GREMLIN Database
Q97ZL6 - Threonine synthase
UniProt: Q97ZL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (307)
Sequences: 13663 (7365)
Seq/√Len: 420.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A136_S4.1131.00
79_N352_K3.4201.00
205_I354_V3.3041.00
142_K164_D3.2401.00
311_E340_K3.0751.00
173_A176_R2.9781.00
72_R79_N2.9221.00
214_N248_I2.7981.00
246_R303_T2.7691.00
147_L151_A2.4991.00
253_E308_S2.4911.00
104_S193_W2.4891.00
135_K159_V2.4321.00
215_V232_F2.4261.00
176_R180_D2.3931.00
139_V177_L2.3711.00
259_V263_I2.3621.00
67_N208_E2.3621.00
137_F159_V2.3591.00
256_S260_T2.3261.00
308_S311_E2.2191.00
348_D351_E2.1241.00
318_T339_I2.1221.00
242_N245_P2.0961.00
137_F161_L2.0791.00
229_W300_S2.0641.00
318_T322_K2.0041.00
250_I337_G1.9981.00
112_T115_A1.9871.00
72_R81_Y1.9571.00
112_T137_F1.9531.00
334_A355_L1.9521.00
70_L354_V1.9421.00
81_Y209_L1.9231.00
319_L327_A1.9021.00
72_R77_N1.8691.00
81_Y352_K1.8431.00
213_D351_E1.8361.00
202_A228_I1.8301.00
106_V109_N1.8051.00
215_V228_I1.7701.00
216_I250_I1.7371.00
282_I333_A1.7291.00
279_A312_I1.7121.00
305_I337_G1.6981.00
90_T127_A1.6861.00
228_I356_I1.6851.00
213_D352_K1.6811.00
67_N207_E1.6721.00
199_K203_F1.6611.00
317_K321_R1.6611.00
212_P354_V1.6401.00
295_K299_E1.6051.00
191_N194_R1.5991.00
256_S306_A1.5981.00
112_T135_K1.5851.00
248_I303_T1.5851.00
214_N353_T1.5671.00
101_A191_N1.5591.00
271_F286_K1.5281.00
233_N302_G1.5051.00
225_I301_N1.4891.00
214_N246_R1.4741.00
216_I341_A1.4661.00
327_A357_L1.4521.00
260_T263_I1.4381.00
209_L354_V1.4281.00
202_A231_G1.4271.00
74_S78_D1.4071.00
216_I338_Y1.4071.00
202_A232_F1.4031.00
214_N351_E1.3941.00
102_V113_V1.3791.00
336_A340_K1.3711.00
115_A138_I1.3681.00
150_L162_E1.3681.00
166_S169_V1.3681.00
278_V313_L1.3431.00
171_M175_M1.3311.00
117_S122_A1.3311.00
315_A336_A1.3291.00
150_L154_I1.3291.00
173_A177_L1.3271.00
175_M179_K1.3151.00
140_L153_S1.3051.00
102_V132_A1.3001.00
260_T264_K1.2911.00
122_A153_S1.2901.00
319_L335_L1.2861.00
206_A235_L1.2821.00
320_A326_G1.2821.00
229_W247_M1.2681.00
71_I84_F1.2631.00
315_A335_L1.2621.00
225_I249_G1.2571.00
70_L209_L1.2551.00
310_S314_D1.2551.00
254_G309_D1.2541.00
259_V306_A1.2421.00
313_L371_A1.2401.00
277_T283_R1.2381.00
151_A154_I1.2271.00
106_V134_I1.2261.00
64_N99_T1.2241.00
176_R179_K1.2231.00
347_V351_E1.2201.00
80_L338_Y1.2201.00
196_E199_K1.2171.00
307_V336_A1.2151.00
248_I305_I1.2101.00
60_I100_V1.2041.00
174_V178_Y1.1911.00
212_P245_P1.1861.00
246_R351_E1.1831.00
75_N78_D1.1781.00
219_V249_G1.1771.00
256_S259_V1.1741.00
177_L181_L1.1741.00
314_D318_T1.1711.00
331_S357_L1.1681.00
70_L205_I1.1641.00
190_F226_Y1.1451.00
203_F231_G1.1401.00
154_I159_V1.1351.00
249_G304_A1.1221.00
172_D176_R1.1191.00
209_L212_P1.1151.00
338_Y355_L1.1091.00
266_K270_D1.0961.00
211_V352_K1.0891.00
73_S82_F1.0891.00
68_T88_N1.0851.00
331_S358_T1.0841.00
140_L162_E1.0841.00
316_Q332_A1.0821.00
265_G298_R1.0821.00
257_P260_T1.0741.00
317_K372_E1.0731.00
130_A136_S1.0701.00
167_F170_A1.0651.00
297_I301_N1.0621.00
258_I287_P1.0591.00
250_I305_I1.0571.00
209_L352_K1.0561.00
75_N322_K1.0481.00
169_V172_D1.0471.00
282_I330_A1.0441.00
252_A282_I1.0401.00
105_A109_N1.0401.00
175_M178_Y1.0391.00
305_I340_K1.0381.00
366_D370_K1.0281.00
258_I297_I1.0231.00
219_V304_A1.0221.00
312_I333_A1.0201.00
190_F291_Q1.0171.00
315_A339_I1.0161.00
264_K270_D1.0131.00
82_F357_L1.0081.00
311_E314_D1.0061.00
295_K298_R1.0041.00
216_I248_I1.0011.00
167_F171_M1.0011.00
206_A232_F0.9931.00
219_V258_I0.9871.00
217_V228_I0.9851.00
316_Q368_M0.9851.00
327_A332_A0.9851.00
205_I212_P0.9831.00
139_V173_A0.9771.00
147_L150_L0.9741.00
201_I228_I0.9741.00
230_K234_E0.9731.00
59_N62_S0.9711.00
165_G169_V0.9681.00
262_I304_A0.9631.00
59_N63_I0.9621.00
232_F245_P0.9601.00
259_V304_A0.9581.00
127_A156_Y0.9511.00
201_I224_N0.9501.00
225_I297_I0.9491.00
125_A138_I0.9481.00
143_G146_A0.9461.00
60_I103_S0.9451.00
266_K269_P0.9451.00
125_A136_S0.9421.00
216_I337_G0.9411.00
253_E306_A0.9411.00
153_S158_S0.9381.00
367_S370_K0.9371.00
65_E88_N0.9361.00
127_A131_R0.9331.00
142_K162_E0.9301.00
201_I356_I0.9291.00
214_N347_V0.9281.00
316_Q362_L0.9251.00
168_D172_D0.9251.00
99_T103_S0.9251.00
114_I174_V0.9231.00
187_L190_F0.9211.00
69_P87_L0.9201.00
137_F183_V0.9161.00
205_I228_I0.9131.00
58_K62_S0.9121.00
172_D175_M0.9101.00
335_L355_L0.9091.00
195_L230_K0.9071.00
292_K295_K0.9051.00
79_N350_D0.9051.00
192_P292_K0.9041.00
258_I304_A0.9021.00
260_T270_D0.9021.00
116_A167_F0.8891.00
150_L160_I0.8851.00
84_F357_L0.8851.00
367_S371_A0.8851.00
246_R302_G0.8841.00
76_I335_L0.8791.00
195_L296_A0.8771.00
263_I303_T0.8741.00
254_G275_P0.8731.00
187_L191_N0.8731.00
278_V309_D0.8731.00
114_I177_L0.8711.00
112_T183_V0.8541.00
311_E336_A0.8531.00
142_K168_D0.8521.00
101_A186_P0.8471.00
228_I247_M0.8411.00
145_V280_T0.8411.00
126_A158_S0.8391.00
104_S108_L0.8381.00
75_N323_E0.8371.00
196_E230_K0.8341.00
226_Y293_A0.8301.00
82_F319_L0.8301.00
123_A153_S0.8271.00
219_V225_I0.8261.00
286_K291_Q0.8251.00
338_Y353_T0.8241.00
151_A155_L0.8211.00
163_V173_A0.8171.00
103_S132_A0.8161.00
340_K343_N0.8121.00
130_A156_Y0.8111.00
65_E95_D0.8111.00
113_V134_I0.8051.00
343_N347_V0.8041.00
86_G325_I0.7971.00
84_F87_L0.7851.00
341_A346_V0.7851.00
66_G89_P0.7841.00
337_G341_A0.7841.00
114_I183_V0.7801.00
98_M124_S0.7761.00
251_Q257_P0.7731.00
313_L329_P0.7691.00
303_T346_V0.7691.00
203_F207_E0.7641.00
215_V354_V0.7551.00
254_G276_D0.7551.00
246_R346_V0.7541.00
159_V181_L0.7511.00
83_K204_E0.7501.00
296_A300_S0.7481.00
205_I356_I0.7471.00
113_V129_A0.7471.00
294_M298_R0.7461.00
106_V132_A0.7451.00
80_L355_L0.7431.00
98_M128_Y0.7411.00
145_V162_E0.7411.00
347_V350_D0.7411.00
57_Y61_V0.7381.00
100_V104_S0.7371.00
139_V163_V0.7341.00
327_A331_S0.7331.00
199_K230_K0.7331.00
95_D127_A0.7321.00
73_S323_E0.7321.00
135_K183_V0.7281.00
264_K269_P0.7261.00
211_V245_P0.7251.00
319_L357_L0.7211.00
217_V225_I0.7191.00
204_E208_E0.7191.00
106_V110_Y0.7191.00
255_A266_K0.7191.00
281_A330_A0.7181.00
101_A194_R0.7151.00
291_Q295_K0.7131.00
154_I162_E0.7101.00
218_P358_T0.7091.00
58_K207_E0.7071.00
90_T95_D0.7031.00
195_L292_K0.7011.00
343_N346_V0.7011.00
142_K165_G0.7001.00
307_V337_G0.6991.00
177_L180_D0.6961.00
58_K203_F0.6931.00
291_Q294_M0.6931.00
293_A304_A0.6921.00
101_A193_W0.6911.00
231_G235_L0.6891.00
320_A368_M0.6871.00
100_V103_S0.6831.00
369_T373_A0.6831.00
139_V180_D0.6831.00
56_R59_N0.6811.00
207_E235_L0.6791.00
310_S313_L0.6791.00
65_E68_T0.6781.00
174_V185_Y0.6771.00
261_A264_K0.6761.00
203_F234_E0.6741.00
233_N299_E0.6731.00
127_A130_A0.6701.00
139_V161_L0.6670.99
70_L81_Y0.6670.99
118_T281_A0.6560.99
161_L173_A0.6530.99
149_K280_T0.6490.99
341_A347_V0.6480.99
251_Q259_V0.6480.99
366_D369_T0.6470.99
215_V247_M0.6420.99
139_V170_A0.6410.99
235_L243_T0.6400.99
171_M174_V0.6350.99
102_V134_I0.6330.99
62_S65_E0.6320.99
233_N244_I0.6320.99
308_S340_K0.6300.99
77_N80_L0.6300.99
201_I205_I0.6290.99
203_F235_L0.6280.99
111_K135_K0.6280.99
103_S107_S0.6270.99
342_I347_V0.6260.99
74_S77_N0.6240.99
235_L242_N0.6230.99
257_P287_P0.6230.99
73_S77_N0.6210.99
270_D273_E0.6190.99
136_S158_S0.6170.99
177_L183_V0.6140.99
101_A104_S0.6120.99
95_D131_R0.6110.99
226_Y230_K0.6110.99
130_A158_S0.6100.99
205_I215_V0.6100.99
174_V177_L0.6100.99
313_L370_K0.6090.99
193_W196_E0.6070.99
104_S107_S0.6040.99
114_I178_Y0.6040.99
56_R60_I0.6040.99
84_F325_I0.6020.99
186_P190_F0.6020.99
251_Q287_P0.6010.99
73_S76_I0.6000.99
105_A184_V0.5950.99
167_F188_N0.5950.99
123_A152_Q0.5940.99
218_P334_A0.5930.99
213_D350_D0.5930.99
107_S111_K0.5920.99
206_A231_G0.5900.99
211_V244_I0.5890.99
62_S67_N0.5880.99
206_A242_N0.5860.99
116_A171_M0.5860.99
248_I337_G0.5820.99
64_N103_S0.5810.99
68_T83_K0.5810.99
76_I80_L0.5800.99
335_L357_L0.5800.99
185_Y189_S0.5800.99
102_V125_A0.5780.99
102_V128_Y0.5780.99
163_V170_A0.5770.99
216_I353_T0.5760.99
199_K231_G0.5750.99
76_I318_T0.5750.99
265_G269_P0.5740.98
191_N195_L0.5730.98
233_N247_M0.5730.98
214_N341_A0.5720.98
206_A211_V0.5710.98
164_D169_V0.5680.98
307_V312_I0.5670.98
86_G357_L0.5670.98
250_I307_V0.5660.98
137_F181_L0.5650.98
121_T198_Q0.5640.98
116_A174_V0.5600.98
65_E99_T0.5600.98
327_A335_L0.5600.98
257_P261_A0.5580.98
107_S110_Y0.5560.98
261_A287_P0.5550.98
231_G234_E0.5540.98
61_V65_E0.5530.98
122_A138_I0.5530.98
152_Q155_L0.5530.98
339_I343_N0.5520.98
217_V224_N0.5520.98
66_G88_N0.5520.98
98_M125_A0.5510.98
261_A294_M0.5500.98
309_D312_I0.5490.98
187_L194_R0.5480.98
102_V186_P0.5480.98
170_A174_V0.5470.98
228_I232_F0.5450.98
337_G340_K0.5440.98
186_P189_S0.5370.98
215_V356_I0.5370.98
297_I304_A0.5370.98
205_I232_F0.5340.98
216_I355_L0.5340.98
148_G365_P0.5340.98
151_A369_T0.5330.98
316_Q329_P0.5330.98
57_Y60_I0.5320.98
232_F235_L0.5310.98
125_A186_P0.5300.97
220_G281_A0.5300.97
82_F325_I0.5290.97
140_L150_L0.5290.97
314_D321_R0.5270.97
313_L317_K0.5270.97
116_A185_Y0.5270.97
307_V333_A0.5230.97
303_T341_A0.5220.97
138_I153_S0.5220.97
194_R198_Q0.5200.97
213_D354_V0.5200.97
114_I139_V0.5200.97
198_Q223_G0.5170.97
137_F177_L0.5130.97
147_L154_I0.5120.97
255_A275_P0.5120.97
312_I332_A0.5100.97
93_F224_N0.5100.97
185_Y188_N0.5090.97
115_A125_A0.5090.97
82_F335_L0.5080.97
61_V64_N0.5070.97
109_N112_T0.5070.97
80_L342_I0.5060.97
189_S223_G0.5050.97
168_D171_M0.5040.97
167_F174_V0.5040.97
330_A333_A0.5020.97
269_P273_E0.5010.96
192_P196_E0.5000.96
250_I306_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5xA 2 0.9394 100 0.193 Contact Map
2zsjA 2 0.8636 100 0.285 Contact Map
3aeyA 2 0.8636 100 0.286 Contact Map
2d1fA 2 0.8636 100 0.288 Contact Map
1tdjA 2 0.8662 100 0.289 Contact Map
3ss7X 1 0.9293 100 0.299 Contact Map
2gn0A 2 0.8182 100 0.322 Contact Map
1v71A 2 0.7904 100 0.326 Contact Map
2rkbA 2 0.7753 100 0.334 Contact Map
4h27A 1 0.7727 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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