GREMLIN Database
Q97ZL7 - Aspartokinase
UniProt: Q97ZL7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (425)
Sequences: 3433 (1949)
Seq/√Len: 94.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_T194_R4.7071.00
211_G219_V4.5831.00
183_L210_L4.1921.00
139_I180_V4.1041.00
401_K442_V3.9391.00
218_E277_I3.8071.00
431_E434_K3.7681.00
39_T127_T3.5711.00
277_I288_I3.4931.00
226_P283_E3.2901.00
140_E179_N3.2501.00
309_K357_S3.1411.00
67_Y91_S3.1071.00
18_Y130_L3.1061.00
131_S141_A3.0691.00
68_E72_K3.0341.00
244_R290_N2.8871.00
215_G272_S2.8821.00
253_L389_V2.8381.00
116_D156_G2.8101.00
382_D429_K2.7931.00
334_E369_E2.6721.00
364_L368_E2.6631.00
393_I397_E2.6041.00
142_E179_N2.6031.00
326_A333_K2.5851.00
161_I164_L2.5761.00
74_L129_L2.5501.00
304_L432_G2.5491.00
330_N334_E2.5151.00
42_I73_L2.4841.00
153_E190_T2.4301.00
434_K437_K2.4091.00
135_R140_E2.3541.00
51_S55_N2.3191.00
243_S285_G2.2991.00
36_I214_V2.2691.00
23_K26_Q2.1871.00
406_A435_L2.1801.00
306_D433_E2.1601.00
386_V439_L2.1001.00
50_I119_L2.0961.00
318_I323_G2.0701.00
306_D429_K2.0451.00
169_I210_L1.9881.00
147_P195_Y1.9811.00
151_T196_T1.9711.00
10_S43_K1.9511.00
72_K76_K1.9431.00
26_Q137_N1.9381.00
164_L168_E1.9201.00
397_E420_N1.9041.00
127_T184_P1.9001.00
17_D20_L1.8881.00
167_N171_N1.8601.00
166_K170_A1.8571.00
19_E76_K1.8141.00
36_I183_L1.8061.00
402_V425_F1.7921.00
90_I94_S1.7901.00
220_R277_I1.7671.00
115_R119_L1.7471.00
25_I134_L1.7381.00
25_I37_V1.7341.00
64_T68_E1.7251.00
325_A351_I1.7051.00
218_E288_I1.7001.00
45_V66_I1.6821.00
402_V439_L1.6741.00
269_V276_V1.6511.00
428_N431_E1.6451.00
208_T219_V1.6351.00
155_Y158_A1.6221.00
62_I65_E1.6141.00
313_V328_I1.6141.00
55_N62_I1.6061.00
13_K43_K1.6051.00
335_A369_E1.6041.00
103_S106_V1.6021.00
144_I172_I1.5891.00
368_E371_R1.5861.00
357_S381_N1.5801.00
60_P98_F1.5761.00
93_L128_L1.5751.00
311_I355_V1.5671.00
10_S13_K1.5521.00
64_T67_Y1.5441.00
16_K76_K1.5241.00
397_E410_D1.5131.00
134_L139_I1.5121.00
67_Y71_I1.5111.00
67_Y94_S1.5101.00
71_I75_S1.5061.00
150_L165_S1.5001.00
19_E137_N1.4991.00
245_L300_K1.4931.00
335_A362_R1.4771.00
220_R279_E1.4671.00
140_E178_A1.4641.00
386_V436_A1.4331.00
67_Y98_F1.4311.00
244_R288_I1.4150.99
39_T130_L1.4060.99
341_S426_I1.4010.99
51_S62_I1.3980.99
386_V427_V1.3900.99
219_V269_V1.3890.99
71_I91_S1.3810.99
77_L133_I1.3760.99
210_L214_V1.3730.99
331_E366_K1.3690.99
61_N65_E1.3680.99
168_E171_N1.3550.99
226_P280_S1.3520.99
89_D128_L1.3430.99
416_R420_N1.3410.99
142_E181_I1.3390.99
273_D291_G1.3350.99
206_T210_L1.3350.99
151_T188_G1.3260.99
23_K137_N1.3240.99
393_I420_N1.3210.99
11_I281_L1.3160.99
384_N429_K1.3070.99
152_D158_A1.3060.99
325_A342_I1.3010.99
22_V26_Q1.3000.99
244_R292_E1.2980.99
237_E437_K1.2980.99
382_D428_N1.2950.99
91_S95_D1.2910.99
132_A135_R1.2830.99
51_S54_S1.2720.99
337_V366_K1.2460.99
307_N357_S1.2210.98
325_A339_I1.2100.98
19_E133_I1.2080.98
181_I184_P1.2050.98
36_I210_L1.2050.98
304_L436_A1.2040.98
385_I426_I1.2010.98
23_K27_D1.1950.98
130_L134_L1.1880.98
95_D99_R1.1850.98
33_D217_R1.1840.98
248_E270_F1.1810.98
120_S124_R1.1780.98
309_K381_N1.1780.98
120_S195_Y1.1750.98
133_I137_N1.1690.98
134_L182_V1.1650.98
22_V133_I1.1620.98
66_I94_S1.1610.98
360_A363_L1.1590.98
238_N441_K1.1560.98
3_L33_D1.1470.98
242_I245_L1.1460.98
318_I324_S1.1440.98
332_A353_L1.1410.98
323_G338_N1.1410.98
399_S403_L1.1380.97
146_T183_L1.1360.97
113_R194_R1.1340.97
332_A339_I1.1200.97
131_S143_G1.1200.97
21_I130_L1.1160.97
170_A215_G1.1140.97
152_D155_Y1.1130.97
99_R102_W1.1000.97
15_E73_L1.0950.97
7_I11_I1.0950.97
4_I216_V1.0940.97
54_S115_R1.0940.97
409_Y435_L1.0910.97
310_L352_Q1.0830.97
433_E437_K1.0800.97
14_D21_I1.0790.97
190_T196_T1.0780.96
235_K436_A1.0770.96
93_L96_E1.0700.96
22_V130_L1.0630.96
386_V435_L1.0600.96
204_D224_E1.0580.96
151_T155_Y1.0570.96
402_V423_M1.0490.96
22_V137_N1.0450.96
116_D197_T1.0440.96
225_V260_R1.0400.96
331_E335_A1.0390.96
384_N432_G1.0370.96
61_N64_T1.0340.96
323_G348_E1.0300.95
326_A330_N1.0290.95
148_P189_R1.0280.95
407_S434_K1.0160.95
393_I410_D1.0150.95
229_M239_A1.0090.95
151_T158_A1.0010.95
20_L24_K0.9990.95
48_E65_E0.9950.95
112_P156_G0.9890.94
405_I442_V0.9880.94
367_L378_I0.9870.94
41_A46_T0.9840.94
26_Q139_I0.9800.94
308_A340_I0.9800.94
341_S424_T0.9700.94
67_Y95_D0.9700.94
15_E19_E0.9680.94
116_D188_G0.9660.94
56_T59_S0.9650.94
309_K360_A0.9600.93
343_S415_S0.9600.93
121_F125_M0.9590.93
15_E77_L0.9520.93
45_V69_R0.9510.93
328_I351_I0.9500.93
52_A63_V0.9490.93
12_Q39_T0.9460.93
231_G304_L0.9450.93
141_A180_V0.9450.93
71_I74_L0.9440.93
65_E68_E0.9410.93
53_T118_I0.9410.93
144_I181_I0.9400.93
17_D21_I0.9390.93
47_N200_R0.9380.93
6_K9_G0.9380.93
97_L121_F0.9360.93
361_N381_N0.9300.92
52_A66_I0.9270.92
141_A182_V0.9270.92
63_V98_F0.9240.92
360_A380_V0.9220.92
325_A340_I0.9220.92
57_D61_N0.9190.92
143_G184_P0.9130.92
161_I191_R0.9120.92
15_E76_K0.9090.91
36_I181_I0.9030.91
42_I70_H0.9030.91
388_I402_V0.9020.91
261_L276_V0.9010.91
53_T115_R0.9000.91
202_G224_E0.8960.91
68_E75_S0.8950.91
44_N259_K0.8950.91
399_S410_D0.8920.91
328_I378_I0.8920.91
328_I353_L0.8870.90
231_G236_F0.8850.90
375_V378_I0.8840.90
242_I312_T0.8820.90
341_S354_V0.8780.90
57_D82_E0.8750.90
20_L23_K0.8720.90
416_R423_M0.8710.90
146_T184_P0.8690.89
98_F102_W0.8670.89
59_S62_I0.8650.89
279_E284_D0.8630.89
266_F289_I0.8570.89
171_N175_N0.8550.89
266_F276_V0.8540.89
397_E400_T0.8530.89
413_A417_G0.8530.89
48_E69_R0.8520.89
409_Y434_K0.8510.88
399_S420_N0.8510.88
158_A196_T0.8500.88
160_V209_L0.8490.88
3_L28_F0.8480.88
383_I412_L0.8450.88
146_T210_L0.8440.88
235_K306_D0.8440.88
329_T347_S0.8410.88
318_I348_E0.8380.88
50_I115_R0.8370.88
223_T281_L0.8330.87
307_N429_K0.8290.87
89_D93_L0.8280.87
306_D384_N0.8200.87
38_V210_L0.8180.86
199_G440_H0.8130.86
387_G424_T0.8110.86
231_G240_K0.8110.86
302_I436_A0.8060.86
153_E192_E0.8050.86
131_S135_R0.8040.85
323_G351_I0.8030.85
93_L97_L0.8020.85
229_M261_L0.8000.85
400_T404_S0.8000.85
405_I438_E0.7990.85
320_G325_A0.7990.85
332_A337_V0.7980.85
64_T71_I0.7980.85
362_R365_S0.7970.85
21_I25_I0.7970.85
130_L182_V0.7930.85
151_T164_L0.7920.85
223_T278_V0.7890.84
230_T240_K0.7890.84
131_S182_V0.7830.84
229_M232_D0.7810.84
414_I417_G0.7800.84
385_I424_T0.7790.84
339_I342_I0.7750.83
127_T143_G0.7730.83
208_T265_T0.7700.83
368_E372_G0.7680.83
207_A219_V0.7670.83
410_D414_I0.7670.83
145_I189_R0.7670.83
12_Q21_I0.7670.83
367_L371_R0.7660.83
92_R96_E0.7630.82
371_R375_V0.7630.82
22_V182_V0.7600.82
403_L423_M0.7590.82
28_F35_I0.7560.82
145_I195_Y0.7550.82
322_I325_A0.7530.82
435_L438_E0.7520.81
52_A118_I0.7510.81
14_D42_I0.7500.81
146_T187_I0.7490.81
17_D282_Y0.7490.81
410_D420_N0.7480.81
166_K215_G0.7450.81
404_S442_V0.7440.81
356_D359_S0.7440.81
153_E158_A0.7420.81
58_N61_N0.7420.81
54_S61_N0.7390.80
391_C421_V0.7390.80
317_K375_V0.7380.80
230_T440_H0.7380.80
92_R95_D0.7370.80
308_A354_V0.7360.80
67_Y80_G0.7360.80
221_L228_I0.7340.80
135_R141_A0.7330.80
413_A416_R0.7320.80
346_A418_I0.7310.80
328_I367_L0.7290.79
42_I69_R0.7290.79
335_A366_K0.7270.79
323_G329_T0.7270.79
357_S429_K0.7260.79
198_L224_E0.7250.79
335_A365_S0.7230.79
74_L90_I0.7210.79
247_L279_E0.7200.79
324_S351_I0.7200.79
312_T352_Q0.7200.79
128_L132_A0.7190.78
16_K26_Q0.7180.78
430_D434_K0.7170.78
50_I54_S0.7150.78
15_E42_I0.7130.78
425_F439_L0.7110.78
212_K274_M0.7100.78
340_I354_V0.7100.78
116_D151_T0.7050.77
237_E441_K0.7030.77
76_K79_D0.7030.77
318_I350_T0.7020.77
101_A118_I0.7020.77
402_V442_V0.7000.77
415_S426_I0.7000.77
18_Y24_K0.6990.76
170_A273_D0.6990.76
134_L141_A0.6980.76
55_N58_N0.6960.76
230_T239_A0.6950.76
155_Y196_T0.6940.76
317_K349_T0.6930.76
360_A367_L0.6870.75
240_K244_R0.6850.75
420_N423_M0.6830.75
322_I336_G0.6820.75
244_R294_Q0.6820.75
171_N174_E0.6810.75
145_I148_P0.6800.74
43_K47_N0.6800.74
246_S291_G0.6770.74
436_A442_V0.6770.74
407_S438_E0.6740.74
349_T413_A0.6730.74
54_S57_D0.6730.74
48_E62_I0.6720.74
387_G422_S0.6720.74
116_D196_T0.6720.74
75_S80_G0.6710.74
269_V272_S0.6690.73
201_G265_T0.6680.73
72_K81_K0.6670.73
152_D159_N0.6670.73
89_D92_R0.6670.73
355_V360_A0.6660.73
60_P64_T0.6650.73
22_V134_L0.6640.73
152_D196_T0.6640.73
157_E247_L0.6630.73
121_F124_R0.6610.72
186_F203_S0.6590.72
328_I370_I0.6590.72
122_G200_R0.6580.72
12_Q42_I0.6570.72
331_E370_I0.6570.72
123_E200_R0.6550.72
226_P229_M0.6550.72
340_I349_T0.6540.72
57_D68_E0.6540.72
388_I408_S0.6540.72
357_S382_D0.6520.71
10_S14_D0.6510.71
95_D98_F0.6510.71
365_S368_E0.6490.71
329_T342_I0.6490.71
434_K438_E0.6490.71
14_D17_D0.6490.71
39_T126_A0.6490.71
109_E113_R0.6480.71
393_I405_I0.6460.71
68_E71_I0.6440.70
175_N179_N0.6440.70
151_T168_E0.6430.70
362_R366_K0.6430.70
247_L275_K0.6430.70
77_L367_L0.6420.70
403_L410_D0.6420.70
164_L191_R0.6410.70
75_S79_D0.6400.70
5_V24_K0.6400.70
235_K304_L0.6390.70
25_I130_L0.6380.70
331_E346_A0.6380.70
227_G241_T0.6370.70
221_L259_K0.6370.70
329_T348_E0.6360.70
393_I416_R0.6360.70
256_L387_G0.6350.69
52_A101_A0.6340.69
323_G346_A0.6330.69
13_K42_I0.6300.69
155_Y190_T0.6300.69
26_Q57_D0.6300.69
329_T339_I0.6280.69
36_I206_T0.6280.69
438_E442_V0.6260.68
404_S408_S0.6250.68
400_T410_D0.6250.68
17_D24_K0.6230.68
160_V205_Y0.6210.68
16_K72_K0.6210.68
186_F200_R0.6180.67
71_I81_K0.6150.67
94_S101_A0.6140.67
63_V66_I0.6140.67
96_E99_R0.6140.67
116_D158_A0.6130.67
127_T182_V0.6110.66
51_S65_E0.6090.66
158_A188_G0.6070.66
227_G258_A0.6060.66
103_S113_R0.6060.66
148_P172_I0.6040.66
124_R143_G0.6030.65
318_I338_N0.6010.65
20_L281_L0.6010.65
397_E435_L0.6000.65
319_V349_T0.6000.65
352_Q415_S0.5990.65
69_R72_K0.5980.65
329_T338_N0.5970.65
10_S223_T0.5960.65
124_R187_I0.5950.64
228_I245_L0.5940.64
386_V425_F0.5940.64
336_G382_D0.5930.64
343_S417_G0.5930.64
378_I439_L0.5910.64
160_V247_L0.5900.64
21_I267_D0.5900.64
165_S213_L0.5890.64
394_K420_N0.5890.64
254_S383_I0.5880.63
129_L181_I0.5880.63
309_K355_V0.5870.63
89_D95_D0.5870.63
393_I399_S0.5870.63
198_L202_G0.5860.63
321_K324_S0.5860.63
304_L384_N0.5850.63
306_D432_G0.5850.63
223_T301_G0.5840.63
178_A358_L0.5830.63
325_A416_R0.5820.63
104_I110_V0.5820.63
168_E172_I0.5820.63
265_T399_S0.5810.63
110_V114_V0.5800.62
70_H219_V0.5790.62
116_D155_Y0.5790.62
29_S180_V0.5780.62
307_N358_L0.5780.62
360_A381_N0.5780.62
261_L266_F0.5770.62
311_I332_A0.5760.62
315_S349_T0.5760.62
394_K400_T0.5750.62
5_V10_S0.5750.62
412_L416_R0.5740.62
221_L224_E0.5740.62
198_L258_A0.5730.62
8_G11_I0.5730.62
369_E372_G0.5720.61
253_L436_A0.5710.61
363_L367_L0.5700.61
149_F169_I0.5700.61
347_S422_S0.5700.61
103_S107_L0.5700.61
205_Y256_L0.5700.61
135_R365_S0.5680.61
40_S46_T0.5680.61
139_I182_V0.5680.61
370_I375_V0.5680.61
228_I260_R0.5670.61
146_T198_L0.5670.61
5_V220_R0.5660.61
96_E117_Y0.5650.60
125_M128_L0.5650.60
324_S346_A0.5620.60
63_V95_D0.5600.60
68_E210_L0.5600.60
314_E349_T0.5600.60
44_N69_R0.5600.60
258_A261_L0.5590.60
11_I24_K0.5590.60
51_S57_D0.5590.60
4_I214_V0.5570.59
340_I346_A0.5570.59
320_G323_G0.5560.59
10_S282_Y0.5560.59
124_R147_P0.5550.59
215_G273_D0.5540.59
227_G232_D0.5530.59
26_Q75_S0.5520.59
147_P150_L0.5510.59
312_T379_E0.5500.58
236_F437_K0.5500.58
74_L78_A0.5500.58
401_K404_S0.5490.58
152_D157_E0.5480.58
327_R330_N0.5480.58
322_I338_N0.5480.58
197_T202_G0.5480.58
266_F356_D0.5480.58
409_Y413_A0.5480.58
399_S414_I0.5470.58
329_T340_I0.5470.58
212_K272_S0.5460.58
70_H201_G0.5450.58
309_K363_L0.5450.58
382_D430_D0.5450.58
48_E94_S0.5450.58
329_T341_S0.5450.58
317_K376_K0.5430.57
16_K19_E0.5420.57
6_K11_I0.5410.57
299_L439_L0.5390.57
323_G422_S0.5370.57
405_I414_I0.5360.56
111_T211_G0.5360.56
80_G92_R0.5350.56
343_S347_S0.5350.56
63_V101_A0.5350.56
263_P348_E0.5350.56
148_P285_G0.5340.56
251_I254_S0.5340.56
56_T108_D0.5340.56
261_L289_I0.5330.56
362_R372_G0.5330.56
205_Y265_T0.5330.56
142_E172_I0.5320.56
156_G435_L0.5310.56
409_Y431_E0.5290.55
71_I90_I0.5290.55
199_G227_G0.5280.55
318_I349_T0.5280.55
3_L220_R0.5270.55
75_S91_S0.5260.55
311_I364_L0.5260.55
133_I136_S0.5250.55
115_R156_G0.5250.55
18_Y133_I0.5250.55
256_L343_S0.5240.55
401_K438_E0.5240.55
19_E77_L0.5230.55
273_D372_G0.5220.55
206_T219_V0.5220.55
10_S201_G0.5210.54
161_I165_S0.5210.54
70_H278_V0.5200.54
293_C365_S0.5200.54
262_H268_P0.5200.54
19_E23_K0.5170.54
229_M241_T0.5170.54
124_R145_I0.5150.54
90_I93_L0.5150.54
250_A347_S0.5150.54
62_I74_L0.5140.53
72_K95_D0.5140.53
394_K444_V0.5120.53
228_I409_Y0.5090.53
312_T347_S0.5090.53
25_I67_Y0.5090.53
116_D199_G0.5090.53
311_I366_K0.5070.52
149_F213_L0.5070.52
107_L111_T0.5070.52
146_T202_G0.5060.52
352_Q413_A0.5060.52
62_I66_I0.5060.52
52_A62_I0.5060.52
37_V180_V0.5040.52
325_A349_T0.5040.52
340_I385_I0.5040.52
51_S58_N0.5040.52
21_I24_K0.5020.52
311_I363_L0.5020.52
333_K369_E0.5020.52
332_A363_L0.5020.52
66_I89_D0.5020.52
243_S316_T0.5010.52
93_L125_M0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.9641 100 0.249 Contact Map
2cdqA 2 0.9709 100 0.266 Contact Map
3c1mA 3 0.9933 100 0.276 Contact Map
3tviA 2 0.935 100 0.315 Contact Map
3l76A 2 0.8565 100 0.37 Contact Map
3ab4A 7 0.8274 100 0.372 Contact Map
4ab7A 3 0.7601 100 0.694 Contact Map
2j4jA 5 0.4619 100 0.747 Contact Map
2a1fA 5 0.4776 100 0.758 Contact Map
2ij9A 3 0.4507 100 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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