.0090.23
83_R112_T1.0060.23
63_G146_L1.0000.22
239_G280_W0.9940.22
202_V222_R0.9870.22
250_N385_K0.9840.22
196_E209_H0.9840.22
133_S174_P0.9780.22
112_T253_N0.9770.22
177_P181_D0.9750.22
297_S344_Y0.9740.22
153_D156_I0.9740.22
235_D290_W0.9710.22
271_L334_I0.9700.22
368_Y377_E0.9690.21
313_G343_E0.9660.21
239_G308_E0.9580.21
211_L346_A0.9580.21
51_G65_P0.9520.21
222_R355_E0.9510.21
106_S267_F0.9460.21
291_S313_G0.9460.21
97_L280_W0.9450.21
70_I236_S0.9440.21
75_P305_G0.9430.21
156_I162_S0.9430.21
99_D296_I0.9430.21
194_I246_I0.9410.21
280_W352_H0.9360.21
24_C284_W0.9340.20
177_P239_G0.9330.20
58_I109_S0.9320.20
257_V271_L0.9320.20
135_N150_L0.9310.20
181_D210_A0.9270.20
291_S311_D0.9270.20
246_I385_K0.9250.20
19_C284_W0.9250.20
130_A294_L0.9240.20
223_R330_R0.9230.20
211_L230_A0.9230.20
48_L62_K0.9220.20
160_G233_A0.9160.20
74_P144_K0.9140.20
174_P322_L0.9140.20
50_E53_T0.9130.20
148_A340_I0.9090.20
245_K329_K0.9080.20
135_N211_L0.9070.20
96_N114_V0.9060.20
280_W311_D0.9050.20
284_W351_W0.9010.20
49_V144_K0.9010.20
238_V326_E0.8940.19
52_S242_L0.8940.19
270_I375_I0.8920.19
86_E119_A0.8890.19
239_G374_A0.8890.19
329_K379_N0.8860.19
108_I263_L0.8840.19
281_I286_P0.8840.19
58_I278_S0.8830.19
317_A379_N0.8820.19
99_D406_F0.8780.19
166_E241_F0.8780.19
101_I339_E0.8760.19
297_S311_D0.8760.19
103_L205_Y0.8730.19
338_R344_Y0.8720.19
299_L315_M0.8700.19
280_W341_T0.8690.19
167_Q246_I0.8670.19
235_D320_A0.8670.19
72_N341_T0.8660.19
30_F346_A0.8630.19
124_D170_V0.8610.19
129_L172_D0.8590.18
186_D238_V0.8570.18
56_S63_G0.8560.18
174_P239_G0.8550.18
86_E89_K0.8540.18
253_N367_K0.8500.18
278_S317_A0.8470.18
105_S253_N0.8460.18
75_P161_P0.8460.18
127_I288_S0.8420.18
91_W104_R0.8420.18
86_E208_I0.8390.18
284_W342_E0.8380.18
187_D235_D0.8370.18
289_L344_Y0.8350.18
263_L289_L0.8320.18
331_Q339_E0.8310.18
235_D276_F0.8220.18
21_L280_W0.8200.17
50_E171_L0.8160.17
176_V181_D0.8160.17
278_S311_D0.8160.17
167_Q404_Y0.8130.17
323_E330_R0.8120.17
104_R186_D0.8080.17
209_H353_I0.8080.17
308_E406_F0.8070.17
107_L350_N0.8070.17
157_L344_Y0.8060.17
126_E129_L0.8040.17
246_I324_H0.8030.17
114_V124_D0.8020.17
252_I364_R0.8020.17
141_A152_F0.8010.17
61_E353_I0.8010.17
128_P215_L0.7990.17
399_N402_S0.7980.17
112_T230_A0.7960.17
313_G344_Y0.7950.17
105_S184_I0.7920.17
107_L224_F0.7920.17
243_Y352_H0.7900.17
285_H384_A0.7900.17
264_G406_F0.7900.17
341_T344_Y0.7890.17
116_V329_K0.7890.17
114_V245_K0.7880.17
54_P79_G0.7880.17
316_A351_W0.7860.17
133_S181_D0.7830.17
264_G352_H0.7810.17
266_Y310_L0.7810.17
194_I360_A0.7790.16
146_L167_Q0.7790.16
292_Q306_E0.7750.16
74_P82_A0.7740.16
138_V190_S0.7740.16
27_M293_E0.7730.16
359_N362_K0.7720.16
319_L358_R0.7720.16
181_D253_N0.7710.16
86_E337_I0.7700.16
202_V288_S0.7660.16
61_E350_N0.7620.16
98_G317_A0.7610.16
86_E211_L0.7600.16
311_D315_M0.7580.16
290_W355_E0.7580.16
131_I140_E0.7580.16
58_I311_D0.7570.16
97_L274_S0.7560.16
20_G54_P0.7550.16
269_V336_I0.7550.16
182_K196_E0.7540.16
82_A313_G0.7530.16
21_L24_C0.7520.16
251_E387_N0.7510.16
236_S311_D0.7480.16
284_W289_L0.7460.16
299_L311_D0.7440.16
274_S277_N0.7390.16
263_L344_Y0.7370.16
243_Y246_I0.7360.15
133_S242_L0.7340.15
108_I192_E0.7340.15
152_F346_A0.7340.15
46_F193_A0.7320.15
280_W361_M0.7300.15
121_E317_A0.7290.15
72_N234_V0.7270.15
60_G65_P0.7250.15
299_L313_G0.7240.15
146_L321_V0.7230.15
18_L205_Y0.7220.15
93_G97_L0.7200.15
246_I364_R0.7190.15
22_P106_S0.7160.15
167_Q272_Y0.7160.15
61_E291_S0.7130.15
49_V178_T0.7130.15
103_L388_L0.7120.15
319_L351_W0.7110.15
130_A345_F0.7060.15
286_P358_R0.7050.15
189_K379_N0.7040.15
206_K249_Y0.7010.15
283_I311_D0.6990.15
284_W310_L0.6980.15
61_E205_Y0.6970.15
402_S405_D0.6970.15
27_M216_L0.6970.15
99_D248_N0.6950.15
315_M331_Q0.6950.15
331_Q350_N0.6910.14
266_Y348_V0.6910.14
252_I392_R0.6890.14
290_W337_I0.6890.14
358_R389_F0.6880.14
228_R290_W0.6880.14
263_L321_V0.6870.14
19_C29_R0.6840.14
347_P360_A0.6840.14
198_Y204_Y0.6840.14
224_F267_F0.6830.14
176_V207_I0.6820.14
185_F314_Y0.6810.14
246_I254_E0.6790.14
240_K267_F0.6780.14
74_P207_I0.6760.14
89_K95_I0.6750.14
210_A288_S0.6740.14
51_G354_R0.6730.14
108_I269_V0.6720.14
307_Y378_V0.6660.14
103_L107_L0.6630.14
106_S266_Y0.6630.14
238_V249_Y0.6620.14
70_I100_I0.6620.14
63_G370_N0.6610.14
331_Q371_L0.6600.14
49_V209_H0.6590.14
170_V178_T0.6560.14
344_Y353_I0.6510.14
280_W335_I0.6500.14
67_V116_V0.6490.14
17_N181_D0.6490.14
102_K180_L0.6490.14
339_E353_I0.6490.14
132_I393_T0.6480.14
239_G297_S0.6450.14
58_I279_T0.6440.14
274_S302_N0.6440.14
140_E288_S0.6430.13
62_K334_I0.6420.13
100_I337_I0.6410.13
71_V350_N0.6400.13
92_W313_G0.6400.13
204_Y291_S0.6380.13
144_K284_W0.6370.13
311_D345_F0.6360.13
99_D143_L0.6350.13
213_F324_H0.6340.13
371_L374_A0.6340.13
239_G344_Y0.6330.13
206_K285_H0.6320.13
194_I261_S0.6320.13
46_F240_K0.6300.13
82_A132_I0.6290.13
255_I270_I0.6290.13
283_I341_T0.6270.13
115_K165_A0.6250.13
152_F310_L0.6250.13
283_I291_S0.6250.13
98_G138_V0.6250.13
186_D325_L0.6240.13
275_K329_K0.6230.13
204_Y306_E0.6230.13
47_K376_S0.6230.13
108_I207_I0.6190.13
253_N369_D0.6180.13
377_E403_I0.6180.13
70_I337_I0.6170.13
53_T71_V0.6170.13
72_N213_F0.6170.13
72_N344_Y0.6160.13
45_S241_F0.6160.13
73_I113_T0.6150.13
106_S137_I0.6150.13
23_Y96_N0.6140.13
236_S336_I0.6130.13
175_K363_N0.6120.13
215_L276_F0.6100.13
166_E224_F0.6100.13
288_S322_L0.6080.13
53_T129_L0.6070.13
53_T342_E0.6050.13
66_K245_K0.6040.13
58_I276_F0.6040.13
203_D238_V0.6040.13
211_L366_G0.6020.13
249_Y377_E0.6020.13
177_P288_S0.6000.13
256_E278_S0.5980.13
31_R230_A0.5980.13
97_L348_V0.5970.13
330_R372_N0.5970.13
223_R252_I0.5960.13
235_D311_D0.5930.13
276_F291_S0.5920.13
163_G344_Y0.5920.13
188_A218_R0.5910.12
71_V128_P0.5900.12
69_L126_E0.5900.12
22_P68_S0.5890.12
178_T373_L0.5890.12
246_I258_Y0.5880.12
263_L356_T0.5870.12
84_K300_K0.5860.12
348_V384_A0.5850.12
106_S247_I0.5830.12
193_A228_R0.5800.12
147_E324_H0.5800.12
172_D266_Y0.5790.12
318_R330_R0.5780.12
326_E329_K0.5780.12
250_N330_R0.5770.12
178_T382_L0.5760.12
209_H373_L0.5740.12
128_P315_M0.5740.12
293_E388_L0.5730.12
145_T148_A0.5720.12
61_E311_D0.5700.12
92_W262_Y0.5690.12
124_D350_N0.5680.12
266_Y344_Y0.5670.12
70_I230_A0.5650.12
86_E267_F0.5650.12
167_Q362_K0.5620.12
177_P202_V0.5620.12
61_E389_F0.5600.12
179_K196_E0.5600.12
177_P216_L0.5590.12
128_P210_A0.5590.12
58_I132_I0.5570.12
176_V340_I0.5550.12
297_S340_I0.5540.12
269_V317_A0.5540.12
236_S318_R0.5530.12
278_S380_K0.5520.12
135_N364_R0.5500.12
367_K371_L0.5490.12
236_S278_S0.5440.12
119_A369_D0.5430.12
212_S350_N0.5430.12
78_Y145_T0.5420.12
189_K198_Y0.5420.12
307_Y315_M0.5420.12
73_I151_K0.5410.12
269_V374_A0.5400.12
168_I392_R0.5400.12
57_G259_H0.5390.12
63_G362_K0.5380.12
281_I353_I0.5380.12
63_G255_I0.5380.12
167_Q245_K0.5370.12
130_A316_A0.5360.11
398_I403_I0.5360.11
16_K40_I0.5360.11
56_S86_E0.5350.11
136_P316_A0.5340.11
117_E376_S0.5330.11
23_Y344_Y0.5330.11
61_E345_F0.5320.11
124_D133_S0.5310.11
33_M135_N0.5310.11
224_F322_L0.5300.11
275_K403_I0.5300.11
52_S340_I0.5290.11
260_S344_Y0.5290.11
64_Y108_I0.5290.11
18_L91_W0.5290.11
126_E406_F0.5290.11
93_G263_L0.5280.11
54_P339_E0.5270.11
85_Y130_A0.5270.11
242_L335_I0.5250.11
247_I289_L0.5240.11
199_R321_V0.5230.11
121_E230_A0.5220.11
53_T172_D0.5220.11
24_C29_R0.5200.11
209_H316_A0.5200.11
132_I279_T0.5200.11
320_A355_E0.5190.11
60_G228_R0.5180.11
71_V299_L0.5150.11
133_S138_V0.5140.11
23_Y297_S0.5130.11
164_I313_G0.5120.11
32_G240_K0.5090.11
95_I103_L0.5090.11
55_P60_G0.5090.11
57_G258_Y0.5070.11
198_Y351_W0.5060.11
209_H304_W0.5050.11
69_L90_E0.5050.11
169_K274_S0.5050.11
299_L309_Y0.5020.11
174_P316_A0.5010.11
89_K203_D0.5010.11
285_H291_S0.5010.11
218_R371_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zvvY 1 0.027 18.9 0.983 Contact Map
1qgpA 1 0.1667 18.7 0.983 Contact Map
4l7mA 1 0.1667 17.4 0.983 Contact Map
2qzqA 1 0.3529 13.2 0.984 Contact Map
1qhkA 1 0.1127 8.8 0.985 Contact Map
2rfbA 1 0.1642 7.9 0.986 Contact Map
2klnA 1 0.2868 7.4 0.986 Contact Map
1nu4A 5 0.2157 7.1 0.986 Contact Map
3pjpA 3 0.424 7.1 0.986 Contact Map
1p7nA 2 0.3284 7 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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