GREMLIN Database
Q97ZL9 - Uncharacterized protein
UniProt: Q97ZL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (185)
Sequences: 2106 (1714)
Seq/√Len: 126.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_A90_C5.2631.00
35_T54_G5.1991.00
65_V95_S4.5641.00
86_K115_D4.3281.00
9_S34_I3.5131.00
25_A30_I2.9671.00
9_S21_I2.7241.00
4_D147_S2.6481.00
84_Y87_E2.5151.00
24_Y27_A2.4951.00
86_K92_V2.4421.00
129_N132_A2.4341.00
66_I85_A2.3981.00
167_E172_D2.3741.00
17_L20_D2.3551.00
5_L33_A2.2661.00
7_V32_V2.2351.00
93_F144_V2.2001.00
93_F116_L2.1781.00
57_V66_I2.1461.00
58_T63_H2.1321.00
67_L93_F2.0791.00
79_A83_D2.0651.00
92_V115_D2.0621.00
77_R80_E2.0111.00
7_V21_I1.9491.00
175_D179_R1.8901.00
119_I143_G1.8791.00
68_C174_L1.7571.00
39_T42_G1.7481.00
174_L178_R1.7191.00
65_V93_F1.7051.00
85_A92_V1.6911.00
38_D58_T1.6291.00
116_L142_P1.6291.00
83_D113_K1.6251.00
23_A27_A1.5741.00
19_K23_A1.5551.00
84_Y88_N1.5441.00
114_F141_L1.5321.00
20_D23_A1.5071.00
83_D87_E1.4791.00
25_A32_V1.4571.00
10_R17_L1.4231.00
4_D7_V1.4211.00
98_F132_A1.4051.00
167_E173_I1.3771.00
16_Y149_A1.3571.00
24_Y28_K1.3551.00
108_K111_R1.3411.00
66_I69_N1.2821.00
55_Q66_I1.2741.00
154_A157_S1.2701.00
64_V85_A1.2401.00
107_D110_F1.2290.99
165_I172_D1.2090.99
82_V113_K1.2030.99
145_S160_N1.1990.99
33_A67_L1.1840.99
32_V51_V1.1710.99
142_P180_G1.1570.99
11_Y41_L1.1540.99
9_S43_L1.1290.99
127_M131_K1.1170.99
65_V146_N1.1070.99
82_V92_V1.1050.99
170_L174_L1.0960.99
46_V50_K1.0900.99
4_D145_S1.0860.99
66_I90_C1.0780.99
175_D178_R1.0740.99
13_D63_H1.0710.99
94_P114_F1.0630.98
91_V174_L1.0620.98
16_Y20_D1.0620.98
128_A131_K1.0610.98
137_I143_G1.0550.98
7_V35_T1.0470.98
2_F159_Y1.0410.98
37_H150_H1.0170.98
2_F161_D1.0160.98
169_N172_D0.9990.98
165_I173_I0.9920.98
17_L21_I0.9780.97
160_N182_I0.9640.97
7_V33_A0.9600.97
71_P88_N0.9510.97
109_T112_Y0.9460.97
4_D30_I0.9430.97
19_K45_T0.9410.97
37_H148_D0.9400.97
156_G159_Y0.9380.97
142_P182_I0.9240.96
156_G160_N0.9180.96
14_G97_P0.9020.96
133_K136_S0.9000.96
18_P22_I0.8870.95
44_N48_E0.8860.95
123_K154_A0.8800.95
145_S158_A0.8790.95
131_K134_E0.8780.95
5_L144_V0.8750.95
59_T62_G0.8730.95
80_E83_D0.8700.95
97_P145_S0.8620.95
23_A26_K0.8610.95
33_A64_V0.8580.95
45_T48_E0.8570.94
40_S69_N0.8490.94
165_I169_N0.8420.94
134_E138_R0.8360.94
146_N160_N0.8340.94
149_A156_G0.8330.94
135_A138_R0.8310.94
3_F173_I0.8300.93
135_A139_L0.8300.93
185_I188_G0.8300.93
16_Y24_Y0.8270.93
83_D86_K0.8230.93
15_K153_Q0.8190.93
3_F162_L0.8000.92
60_E77_R0.7980.92
136_S140_N0.7960.92
119_I133_K0.7950.92
68_C99_D0.7920.92
132_A136_S0.7910.92
145_S186_I0.7880.92
162_L165_I0.7840.91
134_E137_I0.7800.91
131_K135_A0.7740.91
168_F172_D0.7690.91
144_V160_N0.7690.91
38_D59_T0.7670.91
37_H96_H0.7620.90
132_A135_A0.7590.90
36_D39_T0.7580.90
129_N133_K0.7560.90
65_V116_L0.7540.90
125_P128_A0.7490.89
159_Y162_L0.7490.89
11_Y42_G0.7460.89
49_E54_G0.7400.89
21_I34_I0.7400.89
7_V25_A0.7390.89
82_V86_K0.7340.88
120_Y124_A0.7330.88
142_P160_N0.7240.88
5_L67_L0.7240.88
145_S180_G0.7210.88
18_P36_D0.7190.87
65_V144_V0.7180.87
106_G109_T0.7170.87
23_A49_E0.7110.87
33_A170_L0.7080.87
66_I82_V0.7080.87
55_Q69_N0.7060.86
61_Y99_D0.7030.86
134_E139_L0.7030.86
129_N135_A0.7020.86
24_Y149_A0.7000.86
133_K137_I0.6970.86
79_A82_V0.6970.86
133_K143_G0.6960.86
102_R105_I0.6900.85
78_I113_K0.6890.85
97_P117_I0.6870.85
149_A155_I0.6830.85
43_L53_P0.6830.85
64_V92_V0.6810.84
93_F177_L0.6720.84
23_A127_M0.6700.84
80_E87_E0.6680.83
62_G99_D0.6660.83
20_D157_S0.6640.83
166_I172_D0.6600.83
16_Y152_I0.6590.83
121_N129_N0.6580.82
11_Y39_T0.6570.82
54_G149_A0.6540.82
22_I32_V0.6540.82
106_G112_Y0.6530.82
131_K138_R0.6480.81
144_V162_L0.6460.81
116_L177_L0.6460.81
33_A52_I0.6400.81
77_R83_D0.6390.81
69_N90_C0.6370.80
162_L176_N0.6350.80
86_K113_K0.6340.80
162_L167_E0.6300.80
76_N81_L0.6300.80
59_T78_I0.6280.79
25_A147_S0.6270.79
9_S42_G0.6250.79
69_N88_N0.6210.79
43_L85_A0.6210.79
100_I105_I0.6130.78
113_K141_L0.6120.78
80_E175_D0.6120.78
86_K91_V0.6110.78
171_D175_D0.6040.77
89_S113_K0.6020.76
107_D111_R0.6010.76
119_I136_S0.6010.76
73_S76_N0.6000.76
106_G110_F0.6000.76
64_V78_I0.6000.76
98_F135_A0.5990.76
166_I171_D0.5970.76
91_V177_L0.5960.76
30_I147_S0.5950.76
22_I51_V0.5950.76
93_F146_N0.5900.75
59_T64_V0.5890.75
98_F129_N0.5870.75
175_D181_K0.5850.74
61_Y78_I0.5850.74
9_S149_A0.5840.74
66_I81_L0.5820.74
47_K50_K0.5810.74
52_I94_P0.5790.74
66_I88_N0.5770.73
48_E80_E0.5760.73
16_Y21_I0.5750.73
7_V54_G0.5730.73
62_G98_F0.5710.73
130_N133_K0.5710.73
66_I92_V0.5700.73
94_P146_N0.5690.72
18_P99_D0.5680.72
4_D156_G0.5660.72
10_R14_G0.5660.72
131_K136_S0.5640.72
69_N170_L0.5630.72
64_V114_F0.5620.72
58_T95_S0.5610.71
145_S151_V0.5600.71
9_S36_D0.5580.71
105_I108_K0.5570.71
121_N145_S0.5570.71
110_F179_R0.5540.70
79_A112_Y0.5530.70
137_I171_D0.5510.70
155_I162_L0.5500.70
53_P63_H0.5490.70
137_I140_N0.5450.69
103_K107_D0.5450.69
96_H148_D0.5450.69
84_Y137_I0.5410.69
122_S146_N0.5410.69
55_Q63_H0.5390.68
8_H148_D0.5380.68
68_C85_A0.5340.68
33_A173_I0.5330.68
101_F146_N0.5330.68
57_V81_L0.5320.67
96_H150_H0.5320.67
130_N134_E0.5320.67
116_L144_V0.5320.67
162_L173_I0.5320.67
26_K50_K0.5310.67
57_V61_Y0.5290.67
23_A87_E0.5280.67
87_E130_N0.5270.67
9_S54_G0.5220.66
9_S14_G0.5190.65
132_A141_L0.5170.65
63_H96_H0.5160.65
34_I45_T0.5160.65
19_K140_N0.5140.65
14_G17_L0.5090.64
12_S36_D0.5080.64
136_S143_G0.5070.64
99_D123_K0.5070.64
34_I51_V0.5030.63
46_V49_E0.5020.63
4_D25_A0.5000.63
124_A157_S0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o0fA 1 0.8265 100 0.466 Contact Map
3e38A 4 0.9772 100 0.468 Contact Map
2yb1A 1 0.8402 100 0.476 Contact Map
2anuA 5 0.7991 100 0.477 Contact Map
2wjeA 1 0.8584 99.9 0.59 Contact Map
2w9mA 1 0.8311 99.9 0.593 Contact Map
1m65A 3 0.895 99.9 0.596 Contact Map
4gc3A 1 0.8265 99.9 0.607 Contact Map
2hnhA 1 0.9361 99.8 0.622 Contact Map
4gx8A 1 0.9406 99.8 0.622 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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