GREMLIN Database
Q97ZL8 - Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (Asd-1)
UniProt: Q97ZL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (297)
Sequences: 7269 (3884)
Seq/√Len: 225.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_V320_L3.7851.00
161_K165_R3.7271.00
8_S78_V3.4191.00
6_K31_E3.3351.00
152_T178_Q3.1771.00
170_N253_D2.9931.00
286_I307_A2.9801.00
286_I309_T2.9181.00
148_N340_T2.8541.00
103_I344_M2.7301.00
45_K64_E2.7141.00
263_K267_S2.5601.00
197_V238_V2.5211.00
171_A251_V2.5071.00
257_D260_E2.4271.00
80_V341_L2.4211.00
27_H342_E2.3461.00
156_L174_I2.2701.00
159_P248_I2.2291.00
30_I341_L2.2061.00
45_K66_P2.1301.00
155_I246_G2.1211.00
19_K22_R2.0511.00
23_M338_I2.0161.00
156_L246_G1.9961.00
331_R339_L1.9941.00
82_L341_L1.9901.00
47_K64_E1.9871.00
175_V247_V1.9751.00
39_P69_S1.9641.00
260_E263_K1.9441.00
165_R268_F1.9401.00
262_Q266_D1.9241.00
159_P322_L1.9201.00
155_I326_G1.9201.00
146_V344_M1.9121.00
166_L264_A1.8901.00
24_L30_I1.8701.00
91_E110_P1.8601.00
20_M82_L1.8501.00
152_T176_T1.8501.00
5_I345_K1.8491.00
170_N251_V1.8421.00
70_T93_V1.8221.00
163_L252_T1.8191.00
12_S35_V1.7681.00
157_S215_M1.7231.00
19_K242_V1.7211.00
206_E213_N1.7191.00
160_I172_T1.6981.00
290_D293_R1.6781.00
7_V30_I1.6331.00
240_V296_P1.6301.00
266_D289_K1.6291.00
258_E262_Q1.6271.00
185_Y189_P1.6191.00
34_K68_V1.5901.00
7_V80_V1.5861.00
173_Y249_N1.5721.00
176_T246_G1.5591.00
262_Q290_D1.5501.00
44_K48_D1.5471.00
248_I324_V1.5471.00
159_P324_V1.5431.00
6_K32_L1.5351.00
330_V335_G1.5311.00
92_D96_K1.5061.00
166_L260_E1.4831.00
262_Q289_K1.4811.00
76_K100_Q1.4791.00
258_E313_V1.4731.00
202_K210_K1.4651.00
41_K44_K1.4581.00
96_K99_K1.4551.00
21_V32_L1.4531.00
127_E144_L1.4451.00
163_L320_L1.4411.00
265_L322_L1.4371.00
6_K79_D1.4341.00
306_M330_V1.4161.00
16_V334_A1.4081.00
98_V145_L1.3981.00
103_I144_L1.3971.00
163_L265_L1.3941.00
6_K33_V1.3761.00
10_L83_S1.3721.00
156_L248_I1.3661.00
255_N315_F1.3561.00
88_E110_P1.3471.00
263_K266_D1.3401.00
83_S94_E1.3391.00
251_V319_V1.3301.00
25_S61_N1.3301.00
81_V102_K1.3131.00
200_W294_P1.3131.00
93_V96_K1.3051.00
8_S81_V1.2691.00
194_D241_K1.2641.00
95_L99_K1.2591.00
248_I322_L1.2531.00
174_I248_I1.2491.00
75_H97_L1.2491.00
71_E74_D1.2401.00
306_M335_G1.2381.00
226_S229_L1.2351.00
80_V345_K1.2321.00
45_K48_D1.2301.00
308_V326_G1.2211.00
156_L212_I1.2001.00
259_K263_K1.1991.00
30_I33_V1.1911.00
168_K253_D1.1791.00
183_A187_G1.1771.00
159_P265_L1.1761.00
252_T320_L1.1721.00
262_Q287_V1.1581.00
175_V249_N1.1521.00
245_M325_L1.1521.00
255_N318_N1.1461.00
161_K219_F1.1251.00
250_I320_L1.1191.00
288_F301_Q1.1191.00
265_L287_V1.1111.00
288_F309_T1.1041.00
171_A319_V1.1031.00
103_I146_V1.1021.00
160_I250_I1.0971.00
181_S241_K1.0951.00
126_W343_V1.0951.00
155_I176_T1.0891.00
91_E120_I1.0811.00
308_V324_V1.0731.00
114_D218_K1.0661.00
330_V338_I1.0651.00
167_I256_V1.0621.00
177_L238_V1.0621.00
94_E104_V1.0591.00
250_I322_L1.0551.00
13_T67_I1.0531.00
192_A195_G1.0471.00
254_D260_E1.0461.00
201_I207_K1.0391.00
172_T250_I1.0361.00
96_K100_Q1.0351.00
34_K78_V1.0291.00
245_M323_V1.0261.00
187_G191_M1.0251.00
258_E315_F1.0191.00
23_M335_G1.0191.00
213_N316_E1.0171.00
21_V46_Y1.0091.00
35_V65_L1.0041.00
5_I80_V0.9911.00
158_M308_V0.9891.00
78_V81_V0.9881.00
243_G328_N0.9831.00
159_P162_P0.9691.00
301_Q309_T0.9691.00
16_V333_A0.9671.00
121_N157_S0.9651.00
177_L249_N0.9631.00
8_S34_K0.9581.00
72_Y96_K0.9571.00
94_E145_L0.9551.00
164_E226_S0.9521.00
252_T256_V0.9491.00
163_L261_V0.9481.00
238_V296_P0.9471.00
105_V341_L0.9451.00
195_G300_L0.9421.00
82_L337_T0.9411.00
232_H249_N0.9361.00
116_D143_G0.9331.00
249_N321_R0.9321.00
69_S73_E0.9301.00
230_E317_G0.9241.00
259_K262_Q0.9241.00
305_G309_T0.9150.99
97_L104_V0.9130.99
22_R26_K0.9120.99
189_P192_A0.9050.99
236_T247_V0.9050.99
111_F121_N0.9020.99
42_I69_S0.8920.99
35_V46_Y0.8910.99
314_K317_G0.8900.99
267_S270_S0.8880.99
155_I324_V0.8850.99
119_L125_N0.8830.99
180_V193_I0.8830.99
10_L70_T0.8820.99
166_L267_S0.8740.99
188_L191_M0.8690.99
21_V35_V0.8650.99
160_I248_I0.8650.99
28_P61_N0.8650.99
341_L345_K0.8610.99
119_L122_P0.8560.99
127_E130_E0.8550.99
81_V97_L0.8530.99
85_L108_A0.8510.99
13_T38_S0.8490.99
73_E100_Q0.8480.99
89_L92_D0.8470.99
153_A201_I0.8460.99
183_A198_V0.8420.99
197_V236_T0.8390.99
151_C182_G0.8380.99
166_L254_D0.8380.99
38_S41_K0.8360.99
310_V322_L0.8360.99
80_V103_I0.8330.99
220_E229_L0.8250.99
242_V329_L0.8170.99
33_V78_V0.8170.99
41_K67_I0.8160.99
148_N333_A0.8080.99
140_N344_M0.8080.99
255_N264_A0.8070.99
88_E91_E0.8010.99
213_N217_G0.8010.99
196_N295_Q0.7990.99
69_S74_D0.7970.99
164_E169_I0.7970.99
69_S72_Y0.7940.99
23_M330_V0.7930.99
95_L98_V0.7900.99
175_V236_T0.7880.98
62_V65_L0.7880.98
72_Y92_D0.7870.98
158_M268_F0.7800.98
290_D295_Q0.7730.98
177_L236_T0.7730.98
302_Y309_T0.7720.98
129_L343_V0.7710.98
155_I325_L0.7680.98
161_K164_E0.7660.98
27_H306_M0.7650.98
76_K99_K0.7640.98
85_L89_L0.7620.98
37_A41_K0.7580.98
160_I174_I0.7550.98
295_Q301_Q0.7530.98
32_L63_A0.7510.98
247_V321_R0.7460.98
247_V323_V0.7450.98
9_L24_L0.7440.98
85_L90_A0.7440.98
167_I257_D0.7410.98
24_L32_L0.7400.98
12_S17_G0.7390.98
252_T261_V0.7380.98
113_M210_K0.7380.98
154_A336_I0.7330.98
256_V261_V0.7300.98
256_V264_A0.7250.97
259_K290_D0.7250.97
213_N230_E0.7240.97
66_P69_S0.7230.97
97_L108_A0.7220.97
126_W130_E0.7190.97
107_N148_N0.7170.97
107_N336_I0.7150.97
80_V105_V0.7150.97
252_T255_N0.7140.97
114_D214_K0.7140.97
165_R267_S0.7140.97
25_S63_A0.7140.97
123_E331_R0.7130.97
113_M147_K0.7120.97
241_K303_Y0.7110.97
174_I246_G0.7090.97
32_L68_V0.7080.97
262_Q313_V0.7060.97
313_V320_L0.7030.97
174_I212_I0.7020.97
168_K264_A0.6980.97
199_P323_V0.6970.97
167_I264_A0.6950.97
220_E227_S0.6910.97
46_Y67_I0.6890.96
5_I79_D0.6880.96
153_A157_S0.6850.96
220_E226_S0.6840.96
167_I260_E0.6820.96
177_L197_V0.6790.96
295_Q300_L0.6790.96
258_E261_V0.6770.96
199_P236_T0.6770.96
113_M214_K0.6730.96
292_D295_Q0.6720.96
32_L35_V0.6710.96
95_L111_F0.6690.96
293_R311_G0.6690.96
105_V344_M0.6680.96
112_R211_E0.6660.96
199_P245_M0.6640.96
343_V346_E0.6630.96
209_P213_N0.6590.95
291_E295_Q0.6570.95
9_L20_M0.6570.95
47_K63_A0.6550.95
198_V295_Q0.6540.95
65_L68_V0.6540.95
6_K34_K0.6530.95
33_V65_L0.6520.95
163_L250_I0.6510.95
167_I253_D0.6510.95
67_I70_T0.6510.95
243_G303_Y0.6490.95
30_I345_K0.6460.95
204_E213_N0.6440.95
287_V313_V0.6440.95
22_R25_S0.6440.95
95_L104_V0.6440.95
30_I48_D0.6440.95
215_M218_K0.6400.95
291_E294_P0.6400.95
30_I34_K0.6400.95
164_E172_T0.6380.95
9_L21_V0.6360.95
26_K330_V0.6320.94
190_F198_V0.6320.94
122_P126_W0.6230.94
155_I244_H0.6210.94
15_M188_L0.6200.94
83_S104_V0.6180.94
143_G146_V0.6180.94
246_G324_V0.6170.94
309_T325_L0.6160.94
232_H321_R0.6150.93
125_N128_H0.6150.93
129_L140_N0.6140.93
174_I233_P0.6110.93
204_E217_G0.6080.93
78_V102_K0.6070.93
109_S210_K0.6050.93
155_I308_V0.6040.93
90_A111_F0.6040.93
68_V77_D0.6030.93
173_Y251_V0.6020.93
94_E97_L0.6010.93
118_P125_N0.6010.93
47_K62_V0.6010.93
140_N343_V0.6000.93
24_L338_I0.5980.93
168_K252_T0.5970.92
159_P308_V0.5970.92
68_V74_D0.5940.92
74_D77_D0.5930.92
7_V341_L0.5920.92
242_V303_Y0.5920.92
124_V158_M0.5920.92
173_Y247_V0.5910.92
83_S97_L0.5900.92
252_T313_V0.5900.92
82_L105_V0.5890.92
242_V328_N0.5890.92
257_D315_F0.5890.92
83_S90_A0.5860.92
243_G302_Y0.5850.92
320_L323_V0.5830.92
219_F229_L0.5800.91
30_I35_V0.5800.91
155_I328_N0.5790.91
10_L85_L0.5790.91
268_F285_I0.5770.91
168_K256_V0.5760.91
312_R315_F0.5760.91
34_K77_D0.5750.91
87_N109_S0.5740.91
293_R323_V0.5740.91
265_L285_I0.5730.91
12_S67_I0.5720.91
24_L341_L0.5680.90
72_Y100_Q0.5670.90
161_K268_F0.5670.90
151_C211_E0.5660.90
88_E117_V0.5640.90
118_P143_G0.5640.90
88_E108_A0.5630.90
6_K78_V0.5630.90
179_A242_V0.5630.90
103_I345_K0.5610.90
63_A67_I0.5610.90
29_Y341_L0.5590.90
63_A66_P0.5590.90
266_D270_S0.5520.89
117_V120_I0.5520.89
7_V29_Y0.5520.89
156_L176_T0.5510.89
61_N64_E0.5510.89
217_G220_E0.5490.89
149_P154_A0.5480.89
7_V82_L0.5480.89
112_R151_C0.5470.89
255_N317_G0.5460.89
153_A246_G0.5460.89
20_M338_I0.5450.89
38_S43_G0.5420.88
140_N143_G0.5420.88
82_L338_I0.5420.88
97_L102_K0.5400.88
196_N300_L0.5390.88
201_I205_E0.5380.88
97_L100_Q0.5370.88
75_H102_K0.5340.88
156_L324_V0.5340.88
129_L146_V0.5330.88
154_A326_G0.5330.88
174_I231_I0.5320.87
342_E346_E0.5290.87
108_A337_T0.5280.87
42_I66_P0.5270.87
89_L108_A0.5250.87
288_F311_G0.5240.87
336_I340_T0.5240.87
169_I250_I0.5230.87
288_F295_Q0.5210.86
123_E339_L0.5200.86
302_Y305_G0.5190.86
182_G211_E0.5180.86
232_H319_V0.5170.86
71_E93_V0.5170.86
150_N214_K0.5160.86
112_R182_G0.5150.86
11_G14_G0.5140.86
121_N124_V0.5130.86
202_K323_V0.5130.86
204_E208_I0.5120.85
23_M26_K0.5120.85
238_V244_H0.5110.85
217_G229_L0.5110.85
159_P310_V0.5100.85
37_A67_I0.5100.85
91_E114_D0.5090.85
156_L172_T0.5090.85
123_E126_W0.5080.85
187_G190_F0.5080.85
71_E96_K0.5080.85
21_V25_S0.5080.85
314_K319_V0.5030.84
30_I65_L0.5030.84
63_A69_S0.5020.84
75_H78_V0.5020.84
128_H145_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hskA 4 0.9829 100 0.235 Contact Map
1vknA 4 0.8971 100 0.243 Contact Map
2ep5A 4 0.9886 100 0.248 Contact Map
4dplA 4 0.9829 100 0.258 Contact Map
1xygA 4 0.9143 100 0.269 Contact Map
1ys4A 4 0.9714 100 0.272 Contact Map
2yv3A 2 0.8629 100 0.291 Contact Map
3uw3A 2 0.8857 100 0.295 Contact Map
2nqtA 4 0.8886 100 0.299 Contact Map
3pzrA 2 0.8829 100 0.305 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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