Q97ZL8 - SULSO - GREMLIN Contacts

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Q97ZL8 - Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (Asd-1)

UniProt:	Q97ZL8	Sequences: MADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKDAVKWIEPGDIPENVAELPIVSTEYEDHKDVDVVLSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLINPEVNWEHLELLKYQKSSKNWNGLLVKNPNCTAAILSMPIKPLERLIKINATYIVTLQAVSGAGYSGLPFMAIDGNVVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPVKVGHMGVINIVTDDNVDEKEVQKALDSFASLPQHKNLPTAPNKPIIVFKDEDRPQPARDLQYYDGMAVTVGRVKFEGNVLRLVVLGDNLVRGAAGITILTLEVMKELGYF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	350 (297)
Sequences:	7269 (3884)
Seq/√Len:	225.4

ECOLI - USG ARGC DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - Q97ZL8 Q97WN3 ARGC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_V	320_L	3.785	1.00
161_K	165_R	3.727	1.00
8_S	78_V	3.419	1.00
6_K	31_E	3.335	1.00
152_T	178_Q	3.177	1.00
170_N	253_D	2.993	1.00
286_I	307_A	2.980	1.00
286_I	309_T	2.918	1.00
148_N	340_T	2.854	1.00
103_I	344_M	2.730	1.00
45_K	64_E	2.714	1.00
263_K	267_S	2.560	1.00
197_V	238_V	2.521	1.00
171_A	251_V	2.507	1.00
257_D	260_E	2.427	1.00
80_V	341_L	2.421	1.00
27_H	342_E	2.346	1.00
156_L	174_I	2.270	1.00
159_P	248_I	2.229	1.00
30_I	341_L	2.206	1.00
45_K	66_P	2.130	1.00
155_I	246_G	2.121	1.00
19_K	22_R	2.051	1.00
23_M	338_I	2.016	1.00
156_L	246_G	1.996	1.00
331_R	339_L	1.994	1.00
82_L	341_L	1.990	1.00
47_K	64_E	1.987	1.00
175_V	247_V	1.975	1.00
39_P	69_S	1.964	1.00
260_E	263_K	1.944	1.00
165_R	268_F	1.940	1.00
262_Q	266_D	1.924	1.00
159_P	322_L	1.920	1.00
155_I	326_G	1.920	1.00
146_V	344_M	1.912	1.00
166_L	264_A	1.890	1.00
24_L	30_I	1.870	1.00
91_E	110_P	1.860	1.00
20_M	82_L	1.850	1.00
152_T	176_T	1.850	1.00
5_I	345_K	1.849	1.00
170_N	251_V	1.842	1.00
70_T	93_V	1.822	1.00
163_L	252_T	1.819	1.00
12_S	35_V	1.768	1.00
157_S	215_M	1.723	1.00
19_K	242_V	1.721	1.00
206_E	213_N	1.719	1.00
160_I	172_T	1.698	1.00
290_D	293_R	1.678	1.00
7_V	30_I	1.633	1.00
240_V	296_P	1.630	1.00
266_D	289_K	1.629	1.00
258_E	262_Q	1.627	1.00
185_Y	189_P	1.619	1.00
34_K	68_V	1.590	1.00
7_V	80_V	1.586	1.00
173_Y	249_N	1.572	1.00
176_T	246_G	1.559	1.00
262_Q	290_D	1.550	1.00
44_K	48_D	1.547	1.00
248_I	324_V	1.547	1.00
159_P	324_V	1.543	1.00
6_K	32_L	1.535	1.00
330_V	335_G	1.531	1.00
92_D	96_K	1.506	1.00
166_L	260_E	1.483	1.00
262_Q	289_K	1.481	1.00
76_K	100_Q	1.479	1.00
258_E	313_V	1.473	1.00
202_K	210_K	1.465	1.00
41_K	44_K	1.458	1.00
96_K	99_K	1.455	1.00
21_V	32_L	1.453	1.00
127_E	144_L	1.445	1.00
163_L	320_L	1.441	1.00
265_L	322_L	1.437	1.00
6_K	79_D	1.434	1.00
306_M	330_V	1.416	1.00
16_V	334_A	1.408	1.00
98_V	145_L	1.398	1.00
103_I	144_L	1.397	1.00
163_L	265_L	1.394	1.00
6_K	33_V	1.376	1.00
10_L	83_S	1.372	1.00
156_L	248_I	1.366	1.00
255_N	315_F	1.356	1.00
88_E	110_P	1.347	1.00
263_K	266_D	1.340	1.00
83_S	94_E	1.339	1.00
251_V	319_V	1.330	1.00
25_S	61_N	1.330	1.00
81_V	102_K	1.313	1.00
200_W	294_P	1.313	1.00
93_V	96_K	1.305	1.00
8_S	81_V	1.269	1.00
194_D	241_K	1.264	1.00
95_L	99_K	1.259	1.00
248_I	322_L	1.253	1.00
174_I	248_I	1.249	1.00
75_H	97_L	1.249	1.00
71_E	74_D	1.240	1.00
306_M	335_G	1.238	1.00
226_S	229_L	1.235	1.00
80_V	345_K	1.232	1.00
45_K	48_D	1.230	1.00
308_V	326_G	1.221	1.00
156_L	212_I	1.200	1.00
259_K	263_K	1.199	1.00
30_I	33_V	1.191	1.00
168_K	253_D	1.179	1.00
183_A	187_G	1.177	1.00
159_P	265_L	1.176	1.00
252_T	320_L	1.172	1.00
262_Q	287_V	1.158	1.00
175_V	249_N	1.152	1.00
245_M	325_L	1.152	1.00
255_N	318_N	1.146	1.00
161_K	219_F	1.125	1.00
250_I	320_L	1.119	1.00
288_F	301_Q	1.119	1.00
265_L	287_V	1.111	1.00
288_F	309_T	1.104	1.00
171_A	319_V	1.103	1.00
103_I	146_V	1.102	1.00
160_I	250_I	1.097	1.00
181_S	241_K	1.095	1.00
126_W	343_V	1.095	1.00
155_I	176_T	1.089	1.00
91_E	120_I	1.081	1.00
308_V	324_V	1.073	1.00
114_D	218_K	1.066	1.00
330_V	338_I	1.065	1.00
167_I	256_V	1.062	1.00
177_L	238_V	1.062	1.00
94_E	104_V	1.059	1.00
250_I	322_L	1.055	1.00
13_T	67_I	1.053	1.00
192_A	195_G	1.047	1.00
254_D	260_E	1.046	1.00
201_I	207_K	1.039	1.00
172_T	250_I	1.036	1.00
96_K	100_Q	1.035	1.00
34_K	78_V	1.029	1.00
245_M	323_V	1.026	1.00
187_G	191_M	1.025	1.00
258_E	315_F	1.019	1.00
23_M	335_G	1.019	1.00
213_N	316_E	1.017	1.00
21_V	46_Y	1.009	1.00
35_V	65_L	1.004	1.00
5_I	80_V	0.991	1.00
158_M	308_V	0.989	1.00
78_V	81_V	0.988	1.00
243_G	328_N	0.983	1.00
159_P	162_P	0.969	1.00
301_Q	309_T	0.969	1.00
16_V	333_A	0.967	1.00
121_N	157_S	0.965	1.00
177_L	249_N	0.963	1.00
8_S	34_K	0.958	1.00
72_Y	96_K	0.957	1.00
94_E	145_L	0.955	1.00
164_E	226_S	0.952	1.00
252_T	256_V	0.949	1.00
163_L	261_V	0.948	1.00
238_V	296_P	0.947	1.00
105_V	341_L	0.945	1.00
195_G	300_L	0.942	1.00
82_L	337_T	0.941	1.00
232_H	249_N	0.936	1.00
116_D	143_G	0.933	1.00
249_N	321_R	0.932	1.00
69_S	73_E	0.930	1.00
230_E	317_G	0.924	1.00
259_K	262_Q	0.924	1.00
305_G	309_T	0.915	0.99
97_L	104_V	0.913	0.99
22_R	26_K	0.912	0.99
189_P	192_A	0.905	0.99
236_T	247_V	0.905	0.99
111_F	121_N	0.902	0.99
42_I	69_S	0.892	0.99
35_V	46_Y	0.891	0.99
314_K	317_G	0.890	0.99
267_S	270_S	0.888	0.99
155_I	324_V	0.885	0.99
119_L	125_N	0.883	0.99
180_V	193_I	0.883	0.99
10_L	70_T	0.882	0.99
166_L	267_S	0.874	0.99
188_L	191_M	0.869	0.99
21_V	35_V	0.865	0.99
160_I	248_I	0.865	0.99
28_P	61_N	0.865	0.99
341_L	345_K	0.861	0.99
119_L	122_P	0.856	0.99
127_E	130_E	0.855	0.99
81_V	97_L	0.853	0.99
85_L	108_A	0.851	0.99
13_T	38_S	0.849	0.99
73_E	100_Q	0.848	0.99
89_L	92_D	0.847	0.99
153_A	201_I	0.846	0.99
183_A	198_V	0.842	0.99
197_V	236_T	0.839	0.99
151_C	182_G	0.838	0.99
166_L	254_D	0.838	0.99
38_S	41_K	0.836	0.99
310_V	322_L	0.836	0.99
80_V	103_I	0.833	0.99
220_E	229_L	0.825	0.99
242_V	329_L	0.817	0.99
33_V	78_V	0.817	0.99
41_K	67_I	0.816	0.99
148_N	333_A	0.808	0.99
140_N	344_M	0.808	0.99
255_N	264_A	0.807	0.99
88_E	91_E	0.801	0.99
213_N	217_G	0.801	0.99
196_N	295_Q	0.799	0.99
69_S	74_D	0.797	0.99
164_E	169_I	0.797	0.99
69_S	72_Y	0.794	0.99
23_M	330_V	0.793	0.99
95_L	98_V	0.790	0.99
175_V	236_T	0.788	0.98
62_V	65_L	0.788	0.98
72_Y	92_D	0.787	0.98
158_M	268_F	0.780	0.98
290_D	295_Q	0.773	0.98
177_L	236_T	0.773	0.98
302_Y	309_T	0.772	0.98
129_L	343_V	0.771	0.98
155_I	325_L	0.768	0.98
161_K	164_E	0.766	0.98
27_H	306_M	0.765	0.98
76_K	99_K	0.764	0.98
85_L	89_L	0.762	0.98
37_A	41_K	0.758	0.98
160_I	174_I	0.755	0.98
295_Q	301_Q	0.753	0.98
32_L	63_A	0.751	0.98
247_V	321_R	0.746	0.98
247_V	323_V	0.745	0.98
9_L	24_L	0.744	0.98
85_L	90_A	0.744	0.98
167_I	257_D	0.741	0.98
24_L	32_L	0.740	0.98
12_S	17_G	0.739	0.98
252_T	261_V	0.738	0.98
113_M	210_K	0.738	0.98
154_A	336_I	0.733	0.98
256_V	261_V	0.730	0.98
256_V	264_A	0.725	0.97
259_K	290_D	0.725	0.97
213_N	230_E	0.724	0.97
66_P	69_S	0.723	0.97
97_L	108_A	0.722	0.97
126_W	130_E	0.719	0.97
107_N	148_N	0.717	0.97
107_N	336_I	0.715	0.97
80_V	105_V	0.715	0.97
252_T	255_N	0.714	0.97
114_D	214_K	0.714	0.97
165_R	267_S	0.714	0.97
25_S	63_A	0.714	0.97
123_E	331_R	0.713	0.97
113_M	147_K	0.712	0.97
241_K	303_Y	0.711	0.97
174_I	246_G	0.709	0.97
32_L	68_V	0.708	0.97
262_Q	313_V	0.706	0.97
313_V	320_L	0.703	0.97
174_I	212_I	0.702	0.97
168_K	264_A	0.698	0.97
199_P	323_V	0.697	0.97
167_I	264_A	0.695	0.97
220_E	227_S	0.691	0.97
46_Y	67_I	0.689	0.96
5_I	79_D	0.688	0.96
153_A	157_S	0.685	0.96
220_E	226_S	0.684	0.96
167_I	260_E	0.682	0.96
177_L	197_V	0.679	0.96
295_Q	300_L	0.679	0.96
258_E	261_V	0.677	0.96
199_P	236_T	0.677	0.96
113_M	214_K	0.673	0.96
292_D	295_Q	0.672	0.96
32_L	35_V	0.671	0.96
95_L	111_F	0.669	0.96
293_R	311_G	0.669	0.96
105_V	344_M	0.668	0.96
112_R	211_E	0.666	0.96
199_P	245_M	0.664	0.96
343_V	346_E	0.663	0.96
209_P	213_N	0.659	0.95
291_E	295_Q	0.657	0.95
9_L	20_M	0.657	0.95
47_K	63_A	0.655	0.95
198_V	295_Q	0.654	0.95
65_L	68_V	0.654	0.95
6_K	34_K	0.653	0.95
33_V	65_L	0.652	0.95
163_L	250_I	0.651	0.95
167_I	253_D	0.651	0.95
67_I	70_T	0.651	0.95
243_G	303_Y	0.649	0.95
30_I	345_K	0.646	0.95
204_E	213_N	0.644	0.95
287_V	313_V	0.644	0.95
22_R	25_S	0.644	0.95
95_L	104_V	0.644	0.95
30_I	48_D	0.644	0.95
215_M	218_K	0.640	0.95
291_E	294_P	0.640	0.95
30_I	34_K	0.640	0.95
164_E	172_T	0.638	0.95
9_L	21_V	0.636	0.95
26_K	330_V	0.632	0.94
190_F	198_V	0.632	0.94
122_P	126_W	0.623	0.94
155_I	244_H	0.621	0.94
15_M	188_L	0.620	0.94
83_S	104_V	0.618	0.94
143_G	146_V	0.618	0.94
246_G	324_V	0.617	0.94
309_T	325_L	0.616	0.94
232_H	321_R	0.615	0.93
125_N	128_H	0.615	0.93
129_L	140_N	0.614	0.93
174_I	233_P	0.611	0.93
204_E	217_G	0.608	0.93
78_V	102_K	0.607	0.93
109_S	210_K	0.605	0.93
155_I	308_V	0.604	0.93
90_A	111_F	0.604	0.93
68_V	77_D	0.603	0.93
173_Y	251_V	0.602	0.93
94_E	97_L	0.601	0.93
118_P	125_N	0.601	0.93
47_K	62_V	0.601	0.93
140_N	343_V	0.600	0.93
24_L	338_I	0.598	0.93
168_K	252_T	0.597	0.92
159_P	308_V	0.597	0.92
68_V	74_D	0.594	0.92
74_D	77_D	0.593	0.92
7_V	341_L	0.592	0.92
242_V	303_Y	0.592	0.92
124_V	158_M	0.592	0.92
173_Y	247_V	0.591	0.92
83_S	97_L	0.590	0.92
252_T	313_V	0.590	0.92
82_L	105_V	0.589	0.92
242_V	328_N	0.589	0.92
257_D	315_F	0.589	0.92
83_S	90_A	0.586	0.92
243_G	302_Y	0.585	0.92
320_L	323_V	0.583	0.92
219_F	229_L	0.580	0.91
30_I	35_V	0.580	0.91
155_I	328_N	0.579	0.91
10_L	85_L	0.579	0.91
268_F	285_I	0.577	0.91
168_K	256_V	0.576	0.91
312_R	315_F	0.576	0.91
34_K	77_D	0.575	0.91
87_N	109_S	0.574	0.91
293_R	323_V	0.574	0.91
265_L	285_I	0.573	0.91
12_S	67_I	0.572	0.91
24_L	341_L	0.568	0.90
72_Y	100_Q	0.567	0.90
161_K	268_F	0.567	0.90
151_C	211_E	0.566	0.90
88_E	117_V	0.564	0.90
118_P	143_G	0.564	0.90
88_E	108_A	0.563	0.90
6_K	78_V	0.563	0.90
179_A	242_V	0.563	0.90
103_I	345_K	0.561	0.90
63_A	67_I	0.561	0.90
29_Y	341_L	0.559	0.90
63_A	66_P	0.559	0.90
266_D	270_S	0.552	0.89
117_V	120_I	0.552	0.89
7_V	29_Y	0.552	0.89
156_L	176_T	0.551	0.89
61_N	64_E	0.551	0.89
217_G	220_E	0.549	0.89
149_P	154_A	0.548	0.89
7_V	82_L	0.548	0.89
112_R	151_C	0.547	0.89
255_N	317_G	0.546	0.89
153_A	246_G	0.546	0.89
20_M	338_I	0.545	0.89
38_S	43_G	0.542	0.88
140_N	143_G	0.542	0.88
82_L	338_I	0.542	0.88
97_L	102_K	0.540	0.88
196_N	300_L	0.539	0.88
201_I	205_E	0.538	0.88
97_L	100_Q	0.537	0.88
75_H	102_K	0.534	0.88
156_L	324_V	0.534	0.88
129_L	146_V	0.533	0.88
154_A	326_G	0.533	0.88
174_I	231_I	0.532	0.87
342_E	346_E	0.529	0.87
108_A	337_T	0.528	0.87
42_I	66_P	0.527	0.87
89_L	108_A	0.525	0.87
288_F	311_G	0.524	0.87
336_I	340_T	0.524	0.87
169_I	250_I	0.523	0.87
288_F	295_Q	0.521	0.86
123_E	339_L	0.520	0.86
302_Y	305_G	0.519	0.86
182_G	211_E	0.518	0.86
232_H	319_V	0.517	0.86
71_E	93_V	0.517	0.86
150_N	214_K	0.516	0.86
112_R	182_G	0.515	0.86
11_G	14_G	0.514	0.86
121_N	124_V	0.513	0.86
202_K	323_V	0.513	0.86
204_E	208_I	0.512	0.85
23_M	26_K	0.512	0.85
238_V	244_H	0.511	0.85
217_G	229_L	0.511	0.85
159_P	310_V	0.510	0.85
37_A	67_I	0.510	0.85
91_E	114_D	0.509	0.85
156_L	172_T	0.509	0.85
123_E	126_W	0.508	0.85
187_G	190_F	0.508	0.85
71_E	96_K	0.508	0.85
21_V	25_S	0.508	0.85
314_K	319_V	0.503	0.84
30_I	65_L	0.503	0.84
63_A	69_S	0.502	0.84
75_H	78_V	0.502	0.84
128_H	145_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hskA	4	0.9829	100	0.235	Contact Map
1vknA	4	0.8971	100	0.243	Contact Map
2ep5A	4	0.9886	100	0.248	Contact Map
4dplA	4	0.9829	100	0.258	Contact Map
1xygA	4	0.9143	100	0.269	Contact Map
1ys4A	4	0.9714	100	0.272	Contact Map
2yv3A	2	0.8629	100	0.291	Contact Map
3uw3A	2	0.8857	100	0.295	Contact Map
2nqtA	4	0.8886	100	0.299	Contact Map
3pzrA	2	0.8829	100	0.305	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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